Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Fumaric acid-2,3-13C2 disodium is a stable isotope-labeled compound primarily used as a tracer in metabolic research. This labeled fumaric acid serves as a valuable tool for studies in metabolic flux analysis and enzyme kinetics. Its incorporation into biological systems allows for the investigation of metabolic pathways and the tracing of substrate utilization in various biological contexts. -
Stable Isotope
D-Glutamic acid-13C5 is a stable isotope-labeled form of D-glutamic acid, an enantiomer of L-glutamic acid. This compound serves as a valuable tool in metabolic studies and tracer experiments in cellular biology. Its unique isotopic labeling allows researchers to investigate the dynamics of amino acid metabolism and its role in various physiological processes. -
Stable Isotope
p-Toluic acid-d7 is a deuterated form of p-Toluic acid, also known as 4-Methylbenzoic acid. This substituted benzoic acid serves as an important intermediate in the synthesis of various compounds, including para-aminomethylbenzoic acid (PAMBA) and p-tolunitrile. It is commonly utilized in chemical research applications requiring stable isotopes for tracking and analysis in reaction pathways and metabolic studies. -
Stable Isotope
L-Dopa-d3 is a deuterated form of DL-Dopa, a beta-hydroxylated derivative of phenylalanine. As a stable isotope, it is widely utilized in metabolic studies, tracer studies in biochemical research, and pharmacokinetic assessments. Its unique labeling facilitates the investigation of metabolic pathways and the quantification of biomolecules in complex biological systems. -
Stable Isotope
Bisphenol A-d4 is a deuterium-labeled derivative of Bisphenol A, an organic synthetic compound primarily utilized in the manufacture of polycarbonate plastics and epoxy resins. This compound is notable for its role as a reproductive, developmental, and systemic toxicant, frequently identified as an endocrine-disrupting compound (EDC). Bisphenol A is implicated in a range of health conditions, including cardiovascular diseases, respiratory ailments, diabetes, kidney disorders, obesity, and reproductive issues, facilitating its use in toxicological research and environmental studies. -
Stable Isotope
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-d3 is the deuterated form of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a key metabolite of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). This compound plays a critical role in studies of carcinogenesis, particularly within the context of lung cancer, as it undergoes oxidative metabolic pathways linked to carcinogenic activity. Utilization of the deuterium-labeled variant allows for enhanced analytical techniques in the investigation of tobacco-related cancer mechanisms. -
Stable Isotope
L-Aspartic acid-13C-1 is a stable isotope-labeled form of L-Aspartic acid, which is an amino acid capable of penetrating the blood-brain barrier. This compound is utilized in the formulation of prodrugs specifically targeting colon and cecal tissues. Furthermore, L-Aspartic acid-13C-1 is instrumental in the investigation of various inflammatory conditions, making it a valuable tool in biochemical research. -
Stable Isotope
1,3-Diolein-d66 is a deuterium-labeled derivative of 1,3-Diolein, a phospholipid that plays a crucial role in regulating cell membrane fluidity and signal transduction. This stable isotope is valuable in cell biology research for investigating lipid-mediated signaling pathways and interactions involving membrane proteins. Additionally, 1,3-Diolein-d66 can be utilized as a functional carrier in drug delivery systems, enhancing the bioavailability of therapeutic compounds. -
Stable Isotope
Rivaroxaban-d4 is a stable isotope-labeled form of Rivaroxaban, a potent and selective direct Factor Xa (FXa) inhibitor. This compound demonstrates significant anti-FXa activity with an IC50 of 0.7 nM and a Ki of 0.4 nM, making it a valuable tool for pharmacokinetic studies. It is commonly utilized in research applications involving anticoagulant therapy, drug metabolism, and in vivo tracking of Rivaroxaban pharmacodynamics. -
Stable Isotope
Edoxaban-d6 is a deuterium-labeled derivative of Edoxaban, a selective and potent inhibitor of factor Xa (FXa). Edoxaban exhibits high affinity for FXa with an IC50 of 0.561 nM, making it an effective anticoagulant for stroke prevention. It also displays weak inhibitory activity against thrombin and factor IXaβ, while maintaining a selectivity of over 10,000-fold for FXa. This reagent is useful for studying antithrombotic mechanisms and evaluating treatments for thromboembolic diseases in a variety of research applications. -
Stable Isotope
Apixaban-d3 is a deuterium-labeled analogue of Apixaban, a reversible and selective inhibitor of Factor Xa. With inhibition constants of 0.08 nM and 0.17 nM in human and rabbit models respectively, Apixaban demonstrates significant effectiveness in preventing thromboembolic diseases. This stable isotope is particularly useful in pharmacokinetic studies and bioanalytical research, allowing for enhanced tracking of the drug's metabolism and distribution in biological systems. -
Stable Isotope
Apixaban-13C,d3 is a stable isotope-labeled derivative of Apixaban, a potent and selective reversible inhibitor of Factor Xa, exhibiting Ki values of 0.08 nM and 0.17 nM in human and rabbit models, respectively. This high specificity makes Apixaban ideal for investigating anticoagulant mechanisms and studying related pharmacological effects. Researchers can utilize Apixaban-13C,d3 for quantitative analysis in pharmacokinetic studies, metabolic profiling, and isotopic tracing in biochemical assays. -
Stable Isotope
Betrixaban-d4 is a stable isotope-labeled form of Betrixaban, a highly potent and selective inhibitor of factor Xa (fXa) with an IC50 of 1.5 nM. This deuterium-labeled variant enables precise tracking and analysis in pharmacokinetic studies. Betrixaban is utilized for its antithrombotic properties in various research applications related to coagulation and cardiovascular health. -
Stable Isotope
Asundexian-d3 is a deuterium-labeled derivative of Asundexian, an orally active inhibitor of coagulation factor XIa (FXIa). It binds directly and reversibly to the active site of FXIa, effectively inhibiting its activity with an IC50 of 1 nM in human assays. This reagent is valuable for studies aimed at understanding blood coagulation mechanisms and evaluating FXIa's role in thrombosis and related disorders. -
Stable Isotope
Succinyladenosine-13C4 is a stable isotope labeled form of succinyladenosine, which serves as a vital metabolic byproduct derived from the dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase. This compound functions as a biochemical marker for assessing adenylosuccinase (ASL) deficiency. Succinyladenosine-13C4 is instrumental in metabolic studies, enabling researchers to investigate the role of nucleotide metabolism in various physiological and pathological contexts. -
Stable Isotope
Galactose 1-phosphate-13C-1 potassium is a stable isotope-labeled form of galactose 1-phosphate. This compound serves as an important intermediate in galactose metabolism and nucleotide sugar biosynthesis. It is widely used in metabolic studies and tracer experiments to investigate carbohydrate metabolism and cellular functions. Researchers can utilize this reagent for precise analytical applications, enhancing the understanding of galactose-related metabolic pathways. -
Stable Isotope
D-(+)-Trehalose-d2 is a deuterium-labeled form of D-(+)-Trehalose, a naturally occurring disaccharide derived from Saccharomyces cerevisiae. It serves as a stable isotope marker, making it valuable in metabolic studies, labeling experiments, and pharmaceutical formulations. Its unique isotopic signature allows for enhanced tracking and analysis of biological processes involving trehalose metabolism and function. -
Stable Isotope
Ac-Ala-OH-d3 is a deuterium-labeled derivative of Ac-Ala-OH, which serves as an endogenous metabolite. This stable isotope is utilized in metabolic studies and labeling experiments to elucidate metabolic pathways and enzymatic processes. Its incorporation into biochemical assays allows for enhanced tracking and quantification of metabolic activity. -
Stable Isotope
D-Sorbitol-d2-1 is a deuterium-labeled derivative of D-Sorbitol, a six-carbon sugar alcohol. This stable isotope is utilized as a tracer in metabolic studies and analytical applications. D-Sorbitol serves various roles in research, including as a sugar substitute, stabilizing excipient, and humectant, making it valuable in biochemical and pharmaceutical contexts. -
Stable Isotope
2,3-Butanediol-d6 is a stable isotope-labeled form of 2,3-Butanediol, a microbial-derived compound. This reagent serves as a specific urinary biomarker for Fmo5-/- mice and has been shown to inhibit age-related increases in plasma cholesterol levels. Its applications extend to various industries, including the formulation of printing inks, perfumes, fumigants, moistening and softening agents, plasticizers, and as a pharmaceutical carrier. -
Stable Isotope
L-(-)-Sorbose-13C-1 is a stable isotope labeled form of L-(-)-Sorbose, a natural sugar alcohol and an important metabolite in various biochemical pathways. As a stable isotope, it serves as a valuable tool for metabolic studies, tracer experiments, and isotope labeling in analytical chemistry. Its unique labeling provides insights into metabolic processes and enables precise tracking of metabolic flux in various biological systems. -
Stable Isotope
LacCer (d18:1/16:0)-d3 is a deuterium-labeled form of LacCer (d18:1/16:0), a bioactive sphingolipid involved in forming membrane microdomains with Lyn kinase and αi subunits of inhibitory G protein-coupled receptors (GPCRs). This compound is particularly relevant in studies of metabolic disorders, as elevated levels are found in the plasma of insulin-resistant cattle, and it is upregulated in models of Niemann-Pick type C1 disease, a neurodegenerative lysosomal storage disorder. LacCer (d18:1/16:0)-d3 serves as a valuable tool for elucidating the role of sphingolipids in various biological processes and disease pathways. -
Stable Isotope
H-Tyr(3-I)-OH-13C6 is a stable isotope-labeled form of H-Tyr(3-I)-OH, serving as a selective inhibitor of tyrosine hydroxylase. This compound plays a critical role as an intermediate in thyroid hormone synthesis and is relevant in studies of metabolic processes in human and mouse models. It is a valuable tool for researchers investigating neurotransmitter regulation and thyroid hormone metabolism. -
Stable Isotope
Trimethylammonium chloride-13C3,d9 is a stable isotope-labeled form of Trimethylammonium chloride, featuring deuterium and carbon-13 isotopes. This compound serves as an important endogenous metabolite, providing valuable insights into metabolic pathways and cellular processes. It is utilized in various research applications, including metabolic labeling and isotopic tracing studies, aiding in the understanding of biochemical dynamics and cellular metabolism. -
Stable Isotope
L-Thyroxine-13C6-1 is a stable isotope-labeled form of L-Thyroxine, also known as Levothyroxine or T4. This compound serves as a synthetic thyroid hormone and is widely utilized in research related to hypothyroidism. The stable isotope enrichment allows for enhanced tracking and analysis of its metabolic pathways, particularly in studies focused on the conversion of L-Thyroxine to the biologically active form, Triiodothyronine (T3), via deiodinase enzymes. -
Stable Isotope
18-Hydroxycorticosterone-d4 is the deuterium-labeled form of 18-Hydroxycorticosterone, a corticosteroid derived from corticosterone. This stable isotope serves as a valuable internal standard for quantitative analysis in various biological studies, particularly in endocrinology and metabolism research. It is utilized to investigate the metabolic pathways of corticosteroids and their impact on electrolyte balance. -
Stable Isotope
Propane-1,2,3-triyl tripalmitate-13C2 is a stable isotope-labeled form of Propane-1,2,3-triyl tripalmitate, an endogenous metabolite. This compound serves as an important tracer in metabolic studies, enabling researchers to investigate lipid metabolism and fatty acid synthesis pathways. Its stable carbon isotope labeling facilitates precise quantification and tracking in various biological systems. -
Stable Isotope
Trimethylammonium chloride-d10 is a deuterated form of Trimethylammonium chloride, which acts as a stable isotope. This compound serves as an endogenous metabolite and is utilized in various biochemical and metabolic studies. Its unique labeling allows for enhanced tracking and analysis in mass spectrometry and other analytical techniques, facilitating research in metabolic pathways and cellular processes. -
Stable Isotope
D-Mannose-13C-3 is a stable isotope-labeled form of D-Mannose, a pivotal carbohydrate involved in human metabolic processes. This compound is particularly important for studying glycosylation patterns of specific proteins, providing insights into cellular mechanisms and carbohydrate metabolism. D-Mannose-13C-3 serves as a valuable tool for research applications in glycomics and metabolic pathway analysis. -
Stable Isotope
Stearoylethanolamide-d3 is a deuterium-labeled analog of Stearoylethanolamide, which functions as an endocannabinoid-like compound. This stable isotope is utilized in research to investigate the biological pathways associated with apoptosis and the endocannabinoid system. Its pro-apoptotic activity makes it a valuable tool for studies focused on cancer biology and therapeutic applications. -
Stable Isotope
Propane-1,2,3-triyl tripalmitate-d27 is a deuterated stable isotope of Propane-1,2,3-triyl tripalmitate, a naturally occurring endogenous metabolite. This compound can be utilized in metabolic labeling studies to investigate lipid metabolism and the fate of fatty acids in biological systems. Its stable isotopic nature facilitates precise quantification and tracking in various experimental settings, making it suitable for applications in bioanalytical chemistry and metabolic research. -
Stable Isotope
Trimethylammonium chloride-15N is a stable isotope-labeled derivative of trimethylammonium chloride, primarily used as a tracer in metabolic studies. This reagent serves as an endogenous metabolite and is valuable for researching methylation processes, metabolic pathways, and cellular ion regulation. Its stable isotope label enables precise tracking and analysis in various biochemical assays, enhancing the understanding of metabolic functions and interactions in biological systems. -
Stable Isotope
N-Acetyl-D-glucosamine-13C-1 is a stable isotope-labeled form of N-Acetyl-D-glucosamine, a monosaccharide derivative of glucosamine. This compound is commonly used in metabolic studies, isotopic tracing, and in-depth biochemical research due to its ability to participate in glycosylation reactions. Its applications extend to cellular metabolism analysis and the study of glycan structures, providing valuable insights into carbohydrate biochemistry and cellular processes. -
Stable Isotope
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate-d54 is a deuterated derivative of the phospholipid compound, designed to serve as a stable isotope label. This reagent demonstrates enhanced stability and facilitates precise quantification in metabolic studies. It is particularly useful for tracing metabolic pathways and investigating lipid metabolism in various biological research applications. -
Stable Isotope
Muconic acid-d4 is a deuterated form of trans-trans-Muconic acid, serving as a stable isotope for analytical applications. This compound is a urinary metabolite of benzene and is recognized as a reliable biomarker for benzene exposure in humans. Its use in biological research facilitates the study of benzene metabolism and the assessment of environmental and occupational exposure levels. -
Stable Isotope
L-Tyrosine-13C,15N is a stable isotope-labeled version of L-Tyrosine, incorporating both carbon-13 and nitrogen-15 isotopes. L-Tyrosine is a non-essential amino acid that plays a critical role in protein synthesis and neurotransmitter production. This isotopic labeling is valuable for metabolic research and tracer studies, enabling the tracking of metabolic pathways and the investigation of amino acid dynamics in various biological systems. -
Stable Isotope
Hippuric acid-15N is a stable isotope-labeled form of hippuric acid, which is 2-benzamidoacetic acid. This compound is produced through the conjugation of benzoic acid and glycine and serves as a primary metabolite of aromatic compounds derived from dietary intake. Hippuric acid-15N is utilized in research applications such as metabolic profiling, tracer studies, and studies investigating the metabolism and excretion of aromatic substances. -
Stable Isotope
Tetradecanoylcarnitine-d9 is a deuterium-labeled derivative of Tetradecanoylcarnitine, a critical human metabolite that participates in the β-oxidation of long-chain fatty acids. This stable isotope is valuable for metabolic studies, allowing for precise tracing of lipid metabolism and fatty acid utilization in biological systems. Its application spans various research areas, including metabolic disorders and energy homeostasis. -
Stable Isotope
Methoxyacetic acid-d3 is a deuterated derivative of Methoxyacetic acid, primarily utilized as a stable isotope label in chemical research. It serves as a metabolite of ethylene glycol monomethyl ether and exhibits the capacity to inhibit respiratory functions in hepatic and testicular mitochondria at elevated concentrations. Its use in studies of mitochondrial dynamics, toxicology, and metabolic pathways provides valuable insights into cellular function and potential toxicity mechanisms. -
Stable Isotope
Glutaric acid-d2 is a stable isotope-labeled form of glutaric acid, a C5 dicarboxylic acid involved in the catabolism of lysine and tryptophan. This compound plays a significant role in biological processes, influencing pericyte contractility and migration. Glutaric acid-d2 serves as a valuable tool for research applications in metabolic studies and diagnostic assessments related to glutaric aciduria type I. -
Stable Isotope
Decanedioic acid-d16 is a deuterium-labeled derivative of decanedioic acid, a straight-chain dicarboxylic acid. This compound exhibits significant biological activity, particularly in the context of metabolic regulation, and has been shown to prevent and reverse metabolic-associated liver disease and obesity. Research applications include studies on metabolic inflexibility in type 2 diabetes, as well as investigations into conditions related to carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency. -
Stable Isotope
Estrone sulfate-d5 sodium is a deuterium-labeled derivative of estrone sulfate, serving as a stable isotope for metabolic studies. As an inactive endogenous estrogen, it can be converted into active forms, estrone and estradiol, through various biological processes. Estrone sulfate-d5 sodium acts as a substrate for the OATP1B3 transporter and is involved in mammary tumor growth in models of breast cancer. This compound is valuable for research into estrogen metabolism and its role in breast cancer pathophysiology. -
Stable Isotope
3-Hydroxybutyric acid-13C2 sodium is a stable isotope-labeled derivative of 3-Hydroxybutyric acid sodium. This metabolite has been shown to be elevated in type I diabetes and plays a crucial role in modulating the properties of membrane lipids. It is valuable for metabolic research, particularly in studies investigating diabetes mechanisms and lipid metabolism. -
Stable Isotope
Dodecanedioic Acid-13C12 is a stable isotope-labeled version of dodecanedioic acid, functioning as an alternative energy substrate in metabolic studies. This straight-chain dicarboxylic acid is known for its ability to enhance oxidation during physical exertion, thereby mitigating muscle fatigue without causing insulin secretion. Moreover, it demonstrates potential in lowering blood glucose levels in models of non-insulin-dependent diabetes mellitus, making it a valuable reagent for metabolic and diabetes research. -
Stable Isotope
N-Palmitoyl-D-sphingomyelin-13C is a stable isotope-labeled form of N-Palmitoyl-D-sphingomyelin. This compound plays a critical role in lipid nanoparticle synthesis, making it vital for research in drug delivery systems and nanomedicine. The incorporation of the deuterated label allows for precise tracking and analysis of sphingolipid dynamics in biological studies. -
Stable Isotope
1,4-Dimethoxybenzene-d10 is the deuterated form of 1,4-Dimethoxybenzene, a compound recognized as an endogenous metabolite. This stable isotope is utilized in various research applications, including metabolic studies and tracer experiments. It serves as a valuable tool for investigating metabolic pathways and enhancing the accuracy of analytical techniques in chemical research. -
Stable Isotope
D-Lyxose-13C-4 is a stable isotopically labeled form of D-Lyxose, an endogenous metabolite that serves as a rare pentose sugar. This compound plays a crucial role in the synthesis of various pharmaceutical agents, including anti-tumor drugs like alpha-galactose ceramide immunostimulants, and L-nucleoside analogs used for antiviral drug development. Furthermore, D-Lyxose can be employed as a synthetic intermediate for producing other rare sugars, such as L-ribose, enhancing its utility in chemical and biological research applications. -
Stable Isotope
Arabinose-d-1 is a deuterium-labeled form of arabinose, a naturally occurring sugar in metabolic pathways. This stable isotope is useful for tracer studies and metabolic research, allowing for precise tracking of metabolic processes in various biological systems. Its applications extend to investigating carbohydrate metabolism and the role of arabinose in cellular functions. -
Stable Isotope
Lignoceric acid-d9 is a deuterated derivative of lignoceric acid, a long-chain saturated fatty acid (Tetracosanoic acid) comprised of 24 carbon atoms. This stable isotope is prevalent in the developing brain and serves as a by-product of lignin metabolism. Lignoceric acid-d9 is primarily utilized in research focused on Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy, aiding in the investigation of metabolic pathways and disease mechanisms associated with these conditions. -
Stable Isotope
1-Arachidoyl-sn-glycero-3-phosphocholine-d4 is a deuterium-labeled lysophospholipid, specifically 1-Arachidoyl-sn-glycero-3-phosphocholine. This stable isotope is utilized in various biochemical research applications, particularly in mass spectrometry and metabolic studies. Due to its labeled nature, it serves as an effective internal standard for analyzing lipid metabolism and profiling in complex biological samples.
