Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
Firocoxib-d4 is a deuterium-labeled derivative of Firocoxib, acting primarily as a selective inhibitor of cyclooxygenase-2 (COX-2). With an IC50 value of 0.13 μM, Firocoxib demonstrates a notable selectivity, being 58-fold more potent against COX-2 compared to COX-1 (IC50 of 7.5 μM). This compound is primarily utilized in research to investigate COX-2's role in inflammation and associated therapeutic targets. Its stable isotope labeling allows for advanced studies in pharmacokinetics and metabolism in biological systems. -
Stable Isotope
Tolmetin-d3 is a deuterium-labeled analog of Tolmetin, a potent non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase (COX) enzymes. With IC50 values of 0.35 μM for human COX-1 and 0.82 μM for COX-2, Tolmetin effectively modulates inflammatory pathways. This stable isotope variant is ideal for research applications involving pharmacokinetics, metabolic studies, and the assessment of drug interactions. -
Stable Isotope
Vedaprofen-d3 is a deuterium-labeled derivative of Vedaprofen, a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-1. This compound demonstrates significant biological activity by reducing serum TxB2 and exudate PGE2 levels. Additionally, it acts as an inhibitor of the Escherichia coli sliding clamp, with an IC50 value of 222 μM, making it useful for various biochemical and pharmacological research applications. -
Stable Isotope
Mefenamic Acid-d3 is a deuterium-labeled derivative of Mefenamic acid, a non-steroidal anti-inflammatory compound. It functions primarily as a competitive inhibitor of human cyclooxygenase enzymes hCOX-1 and hCOX-2, exhibiting IC50 values of 40 nM and 3 μM, respectively. This reagent is valuable in pharmacokinetic studies and metabolic research, particularly for tracing metabolic pathways and evaluating the bioavailability of Mefenamic acid in various biological systems. -
Stable Isotope
S-(+)-Ketoprofen-d3 is a deuterium-labeled analog of S-(+)-Ketoprofen, a selective inhibitor of cyclooxygenase enzymes COX-1 and COX-2. It exhibits high potency with IC50 values of 1.9 nM for COX-1 and 27 nM for COX-2. This stable isotope-labeled compound is invaluable for pharmacokinetic studies and metabolic research in drug development, allowing for precise tracking of S-(+)-Ketoprofen in biological systems. -
Stable Isotope
(rac)-Etodolac-d3 is a stable isotope-labeled analogue of Etodolac, a racemic non-steroidal anti-inflammatory drug. Its primary mechanism involves the non-selective inhibition of cyclooxygenase (COX) enzymes, with an IC50 value of 53.5 nM. This reagent is valuable for research applications requiring the tracking of Etodolac in biochemical assays or pharmacokinetic studies involving COX inhibition and inflammation pathways. -
Stable Isotope
Corticosterone-d8 is a deuterium-labeled derivative of corticosterone, primarily utilized as a stable isotope. This compound serves as a crucial tool in research applications involving hormone metabolism, signaling pathways, and stress response mechanisms. Its dual activity as both a mineralocorticoid and glucocorticoid enables detailed studies on the physiological effects and interactions of steroid hormones in biological systems. -
Stable Isotope
Hydrocortisone-d4 is a deuterium-labeled form of hydrocortisone, a steroid hormone produced in the adrenal cortex. This stable isotope is utilized in scientific research to analyze metabolic pathways and pharmacokinetics of glucocorticoids. Its unique labeling enables precise quantification and tracking in biological samples, facilitating advancements in studies involving stress response and inflammation regulation. -
Stable Isotope
Cortisone-d8 is a deuterium-labeled derivative of cortisone, a biologically active metabolite of cortisol and a member of the glucocorticoid class. This stable isotope is utilized in metabolic studies and has applications in pharmacokinetic research and the characterization of glucocorticoid receptor interactions. Cortisone exhibits immunosuppressive and anti-inflammatory properties, contributing to its role in a variety of therapeutic applications. -
Stable Isotope
Corticosterone-d4 is a deuterated form of corticosterone, functioning as a stable isotope tracer. It exhibits biological activity as both a mineralocorticoid and glucocorticoid, playing a crucial role in stress response and metabolism regulation. This reagent is primarily utilized in research applications involving hormone quantification, metabolic studies, and tracer experiments in biological assays. -
Stable Isotope
Triamcinolone acetonide-d6 is a deuterium-labeled derivative of the glucocorticoid triamcinolone acetonide. This stable isotope can be utilized in pharmacokinetic studies, allowing for the investigation of drug metabolism and distribution. Its incorporation in tracer studies facilitates the analysis of biological pathways and therapeutic monitoring in research applications related to inflammation and immune responses. -
Stable Isotope
Budesonide-d8 is a deuterium-labeled analog of Budesonide, which acts primarily as a glucocorticoid receptor agonist. This compound exhibits anti-inflammatory properties essential for the management of asthma and has been shown to reduce lung tumor size, reverse DNA hypomethylation, and modulate mRNA expression of various genes. Budesonide-d8 serves as a valuable tool in pharmacokinetic and metabolic research, providing insights into the pharmacological effects and mechanisms of Budesonide in vivo. -
Stable Isotope
Hydrocortisone-d2 is a deuterated form of Hydrocortisone, a naturally occurring glucocorticoid hormone produced by the adrenal cortex. This stable isotope is essential for studies requiring precise tracking and quantification in metabolic and pharmacokinetic research. It is widely utilized in experiments investigating adrenal function, stress response, and corticosteroid therapies. -
Stable Isotope
Hydrocortisone-d3 is a deuterium-labeled derivative of hydrocortisone, a glucocorticoid hormone produced in the adrenal cortex. This stable isotope is primarily utilized in metabolic studies and pharmacokinetic research to trace and quantify the pathways of hydrocortisone in biological systems. Its application aids in understanding the mechanistic roles of glucocorticoids in various physiological and pathological processes. -
Stable Isotope
Cortodoxone-d5 is a deuterium-labeled derivative of Cortodoxone, utilized primarily as a stable isotope internal standard in analytical chemistry. This reagent enables precise quantification of Cortodoxone in various biological samples, enhancing the accuracy of pharmacokinetic studies. Its application is crucial for researchers analyzing steroid metabolism and distribution in physiological contexts. -
Stable Isotope
Cortodoxone-d2 is a deuterium-labeled derivative of Cortodoxone, a glucocorticoid steroid hormone. This stable isotope enables precise tracking and quantification in metabolic studies, particularly in the investigation of cortisol (Hydrocortisone) production and regulation. It serves as a valuable tool in various research applications, including endocrine and pharmacological studies involving steroid hormone dynamics. -
Stable Isotope
Ciclesonide-d7 is a deuterium-labeled derivative of Ciclesonide, a potent glucocorticoid with significant anti-inflammatory properties. This stable isotope is particularly useful in pharmacokinetic studies and metabolic research, allowing for the detailed investigation of Ciclesonide's biological activity and effectiveness in asthma treatment. Its unique isotopic signature facilitates the tracking and quantification of the compound in biological systems, making it an indispensable tool for researchers studying glucocorticoid mechanisms and therapeutic applications. -
Stable Isotope
Betamethasone dipropionate-d10 is a deuterium-labeled derivative of Betamethasone dipropionate, a synthetic glucocorticoid steroid. This compound exhibits significant anti-inflammatory and immunosuppressive properties, making it valuable in various research applications. Betamethasone dipropionate-d10 is utilized in studies that require stable isotope labeling for pharmacokinetic and metabolic investigations. -
Stable Isotope
Beclomethasone-d5 is a deuterium-labeled analogue of Beclometasone, a potent glucocorticoid receptor agonist. This stable isotope is utilized in quantitative analysis of glucocorticoid metabolism and pharmacokinetics. Beclomethasone-d5 serves as an effective tool in research applications focused on inflammatory responses and hormonal regulation. -
Stable Isotope
(22R)-Budesonide-d8 is the deuterium-labeled form of the glucocorticoid (22R)-Budesonide, exhibiting high local anti-inflammatory activity. As a stable isotope, (22R)-Budesonide-d8 serves as an essential tool for pharmacokinetic and metabolic studies, allowing for precise tracking of (22R)-Budesonide in biological systems. This compound is especially valuable in research focused on the mechanisms of inflammation and therapeutic interventions in related conditions. -
Stable Isotope
Cortisone-13C3 is a stable isotope-labeled form of cortisone, specifically 13C-labeled at three sites. Cortisone, an oxidized metabolite of cortisol, exhibits anti-inflammatory and immunosuppressive properties through its interaction with the glucocorticoid receptor. This reagent is valuable for research applications in metabolic studies, pharmacokinetics, and the investigation of glucocorticoid signaling pathways in various biological contexts. -
Stable Isotope
Cortisone-d2 is a deuterium-labeled form of cortisone, an oxidized metabolite of cortisol, and a glucocorticoid. This stable isotope serves as a valuable tool for research applications, including metabolic studies and pharmacokinetic analysis. Cortisone exhibits notable immunosuppressive and anti-inflammatory properties, and its interactions with the glucocorticoid receptor can be examined through labeling to enhance the understanding of glucocorticoid dynamics in biological systems. -
Stable Isotope
2'-Deoxy-2'-fluorouridine-d2 is a deuterated nucleoside analog that targets viral RNA replication. As a derivative of uridine, it inhibits the replication of wild-type viruses by binding to their RNA. This compound is particularly relevant in research focusing on Hepatitis C and respiratory syncytial virus (RSV), as it can be utilized in the synthesis of RSV polymerase inhibitors. Additionally, 2'-Deoxy-2'-fluorouridine-d2 incorporates into DNA and RNA in animal models, making it a valuable tool for anti-viral research. -
Stable Isotope
3-Iodothyronamine hydrochloride-13C6 is a stable isotope-labeled derivative of the endogenous thyroid hormone, 3-Iodothyronamine hydrochloride. It acts as a potent activator of the orphan G protein-coupled receptor TAAR1, demonstrating significant biological activity through the induction of hypothermia in vivo. This compound is valuable for research applications related to thyroid hormone signaling and can contribute to studies on congestive heart failure. -
Stable Isotope
Mozavaptan-d6 is a deuterium-labeled variant of Mozavaptan, a selective competitive antagonist of the vasopressin V2 receptor, with an IC50 of 14 nM. This compound exhibits approximately 85-fold selectivity for the V2 receptor compared to the V1 receptor, which has an IC50 of 1.2 μM. Mozavaptan-d6 is utilized in research studying the modulation of fluid balance and potential therapies for hyponatremia, syndrome of inappropriate antidiuretic hormone secretion (SIADH), and congestive heart failure. Its stable isotope labeling enables advanced pharmacokinetic studies and metabolic profiling. -
Stable Isotope
L-Kynurenine-d4 is the deuterium-labeled form of L-Kynurenine, a metabolite derived from the amino acid L-tryptophan. This compound acts as an agonist of the aryl hydrocarbon receptor, playing a significant role in various biological pathways, including immune responses and neurodegenerative diseases. L-Kynurenine-d4 is primarily used in research applications involving metabolic studies and the investigation of aryl hydrocarbon receptor signaling. -
Stable Isotope
Benzyl butyl phthalate-d4 is a deuterium-labeled derivative of Benzyl butyl phthalate, classified as a phthalic acid ester (PAE). This compound has demonstrated the ability to induce migration and invasion in hemangioma (HA) cells through the upregulation of Zeb1. Additionally, it activates the aryl hydrocarbon receptor (AhR) in breast cancer cells, thereby stimulating the SPHK1/S1P/S1PR3 signaling pathway and promoting the formation of metastasis-initiating breast cancer stem cells (BCSCs). This reagent is valuable for studies involving cellular signaling, cancer biology, and environmental health research. -
Stable Isotope
Carbidopa-d3 monohydrate is a deuterium-labeled derivative of Carbidopa, acting as a peripheral decarboxylase inhibitor. This compound is primarily utilized in Parkinson's disease research due to its ability to modify dopaminergic signaling. Additionally, Carbidopa-d3 monohydrate serves as a selective aryl hydrocarbon receptor modulator and has demonstrated inhibitory effects on pancreatic cancer cell proliferation and tumor growth. -
Stable Isotope
Dibenzothiophene-d8 is a deuterium-labeled analogue of dibenzothiophene, serving as a stable isotope for research applications. This compound acts as a noncompetitive inhibitor of cytochrome P450 1A (CYP1A), demonstrating an inhibition of CYP1A-mediated EROD activity with a Km value of 0.592 μM. Additionally, dibenzothiophene-d8 interacts with the aryl hydrocarbon receptor (AHR) pathway and has been shown to enhance the embryotoxic effects of β-naphthoflavone. Its unique properties make it valuable for investigating the mechanisms of developmental toxicity in various organisms. -
Stable Isotope
L-Kynurenine-d4-1 is a deuterated form of L-Kynurenine, a metabolite derived from the amino acid L-tryptophan. It acts as an agonist of the aryl hydrocarbon receptor, playing a critical role in various biological processes. This stable isotope is valuable for research applications, particularly in isotope labeling studies and metabolic pathway analyses involving tryptophan metabolism and its downstream effects. -
Stable Isotope
Tapinarof-d5 is a deuterium-labeled derivative of Tapinarof, serving as a stable isotope for research applications. Tapinarof functions as an agonist of the aryl hydrocarbon receptor (AhR) with an EC50 of 13 nM. This compound has demonstrated efficacy in resolving skin inflammation in murine models, making it a valuable tool for studies related to dermatological conditions and AhR signaling pathways. -
Stable Isotope
Sudan IV-d6 is a deuterium-labeled analog of Sudan IV, acting as an agonist of the aryl hydrocarbon receptor (AhR). It activates downstream signaling pathways, leading to the induction of CYP1A1 expression, which plays a crucial role in drug metabolism. This reagent is valuable for investigating the toxicity mechanisms of industrial dyes and understanding their interactions with serum proteins, such as bovine serum albumin (BSA). Additionally, Sudan IV-d6 functions as a fat-soluble diazo dye, suitable for lipid, triglyceride, and lipoprotein staining in frozen tissue sections. -
Stable Isotope
α-Vitamin E-d6 is the deuterium-labeled form of α-Vitamin E, serving as a stable isotope for isotopic labeling studies. This compound is utilized in research applications focusing on metabolic pathways, pharmacokinetics, and the bioavailability of vitamin E. Its unique isotopic signature allows for precise tracking and quantification in complex biological systems, enhancing the understanding of vitamin E’s role in health and disease. -
Stable Isotope
Guaiacol-d3 is a deuterated form of guaiacol, a phenolic compound known for its ability to inhibit lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2) expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. This reagent exhibits significant anti-inflammatory properties and is employed in research applications studying inflammatory pathways and the modulation of COX-2 expression. Its stable isotope labeling facilitates tracing studies and enhances the understanding of metabolic processes in biological systems. -
Stable Isotope
Phenacetin-d5 is a deuterium-labeled derivative of Phenacetin, functioning primarily as a stable isotope. As a non-opioid analgesic and antipyretic agent, Phenacetin selectively inhibits COX-3. This compound serves as a valuable probe for studying cytochrome P450 enzymes, particularly CYP1A2, in human liver microsomes and rat models, facilitating research in drug metabolism and pharmacokinetics. -
Stable Isotope
Phenylbutazone (diphenyl-d10) is a deuterium-labeled derivative of Phenylbutazone, functioning as an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). This compound exhibits notable anti-inflammatory properties and has been linked to hepatotoxicity. In addition to its role as a nonsteroidal anti-inflammatory drug (NSAID), Phenylbutazone (diphenyl-d10) is utilized in research focused on the modulation of muscle blind-like protein 1 (MBNL1) expression and may contribute to studies related to ankylosing spondylitis. -
Stable Isotope
γ-Tocopherol-d4 is a deuterium-labeled derivative of γ-Tocopherol, a naturally occurring form of Vitamin E found in various plant oils. As a potent cyclooxygenase (COX) inhibitor, γ-Tocopherol-d4 exhibits significant anti-inflammatory properties and has been studied for its anti-cancer activity. This stable isotope is valuable for metabolic research and tracing studies in biological systems. -
Stable Isotope
Celecoxib-d7 is a deuterium-labeled variant of Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID) known for its potent inhibition of cyclooxygenase-2 (COX-2) with an IC50 of 40 nM. This stable isotope is widely used in pharmacokinetic and metabolic studies, providing valuable insights into drug metabolism and efficacy. Its applications extend to the investigation of COX-2-related pathways in inflammatory diseases and cancer research. -
Stable Isotope
Nabumetone-d3 is a deuterium-labeled analogue of Nabumetone, primarily acting as a selective inhibitor of cyclooxygenase-2 (COX-2). This compound demonstrates significant anti-inflammatory properties and is known to suppress cancer cell proliferation while also providing protective effects against gastric ulcers. Nabumetone-d3 is valuable in research applications focused on elucidating the pharmacokinetics and mechanisms of action of COX-2 inhibitors in various biological contexts. -
Stable Isotope
(±)-Naproxen-d3 is a deuterium-labeled derivative of (±)-Naproxen, a widely used non-steroidal anti-inflammatory drug (NSAID). This stable isotope is employed in pharmacokinetic studies and metabolic research to trace the drug's behavior in biological systems. Its use allows for improved understanding of drug metabolism and efficacy without altering the biological activity of the parent compound. -
Stable Isotope
Celecoxib-d3 is a deuterium-labeled derivative of Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID) that specifically inhibits the COX-2 enzyme, exhibiting an IC50 value of 40 nM. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the kinetics and pathways of Celecoxib metabolism in biological systems. Celecoxib-d3 facilitates enhanced analytical sensitivity for investigating the drug’s biological effects and interactions. -
Stable Isotope
Piroxicam-d3 is a deuterium-labeled derivative of Piroxicam, a non-steroidal anti-inflammatory drug (NSAID) that primarily acts as a cyclooxygenase (COX) inhibitor. It exhibits inhibitory activity against human monocyte COX-1 and COX-2, with IC50 values of 47 μM and 25 μM, respectively. This stable isotope is essential for studies requiring precise tracking of Piroxicam in pharmacokinetic and metabolic research applications. -
Stable Isotope
Phenylbutazone-13C12 is a stable isotope-labeled form of the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone, which acts primarily as a reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). This compound exhibits significant biological activity by inducing expression of muscleblind-like protein 1 (MBNL1) and has potential applications in research related to ankylosing spondylitis. Its stable isotope labeling facilitates tracking and quantification in metabolic studies and pharmacokinetic analysis. -
Stable Isotope
Diflunisal-d3 is a deuterium-labeled derivative of Diflunisal, a salicylate compound recognized for its nonsteroidal anti-inflammatory and uricosuric properties. Its primary mechanism of action involves the inhibition of Cyclooxygenase (COX), making it effective as an analgesic and a treatment option for patients with rheumatoid arthritis. This stable isotope labeled reagent is utilized in pharmacokinetic studies and metabolic research to track and quantify the metabolism of Diflunisal in biological systems. -
Stable Isotope
Apafant-d8 is a deuterium-labeled derivative of Apafant, a potent antagonist of platelet-activating factor (PAF). It effectively inhibits PAF binding to human PAF receptors with an IC50 value of 9.9 nM. Apafant-d8 enhances the expression of PAF receptor, α-globin, and β-globin genes while reducing c-myb gene expression. This compound also demonstrates protective effects against alkyl-PAF-mediated cytotoxicity, making it valuable for research in cellular protection and receptor signaling. -
Stable Isotope
Prostaglandin E2-d4 is a deuterium-labeled analog of Prostaglandin E2 (PGE2), which serves as a significant mediator in various physiological processes. PGE2 is involved in smooth muscle contraction and relaxation, vascular dilation and constriction, blood pressure regulation, and the modulation of inflammatory responses. This stable isotope is commonly utilized in pharmacokinetic studies, metabolic research, and as an internal standard in mass spectrometry assays to accurately quantify PGE2 levels in biological samples. -
Stable Isotope
Prostaglandin D2-d4 is a deuterium-labeled form of Prostaglandin D2 (PGD2), a key lipid mediator. PGD2 is recognized for its potent role in promoting sleep and plays a protective function by reducing inflammation in the central nervous system. This stable isotope is valuable in research applications involving sleep regulation, neuroinflammation, and the broader mechanisms of prostaglandin signaling pathways. -
Stable Isotope
Prostaglandin E2-d9 is a deuterated analog of Prostaglandin E2, a potent bioactive lipid mediator involved in numerous physiological processes. PGE2 plays a critical role in regulating smooth muscle contraction, vascular tone, blood pressure, and inflammation. This stable isotope is particularly useful in analytical studies, allowing for precise quantification and tracing of PGE2 in biological samples and facilitating research in pharmacology, toxicology, and metabolic pathways. -
Stable Isotope
Prostaglandin D2-d9 is a deuterated form of Prostaglandin D2, a key signaling molecule in the central nervous system. This stable isotope is known for its prominent role in promoting sleep and regulating various physiological processes. Prostaglandin D2 exhibits anti-inflammatory properties and is essential in research settings focused on sleep regulation, neurobiology, and inflammation pathways. Its deuterated form aids in quantitative analysis and tracking within biological systems. -
Stable Isotope
Selexipag-d7 is a deuterium-labeled derivative of Selexipag, a highly potent and orally bioavailable agonist of the prostacyclin (PGI2) receptor, also known as the IP receptor. This stable isotope-labeled form is valuable for pharmacokinetic studies and metabolic profiling, enhancing the understanding of drug metabolism and dynamics in biological systems. Selexipag-d7 is particularly relevant in research focused on pulmonary arterial hypertension and cardiovascular diseases, supporting the development of targeted therapies.
