Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is a deuterium-labeled analog of Ercalcitriol, a potent vitamin D receptor (VDR) agonist with high affinity for VDR. Upon binding, Ercalcitriol-d3 interacts with retinoid X receptor (RXR) to modulate gene transcription, leading to increased expression of antimicrobial peptides, such as human cat antimicrobial peptide (hCAP-18/LL-37), which is effective against periodontal pathogens like Porphyromonas gingivalis. This reagent is primarily utilized in research studies focused on periodontal diseases and immune-related conditions of the oral cavity, enhancing understanding of immune defense mechanisms.
Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is a deuterium-labeled analog of Ercalcitriol, a potent vitamin D receptor (VDR) agonist with high affinity for VDR. Upon binding, Ercalcitriol-d3 interacts with retinoid X receptor (RXR) to modulate gene transcription, leading to increased expression of antimicrobial peptides, such as human cat antimicrobial peptide (hCAP-18/LL-37), which is effective against periodontal pathogens like Porphyromonas gingivalis. This reagent is primarily utilized in research studies focused on periodontal diseases and immune-related conditions of the oral cavity, enhancing understanding of immune defense mechanisms.
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