Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Glycine-1-13C is a stable isotope-labeled form of glycine, functioning primarily as an inhibitory neurotransmitter in the central nervous system (CNS). It serves as a co-agonist with glutamate, enhancing excitatory signaling at the glutamatergic N-methyl-D-aspartic acid (NMDA) receptors. This reagent is valuable in metabolic studies, neurotransmission research, and isotopic tracing experiments. -
Stable Isotope
Glycine-15N is a stable isotope-labeled form of glycine, a crucial inhibitory neurotransmitter in the central nervous system. It plays a significant role as a co-agonist with glutamate, enhancing excitatory signaling at NMDA receptors. This compound is widely utilized in research applications such as metabolic studies, neuropharmacology, and isotope tracing in biological systems. -
Stable Isotope
D-Serine-d3 is a deuterium-labeled form of D-Serine, functioning primarily as a stable isotope in biochemical research. D-Serine, an endogenous amino acid, serves as a co-agonist at NMDA glutamate receptors, influencing various neurological processes. Its involvement in NMDA receptor-mediated neurotransmission, synaptic plasticity, and cell migration makes it a valuable tool for studies related to neuropharmacology and neurodevelopmental disorders. This labeled compound facilitates advanced research into the dynamics of neurotransmitter interactions and their implications in brain function. -
Stable Isotope
Glycine-13C2,15N is a stable isotope-labeled form of glycine, incorporating both carbon-13 and nitrogen-15 isotopes. As an important inhibitory neurotransmitter in the central nervous system, glycine also functions as a co-agonist with glutamate, enhancing excitatory signaling at the NMDA receptors. This labeled reagent is valuable for applications in metabolic studies, isotope tracing, and investigating neurotransmitter dynamics in various biological systems. -
Stable Isotope
Decanoic acid-d5 is a deuterium-labeled derivative of decanoic acid, which serves as a stable isotope in research applications. The compound functions as a non-competitive inhibitor of AMPA receptors and exhibits brain-penetrant properties, contributing to its antiseizure effects. This reagent is valuable for studies involving neurotransmission, epilepsy, and the metabolic pathways of medium-chain triglycerides. -
Stable Isotope
S-Benzyl-DL-cysteine-2,3,3-d3 is a deuterium-labeled derivative of Benzylcysteine, functioning as an inhibitor of the ASCT2 transporter. It demonstrates an apparent Ki of 780 μM, acting through a competitive inhibition mechanism by binding to the substrate-binding site of ASCT2. This compound is valuable for studying amino acid transport and cellular uptake mechanisms in various biological systems. -
Stable Isotope
Elacridar-d4(Major) is a deuterium-labeled variant of Elacridar, a potent inhibitor of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP). This stable isotope labeled compound is instrumental in studying the role of efflux transporters in drug distribution, particularly within the brain, and is valuable for cancer research. Its unique deuterated structure allows for detailed metabolic and pharmacokinetic investigations. -
Stable Isotope
L-Phenylalanine-d5 is a stable deuterated form of the essential amino acid L-Phenylalanine, which serves as a competitive antagonist of the glycine and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs). It exhibits an affinity for the α2δ subunit of voltage-dependent calcium channels with a Ki of 980 nM, making it valuable in studies of neurotransmission and synaptic function. This reagent is widely utilized in biochemical research, including metabolic studies and the synthesis of pharmaceuticals and food flavors. -
Stable Isotope
L-Phenylalanine-13C6 is a stable isotope-labeled variant of the essential amino acid L-Phenylalanine. As a competitive antagonist of the glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs), it exhibits a binding affinity (KB) of 573 μM. Additionally, it targets the α2δ subunit of voltage-dependent calcium channels with a Ki of 980 nM. This reagent is valuable in biochemical research, particularly in metabolic studies and the synthesis of pharmaceuticals and food flavorings. -
Stable Isotope
Acetylcholine-d4 chloride is a deuterium-labeled form of the neurotransmitter acetylcholine. It functions as a potent cholinergic agonist and effectively crosses the blood-brain barrier (BBB). This reagent modulates dopaminergic neuronal activity by stimulating nicotinic acetylcholine receptors (nAChRs) and has also been shown to inhibit the aggregation of p53 mutant peptides in vitro. Its unique isotopic labeling makes it a valuable tool for chemical and biological research applications. -
Stable Isotope
L-Phenylalanine-d8 is the deuterated form of the essential amino acid L-Phenylalanine, which is recognized for its role as an antagonist of the α2δ subunit of voltage-dependent calcium channels with an inhibition constant (Ki) of 980 nM. Additionally, it competes for glycine- and glutamate-binding sites at N-methyl-D-aspartate receptors (NMDARs) with a binding affinity (KB) of 573 μM. This stable isotope is essential for applications in metabolic studies, tracer experiments, and the synthesis of pharmaceuticals and food flavoring compounds. -
Stable Isotope
Acetylcholine-d9 chloride is a deuterium-labeled form of acetylcholine chloride, a potent cholinergic agonist that effectively crosses the blood-brain barrier. This compound modulates dopaminergic neuronal activity by stimulating nicotinic acetylcholine receptors (nAChRs). Additionally, it has been shown to inhibit p53 mutant peptide aggregation in vitro, making it valuable for research focused on neurobiology, receptor pharmacology, and protein aggregation studies. -
Stable Isotope
L-Phenylalanine-13C9 is a stable isotope labeled form of the essential amino acid L-Phenylalanine, also known as (S)-2-Amino-3-phenylpropionic acid. This compound serves as an antagonist of the α2δ subunit of voltage-dependent calcium channels, exhibiting a Ki of 980 nM. Additionally, L-Phenylalanine acts as a competitive antagonist at the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) with a KB of 573 μM. It is employed in various research applications, including metabolic studies and tracer experiments in biochemical pathways. -
Stable Isotope
L-Phenylalanine-15N is a stable isotope-labeled form of the essential amino acid L-Phenylalanine, recognized chemically as (S)-2-Amino-3-phenylpropionic acid. It serves as an antagonist of the α2δ subunit of voltage-dependent calcium channels, exhibiting a Ki value of 980 nM. Furthermore, it acts as a competitive antagonist at the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) with a KB value of 573 μM. This compound finds broad applications in biochemical research, particularly in studies related to amino acid metabolism and receptor function. -
Stable Isotope
Acetylcholine-d4 bromide is a stable isotope-labeled form of acetylcholine bromide, featuring deuterium substitution. It serves as a valuable internal standard in quantitative mass spectrometry applications, enabling precise detection and quantification of acetylcholine in biological samples. This reagent is essential for studies involving neurotransmitter dynamics, pharmacokinetics, and metabolic analysis, providing enhanced accuracy in research focused on cholinergic signaling pathways. -
Stable Isotope
DL-Phenylalanine-d5 is a deuterium-labeled derivative of DL-Phenylalanine, a naturally occurring amino acid. This stable isotope is utilized in various biochemical and metabolic research applications, particularly in studies involving protein synthesis and pathways involving phenylalanine metabolism. Its labeling enables precise tracking and quantitative analysis in mass spectrometry and NMR experiments, facilitating advanced studies in metabolic flux and neurochemistry. -
Stable Isotope
Acetylcholine-d9 bromide is a deuterium-labeled derivative of acetylcholine that serves as a stable isotope. This reagent is primarily used in biochemical and pharmacological research to study acetylcholine receptor interactions and metabolic pathways. Its unique isotopic labeling enables precise tracking in mass spectrometry and other analytical techniques, facilitating advancements in neurobiology and drug development. -
Stable Isotope
L-Phenylalanine-d2 is a deuterium-labeled form of the essential amino acid L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid). It serves as a stable isotope and acts as an antagonist of the α2δ subunit of voltage-dependent calcium channels, with a Ki of 980 nM. Additionally, L-Phenylalanine-d2 competitively inhibits glycine- and glutamate-binding sites on both N-methyl-D-aspartate receptors (NMDARs) and non-NMDARs, demonstrating a Ki of 573 μM. This reagent is valuable for applications in biochemical research, including metabolic studies and tracer experiments. -
Stable Isotope
Verapamil-d3 hydrochloride is a deuterium-labeled derivative of the calcium channel blocker, verapamil hydrochloride. It serves as a potent inhibitor of P-glycoprotein (P-gp) and CYP3A4, facilitating detailed pharmacological studies. This stable isotope is primarily utilized in research related to hypertension, cardiac arrhythmias, and angina, providing insight into drug metabolism and transport mechanisms in various biological systems. -
Stable Isotope
L-Phenylalanine-13C9,15N is a stable isotope-labeled version of the essential amino acid L-Phenylalanine, featuring carbon-13 and nitrogen-15 isotopes. This compound serves as an α2δ subunit antagonist for voltage-dependent Ca²⁺ channels, exhibiting a Ki of 980 nM. Additionally, L-Phenylalanine acts as a competitive antagonist at the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs), with a KB of 573 μM. Its applications extend to the fields of metabolic studies, tracer studies in amino acid metabolism, and the development of food flavors and pharmaceuticals. -
Stable Isotope
L-Phenylalanine-3-13C is a stable isotope-labeled analog of the essential amino acid L-Phenylalanine, known to inhibit the α2δ subunit of voltage-dependent calcium channels with a Ki of 980 nM. This compound also competitively antagonizes glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs), exhibiting a KB of 573 μM. L-Phenylalanine-3-13C is utilized in metabolic studies and tracer applications, facilitating insights into amino acid metabolism and neurotransmitter signaling. -
Stable Isotope
Gabapentin-d4 is a deuterium-labeled derivative of Gabapentin, a GABA analog. This stable isotope is primarily utilized in research applications to study the pharmacokinetics and metabolism of Gabapentin. Its use facilitates the investigation of neurological disorders, epilepsy, and neuropathic pain mechanisms. -
Stable Isotope
L-Phenylalanine-13C is a stable isotope-labeled form of L-Phenylalanine, an essential amino acid known for its role in protein synthesis. This compound serves as an antagonist of the α2δ subunit of voltage-dependent Ca2+ channels, showing a Ki of 980 nM, and competes for glycine and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs) with a KB of 573 μM. L-Phenylalanine-13C is utilized in various research applications, including metabolic studies, food flavoring production, and pharmaceutical development. -
Stable Isotope
1-Octanol-d17 is a deuterated derivative of 1-Octanol, serving as a stable isotope for various analytical applications. This saturated fatty alcohol acts as an inhibitor of T-type calcium channels, demonstrating an IC50 value of 4 μM for native T-currents. In addition to its role in calcium signaling research, 1-Octanol is also recognized for its potential as a biofuel due to its diesel-like properties. -
Stable Isotope
Diltiazem-d3 hydrochloride is a deuterated form of Diltiazem hydrochloride, acting as a calcium channel blocker. This stable isotope serves as a valuable tool in pharmacokinetic studies and metabolic research, enabling the investigation of Diltiazem's mechanisms of action and its effects on calcium influx regulation. Its use in isotopic labeling facilitates precise tracking in biological systems, contributing to enhanced understanding in drug metabolism and efficacy studies. -
Stable Isotope
Nifedipine-d6 is a deuterium-labeled derivative of nifedipine, a potent calcium channel blocker. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the metabolism and distribution of nifedipine in biological systems. Its incorporation of deuterium enhances analytical precision in spectroscopic and mass spectrometric techniques, facilitating advanced research in drug development and therapeutic monitoring. -
Stable Isotope
Acetylcholine-d16 bromide is a deuterium-labeled analog of acetylcholine, functioning as a stable isotope. It serves as a valuable standard in analytical studies, particularly in the quantification of acetylcholine dynamics and metabolism. This reagent is instrumental for researchers investigating cholinergic signaling pathways and exploring cholinergic receptor interactions. -
Stable Isotope
Taurolithocholic acid-d4 is a deuterated form of Taurolithocholic acid, serving as a stable isotope internal standard in chemical research. Its primary mechanism involves the conjugation and regulation of bile acids within hepatic pathways. This reagent is essential for accurately quantifying Taurolithocholic acid levels in biological samples, enabling researchers to explore metabolic pathways and bile acid homeostasis. Its isotopic labeling enhances analytical precision in mass spectrometry and other analytical techniques. -
Stable Isotope
Amlodipine-d4 is a deuterium-labeled derivative of Amlodipine, a dihydropyridine calcium channel blocker and antianginal agent. This compound selectively inhibits voltage-dependent L-type calcium channels, leading to reduced calcium influx. Amlodipine-d4 is primarily utilized in pharmacokinetics studies and metabolic research to investigate the pharmacological effects of Amlodipine in conditions such as hypertension and cancer. -
Stable Isotope
Ethosuximide-d3 is a deuterium-labeled derivative of Ethosuximide, which primarily targets low-voltage activated T-type calcium channels. This reagent exhibits significant anti-epileptic properties and has been shown to enhance phenotypic outcomes in various neurodegenerative disease models. Ethosuximide-d3 is valuable for tracing studies and metabolic research, aiding in the understanding of drug disposition and action in biological systems. -
Stable Isotope
Amlodipine-d4 maleate is a deuterium-labeled derivative of Amlodipine maleate, a dihydropyridine calcium channel blocker. This compound selectively inhibits voltage-dependent L-type calcium channels, thereby reducing calcium influx and exerting pharmacological effects as an antianginal agent. Amlodipine-d4 maleate is particularly useful in research applications focused on hypertension and cancer, providing a stable isotopic reference for metabolic studies and pharmacokinetic assessments. -
Stable Isotope
L-Phenylalanine-d7 is a deuterium-labeled form of the essential amino acid L-Phenylalanine, known for its role as an α2δ subunit antagonist of voltage-dependent Ca²⁺ channels, with a Ki value of 980 nM. Additionally, it acts as a competitive antagonist for glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs), exhibiting a KB of 573 μM. This reagent is valuable for studies in amino acid metabolism, neurotransmission, and the synthesis of food flavors and pharmaceuticals. -
Stable Isotope
Lercanidipine-d3 hydrochloride is a deuterated derivative of Lercanidipine, a third-generation dihydropyridine calcium channel blocker. This stable isotope serves as a valuable tool for pharmacokinetic studies and metabolic research, particularly in assessing the antihypertensive effects and renal protective properties of Lercanidipine. Its lipophilic nature enhances its bioavailability, making it suitable for various applications in cardiovascular research. -
Stable Isotope
Taurolithocholic acid-d4 sodium is a deuterium-labeled derivative of Taurolithocholic acid (sodium salt), serving as a stable isotope. It is recognized as a potent cholestatic agent and acts as a calcium ion (Ca2+) agonist. This compound is valuable in research applications that explore cholestasis mechanisms, calcium signaling, and metabolic studies. -
Stable Isotope
Menthol-d4 is a deuterium-labeled analog of menthol, a natural compound known for its analgesic properties. It elicits a cooling sensation by stimulating cold receptors, primarily through the inhibition of calcium currents in neuronal membranes. This stable isotope can be utilized in pharmacokinetic studies and metabolic research to trace menthol's biological pathways and effects. -
Stable Isotope
Ulixacaltamide-d9 hydrochloride is a deuterium-labeled derivative of Ulixacaltamide, designed for stable isotope studies. This compound serves as a useful tool in pharmacokinetic and metabolic research, enabling detailed tracing of drug metabolism and distribution. Its incorporation of deuterium enhances experimental accuracy in biological assays, facilitating a deeper understanding of Ulixacaltamide’s action and potential therapeutic applications. -
Stable Isotope
Ranolazine-d3 is a deuterated form of Ranolazine, an anti-anginal agent that primarily inhibits the late phase of inward sodium current (INa) with an IC50 value of 6 μM and IKr with an IC50 value of 12 μM, leading to its therapeutic effects without altering heart rate or blood pressure. Additionally, Ranolazine acts as a partial fatty acid oxidation (FAO) inhibitor. This compound serves as a valuable tool in cardiovascular research, particularly in studying sodium channel activity and metabolic modulation in heart physiology. -
Stable Isotope
Diltiazem-d6 is a deuterium-labeled derivative of Diltiazem, primarily known for its inhibitory action on L-type Ca2+ channels. This compound exhibits significant antihypertensive and antiarrhythmic properties, making it valuable for studying cardiac arrhythmias, hypertension, and angina pectoris. Diltiazem-d6 serves as a stable isotope for metabolic tracing and pharmacokinetic research in various biological systems. -
Stable Isotope
(R)-Amlodipine-d4 is a stable isotope-labeled form of (R)-Amlodipine, primarily targeting calcium channels. This deuterated compound is utilized in pharmacokinetic studies and metabolic research to track drug metabolism and distribution in various biological systems. Its use aids in the understanding of the pharmacological effects and biological activity of (R)-Amlodipine in cardiovascular research. -
Stable Isotope
Lercanidipine-13C,d3 hydrochloride is a stable isotope-labeled form of Lercanidipine hydrochloride, a third-generation dihydropyridine calcium channel blocker (DHP-CCB). It exhibits prolonged antihypertensive effects and offers renoprotective benefits. This compound is valuable for pharmacokinetic studies and mechanistic research involving calcium signaling and cardiovascular physiology. -
Isotope-Labeled Compound
Ethacrynic acid D5 is a deuterium-labeled analog of Ethacrynic acid, primarily targeting glutathione S-transferases (GSTs). This compound exhibits diuretic properties and serves as a potent inhibitor of the NF-kB signaling pathway, with implications in modulating leukotriene formation. Additionally, it inhibits L-type voltage-dependent and store-operated calcium channels, contributing to the relaxation of airway smooth muscle cells. Ethacrynic acid D5 also demonstrates anti-inflammatory effects, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it valuable in related research applications. -
Stable Isotope
Lercanidipine-13C,d3-1 hydrochloride is a stable isotope-labeled variant of Lercanidipine hydrochloride, a third-generation dihydropyridine calcium channel blocker. This compound exhibits potent antihypertensive properties and provides renal protection. It is particularly useful in pharmacokinetic studies, enabling the investigation of metabolic pathways and the evaluation of drug interactions in hypertension research. -
Stable Isotope
L-Phenylalanine-d is a deuterium-labeled form of the essential amino acid L-Phenylalanine, which serves as a stable isotope. This compound acts as an antagonist to the α2δ subunit of voltage-dependent calcium channels, exhibiting a Ki value of 980 nM. Additionally, L-Phenylalanine-d competitively inhibits glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs) with a KB of 573 μM. It finds applications in research related to neuropharmacology and the synthesis of various pharmaceuticals and food flavorings. -
Stable Isotope
(S)-Lercanidipine-d3 hydrochloride is a deuterium-labeled form of the antihypertensive agent Lercanidipine. It acts primarily as a calcium channel blocker, inhibiting the influx of calcium ions into vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. This stable isotope is useful in pharmacokinetic studies, metabolic research, and drug development to trace the pharmacological effects and biodistribution of the parent compound. -
Stable Isotope
L-Phenylalanine-d1 is a deuterium-labeled form of the essential amino acid L-Phenylalanine, which serves as a stable isotope for diverse research applications. Functioning as an antagonist of the α2δ subunit of voltage-dependent Ca2+ channels, it exhibits a Ki of 980 nM, and it also acts as a competitive antagonist at glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs) with a KB of 573 µM. This compound is valuable in both metabolic studies and the synthesis of pharmaceuticals and flavor agents. -
Stable Isotope
L-Phenylalanine-13C9,15N,d8 is a stable isotope-labeled form of L-Phenylalanine, featuring deuterium and carbon isotopes. As an essential amino acid, it plays a vital role in protein synthesis and is also recognized for its interaction with voltage-dependent Ca2+ channels, acting as an antagonist with a Ki of 980 nM. Additionally, L-Phenylalanine competitively antagonizes the glycine and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs), with a KB of 573 μM. This compound is useful in biochemical research and applications involving metabolic studies, tracer applications, and drug development. -
Stable Isotope
Norverapamil-d7 hydrochloride is a deuterium-labeled analog of Norverapamil, functioning primarily as a stable isotope. This compound is an N-demethylated metabolite of Verapamil and acts as an L-type calcium channel blocker while inhibiting P-glycoprotein (P-gp) functions. It's utilized in pharmacokinetic studies to investigate drug metabolism and transport mechanisms. -
Stable Isotope
1-Octanol-d2 is the deuterium-labeled version of 1-Octanol, a saturated fatty alcohol that serves as an inhibitor of T-type calcium channels (T-channels), exhibiting an IC50 of 4 μM for native T-currents. Its unique chemical properties make it a valuable tool for studying calcium channel modulation and its implications in various physiological processes. Additionally, 1-Octanol is noted for its potential as a biofuel with diesel-like characteristics, offering insights into alternative energy applications. -
Stable Isotope
Ranolazine-d5 is a deuterium-labeled analogue of Ranolazine, which primarily targets the late phase of inward sodium current (INa) and potassium channels (IKr), exhibiting IC50 values of 6 μM and 12 μM, respectively. This compound functions as an anti-anginal agent by alleviating myocardial ischemia without influencing heart rate or blood pressure. Additionally, Ranolazine-d5 serves as a partial inhibitor of fatty acid oxidation (FAO), making it valuable for research in cardiovascular pharmacology and metabolic studies. -
Stable Isotope
Gabapentin-d10 is a deuterated form of Gabapentin, functioning primarily as a stable isotope. It serves as a potent, orally active blocker of P/Q type Ca2+ channels, inhibiting neuronal calcium influx and subsequently reducing neurotransmitter release. This GABA analog is widely utilized in research to explore mechanisms of neuropathic pain relief and related pathways in the nervous system.
