Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
MPP+-d3 iodide is a deuterium-labeled derivative of MPP+ (iodide), primarily targeting dopaminergic neurons. This compound is known for inducing Parkinson’s disease-like symptoms in animal models by selectively damaging dopaminergic neurons in the substantia nigra, primarily through its action on mitochondrial complex I within the respiratory chain. Additionally, MPP+ iodide serves as a high-affinity substrate for the serotonin transporter (SERT), making it useful for studies examining the neurotoxic mechanisms and transport processes in neurodegenerative disease research. -
Stable Isotope
1-Hexanol-d13 is a deuterium-labeled variant of 1-Hexanol, a primary alcohol known for its application as a surfactant in various industrial processes to improve interfacial properties. This compound is also observed to uncouple mitochondrial respiration through a non-protonophoric mechanism, facilitating studies related to energy metabolism. Its stable isotope labeling makes it a valuable tool for tracer studies in biological research. -
Stable Isotope
1-Hexanol-d11 is a deuterated form of 1-hexanol, a primary alcohol known for its surfactant properties. This stable isotope serves as a valuable tool in studies involving the characterization of interfacial properties in various industrial applications. Additionally, 1-Hexanol is recognized for its ability to uncouple mitochondrial respiration through a non-protonophoric mechanism, making it relevant in metabolic and bioenergetics research. -
Stable Isotope
Ethylmalonic acid-d5 is a deuterated form of ethylmalonic acid, serving as a stable isotope for research applications. This short-chain organic dicarboxylic acid is known to synergistically induce mitochondrial permeability transition in conjunction with Ca2+, inhibit mitochondrial creatine kinase (Mi-CK), and disrupt mitochondrial energy metabolism. Ethylmalonic acid-d5 is valuable in studying disorders such as short-chain acyl-CoA dehydrogenase deficiency (SCADD) and other genetic metabolic diseases associated with the accumulation of ethylmalonic acid. -
Stable Isotope
1-Hexanol-d5 is a deuterated form of 1-Hexanol, a primary alcohol recognized for its role as a surfactant in industrial applications, enhancing interfacial properties. This compound is known to uncouple mitochondrial respiration through a non-protonophoric mechanism, making it useful in studies related to cellular energy metabolism and mitochondrial function. The stable isotope labeling facilitates precise tracing in biochemical research and analytical applications. -
Stable Isotope
1-Hexanol-d2 is a deuterated form of 1-Hexanol, serving as a stable isotope for various analytical applications. As a primary alcohol and surfactant, it is utilized in industrial processes to improve interfacial properties. Additionally, 1-Hexanol has been shown to uncouple mitochondrial respiration through a non-protonophoric mechanism, making it valuable for research in bioenergetics and metabolic regulation. -
Stable Isotope
1-Hexanol-d3 is a stable isotope-labeled form of 1-Hexanol, which is a primary alcohol and surfactant. This compound has significant applications in industrial processes to improve interfacial properties. Additionally, 1-Hexanol-d3 is known to uncouple mitochondrial respiration through a non-protonophoric mechanism, making it valuable in metabolic studies and respiratory function research. -
Stable Isotope
o-Phenanthroline-d8 is a deuterium-labeled derivative of o-Phenanthroline, a potent metal chelator. This compound effectively prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+, exhibiting a maximum absorption at 510 nm. Additionally, o-Phenanthroline functions as an inhibitor of matrix metalloproteinases (MMPs), making it valuable in various research applications related to cancer biology and oxidative stress studies. -
Stable Isotope
Hydralazine-d4 hydrochloride is a deuterated form of Hydralazine hydrochloride, known for its action as a direct-acting vasodilator. It primarily targets vascular smooth muscle, leading to relaxation and a reduction in blood pressure, making it valuable in antihypertensive research. This stable isotope is particularly useful for pharmacokinetic studies and metabolic profiling in drug development and cardiovascular research applications. -
Stable Isotope
Lovastatin-d3 hydroxy acid sodium is a deuterium-labeled derivative of Lovastatin hydroxy acid sodium, a potent inhibitor of HMG-CoA reductase, with a Ki of 0.6 nM. This stable isotope is utilized in metabolic studies to investigate cholesterol biosynthesis and regulation. It serves as a valuable tool for researchers examining the pharmacokinetics and pharmacodynamics of statins in biochemical and clinical research applications. -
Stable Isotope
IDO-IN-7-d10 is a deuterium-labeled analogue of IDO-IN-7, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with an IC50 value of 38 nM. This stable isotope derivative is designed for use in metabolic studies and biomarker analysis, enhancing the understanding of IDO1-related pathways in cancer and immune response research. Its use in tracer studies allows for improved tracking of metabolic processes. -
Stable Isotope
(S)-Indoximod-d3 is a deuterium-labeled form of (S)-Indoximod, an inhibitor of indoleamine 2,3-dioxygenase (IDO). This stable isotope retains the biological activity of the parent compound, allowing for precise tracking and measurement in metabolic studies. (S)-Indoximod-d3 is primarily utilized in cancer research, particularly in studies exploring immune modulation and tumor microenvironment interactions. -
Stable Isotope
IDH1 Inhibitor 7-d2 is a deuterium-labeled derivative of IDH1 Inhibitor 7, targeting the isocitrate dehydrogenase 1 (IDH1) enzyme. It exhibits potent inhibitory activity with an IC50 of less than 100 nM. This stable isotope-labeled compound serves as a valuable tool for in vivo and in vitro studies aimed at investigating IDH1-related metabolic pathways and the development of targeted cancer therapies. -
Stable Isotope
Enasidenib-d6 is a deuterated analogue of Enasidenib, a potent, reversible inhibitor selectively targeting mutant IDH2 enzymes. It exhibits IC50 values of 100 nM for IDH2R140Q and 400 nM for IDH2R172K, demonstrating significant biological activity in modulating the pathways associated with these mutations. This stable isotope-labeled compound is useful in research applications such as metabolic studies, pharmacokinetic profiling, and elucidation of IDH2-related cellular mechanisms. -
Stable Isotope
Hexane-1,6-diol-d4 is a deuterated stable isotope form of Hexane-1,6-diol, a six-carbon straight-chain diol characterized by hydroxyl groups at each end. This reagent serves as a valuable additive in drilling fluids and is also utilized as a substrate in various life science research applications. Its stable isotope labeling facilitates the tracking of metabolic pathways and enhances the understanding of biochemical processes. -
Stable Isotope
DSPC-d70, or 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70, is a deuterium-labeled lipid that serves as a cylindrical-shaped phospholipid. It is primarily utilized in the formation of liposomes and acts as a key component in lipid nanoparticle (LNP) systems. DSPC-d70 is beneficial for studying lipid dynamics and membrane interactions, particularly in drug delivery and nanomedicine research applications. -
Stable Isotope
DSPC-d83 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83) is a deuterium-labeled derivative of DSPC, a cylindrical-shaped phospholipid. This reagent is crucial for the synthesis of liposomes and serves as a key lipid component in lipid nanoparticle (LNP) formulations. Its stable isotope labeling facilitates tracking and characterization in biological research, making it valuable for studies involving drug delivery and membrane dynamics. -
Stable Isotope
DSPC-d4 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d4) is a deuterium-labeled derivative of DSPC, a cylindrical-shaped phospholipid. This reagent is crucial for the synthesis of liposomes and functions as a key lipid component in lipid nanoparticle (LNP) formulations. DSPC-d4 is utilized in various biological applications, including drug delivery research and the study of membrane dynamics, contributing valuable insights into lipid biology and nanotechnology. -
Stable Isotope
Dantrolene-13C3 is a stable isotope-labeled analog of Dantrolene, a muscle relaxant that non-competitively inhibits human erythrocyte glutathione reductase, with Ki and IC50 values of 111.6 μM and 52.3 μM, respectively. As a ryanodine receptor antagonist, Dantrolene-13C3 plays a critical role in stabilizing Ca2+ signaling. This reagent is suitable for research applications related to muscle spasticity, malignant hyperthermia, Huntington's disease, and neuroleptic malignant syndrome. -
Stable Isotope
Migalastat hydrochloride-15N is a stable isotope-labeled form of Migalastat hydrochloride, an orally active molecular chaperone targeting α-galactosidase A. It exhibits a potent IC50 of 0.04 μM for human α-Gal A, facilitating the proper folding and lysosomal transport of certain unstable mutant forms of the enzyme. Upon dissociation in the acidic lysosomal environment, Migalastat promotes restoration of biological activity, making it valuable for research in lysosomal storage disorders and enzyme replacement therapies. -
Stable Isotope
Acarbose-d4 is a deuterium-labeled derivative of Acarbose, targeting alpha-glucosidases. This stable isotope maintains the biological activity of its parent compound, functioning as an antihyperglycemic agent with an IC50 of 11 nM. Acarbose-d4 is utilized in research to study glucose metabolism and the enhancement of hypoglycemic effects in combination therapies involving sulfonylureas or insulin. -
Stable Isotope
S-Sulfo-DL-cysteine-d3 is a stable isotope-labeled analog of S-Sulfo-DL-cysteine featuring deuterium at the 2, 3, and 3 positions. This compound is utilized in metabolic studies and isotopic tracing experiments, allowing for precise analysis of cysteine metabolism and biochemical pathways. Its deuterium labeling provides a valuable tool for researchers pursuing kinetic and mechanistic investigations in various biological systems. -
Stable Isotope
Metolachlor-d11 is a deuterated form of Metolachlor, a selective chloroacetanilide herbicide that acts primarily by inhibiting the growth of specific annual grassy and broadleaf weeds in corn and other agricultural crops. This stable isotope variant is utilized for precise quantitative studies in environmental and agronomic research. Metolachlor-d11 provides a valuable tool for understanding the metabolism, persistence, and impact of herbicide residues in various ecosystems. -
Stable Isotope
Bifenox-d3-1 is a stable isotope-labeled form of the potent herbicide Bifenox. This compound primarily targets cellular membranes, promoting the generation of reactive oxygen species (ROS), which leads to membrane disruption and inhibition of photosynthetic processes. Bifenox-d3-1 is useful for research applications requiring tracking of Bifenox in environmental studies and metabolism investigations in plant biology. -
Stable Isotope
Ethofumesate-d5 is a deuterated form of Ethofumesate, a chiral herbicide that primarily inhibits mitosis. This compound is integral for studying the impact of Ethofumesate on photosynthesis and plant respiration in various biological research applications. Its isotopic labeling allows for precise tracking and quantification in experimental settings, aiding in the investigation of herbicide mechanisms and environmental effects. -
Stable Isotope
Norflurazon-13C,d3 is a stable isotope-labeled derivative of Norflurazon, a herbicide recognized for its ability to inhibit carotenoid biosynthesis. This compound exerts its primary action by targeting and inhibiting the enzyme phytoene desaturase, thereby disrupting the synthesis of protective pigments in plants. Norflurazon-13C,d3 serves as a valuable tool for research applications in plant physiology, herbicide mechanism studies, and environmental monitoring of herbicide interactions. -
Stable Isotope
Butachlor-d13 is a deuterium-labeled derivative of Butachlor, an acetanilide-class herbicide. This stable isotope is utilized as a selective pre-emergent herbicide, effectively controlling a variety of grasses and broadleaf weeds. Its isotopic labeling enables precise studies in environmental fate, metabolism, and interaction mechanisms in ecological and agricultural research applications. -
Stable Isotope
Bensulfuron-methyl-d6 is a stable isotope-labeled form of Bensulfuron-methyl, a sulfonylurea herbicide primarily targeting the inhibition of the acetolactate synthase enzyme. This compound exerts significant herbicidal activity against broad-leaf weeds, particularly in rice cultivation. It serves as a valuable analytical tool in environmental and agricultural research, allowing for the monitoring and quantification of Bensulfuron-methyl in various matrices. -
Stable Isotope
Isoproturon-d6-1 is a deuterium-labeled derivative of Isoproturon, a member of the phenylurea herbicide class. This stable isotope is employed in research to trace the fate and behavior of Isoproturon in environmental and agricultural studies. It is particularly useful for investigating the efficacy of Isoproturon against annual grasses and broad-leaved weeds in crops such as spring and winter wheat, winter rye, and both spring and winter barley. -
Stable Isotope
2,5-Dimethylpyrazine-d3 is a deuterated form of 2,5-Dimethylpyrazine, serving as a stable isotope tracer in various biological studies. This compound is an endogenous metabolite, making it suitable for research in metabolic pathways and biomarker identification. Its incorporation into experimental designs enables improved accuracy in quantitative analysis within pharmacokinetic and toxicological studies. -
Stable Isotope
7-Keto Cholesterol-d7 is a deuterium-labeled derivative of 7-Keto Cholesterol, serving as a stable isotope for metabolic studies. Its primary application includes tracking cholesterol metabolism in biological systems, enhancing the understanding of lipid biochemistry and related metabolic pathways. This compound is particularly useful in mass spectrometry and other analytical techniques for quantifying cholesterol levels and their metabolites. -
Stable Isotope
Cuminaldehyde-d8 is a deuterated form of cuminaldehyde, a natural aldehyde predominantly found in Cuminum cyminum. This compound exhibits inhibitory effects on alpha-synuclein fibrillation and reduces cytotoxicity, making it a valuable tool in neurodegenerative research. Additionally, cuminaldehyde demonstrates anticancer properties, contributing to its application in cancer biology studies. -
Stable Isotope
Pyridoxine-d2 is a deuterated form of Pyridoxine, a pyridine derivative known for its role in biological processes. This stable isotope is essential for studies involving metabolic pathways and biochemical analyses. Pyridoxine exhibits antioxidant properties and has shown efficacy in cellular models of Alzheimer's disease through the Nrf-2/HO-1 signaling pathway, making it a valuable tool for research in neurodegenerative disorders. -
Stable Isotope
L-Citrulline-d2 is the deuterium-labeled form of L-Citrulline, an amino acid involved in the metabolic conversion of ornithine and the arginine-citrulline pathway. This stable isotope is utilized in various biological studies, including metabolic tracing and pharmacokinetic analysis. With its unique isotope label, L-Citrulline-d2 aids researchers in elucidating metabolic pathways and the role of citrulline in nitric oxide production and cardiovascular health. -
Stable Isotope
Butyrylcarnitine-d3 hydrochloride is a deuterated form of butyrylcarnitine, serving as a stable isotope. This compound is an endogenous metabolite present in plasma, with elevated levels linked to lipid and energy metabolism disorders. Butyrylcarnitine-d3 can be utilized as a diagnostic and prognostic biomarker in various diseases, including heart failure and head and neck cancer, facilitating research in metabolic health and disease characterization. -
Stable Isotope
2-Hydroxyestradiol-d5 is a stable isotope-labeled derivative of 2-Hydroxyestradiol, a metabolite of 17β-estradiol known for its limited estrogenic activity. This compound exhibits notable antioxidant properties and has the capability to form stable DNA adducts, thereby contributing to genotoxic effects. It is utilized in research applications focusing on estrogen metabolism, oxidative stress, and the mechanisms of genotoxicity in cellular systems. -
Stable Isotope
Dodecanedioic acid-d4 is a deuterated form of dodecanedioic acid, serving as a stable isotope for research purposes. It is an orally active straight-chain dicarboxylic acid that acts as an alternative energy substrate, facilitating rapid oxidation during physical activity, which may help reduce muscle fatigue without triggering insulin secretion. Dodecanedioic acid also demonstrates blood glucose-lowering effects, making it relevant for studies on non-insulin-dependent diabetes mellitus. This compound is valuable for metabolic research and the investigation of energy metabolism in various physiological contexts. -
Stable Isotope
4-Ethylphenol-d2 is a deuterated analog of 4-Ethylphenol, a volatile phenolic compound known for its association with off-odour profiles in wine. This stable isotope variant is valuable for studying the metabolic pathways of 4-Ethylphenol, including its conversion by intestinal microbiota, such as Lactobacillus plantarum, into 4-ethylphenyl sulfate. Applications include investigating microbial fermentation processes and evaluating the sensory impact of phenolic compounds in food and beverage research. -
Stable Isotope
Succinic acid-13C2 is a stable isotope-labeled form of succinic acid, which serves as a key metabolite in the tricarboxylic acid cycle. It plays a significant role as a potent anxiolytic agent and is essential for various biochemical pathways. This compound is valuable in metabolic studies and tracer experiments, as well as for synthesizing industrially important chemicals in the food, chemical, and pharmaceutical industries. -
Stable Isotope
3-Amino-2-methylpropanoic acid-d3 is a stable isotope-labeled variant of 3-Amino-2-methylpropanoic acid. This compound is known to facilitate the browning of white adipose tissue and enhance hepatic β-oxidation, making it an important target for investigating metabolic processes. Its application in research focuses on understanding the relationship between metabolic regulation and cardiometabolic risk factors. -
Stable Isotope
Hypoxanthine-13C2,15N-1 is a stable isotope-labeled form of hypoxanthine, featuring both 15N and 13C isotopes. As a purine derivative, hypoxanthine serves as a potential free radical generator and is utilized in research to indicate hypoxic conditions. This reagent is valuable for studies in metabolic pathways, cellular response to oxygen deprivation, and the effects of hypoxia on various biological systems. -
Stable Isotope
Bis(1-chloro-2-propyl) phosphate-d12 is a deuterium-labeled derivative of Bis(1-chloro-2-propyl) phosphate (BCIPP), targeting organophosphate metabolites. BCIPP has been identified as a disruptor of energy metabolism, potentially influencing the levels of steroid hormones such as cortisol and cortisone. This compound is suitable for research into metabolism-related diseases associated with environmental exposure, providing insights into the biochemical pathways influenced by organophosphate flame retardants. -
Stable Isotope
DEHP-d38 is a deuterated form of bis(2-ethylhexyl) phthalate (DEHP), serving as a stable isotope labeled compound. This reagent is primarily utilized in metabolic studies and compound tracing in biological systems due to its ability to mimic the behavior of endogenous metabolites. DEHP-d38 enables researchers to investigate the pharmacokinetics and dynamics of DEHP, contributing valuable insights in toxicology, environmental studies, and physiological research. -
Stable Isotope
Estradiol-d2-1 is a deuterium-labeled derivative of Estradiol, a steroid sex hormone essential for regulating fertility and the development of secondary sexual characteristics in females. This compound acts primarily through the estrogen receptor β (ERβ) pathway, where it upregulates IL-6 expression. Estradiol-d2-1 is valuable for research applications involving hormone signaling, reproductive biology, and the study of estrogen-related diseases. -
Stable Isotope
Guanidine-13C,15N3 hydrochloride is a stable isotope-labeled form of guanidine hydrochloride, incorporating both carbon-13 and nitrogen-15 isotopes. This compound serves as a potent chaotropic agent and a robust denaturant for proteins, facilitating studies in protein folding and stability. It is utilized in various research applications, including NMR spectroscopy and mass spectrometry, to investigate biomolecular interactions and dynamics in biochemical processes. -
Stable Isotope
Hexadecanal-d5 is a deuterium-labeled derivative of hexadecanal, a long-chain aliphatic aldehyde with various biological activities. As a stable isotope, Hexadecanal-d5 is utilized to study the metabolites of hexadecanal emitted from biological sources such as human feces, skin, and breath. Its interaction with the highly conserved olfactory receptor OR37B suggests a role in modulating brain connectivity related to social appraisal and aggression. This reagent is valuable for research involving behavioral responses, including startle reflexes and aggression in both mammalian models and insect species like Lasius niger. -
Stable Isotope
Matairesinol-d6 is a deuterium-labeled derivative of Matairesinol, which primarily targets anti-allergic pathways. It has demonstrated efficacy in reversing DfE-induced alterations in IL-4 and IFN-γ mRNA expression within an allergic dermatitis mouse model. This compound is valuable for researchers investigating allergic responses and gene expression modulation in immunological studies. -
Stable Isotope
3-Bromopropan-1-ol-d6 is a stable isotope-labeled form of 3-Bromopropan-1-ol, which serves as an endogenous metabolite. This compound is significantly upregulated during the estrus period in buffaloes, making it a valuable tool for investigating reproductive physiology. Research applications include studying buffalo estrus cycles and metabolic pathways related to reproductive hormones. -
Stable Isotope
N-Acetyl-D-glucosamine-13C,15N is a stable isotope-labeled derivative of N-Acetyl-D-glucosamine. This compound serves as a valuable tool in metabolic studies, allowing for the tracking of glucose metabolism and glycosylation processes in biological systems. Its applications extend to research in cell signaling, cancer biology, and the understanding of carbohydrate metabolism. -
Stable Isotope
Sodium 3-methyl-2-oxobutanoate-13C2,d is a stable isotope-labeled compound, incorporating deuterium and carbon-13 isotopes. This reagent serves as a valuable tool in metabolic studies, enabling precise tracing of metabolic pathways and the investigation of biosynthetic processes. Its applications extend to isotopic labeling in both in vitro and in vivo experiments, facilitating enhanced understanding of biomolecular behaviors and interactions.
