Orotic acid-13C,15N2 monohydrate is a stable isotope-labeled compound that serves as a precursor in the biosynthesis of pyrimidine nucleotides and RNA. As a key intermediate, it is released from mitochondrial dihydroorotate dehydrogenase (DHODH) and subsequently converted to UMP by cytoplasmic UMP synthase. This compound is utilized in research focusing on metabolic pathways, particularly in studies of urea cycle disorders and hepatic function, as it can induce hepatic steatosis and hepatomegaly in animal models.
Orotic acid-13C,15N2 monohydrate is a stable isotope-labeled compound that serves as a precursor in the biosynthesis of pyrimidine nucleotides and RNA. As a key intermediate, it is released from mitochondrial dihydroorotate dehydrogenase (DHODH) and subsequently converted to UMP by cytoplasmic UMP synthase. This compound is utilized in research focusing on metabolic pathways, particularly in studies of urea cycle disorders and hepatic function, as it can induce hepatic steatosis and hepatomegaly in animal models.
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