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Catalog No.
Product Name
Application
Product Information
Citations
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Heat-inactivated Bacterial Luciferases Inhibitor
2-Nonanone is a ketone compound that inhibits the DnaKJE-ClpB bichaperone-dependent refolding of heat-inactivated bacterial luciferases. By interacting with hydrophobic segments of heat-inactivated substrates, it competes with chaperones such as IbpAB. This compound is valuable for research into bacterial infections and the mechanisms of chaperone-mediated protein refolding. -
Bacterial Inhibitor
Ethyl Orsellinate is a lichen-derived metabolite and a derivative of lecanoric acid, primarily acting as a bacterial inhibitor. It exhibits notable antiproliferative and antitumor activities, making it useful in cancer research. The compound demonstrates significant cytotoxicity against A. salina, with an LC50 of 495 μM, indicating its potential as a bioactive agent in the study of microbial and tumor biology. -
Bacterial Inhibitor
EcMetAP1-IN-1 is a selective inhibitor of Escherichia coli methionine aminopeptidase 1 (MetAP1), a key enzyme involved in protein maturation. By obstructing the enzymatic activity of MetAP1, this compound effectively disrupts bacterial growth and protein synthesis, making it a valuable tool for research focused on bacterial infections and antibiotic development. Its specificity towards MetAP1 further positions EcMetAP1-IN-1 as a potential candidate for studying the mechanistic roles of methionine aminopeptidases in pathogenic bacteria. -
Bacterial Inhibitor
Urolithin M6 is a polyphenolic compound primarily recognized for its role as a bacterial inhibitor. This metabolite, synthesized through intestinal microbial metabolism, exhibits potential antioxidant properties and may function as an analogue to tannic acid compounds. Urolithin M6's production in humans necessitates the presence of specific bacterial 3-dehydroxylase activity, unveiling a novel pathway for its biotransformation. The metabolic profile of Urolithin M6 can aid in stratifying individuals for research aimed at elucidating its implications in health and disease. -
Bacterial Inhibitor
Methyl octanoate acts as a bacterial inhibitor and is recognized for its role in antimicrobial activity. This compound has applications in food preservation and can be studied for its effects on microbial growth inhibition. Additionally, it serves as a volatile aroma component in various beverages, including persimmon wine, making it of interest in both food science and microbiology research. -
Bacterial Inhibitor
NSC-79887 is a potent nucleoside hydrolase inhibitor that demonstrates significant activity against Bacillus anthracis. This compound serves as a promising candidate for biological testing and further development aimed at countering bacterial infections. Additionally, its pharmacokinetic profile suggests that all physicochemical parameters fall within acceptable ranges, indicating potential suitability for human use. -
Bacterial Inhibitor
Surgumycin is a bacterial inhibitor that exhibits notable antimicrobial activity. Its mechanism involves disrupting essential cellular processes in bacteria, making it a valuable tool for studying bacterial infections and resistance mechanisms. Surgumycin is particularly useful in research applications focused on antibiotic development and the exploration of microbial pathogenesis. -
Bacterial Inhibitor
LL-BM123α is a bacterial inhibitor derived from Nocardia sp., with a primary mechanism of action targeting Gram-negative bacteria. This compound demonstrates moderate antimicrobial activity, making it a valuable tool in research focused on bacterial infections and antibiotic resistance. LL-BM123α can be utilized in studies aimed at understanding the efficacy of novel antibiotics and developing strategies for overcoming bacterial resistance. -
Antibacterial, Biofilm Formation Inhibitor
Majoranaquinone is a potent antibacterial agent that targets various bacterial strains, demonstrating significant inhibitory effects against four Staphylococcus species, one Moraxella species, and one Enterococcus species. Additionally, it exhibits substantial efflux pump inhibitory activity in Escherichia coli ATCC 25922. Majoranaquinone also effectively inhibits biofilm formation in both E. coli ATCC 25922 and E. coli K-12 AG100, making it a valuable reagent for research applications focused on combating bacterial infections and biofilm-related challenges. -
Bacterial Inhibitor
Lauryl-LF 11 is an N-terminally acylated analogue of LF11 that acts as a bacterial inhibitor. This peptide demonstrates significant antibacterial activity, making it a valuable tool for research in microbiology and infectious diseases. It can be utilized in studies focused on the mechanisms of bacterial resistance and the development of novel antimicrobial agents. -
Bacterial Inhibitor
Citreamicin alpha is a potent bacterial inhibitor demonstrated to exhibit significant antimicrobial activity against a range of Gram-positive cocci. In vitro studies reveal that MIC values for Staphylococci range from 0.12-4.0 μg/ml, and for Streptococcus pyogenes, they range from 0.03-0.12 μg/ml. While Citreamicin alpha shows superior efficacy compared to ampicillin, amoxicillin, and ceftriaxone, it exhibits comparable effects to vancomycin. Its effectiveness against various strains makes it a valuable reagent for research in antibiotic development and resistance studies. -
Bacterial Inhibitor
Aniline-MPB-amino-C3-PBD is a cytotoxic agent targeting bacterial cells through minor-groove binding of DNA. This sequence-selective compound serves as an effective payload for antibody-drug conjugates (ADCs), enhancing their therapeutic efficacy. Its antimicrobial properties make it a valuable tool for research in bacterial inhibition and related applications. -
Bacterial Inhibitor
Py-MPB-amino-C3-PBD is a cytotoxic agent that functions as a bacterial inhibitor. This compound serves as a payload for antibody-drug conjugates (ADCs) and exhibits significant antimicrobial activity. Its unique structure, characterized by a non-alkylating group, makes it a valuable tool for research applications aimed at targeting bacterial infections and developing therapeutics in the field of microbiology. -
Bacterial Inhibitor
Resazurin sodium is a non-toxic, stable redox indicator that targets bacterial activity through its membrane-permeable properties. It serves as a vital tool for assessing cell viability, proliferation, and toxicity in various cell types, including human, plant, animal, bacterial, and fungal cells. Upon reduction, Resazurin sodium transforms into Resorufin, a highly fluorescent compound, enabling sensitive detection and quantification of cellular processes under fluorescent microscopy or spectrophotometry. -
Bacterial Inhibitor
4-Methylherniarin, a coumarin derivative, exhibits antibacterial activity by effectively inhibiting both gram-positive and gram-negative bacterial strains. It demonstrates significant antimicrobial efficacy against B. subtilis and S. sonnei, with IC50 values of 11.76 μg/ml and 13.47 μg/ml, respectively. This compound serves as a valuable tool for research applications focused on combating bacterial infections and elucidating mechanisms of action in microbial resistance. -
Bacterial Inhibitor
Procodazole is a potent bacterial inhibitor that enhances immune response, offering protection against various viral and bacterial infections. In addition to its broad-spectrum antibacterial effects, Procodazole demonstrates antiparasitic activity and serves as a carbonic anhydrase inhibitor, contributing to its antitumor properties. This compound is suitable for research applications focused on infectious diseases and cancer biology. -
Bacterial Inhibitor
FR-202306 is a bacterial inhibitor that targets peptide deformylase, an enzyme crucial for bacterial protein synthesis. This compound displays significant antibacterial activity against Staphylococcus aureus by effectively inhibiting its peptide deformylase activity. FR-202306 is valuable for research applications focused on developing antibacterial agents and exploring mechanisms of bacterial resistance. -
Bacterial Inhibitor
LF11 is a peptide that functions as a bacterial inhibitor by disrupting microbial cell membrane integrity. It exhibits potent antibacterial activity, making it a valuable tool for research focused on combating bacterial infections and studying antimicrobial mechanisms. Its application is particularly relevant in the development of new therapies and understanding resistance in pathogenic bacteria. -
Bacterial Inhibitor
Rifametane is a novel 3-azamethyl-rifamycin that acts as a bacterial inhibitor. It exhibits a pharmacokinetic profile that surpasses that of rifampin, demonstrating higher peak serum concentrations in healthy volunteers. This compound is primarily used in research focused on antibacterial activity and the evaluation of new therapeutic strategies against resistant bacterial strains. -
Bacterial Inhibitor
BMS-247243 is a β-lactam antibiotic that targets methicillin-resistant Staphylococcus aureus (MRSA). It exhibits significant antibacterial activity, making it a valuable tool for research into bacterial resistance mechanisms and the development of new antimicrobial therapies. BMS-247243 is particularly relevant for studies focused on treating infections caused by resistant bacterial strains. -
Bacterial Inhibitor, Translation Inhibitor
Sancycline hydrochloride is a bacterial inhibitor that functions by reversibly binding to the 30S ribosomal subunit, thereby inhibiting protein translation. It effectively blocks the entry of aminoacyl-tRNA into the ribosomal A site, similar to other tetracycline derivatives. This semi-synthetic tetracycline, characterized by its four linearly fused six-membered rings and four stereocenters, is primarily utilized in research focusing on bacterial protein synthesis and the development of antibacterial agents. -
Bacterial Inhibitor
Celastramycin A (isomer) is an antibiotic targeting Gram-negative bacteria and Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MIC) between 0.05-3.1 μg/mL. This compound has notable immunosuppressive effects, demonstrated in Drosophila ex vivo through the immunodeficiency pathway with an IC50 of 8 ng/mL. Additionally, Celastramycin A (isomer) inhibits human innate immune responses mediated by the TNF-α pathway and reduces IL-8 production in human umbilical vein endothelial cells (HUVEC) with an IC50 of 60 ng/mL, making it a valuable reagent for research in microbiology and immunology. -
Bacterial Inhibitor
Pivmecillinam is an orally active prodrug of mecillinam, functioning primarily as a bacterial inhibitor. It exhibits potent activity against various gram-negative bacteria by interfering with the synthesis of bacterial cell walls. Pivmecillinam is utilized in research to investigate mechanisms of antibiotic resistance and the efficacy of beta-lactam antibiotics. -
Bacterial Inhibitor
Altromycin F is an anthraquinone-derived antibiotic that functions as a bacterial inhibitor by targeting and disrupting bacterial cell function. This compound exhibits significant antibacterial activity specifically against Gram-positive bacteria, including Streptococcus and Staphylococcus, with a microbial inhibitory concentration (MIC) ranging from 0.2 to 3.12 μg/mL. Altromycin F is valuable for research applications focused on understanding bacterial resistance and developing new antibacterial strategies. -
Bacterial Inhibitor
Cefoselis hydrochloride is a fourth-generation cephalosporin and a β-lactam antibiotic that targets bacterial cell wall synthesis. It demonstrates potent antibacterial activity against a broad spectrum of both Gram-positive and Gram-negative bacteria. Furthermore, cefoselis hydrochloride effectively penetrates the blood-brain barrier, making it a valuable compound for research applications in infectious diseases and central nervous system infections. -
Bacterial Inhibitor
KKL-40 is a small molecule inhibitor that targets the trans-transcription process in bacteria. It exhibits effective antibacterial activity against methicillin-sensitive and -resistant Staphylococcus aureus, as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 demonstrates a synergistic effect with the human antimicrobial peptide LL-37 against S. aureus, while showing no synergy with commonly used antibiotics such as daptomycin, kanamycin, or erythromycin. Notably, KKL-40 selectively inhibits trans-transcription without toxicity to HeLa cells, making it a valuable tool for research in bacterial genetics and antibiotic resistance. -
Bacterial Inhibitor
Norfloxacin hydrochloride is a broad-spectrum antibacterial agent that targets and inhibits DNA gyrase, thus interfering with bacterial DNA replication and repair. It exhibits activity against a wide range of Gram-positive and Gram-negative bacteria, making it a valuable reagent for microbiological research and the study of bacterial resistance mechanisms. This compound is utilized in the investigation of bacterial infections and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Ceforanide (lysine) is a second-generation cephalosporin that functions as a bacterial inhibitor by interfering with bacterial cell wall synthesis. It exhibits a broad spectrum of in vitro antibacterial activity against various Gram-positive and Gram-negative bacteria. Ceforanide is primarily utilized in microbiological research to study bacterial resistance and the effects of cephalosporins on different bacterial strains. -
Bacterial Inhibitor
Deoxypheganomycin D is a specific antimycobacterial agent that demonstrates selective inhibition of Mycobacterium 607 growth without cross-resistance to other antibiotics. At a concentration of 28 μM, it significantly reduces bacterial proliferation while showing minimal impact on DNA, RNA, or protein synthesis pathways. Notably, at 7 μM, Deoxypheganomycin D interferes with leucine influx and alters efflux dynamics, suggesting its action may involve interactions with the cell membrane and distinct mycobacterial lipid components. This reagent is valuable for researchers studying mycobacterial resistance mechanisms and developing alternative treatment strategies. -
Bacterial Inhibitor
Lysostaphin targets the bacterial cell wall, acting as an antistaphylococcal agent. This enzyme exhibits the activities of glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase, and N-acetyl muramyl-L-alanine amidase, leading to effective inhibition of Staphylococcus species. Due to its specific enzymatic action, lysostaphin is valuable in research focused on bacterial resistance, pathogen biology, and the development of antimicrobial therapeutics. -
Bacterial Inhibitor
Cefotaxime is a third-generation cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative bacteria and is notably stable against β-lactamase enzymes. This compound is widely used in microbiological research and clinical settings for the treatment and study of bacterial infections. -
Bacterial Inhibitor
Gastric mucin is a glycoprotein that acts as a bacterial inhibitor, particularly effective against Helicobacter pylori infection. It exhibits natural antibiotic properties and scavenges hydroxyl radicals, contributing to its protective role in the gastrointestinal tract. Gastric mucin plays a critical role in safeguarding against acid, proteases, and pathogenic microorganisms, while also providing defense against mechanical trauma. This functionality makes it a valuable reagent for research focused on gastrointestinal health and microbiome interactions. -
Bacterial Inhibitor
Mecillinam, a β-lactam antibiotic, primarily targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins in gram-negative organisms. It demonstrates a broad spectrum of antibacterial activity, making it valuable in studying bacterial infections and resistance mechanisms. Researchers often utilize Mecillinam for its effectiveness against various pathogenic strains, aiding in the development of therapeutic strategies and understanding bacterial physiology. -
Bacterial Inhibitor
Cecropin A is a linear antimicrobial polypeptide composed of 37 residues that exhibits potent antibacterial activity. Additionally, it demonstrates anticancer and anti-inflammatory properties, making it a valuable tool for research in infectious diseases, cancer therapy, and inflammatory response studies. Its ability to disrupt bacterial membranes can be leveraged in the development of novel antimicrobial agents. -
Bacterial Biofilm Formation Inhibitor
Ethyl acetoacetate is an ester compound that acts as an inhibitor of bacterial biofilm formation. Its unique chemical structure facilitates its role in impairing the ability of bacteria to adhere and form protective biofilms, making it a valuable research tool in studying microbial resistance and infection control. This reagent is useful in various biological applications, particularly in investigations aimed at understanding bacterial behavior and developing new antimicrobial strategies. -
Bacterial Inhibitor
Flomoxef sodium is an oxacephem antibiotic that primarily targets bacterial ribosomes, inhibiting protein synthesis. It exhibits potent activity against a range of Gram-positive bacteria, making it suitable for research in antimicrobial resistance and bacterial infections. Flomoxef sodium can be utilized in studies exploring antibiotic efficacy and drug resistance mechanisms. -
Bacterial Inhibitor
Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic that inhibits bacterial protein synthesis by targeting aminoacyl-tRNA binding and peptide bond formation. As a type B compound in the streptogramin family, it exhibits potent bactericidal activity against a diverse array of Gram-positive bacteria. Virginiamycin S1, particularly in combination with virginiamycin M1, is valuable in research focused on overcoming multidrug-resistant bacterial infections. Its application is relevant in fields such as microbiology and pharmacology, particularly in the study of antibiotic efficacy and resistance mechanisms. -
Bacterial Inhibitor
PNU-105368 is an antibacterial compound that serves as a metabolite of linezolid. It demonstrates efficacy in inhibiting bacterial growth and is primarily excreted via the kidneys and feces. This compound is relevant for research focusing on bacterial resistance and the pharmacokinetics of oxazolidinones. -
Bacterial Inhibitor
Sisomicin is a broad-spectrum aminoglycoside antibiotic that targets bacterial ribosomes, inhibiting protein synthesis. It exhibits potent activity against Gram-positive bacteria, making it valuable in microbiological research. Sisomicin is commonly used in studies investigating bacterial resistance mechanisms and in the evaluation of antibacterial efficacy. -
Bacterial Inhibitor
Thiamphenicol-d3 is a deuterium-labeled variant of the broad-spectrum antibiotic Thiamphenicol, which targets the 50S ribosomal subunit. By binding to this subunit, it inhibits protein synthesis, exhibiting bacteriostatic activity against a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacteria. This reagent is valuable for research applications involving microbiology and the study of antibiotic mechanisms. -
Bacterial Inhibitor
2,2':5',2''-Terthiophene is a heterocyclic oligomer that primarily targets bacterial inhibition. This compound exhibits significant antimicrobial activity, making it a valuable tool for studying bacterial growth and resistance mechanisms. Additionally, 2,2':5',2''-Terthiophene serves as an essential building block in the synthesis of organic semiconductor materials, particularly polythiophene, which has applications in electronic devices and sensors. -
Bacterial Inhibitor
Moxifloxacin hydrochloride monohydrate is a potent bacterial inhibitor that targets DNA gyrase and topoisomerase IV, leading to the disruption of bacterial DNA replication and transcription. It exhibits strong efficacy against Streptococcus pneumoniae and is primarily utilized in the study of bacterial infections, including research on tuberculosis. Its oral bioavailability and broad-spectrum activity make it a valuable reagent for microbiological studies and antibiotic efficacy testing. -
Bacterial Inhibitor
Helvolic acid, also known as Fumigacin, is a natural antibiotic derived from Xylaria sp. It exhibits potent activity against Gram-positive bacteria, making it a valuable tool for investigating bacterial inhibition. This compound can be utilized in microbiological studies to explore mechanisms of antibiotic action and resistance. -
Bacterial Inhibitor
Cefamandole is a semi-synthetic second-generation cephalosporin antibiotic that functions as a bacterial inhibitor by disrupting cell wall synthesis. It exhibits broad-spectrum antimicrobial activity against various Gram-positive cocci and several Gram-negative bacilli, while maintaining resistance to hydrolysis by certain β-lactamases. Although effective in many contexts, it shows limited efficacy against species such as Pseudomonas, Proteus vulgaris, and Providencia stuartii. Cefamandole is primarily excreted in the urine in its active form and is utilized in research applications focused on bacterial infections, although its penetration across the blood-brain barrier is minimal. -
Bacterial Inhibitor
Cinnamycin is a tetracyclic peptide antibiotic that specifically targets phosphatidylethanolamine (PE). Its primary mechanism involves disrupting bacterial membrane integrity, leading to inhibition of growth in Gram-positive bacteria. Cinnamycin is commonly utilized in microbiological research to study antibiotic resistance and bacterial membrane dynamics. -
Bacterial Inhibitor
Aureothricin is a dithiolopyrrolone (DTP) antibiotic with a primary mechanism of inhibiting bacterial growth. It demonstrates broad-spectrum antibiotic activity and has the ability to impede the adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin. This compound is valuable for research applications focused on bacterial inhibition and the modulation of cell adhesion processes. -
Bacterial Inhibitor
Flomoxef is an oxacephem antibiotic that exerts its bactericidal effects primarily by inhibiting bacterial cell wall synthesis. It demonstrates significant activity against a range of Gram-positive bacteria. This compound is utilized in research settings to investigate antibiotic resistance mechanisms and to develop novel antibacterial agents. -
Bacterial Inhibitor
Flucloxacillin is a β-lactam antibiotic that primarily targets bacterial cell wall synthesis by inhibiting transpeptidation enzymes. It exhibits potent antibacterial activity against a variety of gram-positive and some gram-negative bacteria, making it valuable in treating infections caused by staphylococci and streptococci. This reagent is widely utilized in microbiological studies and antibiotic susceptibility testing to evaluate bacterial resistance. -
Bacterial Inhibitor
Sulfadimethoxine-d6 is a deuterated form of Sulfadimethoxine, a sulfonamide antibiotic that acts as a bacterial inhibitor by interfering with folate synthesis in pathogenic microorganisms. This reagent is primarily utilized in pharmacokinetics and metabolic studies, allowing for improved tracking of the compound in biological systems. Its deuterium labeling enhances analytical sensitivity in various applications, including drug metabolism research and isolation studies. -
Bacterial Inhibitor
Bacampicillin is a penicillin antibiotic that serves as a prodrug of ampicillin, designed to enhance oral bioavailability. It exerts its antibacterial activity through the inhibition of cell wall synthesis in susceptible bacteria. This compound is utilized primarily in microbiological research and studies targeting bacterial infections.
