Catalog No.
Product Name
Application
Product Information
Citations
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RSV RdRp Inhibitor
GS-646089 is a potent inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp). This broad-spectrum antiviral nucleoside analog demonstrates robust activity against RSV, human metapneumovirus (hMPV), rhinovirus, and enteroviruses, with an IC50 in the range of 43 to 46 nM. GS-646089 is converted intracellularly into a triphosphate metabolite that competes with ATP for incorporation into growing RNA chains, effectively terminating viral replication. This compound serves as a valuable tool for research into acute respiratory viral infections and related viral pathogens. -
Antibiotic
Erythromycin glutamate is a macrolide antibiotic that primarily targets bacterial 50S ribosomal subunits, inhibiting RNA-dependent protein synthesis by blocking transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity against various bacterial pathogens. In addition to its antibiotic properties, erythromycin glutamate has shown potential antitumor and neuroprotective effects, making it valuable for diverse research applications in microbiology, oncology, and neurobiology. -
AntibioticAgent
GSK299423 is an antibiotic agent primarily targeting DNA gyrase. It exhibits potent inhibition of supercoiling in Staphylococcus aureus with an IC50 of 14 nM and in Escherichia coli with an IC50 of 100 nM. This compound is suitable for research applications focused on antibacterial mechanisms and the evaluation of DNA-targeting therapies. -
Antibiotic
Viquidacin is an antibiotic that primarily targets topoisomerase IV and DNA gyrase. It demonstrates significant antibacterial activity against gram-positive bacteria, particularly Staphylococcus aureus, by inhibiting supercoiling, decatenation, and relaxation processes. Viquidacin also exhibits activity against Escherichia coli and shows a minimum inhibitory concentration (MIC) range of 2-128 mg/L against wild-type and mutant strains of S. aureus, making it a valuable reagent for antibacterial research applications. -
HSV Inhibitor
Abyssinone V is a prenylated flavonoid recognized for its antiviral properties, specifically as an inhibitor of herpes simplex virus (HSV). Isolated from the stem bark of Erythrina melanacantha, Abyssinone V exhibits favorable pharmacodynamic characteristics. Its mechanisms of action include the inhibition of viral polymerase, ATPase activity, and disruption of membrane integrity, making it a valuable compound for research into HSV-related therapies. -
RNA Polymerase Inhibitor
RNA polymerase-IN-4 is a potent inhibitor of RNA polymerase, exhibiting an EC50 of 22.81 nM. This compound demonstrates significant anti-influenza virus activity with an EC50 of 3.76 nM and displays relatively low cytotoxicity, with a CC50 of 29.91 μM. RNA polymerase-IN-4 is suitable for research applications focused on viral infections, particularly those related to influenza virus. -
Antibiotic
Erythromycin hydrochloride is a macrolide antibiotic that acts as a protein synthesis inhibitor, targeting bacterial ribosomes. It demonstrates broad-spectrum activity against both Gram-positive and some Gram-negative bacteria, making it effective in treating various bacterial infections, including respiratory and skin infections. Additionally, erythromycin hydrochloride has been implicated in the inhibition of mammalian mRNA splicing, indicating potential roles in research related to gene expression and cellular function. This compound is widely utilized in biomedical research for its antibacterial properties and mechanisms. -
Anti-HIV Agent
3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analog that serves as an anti-HIV agent by acting as a chain terminator. Incorporated into the nascent DNA strand by HIV reverse transcriptase, AZddCTP halts DNA synthesis due to its lack of a 3'-hydroxyl group, effectively inhibiting viral replication. With IC50 values of 15.6 μM against wild-type HIV and 160.8 μM for AZTR HIV, 3′-Azido-2′,3′-dideoxy-CTP demonstrates significant antiviral activity, making it a valuable tool in HIV research. -
Insecticide/Antibacterial Agent
Satranidazole is an orally active insecticide and antimicrobial agent that primarily targets DNA through the formation of reduced nitro intermediates. By inducing helix instability and strand breakage, it exhibits notable antitrichomonal activity against organisms such as Trichomonas vaginalis and Trichomonas foetus, as well as antiamoebic effects in rodent models of hepatic and caecal amoebiasis. Additionally, Satranidazole has been shown to inhibit the replication of bacteriophage φX174 DNA. This compound is valuable for research exploring caecal amoebiasis, trichomoniasis, and anaerobic bacterial infections. -
SARS-CoV-2 Inhibitor
SARS-CoV-2-IN-115 is a potent inhibitor of SARS-CoV-2, demonstrating significant antiviral activity in infected Calu-3 cells with an EC50 of 1.7 μM. This compound effectively inhibits human dihydroorotate dehydrogenase (HsDHODH) with an IC50 of 1.5 μM. Notably, SARS-CoV-2-IN-115 preserves immune response without exhibiting antiproliferative effects on CD4 T cells, making it a valuable tool for research in antiviral therapeutics and immune modulation. -
Anticancer Agent
Endusamycin is an anticancer agent that inhibits protein and nucleic acid synthesis in Ehrlich ascites carcinoma cells. This selective activity contributes to its efficacy as a potential therapeutic for cancer research, while exhibiting no antibacterial or antifungal effects. Endusamycin is suitable for studies aimed at understanding cancer cell metabolism and the development of new cancer treatment strategies. -
CMV Inhibitor
Soyasaponin II is a saponin known for its antiviral properties, particularly as an inhibitor of cytomegalovirus (CMV) replication. It demonstrates strong efficacy against various viruses, including HSV-1, HCMV, influenza, and HIV-1. Additionally, Soyasaponin II inhibits YB-1 phosphorylation and NLRP3 inflammasome priming, offering potential protective effects in models of acute liver failure induced by LPS/GalN. This compound is valuable for research in virology and inflammation. -
Antibacterial/anti-inflammatory Agent
Sinapaldehyde is a methoxyphenol that primarily functions as a selective COX-2 inhibitor with an IC50 of 47.8 µM. This compound exhibits notable antibacterial and anti-inflammatory properties, demonstrating efficacy against both Gram-positive and Gram-negative bacteria. Additionally, Sinapaldehyde possesses antioxidant activity through its ability to scavenge DPPH free radicals, with an IC50 of 172 μM, making it a valuable reagent for research in inflammation and microbial resistance. -
Antibacterial Agent
1-Tetradecanol is a straight-chain saturated fatty alcohol that serves as an effective antibacterial agent. Isolated from Myristica fragrans, it exhibits notable antibacterial and anti-inflammatory properties, particularly in the context of periodontitis. This compound can be utilized in research applications focusing on antimicrobial activity and the modulation of inflammatory responses. -
Antiviral/Immunomodulator
HEP-1 is a synthetic peptide derived from human ezrin (324 - 337) that exhibits potent antiviral and immunomodulatory properties. It demonstrates efficacy against a range of viral infections, including HIV, HCV, herpes viruses, HPV, and influenza. Additionally, HEP-1 enhances adaptive immunity by promoting B cell and T cell responses, and it has been shown to increase antibody titers following hepatitis B vaccination. This reagent is suitable for research applications focused on viral infections and inflammation-related disorders. -
Antibacterial Agent
Terminolic acid is a pentacyclic triterpene glycoside that acts as an antibacterial agent. It exhibits significant antibacterial activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis, with minimum inhibitory concentrations (MICs) ranging from 64 to 256 μg/mL. Terminolic acid also demonstrates the ability to inhibit pro-inflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6, contributing to a reduction in IL-8 levels. This compound is utilized in research targeting colon cancer and inflammatory conditions. -
RSV Inhibitor
CL-A3-7 is a potent respiratory syncytial virus (RSV) inhibitor that targets the RSV F protein, functioning as a virus-cell fusion inhibitor. By disrupting the interaction between the virus and the host insulin-like growth factor 1 receptor (IGF1R), CL-A3-7 effectively prevents infections caused by both wild-type RSV and the K394R variant. This compound is valuable for use in anti-RSV drug development and studies focused on resistance mechanisms associated with RSV. -
HIV-Ⅰ Inhibitor
HIV-IN-6 is an inhibitor of HIV-1 viral replication, specifically targeting Src family kinases (SFKs) that associate with the viral Nef protein, including Hck. This compound has demonstrated significant antiviral activity by disrupting the functional interactions necessary for viral pathogenesis. Its application in research includes the study of HIV infection mechanisms and the exploration of novel therapeutic strategies against HIV-1. -
Antitumor Antibiotic
Herbimycin B is an ansamycin antibiotic targeting Src family tyrosine kinases. It exhibits significant antitumor activity by inhibiting cell proliferation in various cancer cell lines, including HeLa and Ehrlich cells. Additionally, Herbimycin B demonstrates a herbicidal effect on both monocotyledons and dicotyledons and can inhibit the tobacco mosaic virus (TMV), making it relevant for studies in plant pathology and cancer research. -
Dyrk1A Inhibitor
Dyrk1A-IN-12 is a selective inhibitor of Dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A), demonstrating an IC50 of 95 nM. This compound exhibits significant anti-Enterovirus A71 (EV-A71) activity, with an EC50 of 4.4 μM and a cytotoxicity CC50 of 12.8 μM, resulting in a selectivity index of 2.9. Additionally, Dyrk1A-IN-12 shows strong inhibitory effects against herpes simplex virus (HSV), positioning it as a valuable tool for research in viral infections and Dyrk1A-related pathways. -
Antibacterial Agent
Antibacterial Agent 69 is a novel antimicrobial compound that targets and inhibits the growth of multidrug-resistant bacteria. With a reported minimum inhibitory concentration (MIC) of 2.978 μM, it demonstrates significant antibacterial activity. This agent is primarily employed in research focused on combating antibiotic resistance and developing new therapeutic strategies against challenging bacterial infections. -
Antibiotic
Methicillin is a narrow-spectrum β-lactam antibiotic that targets and inhibits penicillin-binding proteins (PBPs). Its efficacy is primarily observed against Staphylococcus aureus and Staphylococcus epidermidis strains that exhibit resistance to other penicillins. Methicillin is utilized in research investigating various conditions, including skin infections, osteomyelitis, and endocarditis. -
Antibiotic
Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis. Effective against Staphylococcus aureus and Staphylococcus epidermidis, particularly strains resistant to other penicillins, it is utilized in researching conditions such as skin infections, osteomyelitis, and endocarditis. -
Stable Isotope
Loratadine-d4 is a deuterated form of Loratadine, a selective inverse agonist of peripheral histamine H1 receptors. With an IC50 greater than 32 μM, Loratadine demonstrates significant anti-dengue virus (DENV) activity and can inhibit the immunologic release of inflammatory mediators. This stable isotope is valuable in pharmacokinetic studies and for the development of analytical methods in chemical research. -
Anti-inflammatory/Antioxidant/Antibacterial Agent
Eukovoside is a cinnamic acid derivative that primarily exerts anti-inflammatory, antioxidant, and antibacterial effects. This compound shows potential in the study of hyperglycemic diseases and is useful for investigating various inflammatory conditions, including eye inflammation and respiratory tract disorders. Additionally, Eukovoside may contribute to research focused on allergic responses such as hay fever and conjunctivitis, as well as infections like colds, influenza, and sinusitis. -
Stable Isotope
Loratadine-d4-1 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral H1-histamine receptors. With an IC50 value exceeding 32 μM, Loratadine exhibits significant biological activity, including anti-dengue virus (DENV) effects and the inhibition of immunologic release of inflammatory mediators. This stable isotope reagent is valuable for mechanistic studies, pharmacokinetic evaluations, and research applications in allergy and inflammatory response investigations. -
BTK/MNK Dual Inhibitor
QL-X-138 is a selective dual inhibitor of Bruton's tyrosine kinase (BTK) and MAPK-interacting kinase (MNK), demonstrating potent covalent binding to BTK and non-covalent binding to MNK. It exhibits IC50 values of 9.4 nM for BTK, and 107.4 nM and 26 nM for MNK1 and MNK2, respectively. Additionally, QL-X-138 displays antiviral activity against dengue virus serotype 2, with an IC50 of 3.5 μM. This compound is valuable for research involving B-cell malignancies and related therapeutic investigations. -
Anticancer Agent
Antitumor Agent-160 is a derivative of the antifungal compound phenalenone, serving as an anticancer agent. It exhibits significant antitumor activity, making it a valuable tool in cancer research. Its potential applications include the study of cancer cell proliferation and the evaluation of therapeutic strategies in oncological research. -
Detection Substrate
5-Bromo-4-chloro-3-indolyl-α-D-maltotrioside functions as a sensitive enzyme substrate with chemiluminescent properties. It facilitates the detection of various enzymatic activities, making it suitable for diagnostic assays aimed at identifying bacterial and fungal infections, as well as other diseases. Its utility in research applications enhances the reliability of assays in clinical microbiology and molecular diagnostics. -
Chlorinated Phenol
Tetrachloroguaiacol is a chlorinated phenol primarily formed during the chlorine bleaching of wood pulp. It exhibits significant antibacterial and antifungal activities, making it relevant for studies in environmental science and biochemistry. This compound serves as a valuable reagent in research focused on the effects of chlorinated compounds on biological systems and their potential environmental impact. -
α,β-unsaturated Fatty Acid
2-Decenoic acid is an α,β-unsaturated fatty acid known to inhibit plant pollen germination and pollen tube elongation. This compound exhibits significant biological activity, making it a valuable tool for research in plant reproductive biology. Additionally, its antimicrobial properties suggest potential applications in developing antifungal and antibacterial agents. -
Redox Isomer
Neopatulin is a redox isomer and a critical biogenetic precursor of the antibiotic patulin, commonly produced by various fungal species. This compound plays a significant role in studies pertaining to antibiotic synthesis and fungal metabolism. Neopatulin can be synthesized through methods such as Lewis acid-catalyzed aldol reactions or utilizing 2-formyl-1,3-dithiane in conjunction with 2-(tert-butyldimethylsiloxy)-4-[(tert-butyldimethylsiloxy)-methyl]furan, making it a valuable reagent for chemical research applications. -
Phenolic Compound
Daphneolone is a phenolic compound known for its potential antifungal properties against plant pathogenic fungi. Isolated from the roots of Daphneodora, this compound is valuable for research into natural antifungal agents and plant defense mechanisms. Its analogues may offer insights into the development of eco-friendly agricultural solutions. -
Oxylipin
8(R),11(S)-DiHODE is a fungal oxylipin that primarily targets lipid signaling pathways. It is known to play a role in modulating inflammatory responses and cell signaling processes. This compound is of particular interest in research applications related to metabolic diseases, inflammation, and fungal biology, providing insights into the biochemical pathways influenced by oxylipins. -
Active Compound
Nikkomycin J is an active compound that functions as an inhibitor of chitin synthase, targeting fungal cell wall biosynthesis. Its primary biological activity includes antifungal effects, making it particularly valuable in research related to fungal infections and the development of antifungal therapies. Nikkomycin J is utilized in studies focused on fungal pathogenesis and drug resistance mechanisms. -
Penicillium Intermediate
Cyclopeptine is a key intermediate in the biosynthesis of benzodiazepine alkaloids produced by the genus Penicillium. This compound is significant for research into the metabolic pathways of fungal secondary metabolites and their potential applications in pharmacology. Cyclopeptine can also be utilized to study the structural and functional properties of benzodiazepine derivatives in various biological systems. -
Secondary Metabolite of Aspergillus flavus
5,7-Dihydroxy-4-methylphthalide is a secondary metabolite produced by Aspergillus flavus, serving as a crucial intermediate in the synthesis of Mycophenolic acid. This compound exhibits significant biological activity, contributing to the understanding of fungal metabolism and the pharmacological properties of derived compounds. Its applications encompass research into fungal biosynthesis and the exploration of potential therapeutic agents stemming from fungal secondary metabolites. -
Phenolic Compound
3,4,5-Trichloroguaiacol is a phenolic compound primarily targeted for its antibacterial and antifungal properties. It is often utilized in studies examining environmental contaminants, particularly in the context of effluents from bleached kraft pulp mills. This compound serves as an important research tool in understanding the biochemical pathways influenced by chlorinated phenols and their impacts on microbial activity. -
Lanostane-type Triterpenoid Compound
Inonotusane A is a lanostane-type triterpenoid compound isolated from the sclerotia of Inonotus obliquus. This compound exhibits notable biological activity, including potential anticancer properties and immunomodulatory effects. It serves as a valuable reagent for research focused on natural products, herbal medicine, and the therapeutic potential of fungal metabolites in various biological systems. -
Terpenoid
Monardin C is a natural terpenoid known for its ability to modulate various biological pathways. It exhibits significant antibacterial and antifungal activities, making it a valuable compound in microbiological research. Monardin C's unique properties render it useful for studies focused on the therapeutic potential of terpenoids in infectious diseases and alternative medicine approaches. -
Sesquiterpene
10(14)-Cadinene-4,5-diol is a natural sesquiterpene that modulates various biochemical pathways through its interaction with biological targets. Exhibiting antibacterial and antifungal properties, this compound demonstrates significant activity against a range of microbial strains. Its application in research includes the study of plant secondary metabolites and their potential therapeutic uses in combating infections. -
Drug Derivative
Roseofungin is a drug derivative that primarily targets fungal infections by inhibiting fungal cell wall synthesis. Its key biological activity includes antifungal effects against a variety of pathogenic fungi. This compound is valuable in research applications focusing on antifungal drug development and the study of resistance mechanisms in fungal pathogens. -
Sesquiterpene
Phaeocaulisin F is a natural sesquiterpene known for its potential effects on various biological pathways. This compound exhibits significant antibacterial and antifungal activities, making it valuable in research focused on infectious diseases and microbial resistance. Its unique structure and biological properties enable exploration in diverse fields, including pharmacology and natural product chemistry. -
Stable Isotope
Loratadine-d5-1 is a deuterated analog of Loratadine, which serves as a selective inverse agonist of peripheral histamine H1 receptors. It exhibits an IC50 of greater than 32 μM and has been shown to possess anti-dengue virus (DENV) activity. Additionally, Loratadine is capable of inhibiting the immunologic release of inflammatory mediators, making it a valuable tool for research in allergy and inflammation studies. -
Antimicrobial Agent
1,2-Hexanediol serves as a broad-spectrum antimicrobial agent with significant antibacterial and antifungal properties. It exhibits bactericidal activity against both Gram-positive and Gram-negative bacteria, while also effectively inhibiting various fungal organisms. The compound disrupts the cytoplasmic membrane potential of bacteria, making it an essential tool in research focused on bacterial and fungal infections, as well as applications in cosmetic preservation. -
Fungicide
Nuarimol is a fungicide that primarily targets fungal pathogens to protect crops in agricultural applications. This compound functions as a phenobarbital-type inducer of hepatic drug-metabolizing enzymes, leading to transient, significant hepatic regenerative proliferation and accompanying hepatomegaly through reversible hepatocellular injury. Research indicates its potential utility in studies exploring liver regeneration and metabolic enzyme regulation. -
Isomer
(E/Z)-Diniconazole is an isomer of the well-studied fungicide Diniconazole, primarily targeting plant fungal pathogens. Its biological activity includes the inhibition of specific fungal processes, making it valuable for research focused on the control of plant fungal diseases. Additionally, it plays a role in studies regarding plant growth regulation, offering insights into its effects on agricultural practices and crop management. -
Drug Isomer
rel-Hydroxy Itraconazole is a relative stereoisomer of Hydroxy Itraconazole, which serves as the primary active metabolite of the antifungal agent Itraconazole. This compound exhibits significant antifungal activity and is crucial in studying the pharmacological effects of its parent drug. It is primarily utilized in research applications focused on antifungal mechanisms and drug metabolism. -
Angucycline Antibiotic
Urdamycin A is an angucycline antibiotic derived from Streptomyces fradiae. Notably, it functions as an orange pH indicator, shifting to ultramarine blue at pH 7.7. Urdamycin A exhibits significant anticancer activity, showing IC50 values of 2.4 μg/mL in proliferation assays and 0.55 μg/mL in stem cell assays. This compound is relevant for research applications in cancer biology and antibiotic activity studies. -
Azasterol
Fluoro azasterol is an azasterol derivative that functions as a potent inhibitor of parasitic and fungal growth. This compound exhibits significant biological activity against various pathogens, making it a valuable tool for research in the fields of parasitology and mycology. Its applications include studying the mechanisms of anti-parasitic and antifungal action, as well as exploring potential therapeutic uses in infectious disease models.
