Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
rel-Biotin-d4 is a deuterium-labeled derivative of biotin, a crucial enzyme co-factor found in trace amounts in all living cells. This stable isotope-labeled compound is primarily utilized in quantitative mass spectrometry and metabolic studies, providing an effective tool for tracking biotin-related pathways and interactions in biological systems. Its incorporation into experimental designs can enhance the accuracy of analytical results in various biochemical research applications. -
Stable Isotope
Methylcobalamin-d3 is a deuterium-labeled derivative of Methylcobalamin, also known as Mecobalamin. As a form of vitamin B12 (CH3-B12), it serves as a crucial cofactor in cellular metabolism, particularly in the synthesis of methionine from homocysteine. This stable isotope is valuable in metabolic studies, isotopic tracing, and research applications focused on vitamin B12 dynamics in biological systems. -
Stable Isotope
15:0 Lyso PC-d5 is a deuterium-labeled form of 15:0 lysophosphatidylcholine (Lyso PC), which is generated through the hydrolysis of phosphatidylcholine by phospholipase A2. This compound plays a crucial role in cell membrane remodeling and inflammatory signaling pathways. Research indicates that 15:0 Lyso PC is associated with lipid metabolism disturbances in conditions such as ischemic heart disease and ischemic cardiomyopathy, making it a potential lipid biomarker for cardiovascular disease studies. -
Stable Isotope
L-Histidine-13C6,15N3,d5 hydrochloride hydrate is a stable isotope-labeled form of the endogenous amino acid L-Histidine, featuring deuterium and carbon-13 and nitrogen-15 substitutions. This reagent plays a critical role in metabolic studies and analytical applications, particularly in tracing pathways involving amino acids. L-Histidine has been shown to exhibit antioxidant properties, scavenging reactive oxygen species, and regulating the absorption of essential metals such as zinc, copper, and iron. Additionally, it can penetrate the blood-brain barrier, making it valuable for neurobiological research. -
Stable Isotope
Imidazole-d4 is a deuterium-labeled derivative of imidazole, providing a stable isotope for research applications in analytical chemistry and pharmacokinetics. This compound is primarily utilized in studies requiring isotopic labeling for mass spectrometry or NMR spectroscopy. Its incorporation into biological systems allows for enhanced tracking and quantification of metabolic pathways involving imidazole-containing compounds. -
Stable Isotope
2-Phenylacetaldehyde-13C2 is a stable isotope-labeled form of 2-Phenylacetaldehyde, an endogenous metabolite involved in various biochemical pathways. This reagent is primarily utilized in metabolic studies and tracer experiments, enabling researchers to investigate metabolic processes and the fate of phenylacetaldehyde in biological systems. Its stable isotope labeling enhances detection sensitivity and specificity in analytical techniques such as mass spectrometry. -
Stable Isotope
Succinic acid-13C2 is a stable isotope-labeled form of butanedioic acid, utilized as a valuable research tool. As an intermediate in the tricarboxylic acid cycle, it plays a crucial role in cellular metabolism. Succinic acid-13C2 can be applied in various scientific studies, including metabolic tracing and the synthesis of industrially relevant compounds across the food, chemical, and pharmaceutical sectors. -
Stable Isotope
alpha-D-glucose-13C6 is a stable isotope-labeled form of alpha-D-glucose, commonly utilized in metabolic studies. It serves as a crucial tracer in various biological research applications, including metabolic flux analysis, carbohydrate metabolism, and biochemistry investigations. By incorporating this 13C-labeled compound, researchers can track metabolic pathways and identify substrate utilization in living organisms. -
Stable Isotope
13,14-Dihydro PGE1-d4 is a stable isotope-labeled derivative of 13,14-Dihydro PGE1, a metabolite of Prostaglandin E1. This compound functions as an inhibitor of ADP-induced platelet aggregation, exhibiting an ID50 of 10.8 ng/mL in platelet-rich plasma. It is particularly useful in research applications focused on cardiovascular studies and the investigation of platelet function and signaling pathways. -
Stable Isotope
1-Naphthol-d7 is a deuterium-labeled derivative of naphthol, recognized for its role as a stable isotope. This compound functions as an excited state proton transfer (ESPT) fluorescent molecular probe, enabling the detection of hydrophobic domains in micellar systems. Its application extends to the investigation of sol-gel transitions and thermally induced microenvironmental alterations, particularly in the hydration levels of Pluronic F127 in various aqueous environments. This makes 1-Naphthol-d7 valuable for research in physical chemistry and material science. -
Stable Isotope
Thymine-13C5,15N2 is a stable isotope-labeled form of thymine, incorporating five carbon-13 and two nitrogen-15 isotopes. Thymine, a key nucleobase in DNA, plays a critical role in nucleic acid synthesis and is a potential target for therapeutic interventions, including the chemotherapeutic agent, 5-fluorouracil, which exhibits a Km of 2.3 μM. This reagent is valuable for metabolic studies, tracer experiments, and the investigation of nucleotide metabolism in various biological and pathological contexts. -
Isotope-Labeled Compound
Linoleic acid-d2 is an isotope-labeled derivative of linoleic acid, a polyunsaturated fatty acid (PUFA) prevalent in various plant oils, nuts, and seeds. This compound serves as a vital structural component of membrane phospholipids, contributing to the maintenance of membrane fluidity, particularly in the epidermal transdermal water barrier. Linoleic acid-d2 is utilized in metabolic studies and oxidative stress research, where it elucidates mechanisms of oxidative damage in red blood cells and hemoglobin. -
Stable Isotope
Vitamin K-d7 is a deuterium-labeled form of Vitamin K, which plays a crucial role in the blood coagulation process. This stable isotope is essential for the proper function of various proteins, including coagulation factors, osteocalcin, and matrix-Gla protein. Research applications include metabolic studies, tracing pathways in biological systems, and quantification of Vitamin K levels in physiological samples. -
Stable Isotope
Ergothioneine-d3 is a deuterated form of Ergothioneine, a naturally occurring imidazole-2-thione derivative of histidine betaine synthesized by specific bacteria and fungi. This stable isotope is utilized primarily in metabolic research as a tracer for studies on antioxidant mechanisms. Ergothioneine exhibits significant antioxidant properties, providing protection against oxidative stress and acting as a potential therapeutic agent in various biological systems. -
Stable Isotope
5'-Guanylic acid-13C10,15N5 dilithium is a stable isotope-labeled derivative of 5'-guanylic acid, incorporating both carbon-13 and nitrogen-15 isotopes. This compound serves as a crucial tool for metabolic studies and can aid in understanding disorders associated with the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency, and the 2-hydroxyglutaric aciduria pathway. Researchers utilize this reagent for applications in metabolic flux analysis and tracer studies, enhancing insights into nucleotide metabolism and related biochemical pathways. -
Stable Isotope
AalphaC-15N3 (2-Amino-α-carboline-15N3) is a stable isotope-labeled derivative of AalphaC, a compound recognized for its potential carcinogenic activity. AalphaC serves as a significant biomarker for tobacco smoke exposure, with higher urinary concentrations observed in smokers compared to non-smokers. This compound is instrumental in studies assessing the relationship between tobacco use and its metabolites. Additionally, variations in AalphaC levels based on dietary habits, particularly with high-temperature cooked beef, provide valuable insights for research into the impact of diet on carcinogenic exposure. -
Stable Isotope
Acetylcarnitine-d3 is a deuterium-labeled form of acetylcarnitine, a crucial endogenous metabolite involved in fatty acid metabolism and energy production. This stable isotope is valuable for metabolic studies and tracer experiments, allowing researchers to investigate biochemical pathways with enhanced precision. Its application extends to studies of mitochondrial function, neuroprotection, and the metabolic implications of acetylcarnitine in various physiological and pathological contexts. -
Stable Isotope
2,3,5-Trimethylpyrazine-d3 is a deuterated stable isotope of 2,3,5-Trimethylpyrazine, an endogenous metabolite. This compound serves as an important internal standard in analytical chemistry, enhancing the accuracy of quantification in metabolic studies. Its unique isotopic characteristics make it useful for tracing metabolic pathways and understanding biochemical processes in various research applications. -
Stable Isotope
Bisphenol A-13C2 is a stable isotope-labeled form of Bisphenol A, an organic synthetic compound prevalent in polycarbonate plastics and epoxy resins. This compound acts as an endocrine-disrupting agent and has been implicated in various health issues, including reproductive and developmental toxicities, cardiovascular diseases, respiratory illnesses, diabetes, kidney dysfunction, obesity, and reproductive disorders. Bisphenol A-13C2 is valuable for research applications involving toxicological studies, environmental monitoring, and understanding the biological effects of endocrine disruptors. -
Stable Isotope
5-Methyltetrahydrofolic acid-13C6 is a stable isotope-labeled form of 5-Methyltetrahydrofolic acid, which serves as the primary circulating form of folate in human physiology. This compound plays a critical role in various biochemical processes, including the regulation of cardiovascular function through the modulation of endothelin-1 (ET-1) production in endothelial cells exposed to low-density lipoprotein. Researchers utilize 5-Methyltetrahydrofolic acid-13C6 in studies related to cardiovascular diseases and metabolic pathways involving folate metabolism. -
Stable Isotope
2'-Deoxyguanosine-15N5 is a stable isotope-labeled form of 2'-Deoxyguanosine, incorporating nitrogen-15 in its structure. This compound serves as a valuable tool in nucleic acid research, allowing for enhanced tracking and analysis of nucleotide metabolism and incorporation. Its applications extend to studies in molecular biology, biochemistry, and pharmacology, facilitating insights into cellular processes involving DNA and RNA synthesis. -
Stable Isotope
Tyramine-d4 hydrochloride is a deuterium-labeled analog of tyramine hydrochloride, a biogenic amine involved in various physiological processes, including the regulation of blood pressure. This stable isotope can be utilized in metabolic studies and tracing experiments to investigate neurotransmitter dynamics and metabolic pathways. Its incorporation into research enables enhanced accuracy in quantifying tyramine in biological samples while minimizing the isotopic effects typically associated with non-labeled compounds. -
Stable Isotope
Xylose-13C5 is a stable isotope-labeled form of D-(+)-Xylose, primarily targeting metabolic pathways involving xylose isomerase. This pentose sugar is crucial in anaerobic ethanol fermentation, converting xylose into xylulose, thereby facilitating microbial production of fuels, chemicals, and industrial enzymes. Xylose-13C5 serves as an important carbon source for the biosynthesis of high-value chemicals and biofuels, aiding in the investigation of lignocellulosic resource utilization and advancing research in microbial fermentation processes. -
Stable Isotope
2'-Deoxyuridine-1′-13C is a stable isotope-labeled analog of 2'-Deoxyuridine, specifically enriched with carbon-13. This compound has been shown to increase chromosome breakage and decrease thymidylate synthetase activity, making it useful in various biological studies. It serves as a key precursor in the synthesis of Edoxudine and is employed in metabolic labeling studies and experimental research involving nucleic acid metabolism. -
Stable Isotope
Trans-Anethole-d3, a deuterated form of Trans-Anethole, is a stable isotope used in various research applications. Trans-Anethole, a phenylpropene derivative obtained from Foeniculum vulgare, exhibits estrogenic properties at low concentrations and demonstrates cytotoxic effects against tumor cell lines at higher concentrations. Additionally, it possesses anti-aflatoxin, anti-thrombotic, and anti-diabetic activities, making it a valuable compound for studies in oncology and metabolic disorders. Its significance as an odor component in a range of plants, including fennel and myrtle, further supports its utility in flavor and fragrance research. -
Stable Isotope
D-Alanine-13C3 is a stable isotope-labeled form of D-Alanine, distinguished by three carbon-13 isotopes. This compound serves as a weak agonist for glycine receptors (GlyR), demonstrating an EC50 of 9 mM. D-Alanine-13C3 is valuable in metabolic studies, isotopic tracing, and research involving glycine receptor functions. -
Stable Isotope
(S)-Lathosterol-d4 is a deuterium-labeled analogue of (S)-Lathosterol, a sterol compound that closely resembles cholesterol. As a stable isotope, it serves as a valuable tracer for investigations into cholesterol metabolism. The measurement of serum lathosterol levels provides insights into whole-body cholesterol synthesis, making it a useful tool in lipid research and metabolic studies. -
Stable Isotope
Fmoc-Tyr(tBu)-OH-13C9,15N is a stable isotope-labeled derivative of Fmoc-Tyr(tBu)-OH, featuring both nitrogen-15 and carbon-13 isotopes. This compound serves as a valuable tool for studies involving amino acid metabolism and protein synthesis mechanisms. Its isotopic labeling facilitates investigations using NMR spectroscopy and mass spectrometry, enabling detailed analysis of protein interactions and dynamics in various biological systems. -
Stable Isotope
Dihydrozeatin riboside-d3 is a deuterium-labeled analog of dihydrozeatin riboside, a naturally occurring cytokinin. This stable isotope is used for tracing and quantification studies in plant hormone research. Its application includes investigating plant growth regulation, cellular signaling pathways, and the effects of cytokinins on physiological processes. -
Stable Isotope
Norharman-d7 is a deuterium-labeled derivative of Norharmane, a β-carboline alkaloid known for its reversible inhibition of monoamine oxidase (MAO). It exhibits notable biological activity as an antidepressant, with IC50 values of 6.5 μM for MAO-A and 4.7 μM for MAO-B, and demonstrates potential as an anti-cancer photosensitizer. Additionally, Norharmane-d7 influences polar auxin transport by inhibiting transport proteins PIN2, PIN3, and PIN7, significantly affecting the growth of Arabidopsis thaliana seedlings, making it valuable for research in neurochemistry and plant biology. -
Stable Isotope
Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is a deuterium-labeled analog of Ercalcitriol, a potent vitamin D receptor (VDR) agonist with high affinity for VDR. Upon binding, Ercalcitriol-d3 interacts with retinoid X receptor (RXR) to modulate gene transcription, leading to increased expression of antimicrobial peptides, such as human cat antimicrobial peptide (hCAP-18/LL-37), which is effective against periodontal pathogens like Porphyromonas gingivalis. This reagent is primarily utilized in research studies focused on periodontal diseases and immune-related conditions of the oral cavity, enhancing understanding of immune defense mechanisms. -
Stable Isotope
2-Hydroxypalmitic acid-d30 is a deuterated form of 2-Hydroxyhexadecanoic acid, serving as a stable isotope. This compound plays a crucial role as an intermediate in the metabolism of phytosphingosine, contributing to lipid biosynthesis studies. It is useful in isotopic labeling applications, enabling improved tracking and analysis of metabolic pathways involving sphingolipids. -
Stable Isotope
Secalciferol-d6 is the deuterium-labeled derivative of Secalciferol, a key metabolite of Vitamin D. This stable isotope serves as a valuable tool in biochemical studies, particularly in understanding the metabolic pathways of Vitamin D and its potential anti-inflammatory effects. It is useful in research applications such as trace analysis and metabolic tracking in pharmacokinetic studies. -
Stable Isotope
D-Alanine-d is a deuterated form of D-Alanine, designed as a stable isotope for research purposes. This compound serves as a weak agonist for glycine receptors (GlyR), exhibiting an EC50 of 9 mM. D-Alanine-d is valuable in studies focusing on inhibitory neurotransmission and can be utilized in isotopic labeling experiments in metabolic and neuropharmacological research. -
Stable Isotope
4-Acetaminophen sulfate-d4 is a deuterated derivative of 4-acetaminophen sulfate, serving as a stable isotope tracer. This compound is primarily utilized in pharmacokinetic studies and metabolic research to investigate the metabolism and distribution of acetaminophen in biological systems. Its incorporation of deuterium enhances the accuracy of analytical techniques such as mass spectrometry, allowing for precise quantification and tracking of the compound in various biological samples. -
Stable Isotope
Bisphenol B-d8 is a deuterium-labeled analog of Bisphenol B, a compound recognized for its structural similarity to Bisphenol A, a known endocrine-disrupting chemical (EDC). This stable isotope serves as a valuable tool in studies aiming to investigate the biochemical and toxicological effects of endocrine disruptors in various biological systems. It is particularly useful for tracking metabolic pathways and understanding the impacts of EDCs on animal models. -
Stable Isotope
Tristearin-d9 is a deuterium-labeled triglyceride, specifically derived from three units of stearic acid. As a stable isotope, it serves as a valuable tool in metabolic studies and tracer experiments, enhancing the understanding of lipid metabolism and dynamics. Its unique isotopic signature allows for precise quantification and tracking in various biological systems, making it an essential reagent for research in lipid biology and related fields. -
Stable Isotope
L-Ornithine-1,2-13C2 hydrochloride is a stable isotope-labeled version of L-Ornithine, a free amino acid essential in the urea cycle. This compound is integral for nitrogen metabolism, facilitating the disposal of excess nitrogen in biological systems. Its isotopic labeling enables precise tracking in metabolic studies and can be utilized in various research applications, including metabolic flux analysis and nitrogen turnover investigations. -
Stable Isotope
Linoleic acid-d11 is a deuterium-labeled form of linoleic acid, a polyunsaturated fatty acid (PUFA) prevalent in various plant-derived oils, nuts, and seeds. This stable isotope serves as a crucial component of membrane phospholipids, contributing to the structural integrity and fluidity of cellular membranes, particularly in the epidermis. Additionally, linoleic acid-d11 is valuable for studying oxidative stress mechanisms, as it has been shown to induce oxidative damage in red blood cells and hemoglobin. Its applications include metabolic studies, lipid profiling, and research on skin barrier function. -
Stable Isotope
Fumaric acid-2,3-13C2 disodium is a stable isotope-labeled compound primarily used as a tracer in metabolic research. This labeled fumaric acid serves as a valuable tool for studies in metabolic flux analysis and enzyme kinetics. Its incorporation into biological systems allows for the investigation of metabolic pathways and the tracing of substrate utilization in various biological contexts. -
Stable Isotope
D-Glutamic acid-13C5 is a stable isotope-labeled form of D-glutamic acid, an enantiomer of L-glutamic acid. This compound serves as a valuable tool in metabolic studies and tracer experiments in cellular biology. Its unique isotopic labeling allows researchers to investigate the dynamics of amino acid metabolism and its role in various physiological processes. -
Stable Isotope
p-Toluic acid-d7 is a deuterated form of p-Toluic acid, also known as 4-Methylbenzoic acid. This substituted benzoic acid serves as an important intermediate in the synthesis of various compounds, including para-aminomethylbenzoic acid (PAMBA) and p-tolunitrile. It is commonly utilized in chemical research applications requiring stable isotopes for tracking and analysis in reaction pathways and metabolic studies. -
Stable Isotope
L-Dopa-d3 is a deuterated form of DL-Dopa, a beta-hydroxylated derivative of phenylalanine. As a stable isotope, it is widely utilized in metabolic studies, tracer studies in biochemical research, and pharmacokinetic assessments. Its unique labeling facilitates the investigation of metabolic pathways and the quantification of biomolecules in complex biological systems. -
Stable Isotope
Bisphenol A-d4 is a deuterium-labeled derivative of Bisphenol A, an organic synthetic compound primarily utilized in the manufacture of polycarbonate plastics and epoxy resins. This compound is notable for its role as a reproductive, developmental, and systemic toxicant, frequently identified as an endocrine-disrupting compound (EDC). Bisphenol A is implicated in a range of health conditions, including cardiovascular diseases, respiratory ailments, diabetes, kidney disorders, obesity, and reproductive issues, facilitating its use in toxicological research and environmental studies. -
Stable Isotope
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-d3 is the deuterated form of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a key metabolite of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). This compound plays a critical role in studies of carcinogenesis, particularly within the context of lung cancer, as it undergoes oxidative metabolic pathways linked to carcinogenic activity. Utilization of the deuterium-labeled variant allows for enhanced analytical techniques in the investigation of tobacco-related cancer mechanisms. -
Stable Isotope
L-Aspartic acid-13C-1 is a stable isotope-labeled form of L-Aspartic acid, which is an amino acid capable of penetrating the blood-brain barrier. This compound is utilized in the formulation of prodrugs specifically targeting colon and cecal tissues. Furthermore, L-Aspartic acid-13C-1 is instrumental in the investigation of various inflammatory conditions, making it a valuable tool in biochemical research. -
Stable Isotope
1,3-Diolein-d66 is a deuterium-labeled derivative of 1,3-Diolein, a phospholipid that plays a crucial role in regulating cell membrane fluidity and signal transduction. This stable isotope is valuable in cell biology research for investigating lipid-mediated signaling pathways and interactions involving membrane proteins. Additionally, 1,3-Diolein-d66 can be utilized as a functional carrier in drug delivery systems, enhancing the bioavailability of therapeutic compounds. -
Stable Isotope
Rivaroxaban-d4 is a stable isotope-labeled form of Rivaroxaban, a potent and selective direct Factor Xa (FXa) inhibitor. This compound demonstrates significant anti-FXa activity with an IC50 of 0.7 nM and a Ki of 0.4 nM, making it a valuable tool for pharmacokinetic studies. It is commonly utilized in research applications involving anticoagulant therapy, drug metabolism, and in vivo tracking of Rivaroxaban pharmacodynamics. -
Stable Isotope
Edoxaban-d6 is a deuterium-labeled derivative of Edoxaban, a selective and potent inhibitor of factor Xa (FXa). Edoxaban exhibits high affinity for FXa with an IC50 of 0.561 nM, making it an effective anticoagulant for stroke prevention. It also displays weak inhibitory activity against thrombin and factor IXaβ, while maintaining a selectivity of over 10,000-fold for FXa. This reagent is useful for studying antithrombotic mechanisms and evaluating treatments for thromboembolic diseases in a variety of research applications. -
Stable Isotope
Apixaban-d3 is a deuterium-labeled analogue of Apixaban, a reversible and selective inhibitor of Factor Xa. With inhibition constants of 0.08 nM and 0.17 nM in human and rabbit models respectively, Apixaban demonstrates significant effectiveness in preventing thromboembolic diseases. This stable isotope is particularly useful in pharmacokinetic studies and bioanalytical research, allowing for enhanced tracking of the drug's metabolism and distribution in biological systems.
