Xanthomicrol is a monoamine oxidase (MAO) inhibitor derived from the resin of the Chinese bellflower (Scrophulariaceae family). It exhibits significant anti-inflammatory and anti-tumor activities, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells, respectively. Xanthomicrol has been shown to reduce both iNOS protein and mRNA levels, as well as COX-2 protein levels. Additionally, it diminishes the production of the pro-inflammatory cytokine IL-1β and upregulates the antioxidant enzyme HO-1, making it a valuable tool for research in inflammatory and cancer-related studies.
Xanthomicrol is a monoamine oxidase (MAO) inhibitor derived from the resin of the Chinese bellflower (Scrophulariaceae family). It exhibits significant anti-inflammatory and anti-tumor activities, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells, respectively. Xanthomicrol has been shown to reduce both iNOS protein and mRNA levels, as well as COX-2 protein levels. Additionally, it diminishes the production of the pro-inflammatory cytokine IL-1β and upregulates the antioxidant enzyme HO-1, making it a valuable tool for research in inflammatory and cancer-related studies.
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