Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
L-Phenylalanine-d7 is a deuterium-labeled form of the essential amino acid L-Phenylalanine, known for its role as an α2δ subunit antagonist of voltage-dependent Ca²⁺ channels, with a Ki value of 980 nM. Additionally, it acts as a competitive antagonist for glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs), exhibiting a KB of 573 μM. This reagent is valuable for studies in amino acid metabolism, neurotransmission, and the synthesis of food flavors and pharmaceuticals. -
Stable Isotope
Lercanidipine-d3 hydrochloride is a deuterated derivative of Lercanidipine, a third-generation dihydropyridine calcium channel blocker. This stable isotope serves as a valuable tool for pharmacokinetic studies and metabolic research, particularly in assessing the antihypertensive effects and renal protective properties of Lercanidipine. Its lipophilic nature enhances its bioavailability, making it suitable for various applications in cardiovascular research. -
Stable Isotope
Taurolithocholic acid-d4 sodium is a deuterium-labeled derivative of Taurolithocholic acid (sodium salt), serving as a stable isotope. It is recognized as a potent cholestatic agent and acts as a calcium ion (Ca2+) agonist. This compound is valuable in research applications that explore cholestasis mechanisms, calcium signaling, and metabolic studies. -
Stable Isotope
Menthol-d4 is a deuterium-labeled analog of menthol, a natural compound known for its analgesic properties. It elicits a cooling sensation by stimulating cold receptors, primarily through the inhibition of calcium currents in neuronal membranes. This stable isotope can be utilized in pharmacokinetic studies and metabolic research to trace menthol's biological pathways and effects. -
Stable Isotope
Ulixacaltamide-d9 hydrochloride is a deuterium-labeled derivative of Ulixacaltamide, designed for stable isotope studies. This compound serves as a useful tool in pharmacokinetic and metabolic research, enabling detailed tracing of drug metabolism and distribution. Its incorporation of deuterium enhances experimental accuracy in biological assays, facilitating a deeper understanding of Ulixacaltamide’s action and potential therapeutic applications. -
Stable Isotope
Ranolazine-d3 is a deuterated form of Ranolazine, an anti-anginal agent that primarily inhibits the late phase of inward sodium current (INa) with an IC50 value of 6 μM and IKr with an IC50 value of 12 μM, leading to its therapeutic effects without altering heart rate or blood pressure. Additionally, Ranolazine acts as a partial fatty acid oxidation (FAO) inhibitor. This compound serves as a valuable tool in cardiovascular research, particularly in studying sodium channel activity and metabolic modulation in heart physiology. -
Stable Isotope
Diltiazem-d6 is a deuterium-labeled derivative of Diltiazem, primarily known for its inhibitory action on L-type Ca2+ channels. This compound exhibits significant antihypertensive and antiarrhythmic properties, making it valuable for studying cardiac arrhythmias, hypertension, and angina pectoris. Diltiazem-d6 serves as a stable isotope for metabolic tracing and pharmacokinetic research in various biological systems. -
Stable Isotope
(R)-Amlodipine-d4 is a stable isotope-labeled form of (R)-Amlodipine, primarily targeting calcium channels. This deuterated compound is utilized in pharmacokinetic studies and metabolic research to track drug metabolism and distribution in various biological systems. Its use aids in the understanding of the pharmacological effects and biological activity of (R)-Amlodipine in cardiovascular research. -
Stable Isotope
Lercanidipine-13C,d3 hydrochloride is a stable isotope-labeled form of Lercanidipine hydrochloride, a third-generation dihydropyridine calcium channel blocker (DHP-CCB). It exhibits prolonged antihypertensive effects and offers renoprotective benefits. This compound is valuable for pharmacokinetic studies and mechanistic research involving calcium signaling and cardiovascular physiology. -
Isotope-Labeled Compound
Ethacrynic acid D5 is a deuterium-labeled analog of Ethacrynic acid, primarily targeting glutathione S-transferases (GSTs). This compound exhibits diuretic properties and serves as a potent inhibitor of the NF-kB signaling pathway, with implications in modulating leukotriene formation. Additionally, it inhibits L-type voltage-dependent and store-operated calcium channels, contributing to the relaxation of airway smooth muscle cells. Ethacrynic acid D5 also demonstrates anti-inflammatory effects, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it valuable in related research applications. -
Stable Isotope
Lercanidipine-13C,d3-1 hydrochloride is a stable isotope-labeled variant of Lercanidipine hydrochloride, a third-generation dihydropyridine calcium channel blocker. This compound exhibits potent antihypertensive properties and provides renal protection. It is particularly useful in pharmacokinetic studies, enabling the investigation of metabolic pathways and the evaluation of drug interactions in hypertension research. -
Stable Isotope
L-Phenylalanine-d is a deuterium-labeled form of the essential amino acid L-Phenylalanine, which serves as a stable isotope. This compound acts as an antagonist to the α2δ subunit of voltage-dependent calcium channels, exhibiting a Ki value of 980 nM. Additionally, L-Phenylalanine-d competitively inhibits glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs) with a KB of 573 μM. It finds applications in research related to neuropharmacology and the synthesis of various pharmaceuticals and food flavorings. -
Stable Isotope
(S)-Lercanidipine-d3 hydrochloride is a deuterium-labeled form of the antihypertensive agent Lercanidipine. It acts primarily as a calcium channel blocker, inhibiting the influx of calcium ions into vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. This stable isotope is useful in pharmacokinetic studies, metabolic research, and drug development to trace the pharmacological effects and biodistribution of the parent compound. -
Stable Isotope
L-Phenylalanine-d1 is a deuterium-labeled form of the essential amino acid L-Phenylalanine, which serves as a stable isotope for diverse research applications. Functioning as an antagonist of the α2δ subunit of voltage-dependent Ca2+ channels, it exhibits a Ki of 980 nM, and it also acts as a competitive antagonist at glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs) with a KB of 573 µM. This compound is valuable in both metabolic studies and the synthesis of pharmaceuticals and flavor agents. -
Stable Isotope
L-Phenylalanine-13C9,15N,d8 is a stable isotope-labeled form of L-Phenylalanine, featuring deuterium and carbon isotopes. As an essential amino acid, it plays a vital role in protein synthesis and is also recognized for its interaction with voltage-dependent Ca2+ channels, acting as an antagonist with a Ki of 980 nM. Additionally, L-Phenylalanine competitively antagonizes the glycine and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs), with a KB of 573 μM. This compound is useful in biochemical research and applications involving metabolic studies, tracer applications, and drug development. -
Stable Isotope
Norverapamil-d7 hydrochloride is a deuterium-labeled analog of Norverapamil, functioning primarily as a stable isotope. This compound is an N-demethylated metabolite of Verapamil and acts as an L-type calcium channel blocker while inhibiting P-glycoprotein (P-gp) functions. It's utilized in pharmacokinetic studies to investigate drug metabolism and transport mechanisms. -
Stable Isotope
1-Octanol-d2 is the deuterium-labeled version of 1-Octanol, a saturated fatty alcohol that serves as an inhibitor of T-type calcium channels (T-channels), exhibiting an IC50 of 4 μM for native T-currents. Its unique chemical properties make it a valuable tool for studying calcium channel modulation and its implications in various physiological processes. Additionally, 1-Octanol is noted for its potential as a biofuel with diesel-like characteristics, offering insights into alternative energy applications. -
Stable Isotope
Ranolazine-d5 is a deuterium-labeled analogue of Ranolazine, which primarily targets the late phase of inward sodium current (INa) and potassium channels (IKr), exhibiting IC50 values of 6 μM and 12 μM, respectively. This compound functions as an anti-anginal agent by alleviating myocardial ischemia without influencing heart rate or blood pressure. Additionally, Ranolazine-d5 serves as a partial inhibitor of fatty acid oxidation (FAO), making it valuable for research in cardiovascular pharmacology and metabolic studies. -
Stable Isotope
Gabapentin-d10 is a deuterated form of Gabapentin, functioning primarily as a stable isotope. It serves as a potent, orally active blocker of P/Q type Ca2+ channels, inhibiting neuronal calcium influx and subsequently reducing neurotransmitter release. This GABA analog is widely utilized in research to explore mechanisms of neuropathic pain relief and related pathways in the nervous system. -
Stable Isotope
Taurolithocholic acid-d5 is a deuterium-labeled derivative of Taurolithocholic acid, primarily serving as a stable isotope for research applications. It is utilized in pharmacokinetic studies, metabolic tracing, and isotopic labeling experiments to analyze the dynamics of bile acids in biological systems. Researchers can employ this reagent to enhance the accuracy of quantitative mass spectrometry and elucidate the role of bile acids in various physiological and pathological processes. -
Stable Isotope
Gabapentin-d6 hydrochloride is a stable isotope-labeled form of Gabapentin, characterized by the incorporation of six deuterium atoms. This reagent is particularly useful in pharmacokinetic studies and metabolic research, facilitating the tracking of Gabapentin's behavior in biological systems. Its deuterated nature allows for enhanced analytical sensitivity in mass spectrometry applications, aiding in drug development and therapeutic monitoring. -
Stable Isotope
Etiracetam-d3 is a deuterated form of Etiracetam, serving as a stable isotope. As an acetylcholine agonist and member of the racetam family, Etiracetam displays nootropic effects, although it is less potent than its S-enantiomer, Levetiracetam. This compound is primarily utilized in pharmacokinetic studies and metabolic research to trace acetylcholine-related pathways in the brain. -
Isotope-Labeled Compounds
Verapamil-d7 is a deuterium-labeled derivative of Verapamil, a calcium channel blocker and a potent inhibitor of the P-glycoprotein (P-gp) transporter. This isotope-labeled compound is utilized in pharmacokinetic studies and metabolic research, providing insights into drug interactions and transport mechanisms. Its applications extend to investigating conditions such as hypertension, cardiac arrhythmias, and angina, making it a valuable tool in cardiovascular research. -
Stable Isotope
Ethosuximide-d5 is a stable isotopically labeled form of Ethosuximide, an established anti-epileptic agent. This compound acts primarily as a blocker of low voltage activated T-type calcium channels, contributing to its therapeutic effects. Ethosuximide-d5 is valuable for research applications involving neurodegenerative disease models and mechanisms of epilepsy, enabling precise metabolic studies and tracking within biological systems. -
Stable Isotope
Diltiazem-(acetoxy-d3) hydrochloride is a deuterium-labeled derivative of Diltiazem hydrochloride, a calcium channel antagonist. As a stable isotope compound, it serves as a valuable tool for pharmacokinetic studies and metabolic research, allowing for precise tracking of Diltiazem's biological fate. This reagent can facilitate investigations into calcium signaling pathways and cardiovascular pharmacology. -
Stable Isotope
Levamlodipine-d4 is the deuterium-labeled form of Levamlodipine, a selective dihydropyridine calcium channel blocker. This compound exhibits significant vasodilatory activity and is commonly utilized in the management of hypertension and angina. As a stable isotope, Levamlodipine-d4 is a valuable tool for pharmacokinetic studies and related research applications. -
Stable Isotope
Menthol-d2 is a deuterated derivative of menthol, serving as a stable isotope. It acts as an analgesic and modulates the TRPM8 ion channel, which is responsible for sensing cold temperatures. By regulating TRPM8, Menthol-d2 exerts analgesic and anti-irritation effects. Additionally, it stimulates cold receptors, inducing a cooling sensation through the inhibition of Ca++ currents in neuronal cell membranes, making it valuable for research in pain relief and sensory modulation. -
Stable Isotope
Amlodipine-1,1,2,2-d4 maleate is a deuterium-labeled derivative of Amlodipine, a dihydropyridine calcium channel blocker. Its primary mechanism involves the inhibition of voltage-dependent L-type calcium channels, which reduces calcium influx. This reagent is valuable for studies related to hypertension and cancer research, offering insights into calcium signaling pathways and their implications in various pathological conditions. -
Stable Isotope
Diltiazem-d5 hydrochloride is a deuterated isotopic form of Diltiazem, a calcium channel blocker that inhibits L-type calcium channels. Its primary mechanism involves modulation of calcium ion influx, leading to reduced myocardial contractility and vasodilation. This stable isotope is valuable for pharmacokinetic studies, metabolic pathway analysis, and isotopic labeling techniques in chemical research and drug development. -
Stable Isotope
Farnesyl pyrophosphate-d6 is a deuterium-labeled stable isotope derivative of farnesyl pyrophosphate, an important metabolic intermediate in the mevalonate pathway. It acts as an agonist for TRP channel TRPM2, facilitating calcium influx and promoting cell death. Farnesyl pyrophosphate plays a crucial role in cholesterol and ubiquinone synthesis, as well as in protein farnesylation and geranylgeranyl pyrophosphate synthesis. This reagent is utilized in research exploring cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune disorders. -
Stable Isotope
Diltiazem-d4 is a deuterated form of Diltiazem, which acts as a selective L-type calcium channel blocker. It exhibits significant antihypertensive and antiarrhythmic properties, making it useful in the study of cardiac arrhythmias, hypertension, and angina pectoris. This stable isotope is ideal for research applications requiring isotopic tracing and elucidation of pharmacokinetic pathways involved in calcium channel modulation. -
Stable Isotope
Ranolazine-d8 is a deuterated form of Ranolazine, which primarily targets the late phase of inward sodium current (INa) and potassium current (IKr) with IC50 values of 6 μM and 12 μM, respectively. This compound functions as an anti-anginal agent, alleviating symptoms without influencing heart rate or blood pressure. Additionally, Ranolazine acts as a partial fatty acid oxidation inhibitor, making it valuable for research related to cardiac ischemia and metabolic modulation in heart diseases. -
Stable Isotope
Verapamil-d3 is a deuterium-labeled form of Verapamil, a calcium channel blocker that serves as a potent, orally active first-generation inhibitor of P-glycoprotein (P-gp) and CYP3A4. This stable isotope variant is utilized in pharmacokinetic studies and metabolic research, aiding in the investigation of cardiovascular diseases such as hypertension, arrhythmias, and angina. Verapamil-d3's unique properties make it an invaluable tool for studying drug interactions and bioavailability in various biological systems. -
Stable Isotope
1-Octanol-d2-1 is a deuterated form of 1-Octanol, serving as a stable isotope for various research applications. As a saturated fatty alcohol, 1-Octanol acts as an inhibitor of T-type calcium channels with an IC50 value of 4 μM for native T-currents, making it valuable for studies in neurobiology and pharmacology. Additionally, its characteristics as a biofuel with diesel-like properties position it for investigation in energy research and sustainable technologies. -
Stable Isotope
Norverapamil-d6 hydrochloride is a stable isotope-labeled version of Norverapamil, an N-demethylated metabolite of Verapamil. This compound acts as a blocker of L-type calcium channels and inhibits P-glycoprotein (P-gp) function. It is primarily utilized in pharmacokinetic studies, drug metabolism research, and for tracing metabolic pathways in biological systems. -
Stable Isotope
Diltiazem-d6 hydrochloride is a deuterium-labeled derivative of Diltiazem, functioning as a calcium antagonist that inhibits Ca2+ influx. This stable isotope is primarily utilized in research applications involving pharmacokinetics, metabolic studies, and the optimization of drug formulations. Its deuterated form enhances analytical sensitivity and specificity in various biochemical analyses. -
Stable Isotope
Teludipine-d6 is a deuterium-labeled analog of Teludipine hydrochloride, a potent lipophilic calcium channel blocker. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the metabolic pathways of Teludipine without altering its pharmacological properties. It is well-suited for investigations requiring precise quantification of drug concentrations in biological systems. -
Stable Isotope
O-Desmethyl carvedilol-d5 is a deuterium-labeled derivative of O-Desmethylcarvedilol, a potent active metabolite of the non-selective β-adrenergic receptor antagonist Carvedilol. This compound exhibits inhibitory effects on store-overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation, with an IC50 of 7.62 μM. Additionally, O-Desmethyl carvedilol-d5 contributes to cardiovascular research by attenuating heart rate increases and stabilizing diastolic blood pressure in response to Isoproterenol in conscious rabbit models, demonstrating ED50 values of 32 and 5 μg/kg, respectively. -
Stable Isotope
Taurolithocholic Acid-d5 sodium is a deuterium-labeled derivative of Taurolithocholic acid, serving as a stable isotope for analytical studies. This compound exhibits potent cholestatic activity and functions as a significant Ca2+ agonist, making it valuable for research in liver function and bile acid metabolism. Taurolithocholic Acid-d5 sodium can be utilized in pharmacokinetic studies and tracer experiments to elucidate the biological pathways of bile acids and their physiological effects. -
Stable Isotope
DSPC-d9 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9) is a deuterium-labeled form of DSPC, a cylindrical-shaped phospholipid. This reagent is primarily utilized in the preparation of liposomes and serves as a critical component in lipid nanoparticle (LNP) formulations. Its stable isotope labeling enables enhanced tracking and characterization of lipid interactions and dynamics in biological research and drug delivery applications. -
Stable Isotope
DSPC-d13, a deuterated form of 1,2-Distearoyl-sn-glycero-3-phosphorylcholine, serves as a stable isotope for various biological studies. This cylindrical-shaped lipid is integral for the synthesis of liposomes and functions as a key component in lipid nanoparticle (LNP) systems. Its unique labeling with deuterium facilitates advanced research applications in drug delivery and lipid metabolism studies, enabling enhanced tracking and analysis in complex biological environments. -
Stable Isotope
DSPC-d79 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79) is a deuterium-labeled analog of DSPC, a cylindrical-shaped phospholipid. This compound is crucial for the synthesis of liposomes and serves as a key lipid component in lipid nanoparticle (LNP) formulations. DSPC-d79 can be utilized in studies involving drug delivery systems, membrane biology, and biophysical characterization of lipid structures, enabling enhanced tracking and analysis in various biomedical research applications. -
Stable Isotope
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-d70 sodium is a deuterium-labeled form of 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol. This stable isotope serves as a vital component in the formulation of liposomes, enhancing the precision of drug delivery systems. Its application extends to various biochemical and biological research, facilitating the study of lipid dynamics and membrane interactions in a wide range of experimental settings. -
Stable Isotope
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-13C16 is a stable isotope-labeled phospholipid, specifically 13C enriched 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). It serves as a crucial component in the synthesis of liposomes and is utilized for in-depth investigations of lipid bilayer properties and behavior. This reagent supports research in membrane biology and lipid metabolism, aiding in the study of cellular processes and membrane interactions. -
Stable Isotope
DSPC-d74 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74) is a deuterium-labeled derivative of DSPC, a cylindrical-shaped phospholipid. This reagent plays a crucial role in the synthesis of liposomes and is a key component of lipid nanoparticle (LNP) formulations. DSPC-d74 can be utilized in various biological studies, including membrane biology and drug delivery research, due to its unique isotopic labeling which allows for enhanced tracking and analysis in mass spectrometry applications. -
Stable Isotope
Glyceryl monostearate-d5 is a deuterium-labeled version of glyceryl monostearate, a lipidic monoglyceride consisting of a single fatty tail. This stable isotope serves as a valuable tracer in metabolic studies and lipid research, aiding in the synthesis of nanoliposomes for drug delivery applications. Glyceryl monostearate-d5 can be utilized to investigate lipid metabolism and cellular interactions, providing insights into drug formulation and delivery mechanisms. -
Stable Isotope
Atreleuton-d4 is a deuterium-labeled derivative of Atreleuton, which acts as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and metabolic research to improve the understanding of drug absorption, distribution, metabolism, and excretion (ADME) processes. It serves as a valuable tool for scientists investigating the biological activity of Atreleuton in various therapeutic applications. -
Stable Isotope
Lomitapide-d4 is a deuterium-labeled derivative of Lomitapide, a potent inhibitor of microsomal triglyceride transfer protein (MTP). With an IC50 value of 8 nM, Lomitapide effectively disrupts the transport of triglycerides, making it an important tool for studying lipid metabolism and related disorders. This stable isotope variant is valuable for research applications that require the tracing of molecular pathways involving MTP modulation. -
Isotope-Labeled Compounds
Finerenone-d3 is a deuterium-labeled form of finerenone, a selective, orally active nonsteroidal mineralocorticoid receptor (MR) antagonist with an IC50 of 18 nM. This compound exhibits remarkable selectivity against glucocorticoid, androgen, and progesterone receptors, with over 500-fold selectivity. Finerenone-d3 is valuable for studying cardiorenal diseases, including type 2 diabetes mellitus and chronic kidney disease, enabling detailed metabolic and pharmacokinetic investigations in research settings. -
Stable Isotope
Ethylmalonic acid-d3 is a stable isotope-labeled form of ethylmalonic acid. This short-chain organic dicarboxylic acid plays a significant role in inducing mitochondrial permeability transition in conjunction with calcium ions, inhibiting mitochondrial creatine kinase, and disrupting mitochondrial energy metabolism. Ethylmalonic acid-d3 is utilized in the research of short-chain acyl-CoA dehydrogenase deficiency and other genetic metabolic disorders associated with ethylmalonic acid accumulation.
