Celastramycin A (isomer) is an antibiotic targeting Gram-negative bacteria and Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MIC) between 0.05-3.1 μg/mL. This compound has notable immunosuppressive effects, demonstrated in Drosophila ex vivo through the immunodeficiency pathway with an IC50 of 8 ng/mL. Additionally, Celastramycin A (isomer) inhibits human innate immune responses mediated by the TNF-α pathway and reduces IL-8 production in human umbilical vein endothelial cells (HUVEC) with an IC50 of 60 ng/mL, making it a valuable reagent for research in microbiology and immunology.
Celastramycin A (isomer) is an antibiotic targeting Gram-negative bacteria and Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MIC) between 0.05-3.1 μg/mL. This compound has notable immunosuppressive effects, demonstrated in Drosophila ex vivo through the immunodeficiency pathway with an IC50 of 8 ng/mL. Additionally, Celastramycin A (isomer) inhibits human innate immune responses mediated by the TNF-α pathway and reduces IL-8 production in human umbilical vein endothelial cells (HUVEC) with an IC50 of 60 ng/mL, making it a valuable reagent for research in microbiology and immunology.
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