2-Chlorohexadecanoic acid is an inflammatory lipid mediator that interferes with protein palmitoylation, thereby inducing ER-stress markers and reducing ER ATP content. This compound activates the transcription and secretion of pro-inflammatory cytokines, such as IL-6 and IL-8. Additionally, 2-Chlorohexadecanoic acid disrupts mitochondrial membrane potential, leading to the cleavage of procaspase-3 and PARP. Notably, it can cross the blood-brain barrier, impacting ER and mitochondrial functions in human brain endothelial cells.
2-Chlorohexadecanoic acid is an inflammatory lipid mediator that interferes with protein palmitoylation, thereby inducing ER-stress markers and reducing ER ATP content. This compound activates the transcription and secretion of pro-inflammatory cytokines, such as IL-6 and IL-8. Additionally, 2-Chlorohexadecanoic acid disrupts mitochondrial membrane potential, leading to the cleavage of procaspase-3 and PARP. Notably, it can cross the blood-brain barrier, impacting ER and mitochondrial functions in human brain endothelial cells.
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