Catalog No.
Product Name
Application
Product Information
Citations
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Ansamycin Antibiotic
Rifamycin is an orally active ansamycin antibiotic that primarily inhibits DNA-dependent RNA synthesis. It demonstrates significant antibacterial activity against Mycobacterium tuberculosis and can also affect hepatic bile acid metabolism. Additionally, Rifamycin exhibits anti-inflammatory properties, making it useful in the study of infections caused by Mycobacterium tuberculosis and Bacteroides fragilis, as well as in research involving lipopolysaccharide-induced inflammation. -
Bacterial Inhibitor
Mequindox is an antimicrobial agent that functions as a bacterial inhibitor by selectively targeting and inhibiting DNA synthesis. This compound demonstrates significant genotoxic and carcinogenic effects in murine models, making it a valuable tool for studying bacterial resistance mechanisms and the potential impacts of antimicrobial agents on genetic material. Its applications extend to research on the safety and efficacy of antimicrobial treatments in various biological systems. -
Bacterial Inhibitor
Silver sulfadiazine is a sulfonamide antibiotic that functions as a bacterial inhibitor through dual mechanisms. The sulfa moiety inhibits bacterial folate absorption, thereby disrupting essential DNA synthesis. Additionally, silver ions released from silver sulfadiazine bind to and disrupt DNA structures, preventing bacterial DNA replication. This compound is widely used in research applications focusing on bacterial growth inhibition and antimicrobial studies. -
HBV Inhibitor
HBV-IN-4 is a phthalazinone derivative that functions as a potent inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. This compound effectively induces the formation of genome-free capsids, demonstrating substantial anti-HBV activity. Its applications include research into therapeutic strategies for hepatitis B virus infections. -
Antibiotic
Holomycin is a secondary metabolite belonging to the dithiolopyrrolone class, recognized for its broad-spectrum antibiotic properties. It exhibits notable antitumor activity and functions by inhibiting RNA synthesis in vivo. Holomycin serves as a valuable tool in pharmaceutical research, particularly in studies related to antimicrobial resistance and cancer therapeutics. -
Antibacterial Agent
Amicoumacin B is an antibacterial agent produced by the actinomycete strain 04-5195T, primarily targeting bacterial quorum sensing mechanisms. It demonstrates significant inhibitory activity against Chromobacterium violaceum, with a minimum inhibitory concentration (MIC) of 250 µg/mL. Additionally, Amicoumacin B upregulates the expression of bone morphogenetic protein 2 (BMP-2) while simultaneously inhibiting the expression of essential quorum sensing operons vioA, vioB, vioD, and vioE, and enhancing vioC expression. These properties make Amicoumacin B a valuable tool in microbiological research and the study of bacterial communication. -
Antibiotic
10,11-Dehydrocurvularin is an antibiotic derived from fungi, known for its ability to activate the heat shock response. This compound exhibits significant inhibition of the TGF-β signaling pathway, demonstrating anti-tumorigenic properties. Its biological activities make it a valuable reagent for research in antibiotic efficacy and cancer biology. -
Antitumor Antibiotic
Dinactin is an antibiotic ionophore derived from Streptomyces species, primarily targeting the Wnt/β-catenin signaling pathway in cancer cells. This compound exhibits significant inhibition of HCT-116 cell proliferation, with an IC50 value of 1.1 μM, demonstrating its anti-proliferative effects in an apoptosis-independent manner. Additionally, Dinactin serves as a valuable tool in research related to neuropathic pain. -
Antitumor Antibiotic
Sibiromycin is a glycosylated pyrrolobenzodiazepine (PBD) that functions as a potent antitumor antibiotic. It exerts its biological activity by covalently binding to DNA in the minor groove, specifically targeting the amino group of guanine. This mechanism contributes to its effectiveness in cancer research, making it a valuable tool for studies involving DNA interactions and antitumor mechanisms. -
Antineoplastic Antibiotic
Cytogenin, an antineoplastic antibiotic, demonstrates significant antitumor activity by inhibiting the growth of Ehrlich ascites tumors in mouse models. This compound also regulates inflammatory cytokines, effectively reducing levels of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and interleukin-6 (IL-6) in murine macrophages. Additionally, Cytogenin exhibits antidiabetic effects, making it a valuable reagent for research in cancer biology and inflammation. -
Larvicide/Antiviral
Cappariloside A is a potent larvicide primarily targeting Aedes aegypti larvae, demonstrating significant larvicidal activity while inhibiting larval glutathione-S-transferase activity. Additionally, it exhibits antiviral effects by decreasing phosphorylated STAT1 levels, inhibiting the replication of various influenza viruses, including H1N1 and H3N2, and downregulating key pro-inflammatory cytokines such as IL-6 and IFN-β. Cappariloside A is valuable for research involving larvicidal strategies and the investigation of antiviral responses in influenza virus infections. -
HSV Inhibitor
Denotivir is an orally active antiviral agent targeting herpes simplex virus (HSV) and varicella-zoster virus (VZV). It exhibits significant inhibition of viral proliferation and demonstrates anti-cancer properties, influencing the growth of various cancer cell lines. Additionally, Denotivir plays a role in immunosuppression by inhibiting the generation of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6, making it relevant for research in virology and oncology. -
HEVA71/PTP1B Inhibitor
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71) and demonstrates strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 5.5 μM. This compound has significant potential for research applications in virology and metabolic disease studies, particularly in elucidating the roles of HEVA71 and PTP1B in cellular signaling pathways and disease mechanisms. -
Bacterial Inhibitor
Fenvalerate is a highly effective bacterial inhibitor, primarily functioning as a protein phosphatase 2B (calcineurin) inhibitor, with an IC50 of 2-4 nM for PP2B-Aα. As a pyrethroid ester, it exhibits significant insecticidal and acaricidal properties. This compound is utilized in various research applications to study protein phosphatase signaling pathways and to explore potential therapeutic targets in bacterial infections. -
Nephrotoxin
Orellanine is a potent fungal nephrotoxin primarily known for its mechanism as a competitive inhibitor of alkaline phosphatase. This compound effectively induces apoptosis in proximal tubular cells and clear cell renal cell carcinoma (ccRCC) cell lines. Orellanine serves as a valuable tool for research focused on nephrotoxicity and the pathophysiology of ccRCC. -
Antibiotic
Fostriecin is a triene antibiotic that primarily targets topoisomerase II and inhibits protein phosphatase PP2A. It exhibits potent antibacterial activity and has been employed in research focused on mechanisms of antibiotic resistance and cancer therapy. Its unique mechanism of action makes it a valuable tool for studying cellular processes related to gene expression and cell cycle regulation. -
Calcineurin Phosphatase Inhibitor
Dibefurin is a potent inhibitor of calcineurin phosphatase, a critical regulator of calcium-dependent signaling pathways. This fungal metabolite has demonstrated significant biological activity in various cellular processes, making it a valuable tool for studying immune response and neuronal signaling. Its application extends to research focused on autoimmune diseases and neurodegenerative disorders, where calcineurin activity plays a pivotal role. -
IMPase Inhibitor
L-671776 is a non-competitive inhibitor of inositol monophosphatase (IMPase), a critical enzyme in the phosphoinositide signaling pathway. This compound, derived from the fungal strain ATCC 20928B, exhibits significant potential for modulating inositol levels and can be utilized in studies investigating mood disorders, neurodegenerative diseases, and other conditions linked to inositol metabolism. Its application in biochemical research can help elucidate the role of IMPase in cellular signaling processes. -
PTP1B Inhibitor
Deoxyfunicone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating an IC50 value of 24.3 µM through direct active site binding. This secondary fungal metabolite exhibits notable anti-inflammatory properties, making it a valuable tool for research into metabolic regulation and the treatment of inflammatory diseases. Its mechanism of action positions it as a significant compound for studies focused on diabetes and obesity-related conditions. -
HIV Integrase Inhibitor
Equisetin is an N-methylserine-derived acyl tetramic acid that functions as a potent HIV integrase inhibitor. It specifically interferes with the activity of HIV-1 integrase and demonstrates notable inhibition of 11β-HSD1 and Dnp-stimulated ATPase, with an IC50 of approximately 8 nmol per mg of protein. Additionally, Equisetin exhibits significant antibacterial properties, anti-inflammatory effects, and potential benefits in managing lipid-associated disorders while also showcasing cytotoxic activity. This compound is valuable for research applications focused on HIV treatment and the exploration of antimicrobial and anti-inflammatory mechanisms. -
Antibacterial Peptide
Golotimod hydrochloride is an immunomodulating peptide that targets antibacterial pathways. This compound enhances the efficacy of antituberculosis therapy by promoting thymic and splenic cell proliferation and improving macrophage functionality. Additionally, Golotimod hydrochloride inhibits STAT3 signaling, thereby modulating the severity and duration of oral mucositis in animal models subjected to radiation or combined treatments. Furthermore, it shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Antibacterial Peptide
Golotimod TFA is an immunomodulating peptide primarily known for its antibacterial properties. This compound enhances the efficacy of antituberculosis therapy and promotes thymic and splenic cell proliferation while improving macrophage function. It inhibits STAT3 signaling, demonstrating potential in mitigating the duration and severity of oral mucositis in irradiated animal models. Additionally, Golotimod TFA shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Anti-inflammatory/antibacterial Agent
Plumericin is an anti-inflammatory and antibacterial agent that primarily targets key signaling pathways involved in inflammation and cellular stress response. It has been shown to reduce apoptosis, activate Nrf-2, and inhibit both NF-κB and AhR activation, while also blocking STAT3 signaling. Plumericin exhibits inhibitory effects on Mycobacterium tuberculosis growth, making it a valuable compound for studying chronic kidney disease, vascular diseases, inflammatory bowel diseases, peritonitis, and tuberculosis. -
HSV-1 Inhibitor
Gallic aldehyde, also known as 3,4,5-trihydroxybenzaldehyde, targets herpes simplex virus type 1 (HSV-1) through its potent antiviral properties. This phenolic aldehyde exhibits notable anti-HSV-1 activity while also functioning as an effective antioxidant. Additionally, gallic aldehyde inhibits the gelatinolytic activity and expression of matrix metalloproteinase-9 (MMP-9), as well as the activation of ERK1/2, p38, and JNK signaling pathways. Its antibacterial effects are further demonstrated against Oenococcus oeni VF, making it a valuable reagent for diverse biological research applications. -
SARS-CoV PLpro Inhibitor
4'-O-Methylbavachalcone is a prenylated flavonoid that acts as an inhibitor of the SARS-CoV papain-like protease (PLpro), displaying an IC50 value of 10.1 μM and a Ki of 4.6 μM. This compound has demonstrated the ability to inhibit poly (ADP-ribose) polymerase-mediated cell death and reduce cerebral infarct volume. Additionally, it modulates SUCNR1 activity and interferes with ERK1/2 signaling pathways, affecting cardiomyocyte hypertrophy. 4'-O-Methylbavachalcone is applicable in research focused on ischemic stroke, SARS-CoV, and cardiovascular diseases. -
Antibiotic
Tigecycline hydrochloride is a broad-spectrum glycylcycline antibiotic that primarily targets bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits significant antibacterial activity against a variety of gram-positive and gram-negative pathogens, including Escherichia coli and Acinetobacter baumannii, with mean inhibitory concentrations (MIC) of approximately 125 ng/mL for E. coli and MIC50 and MIC90 values of 1 and 2 mg/L for A. baumannii, respectively. Tigecycline hydrochloride is commonly used in research settings to investigate antibiotic resistance mechanisms and to study the efficacy of antimicrobial agents. -
Antibiotic
DCAP is a broad-spectrum antibiotic that targets the membranes of both Gram-positive and Gram-negative bacteria. It exhibits significant antibacterial activity by disrupting autophagic processes, specifically blocking the maturation of autophagolysosomes and interrupting autophagic flux. This compound is utilized in research applications focused on bacterial infections and autophagy regulation. -
Parasite Inhibitor
CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, demonstrating IC50 values of 10 nM and 5.0 nM, respectively. In addition, it shows inhibitory activity against Abl and Src kinases with IC50 values of 75 nM and 65 nM. This compound is suitable for research applications related to toxoplasmosis, providing valuable insights into the therapeutic targeting of these pathways. -
Stable Isotope
Loratadine-d5 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral histamine H1 receptors. It has demonstrated an IC50 of over 32 μM and exhibits anti-Dengue virus (DENV) activity. Loratadine also inhibits the immunologic release of inflammatory mediators, making Loratadine-d5 a valuable reagent for research in pharmacology and immunology. -
Antifungal Agent
Moracin D is a flavonoid derived from Morus alba, known for its antifungal properties. This compound exhibits significant biological activity, including the induction of cell apoptosis, hypoglycemic effects, and antiadipogenic action. Moracin D is primarily utilized in research involving fungal infections and breast cancer, making it a valuable reagent in the investigation of therapeutic strategies. -
Antifungal Agent
Xanthochymol is an antifungal agent derived from Clusia rosea, primarily targeting fungal cells. This compound demonstrates the ability to induce apoptosis in fungi, making it a valuable tool for investigating fungal cell death mechanisms. It is applicable in research focused on antifungal therapies and the study of fungal pathogen responses to stress. -
Antibiotic
Ascochlorin is an isoprenoid antibiotic that primarily targets the STAT3 signaling cascade, leading to the suppression of tumor growth. It has demonstrated the ability to induce apoptosis in cancer cells while exhibiting anti-inflammatory properties. This compound is valuable for research applications focusing on cancer biology, inflammation, and the modulation of intracellular signaling pathways. -
Cation Ionophore
Calcimycin hemicalcium salt is a potent cation ionophore that primarily facilitates the transport of divalent cations such as calcium and magnesium across cellular membranes. This compound is known to induce Ca2+-dependent cell death by elevating intracellular calcium concentrations, making it valuable for research into apoptosis and autophagy mechanisms. Additionally, Calcimycin hemicalcium salt exhibits antibacterial activity against Gram-positive bacteria and some fungal species, while also inhibiting ATPase activity and uncoupling oxidative phosphorylation in mammalian cells. Its diverse biological effects make it a useful reagent for various biochemical and cellular studies. -
Antifungal Agent
Melittin free acid is a 26-amino-acid polypeptide and a potent activator of phospholipase A2 (PLA2) with significant antifungal activity. It demonstrates broad-spectrum antifungal efficacy, displaying minimum inhibitory concentration (MIC) values between 0.4-60 μM. Melittin free acid exerts its biological effects by promoting fungal cell apoptosis, inhibiting (1,3)-β-D-glucan synthase, and engaging in various other cellular pathways, making it a valuable reagent for research in antifungal mechanisms and therapeutic applications. -
HIV Protease Inhibitor
Indinavir sulfate ethanolate is a selective inhibitor of HIV-1 protease, demonstrating a potent Ki of 0.54 nM for the target enzyme. Beyond its antiviral activity, this compound has shown potential in anticancer research through the inhibition of MMPs-2 activation, anti-angiogenic effects, and promotion of apoptosis. Additionally, Indinavir sulfate ethanolate acts as an inhibitor of the SARS-CoV 3CLpro enzyme, highlighting its diverse biological activity and relevance in multiple research applications. -
Antitumor Antibiotic
Peplomycin is an analog of bleomycin that functions as an antitumor antibiotic. It demonstrates significant antitumor activity while exhibiting lower pulmonary toxicity compared to its parent compound. Peplomycin is known to induce apoptosis in oral squamous cell carcinoma (SSCKN) cells and may lead to skin abnormalities and pulmonary fibrosis. This compound is valuable for research related to tumors, pulmonary fibrosis, and associated diseases. -
HBV Inhibitor
Alisol F 24-acetate is a triterpenoid compound that targets Hepatitis B Virus (HBV) by inhibiting the secretion of HBV surface antigens HBsAg and HBeAg, with respective IC50 values of 7.7 µM and 5.1 µM. This compound also exhibits proapoptotic activity, making it a valuable agent for cancer research applications. Its role in regulating viral antigen secretion positions it as a potential therapeutic candidate in HBV-related studies. -
Photosensitizer
Elsinochrome A is a perylene quinone photosensitizer that generates reactive oxygen species (ROS) upon light excitation, thereby inducing apoptosis and autophagy in targeted cells. This compound demonstrates effective antifungal activity against Candida albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A is suitable for research applications in photodynamic therapy (PDT), particularly with excitation wavelengths around 460 nm. -
Antibiotic Agent
Nargenicin A1 is an antibiotic agent primarily targeting Gram-positive bacteria. It exhibits anti-inflammatory properties and has been shown to protect HINAE cells from DNA damage and apoptosis induced by Tacrolimus. Additionally, Nargenicin A1 is relevant for research applications related to acute myeloid leukemia, making it a valuable compound for studies in both infection and cancer biology. -
Antibiotic
Undecylprodigiosin is an antibiotic derived from the prodiginine family, known for its potent antibacterial properties. It has been shown to selectively induce apoptosis in human breast carcinoma cells independently of the p53 pathway, demonstrating its potential as an anticancer agent. Additionally, undecylprodigiosin possesses immunosuppressive and antimicrobial activities, making it a valuable tool in cancer research and antimicrobial studies. -
Antibacterial Agent
(±)-Trolline, also known as (±)-Oleracein E, is an isoquinoline alkaloid with notable antibacterial properties against respiratory pathogens. Additionally, it demonstrates antiviral activity against influenza viruses A and B. (±)-Trolline is also a potent inducer of hepatic stellate cell apoptosis, making it a valuable tool for studying liver fibrosis and associated liver disorders. -
Antibacterial Growth Promoter
Nitrovin is an antibacterial growth promoter that targets thioredoxin reductase 1 (TrxR1). It acts by inducing reactive oxygen species (ROS)-mediated non-apoptotic and apoptotic-like cell death. Nitrovin exhibits anticancer activity, demonstrating IC50 values ranging from 1.31 to 6.60 μM in various tumor and normal cell lines, making it a valuable tool for research in cancer and antibacterial studies. -
Deuterated Labeled Geraniol (Major)
Geraniol-d6 (Major) is a deuterated form of the terpene compound geraniol, which primarily functions as an olefin. This compound exhibits significant biological activities, including the inhibition of cell proliferation and the promotion of apoptosis. Geraniol-d6 (Major) is valuable for research applications related to diabetes, as well as studies focusing on its antibacterial, antifungal, antioxidant, anti-inflammatory, and antitumor properties. -
Antibiotic
Arisostatin A is a microbial secondary metabolite with antibiotic activity specifically against Gram-positive bacteria. It exhibits potent anti-tumor effects by inducing apoptosis through the activation of caspase-3 and the generation of reactive oxygen species (ROS) in AMC-HN-4 cells. This compound is valuable for research applications in cancer biology and antimicrobial studies. -
Nucleoside Reverse Transcriptase Inhibitor
Stavudine sodium is a nucleoside reverse transcriptase inhibitor (NRTI) primarily utilized for its efficacy against HIV-1 and HIV-2. This compound demonstrates the ability to inhibit mitochondrial DNA replication, reduce NLRP3 inflammasome activation, and modulate the autophagy of Amyloid-β, contributing to its therapeutic potential. Additionally, Stavudine sodium is associated with inducing apoptosis in targeted cells, making it a valuable tool in HIV research and related cellular studies. -
Antibacterial Agent
Antibacterial Agent 292 is a 3-pyrazolylindole derivative targeting bacterial pathogens. This compound exhibits potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 and 3.49 μg/mL, respectively. It suppresses biofilm formation, bacterial motility, and extracellular polysaccharide production while inducing morphological changes and promoting ROS accumulation, leading to bacterial apoptosis. Additionally, it down-regulates genes associated with the type VI secretion system (T6SS), making it a valuable tool for research on rice bacterial blight and citrus canker. -
HSV Inhibitor
Acyclovir hydrochloride is an antiviral agent that specifically targets herpes simplex virus (HSV) replication. It exhibits significant antiherpetic activity, with IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2. In addition to its antiviral effects, Acyclovir hydrochloride can induce cell cycle disruption and promote apoptosis in infected cells. This compound is also utilized in the context of bacterial infection prevention during induction therapy for acute leukemia. -
Bacterial
(-)-Isoledene primarily functions as an antibacterial agent, exhibiting significant antibacterial and anti-inflammatory activities. This natural organic compound has been investigated for its role in the synthesis of various compound intermediates, highlighting its potential applications in compound development and pharmaceutical research. Its diverse biological activity positions it as a valuable reagent for studies related to bacterial infections and inflammation. -
Antileishmanial Agent
Antileishmanial agent-36 is an indole-dihydropyrimidinone derivative that targets Leishmania species, demonstrating significant anti-leishmanial activity. This compound induces mitochondrial dysfunction through the generation of reactive oxygen species (ROS), leading to apoptosis in infected cells. It exhibits potent lethality against L. donovani with an IC50 value of 4.54 µM, while displaying low cytotoxicity towards J774.1 macrophages. Antileishmanial agent-36 is suitable for research applications focused on visceral leishmaniasis (VL) and parasite burden clearance. -
Bacterial Inhibitor
(Z)-Methyl tetradec-9-enoate functions as a bacterial inhibitor, primarily exerting its cytotoxic effects in human prostate cancer LNCaP cells through the induction of apoptosis and necrosis. Isolated from S. repens fruit extract, this compound also demonstrates antifungal activity, effectively inhibiting the germination of Candida albicans with a minimum inhibitory concentration (MIC) of 9 μM in vivo. Its applications extend to studies in both cancer research and microbiology, making it a valuable reagent for understanding cellular processes and developing therapeutic strategies.
