Catalog No.
Product Name
Application
Product Information
Citations
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Linker-Antibiotic Intermediate
MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate specifically designed for use in antibody-antibiotic conjugate (AAC) applications. This compound features a conjugation with the antibiotic Gemcitabine, facilitating targeted delivery and enhancing the therapeutic potential against bacterial infections. Its utility in research encompasses the exploration of immunotherapy strategies and the development of novel antibacterial agents. -
Cephalosporin Antibiotic
Ceftolozane TFA is a cephalosporin antibiotic that targets Gram-negative bacteria by disrupting cell wall synthesis. Its potent antibacterial activity makes it a valuable tool in combating resistant infections. Ceftolozane TFA can be utilized in research aimed at developing novel antibiotics with improved efficacy and safety profiles. -
Antibiotic Peptide
Aurein 1.2 is an antibiotic peptide derived from amphibian sources, exhibiting potent antimicrobial and anticancer properties. This peptide targets bacterial membranes, leading to disruption and cell death, making it valuable in the study of antibiotic resistance and cancer therapeutics. Aurein 1.2 is ideal for research applications focused on the development of novel antimicrobial agents and exploring mechanisms of cancer cell apoptosis. -
Aminoglycoside Antibiotic
Neamine is an aminoglycoside antibiotic and a degradation product of Neomycin, known for its broad-spectrum antibacterial properties. It exerts anti-angiogenic effects by targeting angiogenin, making it valuable in cancer research. Additionally, Neamine demonstrates neuroprotective and antitumor activities, supporting its potential in diverse biological studies. -
β-Lactam Antibiotic
Cephalothin is a semi-synthetic cephalosporin antibiotic classified as a β-lactam antibiotic. It exerts its antibacterial activity by inhibiting class C β-lactamase AmpC with a Ki of 0.32 µM while also binding to penicillin-binding proteins, thereby disrupting the cross-linking of peptidoglycan in the bacterial cell wall. This mechanism impedes bacterial cell wall synthesis, allowing it to effectively target a broad spectrum of bacteria. Cephalothin is applicable in studies related to hematology and nephrotoxicity. -
Cephem Antibiotic
Cefcapene pivoxil hydrochloride is a pivalate ester prodrug of Cefcapene, functioning as a third-generation cephalosporin antibiotic. It demonstrates a broad spectrum of antibacterial activity, making it valuable in various microbiological studies. Additionally, this compound may hold potential for research applications related to palmoplantar pustulosis (PPP). -
Antitumor Antibiotic/AdoHcy hydrolase Inhibitor
Neplanocin A is an antitumor antibiotic that functions as an irreversible inhibitor of AdoHcy hydrolase, with a Ki of 8.39 nM. It exhibits significant antitumor activity against murine L1210 leukemia cells and also demonstrates antiviral properties, notably against the vaccinia virus. This compound is isolated from the marine-derived organism Ampulariella regularis, making it a valuable reagent for research in cancer therapeutics and virology. -
Antibiotic
Avrainvillamide is a naturally occurring alkaloid that functions as an antibiotic by targeting the nuclear chaperone nucleophosmin (NPM1), which is often overexpressed in various human tumors. This compound exhibits antiproliferative properties by directly binding to NPM1 and Crm1, and disrupting their interactions with native cellular partners. Avrainvillamide demonstrates strong antibacterial activity against multi-drug resistant strains of Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with minimum inhibitory concentrations (MICs) of 12.5, 12.5, and 25 μg/ml, respectively. Its unique mechanism and efficacy make it a valuable tool in antibiotic research and cancer biology studies. -
Gentamicin-Type Antibiotic
Micronomicin sulfate is a gentamicin-type aminoglycoside antibiotic derived from Micromonospora. It exhibits broad-spectrum antibacterial activity, particularly effective against Pseudomonas, Proteus, Klebsiella pneumoniae, and Serratia, with MIC values ranging from 0.001 to 8.3 μg/ml. This compound is utilized in research focused on bacterial infections and antibiotic resistance mechanisms, making it a valuable tool in microbiological studies and drug development. -
Carbapenem Antibiotic
Meropenem-vaborbactam is a carbapenem antibiotic combined with a boronic acid-based beta-lactamase inhibitor, designed to effectively combat Enterobacteriaceae, particularly Klebsiella pneumoniae strains producing carbapenemases. This compound demonstrates notable in vitro activity against Pseudomonas aeruginosa, with MIC50 values of 0.5 μg/mL and MIC90 values of 8 μg/mL, making it a valuable tool for research in antimicrobial resistance and the development of new therapeutic strategies. -
Antibiotic
Virginiamycin Complex is a synergistic antibiotic comprised of two streptogramins, virginiamycin M (VM) and virginiamycin S (VS), derived from Streptomyces virginiae. This complex effectively irreversibly inhibits protein synthesis in bacteria, leveraging the persistent and catalytic action of VM to enhance the affinity of ribosomes for VS. Virginiamycin Complex exhibits significant antibacterial activity and is applied in research focused on studying bacterial resistance mechanisms and developing novel antimicrobial strategies. -
antibiotic
Etimicin sulfate is a fourth-generation aminoglycoside antibiotic that primarily targets bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits potent antibacterial activity against a broad spectrum of Gram-negative and Gram-positive bacteria, making it valuable in treating various infections. Etimicin sulfate is particularly useful in clinical settings due to its high efficacy and low toxicity profile. -
Antibiotic for Poultry
Tylosin phosphate is a macrolide antibiotic that targets Gram-positive bacteria, exhibiting significant antimicrobial activity. It is commonly used as a feed additive in veterinary applications to promote growth in poultry, pigs, and cattle. Tylosin phosphate is effective in treating bacterial dysentery and respiratory diseases, making it an essential reagent in veterinary medicine and animal health research. -
Antibiotic
CRS3123 is a potent, orally active narrow-spectrum antibiotic that specifically targets bacterial methionyl-tRNA synthetase. It demonstrates significant efficacy against Clostridium difficile and aerobic Gram-positive bacteria while exhibiting minimal activity against Gram-negative bacteria, including anaerobes. CRS3123 is a valuable reagent for research focused on C. difficile infections and their treatment options. -
Antibiotic
Nemonoxacin is a potent, orally active broad-spectrum antibiotic that primarily targets bacterial infections. It demonstrates significant inhibitory effects against various species, including staphylococci, streptococci, enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. This compound is valuable for research applications related to bacterial infections and the study of community-acquired pneumonia. -
Antibiotic
Cefodizime is a third-generation cephalosporin antibiotic that exhibits a broad spectrum of antibacterial activity. It is characterized by its low renal toxicity and favorable tolerance profile, along with immune modulation capabilities. This compound is particularly useful in the treatment of severe infections affecting the respiratory and urinary tracts. -
Antibiotic
Platensimycin is an antibiotic derived from Streptomyces platensis that selectively inhibits the biosynthesis of cellular lipids in gram-positive bacteria. It targets the β-ketoacyl-acyl-carrier-protein synthase I/II enzymes, FabF/B, with IC50 values of 48 nM and 160 nM for Staphylococcus aureus and Escherichia coli, respectively. With its unique mechanism of action, Platensimycin shows potential as a therapeutic agent to combat antibiotic resistance. -
Fluoroquinolone Antibiotic
Grepafloxacin hydrochloride is a fluoroquinolone antibiotic that exhibits potent activity against community-acquired respiratory pathogens, particularly Streptococcus pneumoniae. This compound demonstrates high tissue penetration and a favorable pharmacodynamic profile, making it suitable for research applications focused on antimicrobial resistance and respiratory infections. Its unique properties allow for the investigation of effective treatment strategies in microbiology and pharmacology research. -
Antibiotic
Spiramycin I is a macrolide antibiotic that primarily targets bacterial protein synthesis by inhibiting the 50S ribosomal subunit. It exhibits significant antibacterial and antiparasitic activity, making it useful in the treatment of various infections. This reagent is valuable for research applications focused on antimicrobial resistance mechanisms and the development of new therapeutic strategies. -
Antibiotic
Anhydrotetracycline is an antibiotic that functions primarily through the inhibition of tetracycline destructases, thereby preserving the activity of tetracycline antibiotics. This compound demonstrates dose-dependent potency, making it a valuable tool for studying antibiotic resistance mechanisms and enhancing the efficacy of tetracycline-based therapies. Its application in molecular biology and microbiology research helps elucidate bacterial response to antibiotic treatment. -
Antibiotic
Sanfetrinem sodium is a beta-lactamase-stable antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against both gram-positive and gram-negative bacteria, making it a valuable reagent for research applications aimed at understanding bacterial resistance mechanisms and developing new antimicrobial therapies. -
β-Lactam Antibiotic
Loracarbef hydrate is a β-lactam antibiotic that belongs to the carbacephem class, exhibiting a synthetic origin. This second-generation cephalosporin antibiotic demonstrates significant antibacterial activity against a variety of Gram-positive and selected Gram-negative bacteria. It is primarily utilized in research applications focused on microbiology and antibiotic resistance studies. -
Antibiotic
Levonadifloxacin is a broad-spectrum antibiotic that targets bacterial infections, particularly against staphylococcal strains. It exhibits potent antibacterial activity against both Methicillin-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA). This compound is valuable for research applications focused on the mechanisms of antibiotic resistance and the efficacy of therapeutic strategies in treating resistant infections. -
Antibiotic
Kendomycin ((−)-TAN 2162) is a polyketide antibiotic primarily targeting bacterial growth inhibition. It exhibits significant antibacterial activity, particularly against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 5 μg/mL. In addition to its antibacterial properties, Kendomycin acts as a potent antagonist of the endothelin receptor and a calcitonin receptor agonist, highlighting its potential applications in anti-osteoporotic research. -
Antibiotic
AMOZ, a metabolite associated with Furaltadone, functions as an antibiotic by forming stable tissue residues through covalent binding to proteins. This property allows for the coupling of AMOZ with carrier proteins, such as BSA or OVA, to elicit an immune response and release upon acid hydrolysis. AMOZ is instrumental in monitoring antibiotic residues in animal-derived foods, with detection capabilities via competitive ELISA methods achieving limits as low as 0.16 μg/kg in shrimp samples. Its utility makes it a critical marker in food safety research. -
Antibiotic
PAMAM Dendrimer G0.0 amine is an antibiotic targeting pore-forming toxins, specifically acting as an antagonist to anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, it demonstrates protective effects against C2 toxin-induced cytotoxicity in HeLa cells. Additionally, this compound acts as a nickel chelator and has been employed in the selective capture and storage of carbon dioxide in gas-feed systems when used in conjunction with polysulfone membrane-bound chitosan. PAMAM Dendrimer G0.0 amine serves as a valuable reagent in research focused on infectious diseases, cancer biology, and drug delivery systems. -
Glycopeptide Antibiotic
A40926 is a glycopeptide antibiotic that targets the bacterial cell wall peptidoglycan precursor D-alanyl-D-alanine (D-Ala-D-Ala). It functions by irreversibly inhibiting cell wall synthesis through competitive binding, demonstrating significant bactericidal activity against Gram-positive bacteria, including Staphylococcus and Streptococcus, as well as Neisseria gonorrhoeae, with MIC values ranging from 0.06 to 2 μg/mL. Additionally, A40926 is effective against penicillin-resistant strains, disrupting peptidoglycan cross-linking and leading to bacterial lysis and death. The compound's fat-soluble fatty acid structure enhances serum concentrations and extends its duration of action, with a terminal half-life of 61.22 hours in rats. -
Antibiotic Peptide
Dermcidin-1L (human) is an antibiotic peptide that targets microbial pathogens with its inherent antimicrobial activity. Secreted by sweat glands, it plays a crucial role in skin defense mechanisms. Research applications include studies of inflammatory skin disorders and the investigation of innate immune responses. -
Antibiotic
Indolmycin is a competitive inhibitor of prokaryotic tryptophanyl-tRNA synthetase (TrpS), serving as an effective antibiotic. This compound exhibits significant antibacterial and antiviral properties, making it valuable in various research applications focused on microbial resistance and viral infection mechanisms. Its unique mode of action allows for exploration into strategies for combating infectious diseases. -
Antibiotic
Ristocetin A sulfate is an antibiotic primarily targeting staphylococcal infections. Its biological activity includes promoting thrombocytopenia and platelet agglutination. Ristocetin A sulfate is instrumental in two important assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay, both of which are utilized in diagnosing von Willebrand disease and various bleeding disorders. -
Antibiotic
trans-Clopenthixol dihydrochloride is an antibiotic agent that exhibits activity against Pseudomonas aeruginosa and Plasmodium falciparum in vitro, while lacking neuroleptic effects. This compound is valuable for research applications focusing on bacterial and parasitic infections. Its structural properties enable investigations into potential therapeutic pathways for managing these pathogens. -
Antibiotics
Sulfathiazole-d4 is a deuterium-labeled variant of Sulfathiazole, which serves as a selective antibiotic with specific endocrine-disrupting properties. It primarily targets the steroidogenic pathway by enhancing the activity of CYP19 in human adrenal cancer cells (H295R) while upregulating mRNA expression of CYP17, CYP19, and 3β-HSD. This compound is instrumental in increasing the production of 17-estradiol (E2) and has been shown to exert endocrine-disrupting effects in aquatic organisms, including species such as the Japanese medaka fish, making it a valuable tool for studies on endocrine disruption and steroid metabolism. -
Bacteriostatic Antibiotic
Trimethoprim hydrochloride is a bacteriostatic antibiotic that functions primarily as a dihydrofolate reductase inhibitor. It exhibits efficacy against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, making it valuable in the study of urinary tract infections, Shigellosis, and Pneumocystis pneumonia. Additionally, trimethoprim hydrochloride has been shown to inhibit Influenza A virus infection in chick embryos when combined with zinc, highlighting its potential for further virological research applications. -
Cephalosporin Antibiotic
Cephalexin hydrochloride is a semisynthetic cephalosporin antibiotic that exhibits potent activity against a broad spectrum of gram-positive and gram-negative bacteria. It acts primarily by targeting penicillin-binding proteins (PBPs), leading to the inhibition of bacterial cell wall synthesis. This compound is commonly utilized in research related to bacterial infections, including pneumonia, streptococcal throat infections, and bacterial endocarditis. -
Antibiotic
Hordenine hydrochloride is an alkaloid known for its antibiotic properties and its mechanism of action involves the inhibition of melanogenesis through the suppression of cyclic adenosine monophosphate (cAMP) production. This compound is of significant interest in research focused on skin biology and pigmentation processes. Additionally, hordenine hydrochloride may be explored for its potential therapeutic applications in various dermatological conditions. -
Veterinary Antibiotic
Nifursol is an orally active veterinary antibiotic that targets Histomonas meleagridis, effectively preventing histomoniasis in turkeys. This agent is utilized in research focused on Escherichia coli gastroenteritis, particularly in the context of Salmonella infections in poultry and aquatic animals. Its application in veterinary medicine supports studies investigating antibiotic efficacy and disease prevention in livestock. -
Antibiotic
trans-Clopenthixol is an antibiotic that exhibits no neuroleptic effects. It has demonstrated the ability to inhibit the growth of Pseudomonas aeruginosa and Plasmodium falciparum in vitro. This compound may be valuable for research applications focused on bacterial and parasitic infections. -
Aminoglycoside Antibiotic
Neamine tetrahydrochloride is an aminoglycoside antibiotic that exhibits broad-spectrum antibacterial activity. It serves as an anti-angiogenesis agent by specifically targeting angiogenin, contributing to its antitumor properties. Additionally, Neamine tetrahydrochloride demonstrates neuroprotective effects, making it valuable in various biomedical research applications, including studies focused on cancer and neurodegenerative diseases. -
Cephalosporin Antibiotic
Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum efficacy against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, as well as common Gram-negative bacteria. This compound is valuable for research focused on complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP). -
Antibiotic
Ribostamycin is a broad-spectrum aminoglycoside antibiotic that targets bacterial protein synthesis, primarily by binding to the ribosome. It exhibits activity against both Gram-negative and Gram-positive bacterial infections. Additionally, Ribostamycin has been shown to inhibit the chaperone activity of protein disulfide isomerase (PDI), making it useful in various research applications related to microbial resistance and protein folding studies. -
Antibiotic
Nybomycin is an antibiotic that demonstrates significant antiphage and antibacterial activity. It functions by binding to DNA, resulting in distinctive morphological alterations in mycobacterial bacilli, ultimately leading to bacterial cell death. This compound is valuable in research applications focused on understanding bacterial resistance and developing new antimicrobial therapies. -
Cephalosporin Antibiotic
Cefteram pivoxil is an orally active cephalosporin antibiotic that targets bacterial cell wall synthesis. Its primary mechanism involves the inhibition of penicillin-binding proteins, leading to bacterial lysis and death. This compound exhibits broad-spectrum antibacterial activity and is commonly utilized in the treatment of various bacterial infections, including respiratory and urinary tract infections. -
Cephamycin Antibiotic
Cefmetazole is a semisynthetic cephamycin antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall biosynthesis. With broad-spectrum antibacterial activity, it effectively combats gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole is commonly utilized in research focused on gynecologic, intraabdominal, urinary tract, respiratory tract, and skin and soft tissue infections. -
Antibiotic
Alafosfalin is a phosphonodipeptide that functions as an inhibitor of cell wall biosynthesis. It exhibits antibacterial activity, making it a valuable tool for research in the study of bacterial infections and the mechanisms of antibiotic resistance. This compound is applicable in investigations focusing on cell wall integrity and the development of novel antibacterial strategies. -
Antibiotic
Cefixime trihydrate is a third-generation cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum activity against various gram-positive and gram-negative bacteria, making it effective for treating a range of bacterial infections, including urinary tract infections and respiratory tract infections. This compound is valuable in microbiological research and the study of antibiotic resistance mechanisms. -
Antibiotic
Fluoroquinolonic acid is a bacteriostatic antibiotic that primarily targets bacterial DNA gyrase and topoisomerase IV. This compound demonstrates broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, making it useful in various microbiological studies. Its ability to inhibit bacterial growth positions it as a valuable reagent for research applications in antibiotic resistance and pathogen profiling. -
Lipopeptide Antibiotic
Globomycin is a lipopeptide antibiotic that acts as an irreversible inhibitor of signal peptidase II (LspA). By binding to the peptidase, Globomycin disrupts the processing of prolipoproteins, demonstrating significant antibacterial activity against the mollicute Spiroplasma melliferum with a minimum inhibitory concentration (MIC) of 6.25-12.5 μM. This compound is valuable for research applications focused on bacterial protein processing and antibiotic resistance mechanisms. -
Antibiotic
AMOZ-d5 is a deuterated form of AMOZ, a tissue-bound metabolite of the synthetic nitrofuran antibiotic Furaltadone. This compound exhibits potent antibacterial activity and is primarily utilized in research to study the pharmacokinetics and metabolism of nitrofuran antibiotics. Its stable isotopic labeling allows for detailed analytical investigations in various biological samples. -
Chloramphenicol-Like Antibiotic
Azidamfenicol is a chloramphenicol-like antibiotic that functions by inhibiting ribosomal peptidyltransferase with a Ki value of 22 μM. This broad-spectrum agent exhibits significant antibacterial activity, making it useful in studying bacterial protein synthesis. Additionally, Azidamfenicol serves as a click chemistry reagent due to the presence of an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, DBCO, or BCN groups. This dual functionality allows for versatile applications in chemical biology and bioconjugation strategies. -
Antibiotic
Mellein is an antibiotic derived from the culture fluids of Aspergillus species. This compound exhibits potent antibacterial activity, making it valuable in studying microbial resistance and the mechanisms of action of antibiotics. Its application extends to various fields of microbiological research and drug development, providing insights into potential therapeutic uses.
