Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Fmoc-Tyr(tBu)-OH-13C9,15N is a stable isotope-labeled derivative of Fmoc-Tyr(tBu)-OH, featuring both nitrogen-15 and carbon-13 isotopes. This compound serves as a valuable tool for studies involving amino acid metabolism and protein synthesis mechanisms. Its isotopic labeling facilitates investigations using NMR spectroscopy and mass spectrometry, enabling detailed analysis of protein interactions and dynamics in various biological systems. -
Stable Isotope
Dihydrozeatin riboside-d3 is a deuterium-labeled analog of dihydrozeatin riboside, a naturally occurring cytokinin. This stable isotope is used for tracing and quantification studies in plant hormone research. Its application includes investigating plant growth regulation, cellular signaling pathways, and the effects of cytokinins on physiological processes. -
Stable Isotope
Norharman-d7 is a deuterium-labeled derivative of Norharmane, a β-carboline alkaloid known for its reversible inhibition of monoamine oxidase (MAO). It exhibits notable biological activity as an antidepressant, with IC50 values of 6.5 μM for MAO-A and 4.7 μM for MAO-B, and demonstrates potential as an anti-cancer photosensitizer. Additionally, Norharmane-d7 influences polar auxin transport by inhibiting transport proteins PIN2, PIN3, and PIN7, significantly affecting the growth of Arabidopsis thaliana seedlings, making it valuable for research in neurochemistry and plant biology. -
Stable Isotope
Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is a deuterium-labeled analog of Ercalcitriol, a potent vitamin D receptor (VDR) agonist with high affinity for VDR. Upon binding, Ercalcitriol-d3 interacts with retinoid X receptor (RXR) to modulate gene transcription, leading to increased expression of antimicrobial peptides, such as human cat antimicrobial peptide (hCAP-18/LL-37), which is effective against periodontal pathogens like Porphyromonas gingivalis. This reagent is primarily utilized in research studies focused on periodontal diseases and immune-related conditions of the oral cavity, enhancing understanding of immune defense mechanisms. -
Stable Isotope
2-Hydroxypalmitic acid-d30 is a deuterated form of 2-Hydroxyhexadecanoic acid, serving as a stable isotope. This compound plays a crucial role as an intermediate in the metabolism of phytosphingosine, contributing to lipid biosynthesis studies. It is useful in isotopic labeling applications, enabling improved tracking and analysis of metabolic pathways involving sphingolipids. -
Stable Isotope
Secalciferol-d6 is the deuterium-labeled derivative of Secalciferol, a key metabolite of Vitamin D. This stable isotope serves as a valuable tool in biochemical studies, particularly in understanding the metabolic pathways of Vitamin D and its potential anti-inflammatory effects. It is useful in research applications such as trace analysis and metabolic tracking in pharmacokinetic studies. -
Stable Isotope
D-Alanine-d is a deuterated form of D-Alanine, designed as a stable isotope for research purposes. This compound serves as a weak agonist for glycine receptors (GlyR), exhibiting an EC50 of 9 mM. D-Alanine-d is valuable in studies focusing on inhibitory neurotransmission and can be utilized in isotopic labeling experiments in metabolic and neuropharmacological research. -
Stable Isotope
4-Acetaminophen sulfate-d4 is a deuterated derivative of 4-acetaminophen sulfate, serving as a stable isotope tracer. This compound is primarily utilized in pharmacokinetic studies and metabolic research to investigate the metabolism and distribution of acetaminophen in biological systems. Its incorporation of deuterium enhances the accuracy of analytical techniques such as mass spectrometry, allowing for precise quantification and tracking of the compound in various biological samples. -
Stable Isotope
Bisphenol B-d8 is a deuterium-labeled analog of Bisphenol B, a compound recognized for its structural similarity to Bisphenol A, a known endocrine-disrupting chemical (EDC). This stable isotope serves as a valuable tool in studies aiming to investigate the biochemical and toxicological effects of endocrine disruptors in various biological systems. It is particularly useful for tracking metabolic pathways and understanding the impacts of EDCs on animal models. -
Stable Isotope
Tristearin-d9 is a deuterium-labeled triglyceride, specifically derived from three units of stearic acid. As a stable isotope, it serves as a valuable tool in metabolic studies and tracer experiments, enhancing the understanding of lipid metabolism and dynamics. Its unique isotopic signature allows for precise quantification and tracking in various biological systems, making it an essential reagent for research in lipid biology and related fields. -
Stable Isotope
L-Ornithine-1,2-13C2 hydrochloride is a stable isotope-labeled version of L-Ornithine, a free amino acid essential in the urea cycle. This compound is integral for nitrogen metabolism, facilitating the disposal of excess nitrogen in biological systems. Its isotopic labeling enables precise tracking in metabolic studies and can be utilized in various research applications, including metabolic flux analysis and nitrogen turnover investigations. -
Stable Isotope
Linoleic acid-d11 is a deuterium-labeled form of linoleic acid, a polyunsaturated fatty acid (PUFA) prevalent in various plant-derived oils, nuts, and seeds. This stable isotope serves as a crucial component of membrane phospholipids, contributing to the structural integrity and fluidity of cellular membranes, particularly in the epidermis. Additionally, linoleic acid-d11 is valuable for studying oxidative stress mechanisms, as it has been shown to induce oxidative damage in red blood cells and hemoglobin. Its applications include metabolic studies, lipid profiling, and research on skin barrier function. -
Stable Isotope
Fumaric acid-2,3-13C2 disodium is a stable isotope-labeled compound primarily used as a tracer in metabolic research. This labeled fumaric acid serves as a valuable tool for studies in metabolic flux analysis and enzyme kinetics. Its incorporation into biological systems allows for the investigation of metabolic pathways and the tracing of substrate utilization in various biological contexts. -
Stable Isotope
D-Glutamic acid-13C5 is a stable isotope-labeled form of D-glutamic acid, an enantiomer of L-glutamic acid. This compound serves as a valuable tool in metabolic studies and tracer experiments in cellular biology. Its unique isotopic labeling allows researchers to investigate the dynamics of amino acid metabolism and its role in various physiological processes. -
Stable Isotope
p-Toluic acid-d7 is a deuterated form of p-Toluic acid, also known as 4-Methylbenzoic acid. This substituted benzoic acid serves as an important intermediate in the synthesis of various compounds, including para-aminomethylbenzoic acid (PAMBA) and p-tolunitrile. It is commonly utilized in chemical research applications requiring stable isotopes for tracking and analysis in reaction pathways and metabolic studies. -
Stable Isotope
L-Dopa-d3 is a deuterated form of DL-Dopa, a beta-hydroxylated derivative of phenylalanine. As a stable isotope, it is widely utilized in metabolic studies, tracer studies in biochemical research, and pharmacokinetic assessments. Its unique labeling facilitates the investigation of metabolic pathways and the quantification of biomolecules in complex biological systems. -
Stable Isotope
Bisphenol A-d4 is a deuterium-labeled derivative of Bisphenol A, an organic synthetic compound primarily utilized in the manufacture of polycarbonate plastics and epoxy resins. This compound is notable for its role as a reproductive, developmental, and systemic toxicant, frequently identified as an endocrine-disrupting compound (EDC). Bisphenol A is implicated in a range of health conditions, including cardiovascular diseases, respiratory ailments, diabetes, kidney disorders, obesity, and reproductive issues, facilitating its use in toxicological research and environmental studies. -
Stable Isotope
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-d3 is the deuterated form of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a key metabolite of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). This compound plays a critical role in studies of carcinogenesis, particularly within the context of lung cancer, as it undergoes oxidative metabolic pathways linked to carcinogenic activity. Utilization of the deuterium-labeled variant allows for enhanced analytical techniques in the investigation of tobacco-related cancer mechanisms. -
Stable Isotope
L-Aspartic acid-13C-1 is a stable isotope-labeled form of L-Aspartic acid, which is an amino acid capable of penetrating the blood-brain barrier. This compound is utilized in the formulation of prodrugs specifically targeting colon and cecal tissues. Furthermore, L-Aspartic acid-13C-1 is instrumental in the investigation of various inflammatory conditions, making it a valuable tool in biochemical research. -
Stable Isotope
1,3-Diolein-d66 is a deuterium-labeled derivative of 1,3-Diolein, a phospholipid that plays a crucial role in regulating cell membrane fluidity and signal transduction. This stable isotope is valuable in cell biology research for investigating lipid-mediated signaling pathways and interactions involving membrane proteins. Additionally, 1,3-Diolein-d66 can be utilized as a functional carrier in drug delivery systems, enhancing the bioavailability of therapeutic compounds. -
Stable Isotope
Rivaroxaban-d4 is a stable isotope-labeled form of Rivaroxaban, a potent and selective direct Factor Xa (FXa) inhibitor. This compound demonstrates significant anti-FXa activity with an IC50 of 0.7 nM and a Ki of 0.4 nM, making it a valuable tool for pharmacokinetic studies. It is commonly utilized in research applications involving anticoagulant therapy, drug metabolism, and in vivo tracking of Rivaroxaban pharmacodynamics. -
Stable Isotope
Edoxaban-d6 is a deuterium-labeled derivative of Edoxaban, a selective and potent inhibitor of factor Xa (FXa). Edoxaban exhibits high affinity for FXa with an IC50 of 0.561 nM, making it an effective anticoagulant for stroke prevention. It also displays weak inhibitory activity against thrombin and factor IXaβ, while maintaining a selectivity of over 10,000-fold for FXa. This reagent is useful for studying antithrombotic mechanisms and evaluating treatments for thromboembolic diseases in a variety of research applications. -
Stable Isotope
Apixaban-d3 is a deuterium-labeled analogue of Apixaban, a reversible and selective inhibitor of Factor Xa. With inhibition constants of 0.08 nM and 0.17 nM in human and rabbit models respectively, Apixaban demonstrates significant effectiveness in preventing thromboembolic diseases. This stable isotope is particularly useful in pharmacokinetic studies and bioanalytical research, allowing for enhanced tracking of the drug's metabolism and distribution in biological systems. -
Stable Isotope
Apixaban-13C,d3 is a stable isotope-labeled derivative of Apixaban, a potent and selective reversible inhibitor of Factor Xa, exhibiting Ki values of 0.08 nM and 0.17 nM in human and rabbit models, respectively. This high specificity makes Apixaban ideal for investigating anticoagulant mechanisms and studying related pharmacological effects. Researchers can utilize Apixaban-13C,d3 for quantitative analysis in pharmacokinetic studies, metabolic profiling, and isotopic tracing in biochemical assays. -
Stable Isotope
Betrixaban-d4 is a stable isotope-labeled form of Betrixaban, a highly potent and selective inhibitor of factor Xa (fXa) with an IC50 of 1.5 nM. This deuterium-labeled variant enables precise tracking and analysis in pharmacokinetic studies. Betrixaban is utilized for its antithrombotic properties in various research applications related to coagulation and cardiovascular health. -
Stable Isotope
Asundexian-d3 is a deuterium-labeled derivative of Asundexian, an orally active inhibitor of coagulation factor XIa (FXIa). It binds directly and reversibly to the active site of FXIa, effectively inhibiting its activity with an IC50 of 1 nM in human assays. This reagent is valuable for studies aimed at understanding blood coagulation mechanisms and evaluating FXIa's role in thrombosis and related disorders. -
Stable Isotope
Succinyladenosine-13C4 is a stable isotope labeled form of succinyladenosine, which serves as a vital metabolic byproduct derived from the dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase. This compound functions as a biochemical marker for assessing adenylosuccinase (ASL) deficiency. Succinyladenosine-13C4 is instrumental in metabolic studies, enabling researchers to investigate the role of nucleotide metabolism in various physiological and pathological contexts. -
Stable Isotope
Galactose 1-phosphate-13C-1 potassium is a stable isotope-labeled form of galactose 1-phosphate. This compound serves as an important intermediate in galactose metabolism and nucleotide sugar biosynthesis. It is widely used in metabolic studies and tracer experiments to investigate carbohydrate metabolism and cellular functions. Researchers can utilize this reagent for precise analytical applications, enhancing the understanding of galactose-related metabolic pathways. -
Stable Isotope
D-(+)-Trehalose-d2 is a deuterium-labeled form of D-(+)-Trehalose, a naturally occurring disaccharide derived from Saccharomyces cerevisiae. It serves as a stable isotope marker, making it valuable in metabolic studies, labeling experiments, and pharmaceutical formulations. Its unique isotopic signature allows for enhanced tracking and analysis of biological processes involving trehalose metabolism and function. -
Stable Isotope
Ac-Ala-OH-d3 is a deuterium-labeled derivative of Ac-Ala-OH, which serves as an endogenous metabolite. This stable isotope is utilized in metabolic studies and labeling experiments to elucidate metabolic pathways and enzymatic processes. Its incorporation into biochemical assays allows for enhanced tracking and quantification of metabolic activity. -
Stable Isotope
D-Sorbitol-d2-1 is a deuterium-labeled derivative of D-Sorbitol, a six-carbon sugar alcohol. This stable isotope is utilized as a tracer in metabolic studies and analytical applications. D-Sorbitol serves various roles in research, including as a sugar substitute, stabilizing excipient, and humectant, making it valuable in biochemical and pharmaceutical contexts. -
Stable Isotope
2,3-Butanediol-d6 is a stable isotope-labeled form of 2,3-Butanediol, a microbial-derived compound. This reagent serves as a specific urinary biomarker for Fmo5-/- mice and has been shown to inhibit age-related increases in plasma cholesterol levels. Its applications extend to various industries, including the formulation of printing inks, perfumes, fumigants, moistening and softening agents, plasticizers, and as a pharmaceutical carrier. -
Stable Isotope
L-(-)-Sorbose-13C-1 is a stable isotope labeled form of L-(-)-Sorbose, a natural sugar alcohol and an important metabolite in various biochemical pathways. As a stable isotope, it serves as a valuable tool for metabolic studies, tracer experiments, and isotope labeling in analytical chemistry. Its unique labeling provides insights into metabolic processes and enables precise tracking of metabolic flux in various biological systems. -
Stable Isotope
LacCer (d18:1/16:0)-d3 is a deuterium-labeled form of LacCer (d18:1/16:0), a bioactive sphingolipid involved in forming membrane microdomains with Lyn kinase and αi subunits of inhibitory G protein-coupled receptors (GPCRs). This compound is particularly relevant in studies of metabolic disorders, as elevated levels are found in the plasma of insulin-resistant cattle, and it is upregulated in models of Niemann-Pick type C1 disease, a neurodegenerative lysosomal storage disorder. LacCer (d18:1/16:0)-d3 serves as a valuable tool for elucidating the role of sphingolipids in various biological processes and disease pathways. -
Stable Isotope
H-Tyr(3-I)-OH-13C6 is a stable isotope-labeled form of H-Tyr(3-I)-OH, serving as a selective inhibitor of tyrosine hydroxylase. This compound plays a critical role as an intermediate in thyroid hormone synthesis and is relevant in studies of metabolic processes in human and mouse models. It is a valuable tool for researchers investigating neurotransmitter regulation and thyroid hormone metabolism. -
Stable Isotope
Trimethylammonium chloride-13C3,d9 is a stable isotope-labeled form of Trimethylammonium chloride, featuring deuterium and carbon-13 isotopes. This compound serves as an important endogenous metabolite, providing valuable insights into metabolic pathways and cellular processes. It is utilized in various research applications, including metabolic labeling and isotopic tracing studies, aiding in the understanding of biochemical dynamics and cellular metabolism. -
Stable Isotope
L-Thyroxine-13C6-1 is a stable isotope-labeled form of L-Thyroxine, also known as Levothyroxine or T4. This compound serves as a synthetic thyroid hormone and is widely utilized in research related to hypothyroidism. The stable isotope enrichment allows for enhanced tracking and analysis of its metabolic pathways, particularly in studies focused on the conversion of L-Thyroxine to the biologically active form, Triiodothyronine (T3), via deiodinase enzymes. -
Stable Isotope
18-Hydroxycorticosterone-d4 is the deuterium-labeled form of 18-Hydroxycorticosterone, a corticosteroid derived from corticosterone. This stable isotope serves as a valuable internal standard for quantitative analysis in various biological studies, particularly in endocrinology and metabolism research. It is utilized to investigate the metabolic pathways of corticosteroids and their impact on electrolyte balance. -
Stable Isotope
Propane-1,2,3-triyl tripalmitate-13C2 is a stable isotope-labeled form of Propane-1,2,3-triyl tripalmitate, an endogenous metabolite. This compound serves as an important tracer in metabolic studies, enabling researchers to investigate lipid metabolism and fatty acid synthesis pathways. Its stable carbon isotope labeling facilitates precise quantification and tracking in various biological systems. -
Stable Isotope
Trimethylammonium chloride-d10 is a deuterated form of Trimethylammonium chloride, which acts as a stable isotope. This compound serves as an endogenous metabolite and is utilized in various biochemical and metabolic studies. Its unique labeling allows for enhanced tracking and analysis in mass spectrometry and other analytical techniques, facilitating research in metabolic pathways and cellular processes. -
Stable Isotope
D-Mannose-13C-3 is a stable isotope-labeled form of D-Mannose, a pivotal carbohydrate involved in human metabolic processes. This compound is particularly important for studying glycosylation patterns of specific proteins, providing insights into cellular mechanisms and carbohydrate metabolism. D-Mannose-13C-3 serves as a valuable tool for research applications in glycomics and metabolic pathway analysis. -
Stable Isotope
Stearoylethanolamide-d3 is a deuterium-labeled analog of Stearoylethanolamide, which functions as an endocannabinoid-like compound. This stable isotope is utilized in research to investigate the biological pathways associated with apoptosis and the endocannabinoid system. Its pro-apoptotic activity makes it a valuable tool for studies focused on cancer biology and therapeutic applications. -
Stable Isotope
Propane-1,2,3-triyl tripalmitate-d27 is a deuterated stable isotope of Propane-1,2,3-triyl tripalmitate, a naturally occurring endogenous metabolite. This compound can be utilized in metabolic labeling studies to investigate lipid metabolism and the fate of fatty acids in biological systems. Its stable isotopic nature facilitates precise quantification and tracking in various experimental settings, making it suitable for applications in bioanalytical chemistry and metabolic research. -
Stable Isotope
Trimethylammonium chloride-15N is a stable isotope-labeled derivative of trimethylammonium chloride, primarily used as a tracer in metabolic studies. This reagent serves as an endogenous metabolite and is valuable for researching methylation processes, metabolic pathways, and cellular ion regulation. Its stable isotope label enables precise tracking and analysis in various biochemical assays, enhancing the understanding of metabolic functions and interactions in biological systems. -
Stable Isotope
N-Acetyl-D-glucosamine-13C-1 is a stable isotope-labeled form of N-Acetyl-D-glucosamine, a monosaccharide derivative of glucosamine. This compound is commonly used in metabolic studies, isotopic tracing, and in-depth biochemical research due to its ability to participate in glycosylation reactions. Its applications extend to cellular metabolism analysis and the study of glycan structures, providing valuable insights into carbohydrate biochemistry and cellular processes. -
Stable Isotope
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate-d54 is a deuterated derivative of the phospholipid compound, designed to serve as a stable isotope label. This reagent demonstrates enhanced stability and facilitates precise quantification in metabolic studies. It is particularly useful for tracing metabolic pathways and investigating lipid metabolism in various biological research applications. -
Stable Isotope
Muconic acid-d4 is a deuterated form of trans-trans-Muconic acid, serving as a stable isotope for analytical applications. This compound is a urinary metabolite of benzene and is recognized as a reliable biomarker for benzene exposure in humans. Its use in biological research facilitates the study of benzene metabolism and the assessment of environmental and occupational exposure levels. -
Stable Isotope
Lovastatin-d3 hydroxy acid sodium is a deuterium-labeled derivative of Lovastatin hydroxy acid sodium, a potent inhibitor of HMG-CoA reductase, with a Ki of 0.6 nM. This stable isotope is utilized in metabolic studies to investigate cholesterol biosynthesis and regulation. It serves as a valuable tool for researchers examining the pharmacokinetics and pharmacodynamics of statins in biochemical and clinical research applications. -
Stable Isotope
IDO-IN-7-d10 is a deuterium-labeled analogue of IDO-IN-7, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with an IC50 value of 38 nM. This stable isotope derivative is designed for use in metabolic studies and biomarker analysis, enhancing the understanding of IDO1-related pathways in cancer and immune response research. Its use in tracer studies allows for improved tracking of metabolic processes. -
Stable Isotope
(S)-Indoximod-d3 is a deuterium-labeled form of (S)-Indoximod, an inhibitor of indoleamine 2,3-dioxygenase (IDO). This stable isotope retains the biological activity of the parent compound, allowing for precise tracking and measurement in metabolic studies. (S)-Indoximod-d3 is primarily utilized in cancer research, particularly in studies exploring immune modulation and tumor microenvironment interactions.
