Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Apixaban-13C,d3 is a stable isotope-labeled derivative of Apixaban, a potent and selective reversible inhibitor of Factor Xa, exhibiting Ki values of 0.08 nM and 0.17 nM in human and rabbit models, respectively. This high specificity makes Apixaban ideal for investigating anticoagulant mechanisms and studying related pharmacological effects. Researchers can utilize Apixaban-13C,d3 for quantitative analysis in pharmacokinetic studies, metabolic profiling, and isotopic tracing in biochemical assays. -
Stable Isotope
Betrixaban-d4 is a stable isotope-labeled form of Betrixaban, a highly potent and selective inhibitor of factor Xa (fXa) with an IC50 of 1.5 nM. This deuterium-labeled variant enables precise tracking and analysis in pharmacokinetic studies. Betrixaban is utilized for its antithrombotic properties in various research applications related to coagulation and cardiovascular health. -
Stable Isotope
Asundexian-d3 is a deuterium-labeled derivative of Asundexian, an orally active inhibitor of coagulation factor XIa (FXIa). It binds directly and reversibly to the active site of FXIa, effectively inhibiting its activity with an IC50 of 1 nM in human assays. This reagent is valuable for studies aimed at understanding blood coagulation mechanisms and evaluating FXIa's role in thrombosis and related disorders. -
Stable Isotope
Succinyladenosine-13C4 is a stable isotope labeled form of succinyladenosine, which serves as a vital metabolic byproduct derived from the dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase. This compound functions as a biochemical marker for assessing adenylosuccinase (ASL) deficiency. Succinyladenosine-13C4 is instrumental in metabolic studies, enabling researchers to investigate the role of nucleotide metabolism in various physiological and pathological contexts. -
Stable Isotope
Galactose 1-phosphate-13C-1 potassium is a stable isotope-labeled form of galactose 1-phosphate. This compound serves as an important intermediate in galactose metabolism and nucleotide sugar biosynthesis. It is widely used in metabolic studies and tracer experiments to investigate carbohydrate metabolism and cellular functions. Researchers can utilize this reagent for precise analytical applications, enhancing the understanding of galactose-related metabolic pathways. -
Stable Isotope
D-(+)-Trehalose-d2 is a deuterium-labeled form of D-(+)-Trehalose, a naturally occurring disaccharide derived from Saccharomyces cerevisiae. It serves as a stable isotope marker, making it valuable in metabolic studies, labeling experiments, and pharmaceutical formulations. Its unique isotopic signature allows for enhanced tracking and analysis of biological processes involving trehalose metabolism and function. -
Stable Isotope
Ac-Ala-OH-d3 is a deuterium-labeled derivative of Ac-Ala-OH, which serves as an endogenous metabolite. This stable isotope is utilized in metabolic studies and labeling experiments to elucidate metabolic pathways and enzymatic processes. Its incorporation into biochemical assays allows for enhanced tracking and quantification of metabolic activity. -
Stable Isotope
D-Sorbitol-d2-1 is a deuterium-labeled derivative of D-Sorbitol, a six-carbon sugar alcohol. This stable isotope is utilized as a tracer in metabolic studies and analytical applications. D-Sorbitol serves various roles in research, including as a sugar substitute, stabilizing excipient, and humectant, making it valuable in biochemical and pharmaceutical contexts. -
Stable Isotope
2,3-Butanediol-d6 is a stable isotope-labeled form of 2,3-Butanediol, a microbial-derived compound. This reagent serves as a specific urinary biomarker for Fmo5-/- mice and has been shown to inhibit age-related increases in plasma cholesterol levels. Its applications extend to various industries, including the formulation of printing inks, perfumes, fumigants, moistening and softening agents, plasticizers, and as a pharmaceutical carrier. -
Stable Isotope
L-(-)-Sorbose-13C-1 is a stable isotope labeled form of L-(-)-Sorbose, a natural sugar alcohol and an important metabolite in various biochemical pathways. As a stable isotope, it serves as a valuable tool for metabolic studies, tracer experiments, and isotope labeling in analytical chemistry. Its unique labeling provides insights into metabolic processes and enables precise tracking of metabolic flux in various biological systems. -
Stable Isotope
LacCer (d18:1/16:0)-d3 is a deuterium-labeled form of LacCer (d18:1/16:0), a bioactive sphingolipid involved in forming membrane microdomains with Lyn kinase and αi subunits of inhibitory G protein-coupled receptors (GPCRs). This compound is particularly relevant in studies of metabolic disorders, as elevated levels are found in the plasma of insulin-resistant cattle, and it is upregulated in models of Niemann-Pick type C1 disease, a neurodegenerative lysosomal storage disorder. LacCer (d18:1/16:0)-d3 serves as a valuable tool for elucidating the role of sphingolipids in various biological processes and disease pathways. -
Stable Isotope
H-Tyr(3-I)-OH-13C6 is a stable isotope-labeled form of H-Tyr(3-I)-OH, serving as a selective inhibitor of tyrosine hydroxylase. This compound plays a critical role as an intermediate in thyroid hormone synthesis and is relevant in studies of metabolic processes in human and mouse models. It is a valuable tool for researchers investigating neurotransmitter regulation and thyroid hormone metabolism. -
Stable Isotope
Trimethylammonium chloride-13C3,d9 is a stable isotope-labeled form of Trimethylammonium chloride, featuring deuterium and carbon-13 isotopes. This compound serves as an important endogenous metabolite, providing valuable insights into metabolic pathways and cellular processes. It is utilized in various research applications, including metabolic labeling and isotopic tracing studies, aiding in the understanding of biochemical dynamics and cellular metabolism. -
Stable Isotope
L-Thyroxine-13C6-1 is a stable isotope-labeled form of L-Thyroxine, also known as Levothyroxine or T4. This compound serves as a synthetic thyroid hormone and is widely utilized in research related to hypothyroidism. The stable isotope enrichment allows for enhanced tracking and analysis of its metabolic pathways, particularly in studies focused on the conversion of L-Thyroxine to the biologically active form, Triiodothyronine (T3), via deiodinase enzymes. -
Stable Isotope
18-Hydroxycorticosterone-d4 is the deuterium-labeled form of 18-Hydroxycorticosterone, a corticosteroid derived from corticosterone. This stable isotope serves as a valuable internal standard for quantitative analysis in various biological studies, particularly in endocrinology and metabolism research. It is utilized to investigate the metabolic pathways of corticosteroids and their impact on electrolyte balance. -
Stable Isotope
Propane-1,2,3-triyl tripalmitate-13C2 is a stable isotope-labeled form of Propane-1,2,3-triyl tripalmitate, an endogenous metabolite. This compound serves as an important tracer in metabolic studies, enabling researchers to investigate lipid metabolism and fatty acid synthesis pathways. Its stable carbon isotope labeling facilitates precise quantification and tracking in various biological systems. -
Stable Isotope
Trimethylammonium chloride-d10 is a deuterated form of Trimethylammonium chloride, which acts as a stable isotope. This compound serves as an endogenous metabolite and is utilized in various biochemical and metabolic studies. Its unique labeling allows for enhanced tracking and analysis in mass spectrometry and other analytical techniques, facilitating research in metabolic pathways and cellular processes. -
Stable Isotope
D-Mannose-13C-3 is a stable isotope-labeled form of D-Mannose, a pivotal carbohydrate involved in human metabolic processes. This compound is particularly important for studying glycosylation patterns of specific proteins, providing insights into cellular mechanisms and carbohydrate metabolism. D-Mannose-13C-3 serves as a valuable tool for research applications in glycomics and metabolic pathway analysis. -
Stable Isotope
Stearoylethanolamide-d3 is a deuterium-labeled analog of Stearoylethanolamide, which functions as an endocannabinoid-like compound. This stable isotope is utilized in research to investigate the biological pathways associated with apoptosis and the endocannabinoid system. Its pro-apoptotic activity makes it a valuable tool for studies focused on cancer biology and therapeutic applications. -
Stable Isotope
Propane-1,2,3-triyl tripalmitate-d27 is a deuterated stable isotope of Propane-1,2,3-triyl tripalmitate, a naturally occurring endogenous metabolite. This compound can be utilized in metabolic labeling studies to investigate lipid metabolism and the fate of fatty acids in biological systems. Its stable isotopic nature facilitates precise quantification and tracking in various experimental settings, making it suitable for applications in bioanalytical chemistry and metabolic research. -
Stable Isotope
Trimethylammonium chloride-15N is a stable isotope-labeled derivative of trimethylammonium chloride, primarily used as a tracer in metabolic studies. This reagent serves as an endogenous metabolite and is valuable for researching methylation processes, metabolic pathways, and cellular ion regulation. Its stable isotope label enables precise tracking and analysis in various biochemical assays, enhancing the understanding of metabolic functions and interactions in biological systems. -
Stable Isotope
N-Acetyl-D-glucosamine-13C-1 is a stable isotope-labeled form of N-Acetyl-D-glucosamine, a monosaccharide derivative of glucosamine. This compound is commonly used in metabolic studies, isotopic tracing, and in-depth biochemical research due to its ability to participate in glycosylation reactions. Its applications extend to cellular metabolism analysis and the study of glycan structures, providing valuable insights into carbohydrate biochemistry and cellular processes. -
Stable Isotope
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate-d54 is a deuterated derivative of the phospholipid compound, designed to serve as a stable isotope label. This reagent demonstrates enhanced stability and facilitates precise quantification in metabolic studies. It is particularly useful for tracing metabolic pathways and investigating lipid metabolism in various biological research applications. -
Stable Isotope
Muconic acid-d4 is a deuterated form of trans-trans-Muconic acid, serving as a stable isotope for analytical applications. This compound is a urinary metabolite of benzene and is recognized as a reliable biomarker for benzene exposure in humans. Its use in biological research facilitates the study of benzene metabolism and the assessment of environmental and occupational exposure levels. -
Stable Isotope
Lovastatin-d3 hydroxy acid sodium is a deuterium-labeled derivative of Lovastatin hydroxy acid sodium, a potent inhibitor of HMG-CoA reductase, with a Ki of 0.6 nM. This stable isotope is utilized in metabolic studies to investigate cholesterol biosynthesis and regulation. It serves as a valuable tool for researchers examining the pharmacokinetics and pharmacodynamics of statins in biochemical and clinical research applications. -
Stable Isotope
IDO-IN-7-d10 is a deuterium-labeled analogue of IDO-IN-7, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with an IC50 value of 38 nM. This stable isotope derivative is designed for use in metabolic studies and biomarker analysis, enhancing the understanding of IDO1-related pathways in cancer and immune response research. Its use in tracer studies allows for improved tracking of metabolic processes. -
Stable Isotope
(S)-Indoximod-d3 is a deuterium-labeled form of (S)-Indoximod, an inhibitor of indoleamine 2,3-dioxygenase (IDO). This stable isotope retains the biological activity of the parent compound, allowing for precise tracking and measurement in metabolic studies. (S)-Indoximod-d3 is primarily utilized in cancer research, particularly in studies exploring immune modulation and tumor microenvironment interactions. -
Stable Isotope
IDH1 Inhibitor 7-d2 is a deuterium-labeled derivative of IDH1 Inhibitor 7, targeting the isocitrate dehydrogenase 1 (IDH1) enzyme. It exhibits potent inhibitory activity with an IC50 of less than 100 nM. This stable isotope-labeled compound serves as a valuable tool for in vivo and in vitro studies aimed at investigating IDH1-related metabolic pathways and the development of targeted cancer therapies. -
Stable Isotope
Enasidenib-d6 is a deuterated analogue of Enasidenib, a potent, reversible inhibitor selectively targeting mutant IDH2 enzymes. It exhibits IC50 values of 100 nM for IDH2R140Q and 400 nM for IDH2R172K, demonstrating significant biological activity in modulating the pathways associated with these mutations. This stable isotope-labeled compound is useful in research applications such as metabolic studies, pharmacokinetic profiling, and elucidation of IDH2-related cellular mechanisms. -
Stable Isotope
Hexane-1,6-diol-d4 is a deuterated stable isotope form of Hexane-1,6-diol, a six-carbon straight-chain diol characterized by hydroxyl groups at each end. This reagent serves as a valuable additive in drilling fluids and is also utilized as a substrate in various life science research applications. Its stable isotope labeling facilitates the tracking of metabolic pathways and enhances the understanding of biochemical processes. -
Stable Isotope
DSPC-d70, or 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70, is a deuterium-labeled lipid that serves as a cylindrical-shaped phospholipid. It is primarily utilized in the formation of liposomes and acts as a key component in lipid nanoparticle (LNP) systems. DSPC-d70 is beneficial for studying lipid dynamics and membrane interactions, particularly in drug delivery and nanomedicine research applications. -
Stable Isotope
DSPC-d83 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83) is a deuterium-labeled derivative of DSPC, a cylindrical-shaped phospholipid. This reagent is crucial for the synthesis of liposomes and serves as a key lipid component in lipid nanoparticle (LNP) formulations. Its stable isotope labeling facilitates tracking and characterization in biological research, making it valuable for studies involving drug delivery and membrane dynamics. -
Stable Isotope
DSPC-d4 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d4) is a deuterium-labeled derivative of DSPC, a cylindrical-shaped phospholipid. This reagent is crucial for the synthesis of liposomes and functions as a key lipid component in lipid nanoparticle (LNP) formulations. DSPC-d4 is utilized in various biological applications, including drug delivery research and the study of membrane dynamics, contributing valuable insights into lipid biology and nanotechnology. -
Stable Isotope
Dantrolene-13C3 is a stable isotope-labeled analog of Dantrolene, a muscle relaxant that non-competitively inhibits human erythrocyte glutathione reductase, with Ki and IC50 values of 111.6 μM and 52.3 μM, respectively. As a ryanodine receptor antagonist, Dantrolene-13C3 plays a critical role in stabilizing Ca2+ signaling. This reagent is suitable for research applications related to muscle spasticity, malignant hyperthermia, Huntington's disease, and neuroleptic malignant syndrome. -
Stable Isotope
Migalastat hydrochloride-15N is a stable isotope-labeled form of Migalastat hydrochloride, an orally active molecular chaperone targeting α-galactosidase A. It exhibits a potent IC50 of 0.04 μM for human α-Gal A, facilitating the proper folding and lysosomal transport of certain unstable mutant forms of the enzyme. Upon dissociation in the acidic lysosomal environment, Migalastat promotes restoration of biological activity, making it valuable for research in lysosomal storage disorders and enzyme replacement therapies. -
Stable Isotope
Acarbose-d4 is a deuterium-labeled derivative of Acarbose, targeting alpha-glucosidases. This stable isotope maintains the biological activity of its parent compound, functioning as an antihyperglycemic agent with an IC50 of 11 nM. Acarbose-d4 is utilized in research to study glucose metabolism and the enhancement of hypoglycemic effects in combination therapies involving sulfonylureas or insulin. -
Stable Isotope
S-Sulfo-DL-cysteine-d3 is a stable isotope-labeled analog of S-Sulfo-DL-cysteine featuring deuterium at the 2, 3, and 3 positions. This compound is utilized in metabolic studies and isotopic tracing experiments, allowing for precise analysis of cysteine metabolism and biochemical pathways. Its deuterium labeling provides a valuable tool for researchers pursuing kinetic and mechanistic investigations in various biological systems. -
Stable Isotope
Decanoic acid-d3 is a deuterium-labeled derivative of decanoic acid, which serves as a stable isotope for research applications. As a component of medium-chain triglycerides, it is known for its ability to penetrate the blood-brain barrier and act as a non-competitive inhibitor of AMPA receptors. Its biological activity includes antiseizure effects, making it a valuable tool for studies related to neuropharmacology and epilepsy research. -
Stable Isotope
Glycine-2-13C,15N is a stable isotope-labeled form of glycine that incorporates both 13C and 15N isotopes. Glycine serves as an inhibitory neurotransmitter in the central nervous system and functions as a co-agonist with glutamate, enhancing excitatory signaling at NMDA receptors. This reagent is valuable for metabolic studies, tracing pathways of glycine metabolism, and investigating neurotransmitter dynamics in neurological research. -
Stable Isotope
Glycine-d3 is a deuterium-labeled form of glycine, an important inhibitory neurotransmitter in the central nervous system (CNS). It serves as a co-agonist with glutamate, enhancing excitatory signaling at NMDA receptors. Glycine-d3 is valuable for studying neurotransmission, metabolic pathways, and isotopic labeling in various biochemical and pharmacological research applications. -
Stable Isotope
Felbamate-d4 is a deuterated analog of Felbamate, functioning primarily as a stable isotope. It exhibits significant anticonvulsant activity, which is thought to result from its inhibition of N-methyl-D-aspartate (NMDA) receptors. This reagent is valuable in pharmacokinetic studies and metabolic labeling applications, facilitating detailed investigations into the drug's mechanisms and effects in neurological research. -
Stable Isotope
Quinolinic acid-13C3,15N is a stable isotope-labeled derivative of quinolinic acid, classified as 2,3-Pyridinedicarboxylic Acid-13C3,15N. This compound acts as an agonist for N-methyl-D-aspartate (NMDA) receptors and is produced through the metabolism of L-tryptophan via the kynurenine pathway. Quinolinic acid-13C3,15N is valuable for research investigating NMDA receptor-mediated neuronal damage and dysfunction, enabling the study of neurobiology and related disorders. -
Stable Isotope
Glycine-1-13C,15N is a stable isotope-labeled form of glycine, featuring carbon-13 and nitrogen-15 isotopes. Glycine functions as an inhibitory neurotransmitter in the central nervous system (CNS) and serves as a co-agonist with glutamate at the N-methyl-D-aspartic acid (NMDA) receptors, enhancing excitatory synaptic transmission. This labeled compound is essential for research in metabolic studies, neuropharmacology, and the evaluation of neurotransmitter dynamics in various biological processes. -
Stable Isotope
Glycine-15N,d2 is a stable isotope-labeled form of glycine, incorporating deuterium and nitrogen-15 isotopes. Glycine functions as an inhibitory neurotransmitter in the central nervous system and serves as a co-agonist with glutamate at NMDA receptors, promoting excitatory signaling. This isotopically enriched reagent is valuable for studies involving metabolic pathways, molecular labeling, and neurochemical research applications. -
Stable Isotope
CX516-d10 is a deuterated form of CX516, functioning as an ampakine and a positive allosteric modulator of AMPA receptors. This compound is significant for research into neurological disorders such as Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI), providing valuable insights into the modulation of cognitive functions and synaptic transmission. Its stable isotope labeling facilitates advanced studies in pharmacokinetics and metabolic profiling. -
Stable Isotope
Glycine-13C2,15N,d2 is a stable isotope-labeled form of Glycine, incorporating deuterium, carbon-13, and nitrogen-15. Glycine functions as an inhibitory neurotransmitter in the central nervous system while also acting as a co-agonist with glutamate at the NMDA receptors, enhancing excitatory signaling. This labeled compound is valuable for metabolic studies, tracer experiments, and isotopic labeling in various biochemical and neurobiological research applications. -
Stable Isotope
N,N-Dimethylglycine-d3 hydrochloride is a deuterium-labeled derivative of N,N-Dimethylglycine hydrochloride, primarily utilized as a stable isotope in research. This compound functions as a partial agonist at the N-methyl-D-aspartate receptor (NMDAR) glycine binding site, making it valuable for studies related to neurotransmission and receptor signaling. Additionally, N,N-Dimethylglycine-d3 has been shown to possess immunomodulatory properties and may aid in antioxidant defense by mitigating oxidative stress. Its applications extend to research in mental health and surfactant activity. -
Stable Isotope
Indole-2-carboxylic acid-13C is a stable isotope-labeled variant of Indole-2-carboxylic acid, which acts as a potent inhibitor of lipid peroxidation. It specifically and competitively inhibits the glycine-mediated potentiation of NMDA receptor-gated currents, making it a valuable tool for investigating excitatory neurotransmission and oxidative stress pathways. This compound is suitable for applications in pharmacological research and metabolic studies focusing on neuroprotection and lipid metabolism. -
Stable Isotope
Memantine-d3 hydrochloride is a deuterium-labeled analog of Memantine, a noncompetitive antagonist of the N-methyl-D-aspartate receptor (NMDAR). This stable isotope is utilized in research on moderate-to-severe Alzheimer's disease (AD), providing insights into the pharmacokinetics and action of Memantine in a biological context. Memantine's mechanism of action allows for the exploration of glutamatergic signaling pathways relevant to neurodegenerative diseases. -
Stable Isotope
Decanoic acid-d2 is a deuterium-labeled derivative of decanoic acid, a medium-chain triglyceride. It acts as a non-competitive inhibitor of the AMPA receptor, demonstrating notable antiseizure properties. This stable isotope is essential for research applications involving metabolic studies and neuropharmacology, particularly in understanding the mechanisms behind its anticonvulsant effects.
