Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Cytidine-13C9,15N3 is a stable isotope-labeled variant of cytidine, incorporating both carbon-13 and nitrogen-15 isotopes. As a pyrimidine nucleoside, cytidine plays a crucial role in RNA synthesis and acts as a precursor to uridine. This compound is essential for studies investigating neuronal-glial glutamate cycling, as well as its implications on cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function in various biological systems. -
Stable Isotope
Fingolimod-d4 is a stable isotope-labeled form of Fingolimod, a potent sphingosine 1-phosphate (S1P) antagonist. With an IC50 of 0.033 nM, it effectively modulates the activity of K562 and NK cells and serves as a Pak1 activator and immunosuppressant. This reagent is valuable for pharmacokinetic studies, metabolic research, and cellular signaling investigations. -
Stable Isotope
Fingolimod-d4 hydrochloride is a deuterium-labeled form of Fingolimod hydrochloride, a potent sphingosine 1-phosphate (S1P) receptor antagonist. It exhibits high affinity, with an IC50 of 0.033 nM in K562 and NK cells, and is known for its ability to penetrate the blood-brain barrier. This reagent is utilized in research exploring immunosuppressive pathways and the modulation of immune responses, as well as for studying the role of S1P in various biological systems. -
Stable Isotope
Milnacipran-d5 hydrochloride is a deuterated form of Milnacipran hydrochloride, a potent serotonin and norepinephrine reuptake inhibitor. It targets monoamine transporters, exhibiting Ki values of 31 nM for the norepinephrine transporter and 8.5 nM for the serotonin transporter. With notable antidepressant, anxiolytic, and analgesic properties, Milnacipran-d5 hydrochloride is valuable for research on major depressive disorder, anxiety disorders, and neuropathic pain conditions such as fibromyalgia. Additionally, it has been shown to affect behavior in preclinical models, providing insights into its pharmacological mechanisms. -
Stable Isotope
Milnacipran-d10 hydrochloride is a deuterium-labeled form of the serotonin and norepinephrine reuptake inhibitor, Milnacipran hydrochloride. It effectively inhibits monoamine transporters, targeting the norepinephrine and serotonin transporters with reported Ki values of 31 nM and 8.5 nM, respectively. This compound exhibits antidepressant, anxiolytic, and analgesic properties, and has demonstrated efficacy in reducing biting behavior in murine models. Milnacipran-d10 hydrochloride is valuable for research applications focused on major depressive disorder, anxiety disorders, and neuropathic pain syndromes, such as fibromyalgia. -
Stable Isotope
Nicotinamide-d4 is a deuterated form of Nicotinamide, a vital derivative of vitamin B3. This stable isotope is essential for studying NAD+ redox homeostasis and serves as a substrate for various enzymes involved in non-redox reactions. Additionally, Nicotinamide acts as an inhibitor of SIRT1, making Nicotinamide-d4 a valuable tool for investigating metabolic pathways and enzyme activities in cellular research. -
Stable Isotope
Nicotinamide-13C6 is a stable isotope-labeled form of Nicotinamide, also known as vitamin B3. This compound is crucial for maintaining NAD+ redox homeostasis and serves as a substrate for various enzymes involved in non-redox reactions. Additionally, Nicotinamide acts as an inhibitor of SIRT1, making it significant in research focusing on metabolic pathways, aging, and cellular stress responses. Its isotopic labeling allows for precise tracking in metabolic studies and applications in mass spectrometry. -
Stable Isotope
Nicotinamide-15N,13C3 is a stable isotope-labeled form of nicotinamide, featuring both 13C and 15N labels. As a critical derivative of vitamin B3, nicotinamide is integral to cellular physiology, supporting NAD+ redox homeostasis and serving as a substrate for various enzymes involved in non-redox reactions. Additionally, nicotinamide acts as an inhibitor of SIRT1, making it valuable in research applications focused on metabolic regulation and aging. -
Stable Isotope
Ilaprazole-d3 is a deuterium-labeled derivative of Ilaprazole, serving as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and metabolic profiling. It allows for the accurate quantification of Ilaprazole in biological samples, facilitating research applications in drug metabolism and pharmacodynamics. -
Stable Isotope
Belotecan-d7 hydrochloride is a deuterium-labeled derivative of Belotecan hydrochloride, a potent Topoisomerase I inhibitor. This stable isotope is utilized in pharmacokinetic studies and metabolic research, providing insights into the mechanism of action and therapeutic efficacy of camptothecin analogs. It is particularly valuable for tracing metabolic pathways and studying drug interactions in various biological systems. -
Stable Isotope
Mitoxantrone-d8 is a deuterium-labeled derivative of Mitoxantrone, a known inhibitor of topoisomerase II. This compound also shows inhibition of protein kinase C (PKC) with an IC50 value of 8.5 μM. Mitoxantrone-d8 is particularly useful in studies involving pharmacokinetics and drug metabolism, providing a stable isotope for quantitative analysis in research applications. -
Stable Isotope
RPR132595A-d3 is a deuterated form of RPR132595A, a prominent active metabolite of Irinotecan (CPT-11). This compound undergoes metabolism via cytochrome P-450 3A4 (CYP3A4) and is ultimately eliminated through the urine. RPR132595A-d3 serves as a valuable stable isotope for studies in drug metabolism and pharmacokinetics, enabling precise tracking and quantification of metabolic pathways involving Irinotecan. -
Stable Isotope
RPR121056-d3 is a deuterated analog of RPR121056, a metabolite of the anticancer drug Irinotecan. It primarily targets and inhibits topoisomerase type I, leading to apoptosis in cancer cells. RPR121056-d3 is utilized in research applications focused on understanding the metabolic pathways and pharmacokinetics of Irinotecan, particularly in the context of colorectal cancer therapy. Additionally, it may also provide insights into the inhibition of acetylcholinesterase (AChE). -
Stable Isotope
1-Hydroxypyrene-d9 is a deuterated form of 1-Hydroxypyrene, serving as a stable isotope used for analytical applications. It functions as a biomarker for exposure to polycyclic aromatic hydrocarbons (PAHs), particularly in urine samples. Additionally, 1-Hydroxypyrene serves as an agonist for the aryl hydrocarbon receptor (AhR), implicating its role in various biological pathways, including renal fibrosis. This compound is valuable for research focused on environmental health and toxicology. -
Stable Isotope
Doxifluridine-d2 is a deuterium-labeled analog of Doxifluridine, which functions as a thymidine phosphorylase activator. It exhibits a significant biological activity with an IC50 value of 0.62 μM in PC9-DPE2 cells. This stable isotope can be utilized in research applications involving metabolic studies and pharmacokinetic assessments, providing insights into the interactions and mechanisms of nucleoside metabolism. -
Stable Isotope
Uridine-d is a deuterium-labeled analog of uridine, designed for use in stable isotope labeling studies. It is utilized primarily in metabolic and biochemical research to trace nucleoside metabolism and RNA synthesis pathways. This reagent is invaluable for elucidating cellular processes and improving the understanding of nucleic acid function in various biological systems. -
Stable Isotope
Uridine-13C-1 is a stable isotope-labeled analog of uridine, serving as a valuable tool in metabolic research. Its incorporation into RNA and nucleotides allows for tracing metabolic pathways and studying nucleoside metabolism in various biological systems. This reagent is particularly useful in isotopic labeling experiments and for exploring cellular pathways involving RNA synthesis, turnover, and degradation. -
Stable Isotope
Cytidine-d is a deuterium-labeled derivative of cytidine, a pyrimidine nucleoside essential for RNA synthesis. This stable isotope allows for detailed metabolic tracing in biological systems, particularly in studies of RNA metabolism and neuronal-glial interactions. Cytidine-d is valuable for investigating glutamate cycling and its impact on cerebral phospholipid metabolism and catecholamine levels, making it a useful tool in neurobiological research. -
Stable Isotope
Uridine 13C-4 is a stable isotope-labeled form of uridine, featuring four carbon atoms in the 13C configuration. It serves as a vital tool for metabolic studies, allowing researchers to trace metabolic pathways and analyze nucleoside metabolism. Its applications extend to various fields, including cell biology, biochemistry, and pharmacokinetics, providing essential insight into cellular processes and nucleotide dynamics. -
Stable Isotope
N-6-Methyl-2-deoxyadenosine-d3 is a deuterated analogue of N-6-Methyl-2-deoxyadenosine, featuring enhanced stability for research applications. This stable isotope is utilized for studies involving nucleotide metabolism and epigenetics, providing insights into cellular processes that involve adenine nucleosides. Its unique labeling allows for precise tracking and analysis in various biochemical experiments. -
Stable Isotope
Uridine-d2 is a deuterium-labeled derivative of uridine, functioning as a stable isotope. This reagent serves as a valuable tool in metabolic studies and tracer experiments, facilitating the investigation of nucleotide metabolism and RNA synthesis pathways. Researchers can utilize Uridine-d2 to enhance the sensitivity of detection methods, such as mass spectrometry, in diverse biological assays. -
Stable Isotope
Uridine-13C-2 is a stable isotope-labeled form of uridine, utilized for metabolic tracing and studies in cellular metabolism. Its incorporation into nucleic acids allows for precise tracking of nucleotide turnover and cellular uptake in various biological systems. This reagent is essential for applications in metabolic flux analysis, isotopic labeling experiments, and understanding nucleotide metabolism in research contexts. -
Stable Isotope
5,6-Dihydro-5-Fluorouracil-13C,15N2 is a stable isotope-labeled derivative of 5,6-Dihydro-5-Fluorouracil, which acts as a thymidylate synthase inhibitor through its active metabolite formation from the prodrug 5-fluorouracil via dihydropyrimidine dehydrogenase. This compound demonstrates cytotoxic effects on HaCaT keratinocytes with an IC50 of 13.5 μM. Research applications include investigating tumor growth inhibition, particularly in combination with 5-fluorouracil and dihydropyrimidine dehydrogenase inhibitors, in oncological studies such as rat colon cancer models. -
Stable Isotope
7-Methylguanosine 5'-Monophosphate-d3 is a deuterated form of 7-Methylguanosine 5'-monophosphate, serving as a stable isotope labeled nucleotide. This compound is an important building block for nucleic acids, aiding in the study of RNA synthesis and modification. Its unique isotopic labeling allows for advanced applications in metabolomics and isotopic tracing studies in biochemical research. -
Stable Isotope
N6-Threonylcarbamoyladenosine-13C4,15N is a stable isotope-labeled derivative of N6-Threonylcarbamoyladenosine. This compound acts as a nucleoside that plays a critical role in the modification of tRNA molecules. Its unique isotopic labeling makes it valuable for biological studies, particularly in metabolic tracking and analytical research involving nucleoside metabolism and modification processes. -
Stable Isotope
Uridine-13C,15N2 is a stable isotope-labeled form of uridine, incorporating both carbon-13 and nitrogen-15 isotopes. This compound is particularly valuable in metabolic studies, enabling researchers to trace nucleotide metabolism and investigate cellular processes involving RNA synthesis. Its application in stable isotope labeling techniques aids in elucidating metabolic pathways and biochemical interactions in various organisms. -
Stable Isotope
Cytidine-1',2',3',4',5'-13C5 is a stable isotope-labeled form of cytidine, a pyrimidine nucleoside integral to RNA structure. As a precursor of uridine, it plays a key role in various biological processes, including neuronal-glial glutamate cycling, cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function. This reagent is valuable for metabolic studies and isotopic tracing in cellular and molecular biology research. -
Stable Isotope
Tegafur-13C,15N2 is a stable isotope-labeled form of Tegafur, a chemotherapeutic prodrug of 5-fluorouracil (5-FU). This compound is utilized in cancer therapy and forms part of the tegafur-uracil combination. Its stable isotopic labels enable precise metabolic studies and pharmacokinetic research, making it a valuable tool for understanding the mechanisms of drug action and metabolism in cancer treatments. -
Stable Isotope
Uridine-13C-3 is a stable isotope-labeled form of uridine, featuring three carbon atoms labeled with the carbon-13 isotope. This reagent is primarily used in metabolic studies and tracer experiments to investigate nucleoside metabolism and cellular processes. It facilitates research in areas such as RNA synthesis and nucleotide metabolism, providing insights into cellular dynamics and biochemical pathways. -
Stable Isotope
Cytidine-13C-1 is a stable isotope-labeled form of cytidine, a pyrimidine nucleoside integral to RNA structure. As a precursor to uridine, it plays a critical role in nucleic acid metabolism. This isotope-labeled reagent is utilized in metabolic studies to investigate neuronal and glial glutamate cycling and its impact on cerebral phospholipid metabolism and catecholamine biosynthesis. -
Stable Isotope
DL-Alanosine-15N2 is a stable isotope-labeled form of DL-Alanosine, an amino acid analogue known for its antitumor properties. This compound serves as a valuable tool in biological research, enabling the study of metabolic pathways and tumor biology through isotopic incorporation techniques. Its unique labeling provides insight into amino acid metabolism, making it suitable for applications in cancer research and biomolecular tracking. -
Stable Isotope
Cytidine-d2-1 is a deuterium-labeled pyrimidine nucleoside that serves as a stable isotope. This compound plays a crucial role as a building block of RNA and is a precursor to uridine. Its unique isotopic composition makes it valuable for tracing studies in metabolic pathways and investigating neuronal-glial glutamate cycling, impacting cerebral phospholipid metabolism and neurotransmitter dynamics in various research applications. -
Stable Isotope
Trifluralin-d14 is a deuterated form of the herbicide Trifluralin, which functions as a selective preemergence soil-applied herbicide. It effectively controls various annual grass and broadleaf weeds by inhibiting root development through disruption of mitosis, primarily targeting tubulin to hinder spindle apparatus and cell plate formation. This compound is useful in research applications focused on herbicidal mechanisms, plant development studies, and the assessment of neurotoxic and hematotoxic effects associated with Trifluralin. -
Stable Isotope
Orotic acid-13C,15N2 monohydrate is a stable isotope-labeled compound that serves as a precursor in the biosynthesis of pyrimidine nucleotides and RNA. As a key intermediate, it is released from mitochondrial dihydroorotate dehydrogenase (DHODH) and subsequently converted to UMP by cytoplasmic UMP synthase. This compound is utilized in research focusing on metabolic pathways, particularly in studies of urea cycle disorders and hepatic function, as it can induce hepatic steatosis and hepatomegaly in animal models. -
Stable Isotope
Uridine-13C is a stable isotope-labeled form of uridine, enriched with carbon-13. This reagent is utilized predominantly in metabolic studies and tracer experiments, helping to elucidate pathways in nucleic acid metabolism. Its unique isotopic labeling allows researchers to track uridine utilization and distribution in biological systems, facilitating insights into cellular processes and disease mechanisms. -
Stable Isotope
Uridine-13C9,15N2 is a stable isotope-labeled analog of uridine, featuring both 13C and 15N isotopes. As a glycosylated pyrimidine, it connects uracil to a ribose (arabinofuranose) structure through a β-N1-glycosidic bond. This compound is valuable for metabolic tracing studies and isotopic labeling applications in biochemical research, enabling insights into nucleic acid metabolism and cellular processes involving RNA and nucleotides. -
Stable Isotope
Uridine-15N2 is a stable isotope-labeled form of uridine, incorporating two nitrogen-15 isotopes. It serves as a valuable tool for metabolic studies and tracer experiments, allowing researchers to investigate nucleotide metabolism and cellular processes involving RNA synthesis. Its application extends to systems biology and pharmacokinetics, enabling precise analysis of metabolic pathways in various biological contexts. -
Stable Isotope
Uridine-d2-1 is a deuterium-labeled derivative of uridine, designed for use as a stable isotope in biochemical research. This compound serves as a valuable tracer in metabolic studies and can be utilized in nucleic acid research, allowing for enhanced detection and quantification of uridine-related metabolic pathways. Its stable nature makes it ideal for isotope labeling experiments and provides insights into biological processes in various cellular systems. -
Stable Isotope
Cytidine-d2 is a deuterium-labeled analog of cytidine, a pyrimidine nucleoside that serves as a fundamental component of RNA. It functions as a precursor to uridine and plays a critical role in neuronal-glial glutamate cycling, influencing cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function. Cytidine-d2 is primarily utilized in stable isotope labeling studies to investigate metabolic pathways and cellular processes in biochemical research. -
Stable Isotope
Cytidine-13C is a stable isotope-labeled form of cytidine, a pyrimidine nucleoside crucial for RNA synthesis. As a precursor to uridine, it plays a pivotal role in various cellular processes, including neuronal-glial glutamate cycling, which impacts cerebral phospholipid metabolism and catecholamine signaling. This reagent is valuable in metabolic tracing studies and isotopic labeling experiments in cellular and molecular biology research. -
Stable Isotope
L-Arginine-13C6,15N4 hydrochloride is a stable isotope-labeled form of L-Arginine, featuring six carbon-13 and four nitrogen-15 isotopes. This compound serves as a critical nitrogen donor for the biosynthesis of nitric oxide, a vital vasodilator whose deficiency can occur during sickle cell crisis. L-Arginine-13C6,15N4 hydrochloride is valuable for research applications involving metabolic studies, tracer experiments, and the exploration of nitric oxide's role in vascular physiology. -
Stable Isotope
L-Arginine-13C6 hydrochloride is a stable isotopically labeled form of L-Arginine, serving as a nitrogen donor for nitric oxide synthesis. Nitric oxide plays a critical role in vascular function and is particularly important in contexts such as vascular biology and diseases including sickle cell crises. This reagent is valuable for metabolic studies and tracer experiments that seek to explore the pathways and effects of nitric oxide in physiological and pathophysiological processes. -
Stable Isotope
L-Arginine-15N4 hydrochloride is a stable isotope-labeled form of L-Arginine, serving as a nitrogen donor in the synthesis of nitric oxide. Nitric oxide functions as a potent vasodilator, which may be particularly beneficial in addressing deficits observed during sickle cell crises. This reagent is valuable for research applications in cardiovascular studies and the investigation of metabolic pathways related to nitric oxide production. -
Stable Isotope
L-Arginine-d7 hydrochloride is a deuterium-labeled form of L-Arginine hydrochloride, serving as a stable isotope for analytical studies. This compound acts as a nitrogen donor in the biosynthesis of nitric oxide, a critical vasodilator whose levels may decrease during sickle cell crises. It is utilized in metabolic research, particularly in studies investigating nitric oxide pathways and vascular function. -
Stable Isotope
L-Arginine-13C hydrochloride is a stable isotope-labeled derivative of L-Arginine hydrochloride. This compound serves as a nitrogen donor in the synthesis of nitric oxide, a critical vasodilator involved in various physiological processes. L-Arginine-13C hydrochloride is particularly useful in metabolic studies and research applications related to cardiovascular health, particularly in conditions such as sickle cell disease where nitric oxide production may be compromised. -
Stable Isotope
Asymmetric-dimethylarginine-d6 dihydrochloride is a stable isotope-labeled form of Asymmetric-dimethylarginine. This compound serves as an important tool for metabolic studies and mass spectrometry applications, enabling precise quantification of Asymmetric-dimethylarginine levels in biological samples. Its use in research contributes to the understanding of nitric oxide synthesis and endothelial function. -
Stable Isotope
L-Arginine-1,2-13C2 hydrochloride is a stable isotopically labeled form of L-Arginine, serving as a nitrogen donor in nitric oxide synthesis. Nitric oxide functions as a potent vasodilator and plays a crucial role in various physiological processes. This reagent is valuable for metabolic studies and research applications involving nitric oxide pathways, particularly in the context of vascular health and disorders such as sickle cell disease. -
Stable Isotope
L-Arginine-15N2 hydrochloride is a stable isotope-labeled form of L-Arginine, functioning primarily as a nitrogen donor in biological systems. It plays a crucial role in the synthesis of nitric oxide, a key vasodilator implicated in various physiological processes. This reagent is particularly valuable for research applications focusing on nitric oxide metabolism and related cardiovascular studies, especially in conditions such as sickle cell crisis where nitric oxide bioavailability may be compromised. -
Stable Isotope
L-Arginine-1-13C hydrochloride is a stable isotope-labeled form of L-Arginine hydrochloride, serving as a nitrogen donor for nitric oxide synthesis. Nitric oxide acts as a potent vasodilator and is essential for various physiological processes. This reagent is particularly useful in metabolic and cardiovascular research, helping to elucidate the role of nitric oxide in conditions such as sickle cell disease and other vascular dysfunctions. -
Stable Isotope
7-Ethoxyresorufin-d5 is a deuterated form of 7-Ethoxyresorufin, serving as a stable isotope for analytical applications. This compound acts as a fluorometric substrate and competitive inhibitor of cytochrome P450, predominantly targeting CYP1A1. Additionally, 7-Ethoxyresorufin-d5 demonstrates inhibitory activity toward nitric oxide synthase, making it a valuable tool for research in pharmacology and toxicology, particularly in studies involving drug metabolism and enzymatic activity.
