Norharman-d7 is a deuterium-labeled derivative of Norharmane, a β-carboline alkaloid known for its reversible inhibition of monoamine oxidase (MAO). It exhibits notable biological activity as an antidepressant, with IC50 values of 6.5 μM for MAO-A and 4.7 μM for MAO-B, and demonstrates potential as an anti-cancer photosensitizer. Additionally, Norharmane-d7 influences polar auxin transport by inhibiting transport proteins PIN2, PIN3, and PIN7, significantly affecting the growth of Arabidopsis thaliana seedlings, making it valuable for research in neurochemistry and plant biology.
Norharman-d7 is a deuterium-labeled derivative of Norharmane, a β-carboline alkaloid known for its reversible inhibition of monoamine oxidase (MAO). It exhibits notable biological activity as an antidepressant, with IC50 values of 6.5 μM for MAO-A and 4.7 μM for MAO-B, and demonstrates potential as an anti-cancer photosensitizer. Additionally, Norharmane-d7 influences polar auxin transport by inhibiting transport proteins PIN2, PIN3, and PIN7, significantly affecting the growth of Arabidopsis thaliana seedlings, making it valuable for research in neurochemistry and plant biology.
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