Catalog No.
Product Name
Application
Product Information
Citations
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Antibacterial Agent
Antibacterial Agent 255 is a selective inhibitor of 4-diphosphocytidyl-2-C-methyl-D-erythritol (IspE), demonstrating potent antibacterial activity with IC50 values of 13.0 µM for E. coli IspE, 8.0 µM for K. pneumoniae IspE, and 20 µM for A. baumannii IspE. This compound is instrumental in the study of bacterial biosynthesis pathways and can be utilized in antibacterial drug development research. -
Bacterial Inhibitor
Ethionamide hydrochloride is an antituberculosis agent that acts as a bacterial inhibitor. It disrupts mycobacterial cell wall synthesis by inhibiting fatty acid synthesis, leading to potential bacteriostatic or bactericidal effects based on concentration and microorganism susceptibility. Ethionamide hydrochloride forms an adduct with NAD+, which is crucial for its antimicrobial activity. This compound is primarily utilized in research for understanding tuberculosis treatment and the mechanisms of drug resistance in Mycobacterium tuberculosis. -
Antibacterial Agent
5-Hydroxymethyl flucloxacillin is an active metabolite of Flucloxacillin, targeting bacterial infections. This compound demonstrates notable antibacterial activity, making it useful for research applications focused on antimicrobial resistance and bacterial pathogenesis studies. Its efficacy in inhibiting bacterial growth supports investigations into therapeutic strategies for treating infections caused by resistant strains. -
Antibiotic
Andrimid is a lipoacyl peptide that functions as an antibiotic through its action on bacterial cell envelope synthesis. It demonstrates significant antimicrobial activity, making it a valuable compound for researching antibiotic mechanisms and resistance. Additionally, Andrimid has potential applications in both biomedical research and agricultural biotechnology, particularly in developing strategies for disease control. -
Anti-Bacterial Agent
Saquayamycin C is an anti-bacterial agent with significant antimicrobial activity, though it exhibits a weaker efficacy against Gram-negative bacteria. This compound also demonstrates cytotoxic effects against leukemia P388 cells, including those resistant to Adriamycin. Its applications extend to research in cancer biology and microbial resistance, making it valuable for studies focused on therapeutic development and resistance mechanisms. -
Mitotic kinesin Inhibitor
Mitotic kinesin-IN-1 hydrochloride is a potent inhibitor of mitotic kinesin, specifically designed to disrupt the process of mitosis. This compound effectively impairs cell proliferation and has applications in cancer research, as well as investigations into cardiac hypertrophy, immune and inflammatory disorders, and fungal infections. Its ability to hinder mitotic activity makes it a valuable tool for studying various cellular processes and pathways related to these conditions. -
Griseofulvin Metabolite
6-O-Demethyl griseofulvin is a significant metabolite of Griseofulvin, primarily acting on fungal cell division by inhibiting microtubule formation. This compound demonstrates antifungal activity, making it valuable in studying the efficacy of antifungal treatments and the metabolic pathways involving Griseofulvin. Its applications extend to research focused on dermatophyte infections and fungal resistance mechanisms. -
Metabolite
BTS44596 (Prochloraz-desimidazole-formylamino) is a key metabolite of the antifungal agent Prochloraz, primarily targeting regulatory monitoring applications. This compound serves as a critical target analyte for assessing Prochloraz residue limits in fruits and vegetables. Additionally, it facilitates simultaneous detection using LC-MS/MS methodology, making it an essential tool for food safety and environmental studies. -
Fungicidal Agent
N,N-Bis(3-aminopropyl)dodecylamine serves as a potent fungicidal agent targeting Aspergillus niger. It exerts its antifungal activity by inducing oxidative stress and modulating the activity of various antioxidant and mitochondrial enzymes in a concentration- and time-dependent manner. Additionally, this compound disrupts fungal organelles and alters mitochondrial morphology, leading to impaired mitochondrial functions. N,N-Bis(3-aminopropyl)dodecylamine is valuable for research into fungicidal mechanisms and the role of oxidative stress in Aspergillus niger. -
Active Compound
Phenylpyruvic acid is a precursor to phenyllactic acid and serves as an active compound with antifungal properties. This reagent enhances the antifungal activity of various lactic acid bacterial strains when incorporated into defined growth media. Phenylpyruvic acid exhibits significant inhibitory effects against fungal contaminants such as Aspergillus niger and Penicillium roqueforti. Additionally, it influences the enzymatic activity of the pentose phosphate pathway in rat brain homogenates, notably reducing glucose-6-phosphate dehydrogenase activity. This compound is valuable for research applications in microbiology and metabolic studies. -
Telomerase
Diazaphilonic acid is a compound that targets telomerase, functioning by inhibiting its activity. Derived from the fungal strain Talaramuces flavus PF1195, it demonstrates significant potential in disrupting DNA amplification processes. This makes it a valuable reagent for research applications focused on telomere biology and cancer studies. -
Antitumor Antibiotic
Saintopin is an antitumor antibiotic that selectively inhibits DNA topoisomerases I and II, key enzymes involved in DNA replication and transcription. By inducing DNA cleavage, Saintopin disrupts the integrity of the genetic material, leading to apoptosis in cancer cells. This compound is utilized in research focused on cancer biology, particularly in studies involving mechanisms of chemotherapy resistance and DNA repair processes. -
Antibacterial Agent
Octyl decyldimethyl ammonium chloride is a quaternary ammonium compound functioning as an antibacterial agent. This reagent disrupts microbial cell membranes, resulting in cytotoxic effects. Additionally, it has been observed to increase the secretion of pro-inflammatory cytokine IL-1α, indicating potential immunological implications. Its application may be relevant in studying antibacterial mechanisms and evaluating skin irritation effects in research settings. -
Drug Derivative
Fluopicolide is a novel drug derivative with a primary mechanism targeting specific protein interactions. It exhibits significant antifungal activity, making it suitable for studying plant pathogen resistance and developing effective agricultural fungicides. Fluopicolide is particularly valuable for research applications focused on crop protection and plant disease management strategies. -
Alternaria Metabolite
4-Hydroxyalternariol is a metabolite derived from the fungus Alternaria. It exhibits significant cytotoxic activity and serves as a potent inhibitor of various cell proliferation pathways. This compound is valuable in research focused on mycotoxin studies, apoptosis, and cancer biology, facilitating investigations into the biological effects of fungal metabolites on human health. -
Metabolite
(Z)-2-Octenoic acid is the Z-isomer of 2-Octenoic acid, a significant metabolite derived from Mucor species. It plays a role in various biochemical pathways and can be utilized in studies exploring fungal metabolism and organic compound synthesis. This compound may aid in the investigation of microbial interactions and the functional roles of metabolites in ecological systems. -
Secondary Metabolite
4-Hydroxyscytalone is a microbial secondary metabolite isolated from the oak fungus Diplodia corticola. This compound exhibits toxicity toward Artemia salina with an LC50 value of 90.6 μg/mL, indicating its potential as a bioactive agent. While it does not demonstrate significant antifungal activity, 4-Hydroxyscytalone may serve as a valuable tool in cancer therapy research, facilitating investigations into novel treatment strategies. -
Squalene Synthase Inhibitor
Squalestatin 3 is a potent squalene synthase inhibitor, demonstrating an IC50 of 6 nM. This secondary metabolite, isolated from the fungus Phoma, plays a critical role in regulating the biosynthesis of sterols and terpenes. It is valuable for research applications focused on cholesterol biosynthesis, antifungal research, and the exploration of lipid metabolism pathways. -
Fungal Lactone
Pestalotin is a fungal lactone and a secondary metabolite derived from the endophytic fungus Pestalotiopsis microspora. This compound exhibits significant antifungal activity, making it a valuable tool for research in mycology and natural product chemistry. Its bioactive properties may facilitate the exploration of new antimicrobial agents and contribute to the study of plant-fungal interactions. -
Secondary Metabolite
Fumiquinazoline D is a secondary metabolite that acts as a mycotoxin. It exhibits significant biological activity by inhibiting various cellular processes, potentially impacting cell viability and proliferation. Fumiquinazoline D is utilized in research to study the effects of mycotoxins on human health and to explore its mechanisms of action in fungal biology and toxicity. -
Anticancer Agent/SV40 Promoter Activator
TMC-205 is a natural fungal metabolite that acts as an SV40 promoter activator. It exhibits significant antiproliferative activity against various cancer cell lines, making it a valuable tool for cancer research. This compound is useful for studies on transcriptional regulation and the mechanisms of oncogenesis. -
Antibiotic
Neohydroxyaspergillic acid is an antibiotic that exhibits activity against specific bacteriophages. This compound can be utilized in research focusing on antibacterial mechanisms and the interaction between antibiotics and bacteriophages. Its potential applications extend to studying resistance and susceptibility patterns in microbial populations. -
Bacterial Metabolite
Corynecin IV is a chloramphenicol-like bacterial metabolite that targets bacterial protein synthesis through inhibition of the bacterial ribosome. This compound exhibits antimicrobial activity against a range of Gram-positive bacteria, making it valuable for research in antibiotic development and resistance studies. Additionally, Corynecin IV can be utilized to explore mechanisms of action for similar anti-infective agents. -
Fungi Metabolites
Scytalone is a naphthalenone pentaketide that serves as a natural precursor to melanin. This compound is derived from certain tracheiphilous fungi and is relevant in the study of fungal metabolites. Research indicates that scytalone may play a role in grape esca disease, making it a valuable reagent for investigations into plant pathology and fungal biology. -
Ciosynthetic Precursor of Satratoxin G
Roridin L2 is a fungal metabolite that serves as a biosynthetic precursor to Satratoxin G. This compound plays a crucial role in the synthesis of Satratoxin G, which is known for its potential biological activities. Despite its significance in research applications, Roridin L2 exhibits minimal toxic activity both in vitro and in vivo, making it a valuable reagent for studying fungal metabolites and their derivatives. -
Bacterial Metabolite
4-Hydroxycinnamide is a bacterial metabolite derived from Streptomyces sp. PU-KB10-4. This compound exhibits significant biological activity, making it a valuable tool in microbial research. Its role in bacterial metabolism may provide insights into host-microbe interactions and potential therapeutic applications. -
Metabolite
Eremofortin A is a natural metabolite derived from the fungus Penicillium roqueforti. This compound exhibits a range of biological activities, including potential antifungal and cytotoxic effects. Eremofortin A is primarily utilized in research applications focused on exploring fungal metabolites and their therapeutic potentials in the treatment of various diseases. -
Acinar Morphogenesis Inhibitor
Fusarisetin A is a pentacyclic fungal metabolite that functions as an acinar morphogenesis inhibitor. This compound disrupts the normal formation and development of acinar structures in cells, making it a valuable tool for investigating the mechanisms of acinar morphogenesis. Its unique biological activity supports research in developmental biology and tissue engineering. -
C-14 Epimer
14-epi-Berkeleylactone F is a C-14 epimer of Berkeleylactone F, isolated from the fungus Penicillium turbatum NRRL 5630. While it demonstrates structural similarity to its counterpart, 14-epi-Berkeleylactone F exhibits no significant biological activity against a range of pathogens, including Staphylococcus aureus, Bacillus subtilis, E. coli, Candida albicans, and the parasite Giardia duodenalis, as well as NS-1 murine myeloma cells. This compound may be relevant for studies focusing on epimerization and structural analysis in fungal metabolites. -
Secondary Metabolite
Neosartoricin D is a polyketide and a microbial secondary metabolite isolated from the culture of Aspergillus nidulans. This compound exhibits biological activity that suggests potential immunomodulatory effects, influencing host-pathogen interactions during fungal infections. Neosartoricin D serves as a valuable research tool for studying the mechanisms of fungal pathology and its impact on host immune responses. -
Fungal Phytotoxin
Radicinin is a fungal phytotoxin that functions as a target-specific bioherbicide, effectively inhibiting the growth of invasive Buffelgrass (Cenchrus ciliaris). This compound exhibits significant biological activity by disrupting the metabolic processes of the plant, making it a valuable tool for managing invasive species. It is primarily applied in research focused on ecological restoration and integrated weed management strategies. -
Mycotoxin Metabolite
Asticolorin C is a mycotoxin metabolite derived from the fungus Aspergillus multicolor. It exhibits biological activity by potentially influencing cellular processes related to mycotoxin detoxification and metabolism. This compound serves as a valuable tool in research applications focusing on mycotoxin biology, fungal ecology, and the assessment of mycotoxin contamination in food and agricultural products. -
Mycotoxin Metabolite
Asticolorin A is a mycotoxin metabolite derived from Aspergillus multicolor. It exhibits biological activity related to fungal metabolism and can be utilized in research exploring mycotoxin effects and toxicology. This compound may serve as a valuable tool for studying the biochemical pathways involved in mycotoxin metabolism and the impact of fungal metabolites on health. -
Antibiotic
Cefonicid monosodium is a long-acting cephalosporin antibiotic that primarily targets bacterial cell wall synthesis. It possesses broad-spectrum antimicrobial activity, effectively combating a range of Gram-positive and Gram-negative bacteria. Additionally, Cefonicid acts as a noncompetitive inhibitor of class I β-lactamase, with a Ki value of 0.8 μM, making it a valuable reagent for research on bacterial infections and antibiotic resistance. -
Bacterial Glycoside Hydrolase Activator
4-Ethoxyquinazoline is a selective activator of bacterial glycoside hydrolases, demonstrating an AC50 of 3.5 mM. This compound enhances the enzymatic activity of glycoside hydrolases, supporting research focused on bacterial metabolism and cell wall remodeling. Its role in modulating enzyme activity makes it a valuable tool for studies on bacterial physiology and potential therapeutic applications. -
Bacterial Metabolite
Corynecin V is a chloramphenicol-like bacterial metabolite that targets bacterial protein synthesis. It exhibits antibacterial activity against a range of gram-positive bacteria by inhibiting peptidyl transferase activity in the ribosome. This compound is of significant interest in microbiological research and antibiotic development, providing insights into novel therapeutic strategies against antibiotic-resistant strains. -
α-glucosidase Inhibitor
CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis. -
Anti-Viral Agent
IHVR-17028 is a broad-spectrum antiviral agent that primarily targets endoplasmic reticulum α-glucosidase I. It demonstrates significant antiviral activity against various viruses, including Bovine viral diarrhea virus (BVDV), Tick-borne choriomeningitis virus (TCRV), and Dengue virus (DENV), with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively. With an IC50 of 0.24 μM, it effectively inhibits ER α-glucosidase I, making it a valuable tool for research into infectious diseases. -
Fungicide
Cyazofamid is a fungicide that primarily targets the impairment of ATP production in fungal cells. It acts by inhibiting organic cation transporter 3 (OCT3) and organic anion transporter 1 (OAT1), with IC50 values of 1.54 μM and 17.3 μM, respectively. This compound is utilized in research to explore mechanisms of fungicidal activity and to develop effective strategies for managing fungal diseases in agricultural settings. -
Fungicide
Fenaminstrobin is a strobilurin fungicide that targets the cytochrome bc1 complex within the mitochondrial respiratory chain, leading to the inhibition of ATP production. This compound demonstrates significant biological activity in controlling a variety of fungal diseases, including Fusarium ear rot, downy mildew, rice blast, and pear scab. Additionally, Fenaminstrobin exhibits acute toxicity to the aquatic organism Daphnia magna, making it relevant for ecological impact studies. Its application in agricultural research focuses on crop protection and disease management in various plant systems. -
Antifungal Agent
Dapaconazole is an antifungal agent that primarily inhibits the activity of sterol 14α-demethylase cytochrome P450, exhibiting an IC50 of 1.4 μM. This inhibition disrupts the synthesis of ergosterol, a critical component of fungal cell membranes, thereby exerting antifungal effects. Dapaconazole is applicable in research focused on fungal infections and the development of novel antifungal therapies. -
Antifungal Agent
VT-1598 tosylate is an orally active antifungal agent that selectively inhibits CYP51, demonstrating effective antifungal properties against Candida auris. Additionally, VT-1598 tosylate serves as a click chemistry reagent, incorporating an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This dual functionality positions VT-1598 tosylate as a valuable tool in both antifungal research and synthetic chemistry applications. -
CYP51 Inhibitor
CYP51-IN-21 is a potent inhibitor of cytochrome P450 51 (CYP51), demonstrating significant antifungal activity against various pathogenic fungi, including drug-resistant strains. By targeting CYP51, CYP51-IN-21 disrupts the biosynthesis of essential sterols, impairing fungal growth and viability. Additionally, CYP51-IN-21 effectively inhibits the formation of fungal biofilms, making it a valuable candidate for research in antifungal therapeutics and biofilm-related studies. -
Fungal Terpenoid
Terretonin is a fungal terpenoid derived from Aspergillus terreus, primarily targeting enzymatic pathways involved in its biosynthesis. Its production involves a complex sequence of reactions, including oxidation by cytochrome P450 Trt6, isomerization by Trt14, and final processing by the non-heme iron-dependent dioxygenase Trt7. This compound exhibits significant biological activity with potential applications in pharmaceutical research, particularly as a lead for developing novel antifungal agents. -
Mitochondrial Inhibitor
Fusaramin is a mitochondrial inhibitor that demonstrates potent activity against plant pathogenic fungi. It disrupts mitochondrial function, leading to the impairment of fungal growth and viability. This compound is valuable for research applications focused on plant disease management and the study of mitochondrial biology in pathogenic organisms. -
SDH Inhibitor
Inpyrfluxam is a potent inhibitor of succinate dehydrogenase (SDH), specifically targeting the ubiquinone binding pocket of the mitochondrial SDH complex subunits ViSDHB, ViSDHC, and ViSDHD. This inhibition disrupts cellular respiration, demonstrating efficacy in inhibiting conidial germination and mycelial growth of Venturia inaequalis in vitro. Inpyrfluxam is valuable for research studies focused on apple scab and related fungal pathogens. -
HIV-1 Integrase Inhibitor
GSK-1264 is an HIV-1 integrase inhibitor that targets the catalytic core and C-terminal domains of the HIV-1 integrase enzyme. By promoting the formation of an open polymer structure of integrase dimers, GSK-1264 disrupts the late stages of HIV replication and interferes with viral particle assembly. This compound is valuable for research focused on HIV infection and understanding integrase-mediated processes in the viral life cycle. -
HIV-1 Integrase Inhibitor
HIV-1 Integrase Inhibitor 8 is a selective inhibitor targeting the HIV-1 integrase enzyme. It demonstrates potent activity against viral replication by disrupting the integration of viral DNA into the host genome, which is essential for the HIV life cycle. This compound is primarily utilized in research focused on antiretroviral therapy and the development of HIV treatments, contributing to the understanding of integrase inhibition mechanisms. -
HIV-1Integrase Inhibitor
GSK3839919A is a potent allosteric inhibitor of HIV-1 integrase, targeting the enzyme responsible for the integration of viral DNA into the host genome. This compound exhibits significant antiviral activity against HIV-1, making it a valuable tool for research applications focused on the development of novel antiretroviral therapies and the study of HIV replication mechanisms. Its unique mechanism of action may provide insights into resistance pathways and inform drug design strategies. -
HIV Integrase Inhibitor
His-Cys-Lys-Phe-Trp-Trp is an HIV integrase inhibitor, exhibiting an IC50 of 2 μM. This compound impedes the integrase enzyme's function, thereby preventing viral DNA integration into the host genome. His-Cys-Lys-Phe-Trp-Trp is valuable for research focused on HIV pathogenesis and the development of antiretroviral therapies.
