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Catalog No.
Product Name
Application
Product Information
Citations
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Serine Palmitoyltransferase Inhibitor
Lipoxamycin is a potent serine palmitoyltransferase inhibitor, exhibiting an IC50 of 21 nM. This compound demonstrates significant antifungal activity, making it a valuable tool for studying lipid metabolism and sphingolipid biosynthesis. Lipoxamycin is applicable in research focused on fungal infections and potential avenues for therapeutic interventions targeting lipid-related pathways. -
SDH Iinhibitor
SDH-IN-5 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 3.293 μM. It exhibits significant antifungal activity, achieving an EC50 of 0.046 μg/mL against Rhizoctonia solani. In agricultural applications, SDH-IN-5 effectively inhibits the growth of R. solani in rice leaves, showcasing substantial protective and curative efficacies against this pathogen. -
Fungal Inhibitor
2,4′-Dichloroacetanilide is a fungistatic agent that inhibits the growth of fungi by targeting key cellular processes. It demonstrates significant antifungal activity against Trichosporon asteroides, with a minimum inhibitory concentration (MIC) of 6.25 μg/mL. This compound is valuable for research applications involving fungal pathogenesis and the development of antifungal therapies. -
Fungal Inhibitor
Cyclo(Pro-dArg) is a potent chitinase inhibitor, primarily targeting fungal cell wall integrity. It effectively disrupts cell separation in Saccharomyces cerevisiae while having no significant impact on its overall growth. Additionally, Cyclo(Pro-dArg) inhibits the morphological transition of Candida albicans from yeast to filamentous forms, making it valuable for research in fungal biology and antifungal drug development. -
Fungal Inhibitor
4-Chlorosalicylic acid is a potent fungal inhibitor that functions primarily by inhibiting monophenolase and diphenolase activities, demonstrating IC50 values of 1.89 mM and 1.10 mM, respectively. It exhibits significant antimicrobial properties, displaying an MIC of 250 μg/mL and an MBC of 500 μg/mL against E. coli. This compound is useful in research applications focused on elucidating mechanisms of fungal and bacterial inhibition. -
Fungal Inhibitor
(E)-Coniferyl alcohol is a fungal inhibitor that acts as an intermediate in the biosynthetic pathways of eugenol, stilbenoids, and coumarin. This compound demonstrates potent activity against fungal species, making it valuable for studies focused on fungal growth inhibition. Its applications span research on plant defense mechanisms and the development of antifungal agents. -
BoNT A Inhibitor
Chaetochromin A is a fungal metabolite that acts as an inhibitor of botulinum neurotoxin serotype A (BoNT A). With an IC50 value of 24.6 μM, it demonstrates significant inhibitory effects, making it a valuable tool for research into neurotoxicology and the mechanistic pathways of neurotoxin action. Its role in understanding BoNT A interactions provides insights for potential therapeutic applications. -
Fungal Inhibitor
Isopyrazam serves as a potent fungal inhibitor, demonstrating significant efficacy against various plant pathogenic fungi. Its mechanism of action enhances disease resistance in crops, making it a valuable tool in agricultural research focused on plant protection and disease management. The use of Isopyrazam can lead to improved crop yield and quality, highlighting its potential applications in agro-biological studies. -
Mpro Inhibitor/Anti-Coronaviral Agent
Polycarpine hydrochloride is a potent inhibitor of the main protease (Mpro) with an IC50 of 30 nM, making it a valuable anti-coronaviral agent. This compound, derived from Polycarpa aurata, exhibits significant antiviral properties, demonstrating effectiveness against SARS-CoV-2 Mpro and PEDV Mpro, with IC50 values of 30.0 nM and 0.12 μM respectively. It also possesses antifungal activity, positioning it as a versatile tool for research in virology and infectious diseases. -
Fungal Inhibitor
Ethyl Vanillate is a potent fungal inhibitor that primarily targets 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), with an IC50 of 1.3 µM. This compound demonstrates significant antifungal properties, making it valuable for research focused on fungal infections and related metabolic pathways. Its ability to modulate steroid hormone activity positions Ethyl Vanillate as an important tool in studies of fungal biology and therapeutic strategies. -
Fungal Inhibitor
(S,S)-Valifenalate is an acylamino acid fungicide targeting the cell-wall synthesis of Oomycetes fungi. By disrupting the structural integrity of the cell wall, it effectively hinders the growth stages of fungal pathogens, both externally on spores and internally within plant mycelium. This compound is employed in various agricultural research applications aimed at developing strategies for fungal control and improving crop health. -
Succinate Dehydrogenase Inhibitor
Isofetamid is a potent inhibitor of succinate dehydrogenase, primarily utilized as a fungicide. It demonstrates effective control against a range of fungal pathogens, including gray mold, white mold, and powdery mildew. This compound is valuable for research related to plant fungal diseases, contributing to the understanding of fungal inhibition mechanisms and disease management strategies. -
Fungal Inhibitor
Thalifoline is an alkaloid recognized for its antifungal properties, primarily targeting fungal cell integrity. Its mode of action involves disrupting fungal growth and proliferation, making it a valuable reagent for research focused on antifungal drug development and potential therapeutic applications against fungal infections. -
Calcineurin Inhibitor
APX879 is a calcineurin inhibitor that selectively targets fungal cells, exhibiting reduced immunosuppressive effects and lower toxicity compared to traditional agents. As a C22-modified analog of FK506, APX879 retains broad-spectrum antifungal activity, making it a valuable tool for studying fungal pathogenesis and the immune response. It holds potential applications in antifungal drug development and research focused on fungal infections. -
Fungal Inhibitor
Saperconazole is a broad-spectrum antifungal triazole that primarily targets fungal growth by inhibiting 14α-demethylase, an enzyme essential for ergosterol biosynthesis. It exhibits potent activity against Aspergillus species, with a minimum inhibitory concentration (MIC90) of 0.19 mg/L. Saperconazole is utilized in research applications involving antifungal efficacy and mechanistic studies of fungal pathogens. -
CHS Inhibitor
Chitin Synthase Inhibitor 4 is a selective inhibitor of chitin synthase (CHS), functioning primarily by disrupting chitin biosynthesis in fungal pathogens. This compound demonstrates significant fungicidal activity, making it a promising candidate for agricultural applications aimed at controlling fungal infections. Its mechanism supports research into chitin synthase-targeted approaches in crop protection and fungal biology. -
Fungal Inhibitor
Kakuol is a naturally derived compound that acts as a fungal inhibitor, targeting fungal cell growth and proliferation. Exhibiting potent antifungal activity, Kakuol is valuable for research applications involving the investigation of fungal infections and the development of antifungal therapies. Its mechanism of action provides insights into novel approaches for combating fungal pathogens. -
SDH Inhibitor
SDH-IN-2 is a potent inhibitor of succinate dehydrogenase (SDH) with an IC50 value of 0.55 μg/mL, demonstrating strong antifungal activity against phytopathogenic fungi, with an average EC50 range of 3.82-9.81 μg/mL. This compound also features an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its dual role as an SDH inhibitor and antifungal agent makes SDH-IN-2 a valuable tool for biochemical research and drug development studies focused on metabolic pathways and fungal diseases. -
Fungal Inhibitor
SCH 51048 is a potent fungal inhibitor that generates active metabolites with demonstrated antifungal properties. Research studies have shown that these metabolites exhibit enhanced activity, making SCH 51048 a valuable compound for investigating antifungal mechanisms and evaluating therapeutic options in fungal infections. This compound serves as a useful tool in the study of fungal biology and the development of new antifungal agents. -
Fungal Inhibitor
Picropodophyllone is an aryltetralin lignan that functions as a fungal inhibitor. This compound exhibits significant antifungal activity, making it a valuable tool for research applications in mycology and the study of fungal pathogenesis. Its isolation from the leaves of Podophyllum hexandrum underlines its natural origin and potential therapeutic implications in combating fungal infections. -
Fungal Inhibitor
L-4-Oxalysine hydrochloride is a naturally occurring compound that acts as a fungal inhibitor. Traditionally isolated from the culture media of Streptomyces roseovirdofuscus, this reagent demonstrates significant antitumor activity. It is utilized in research studies focused on fungal pathogenesis and potential therapeutic applications in oncology. -
Fungal Inhibitor
Exalamide is a potent antifungal agent targeting fungal growth through the inhibition of specific enzymes involved in cellular processes. This compound exhibits significant biological activity against a range of fungal pathogens, making it a valuable tool for research on fungal infections and related diseases. Its application is suited for studies focused on antifungal mechanisms and the development of new therapeutic strategies. -
Fungal Inhibitor
2-Butylbenzo[d]isothiazol-3(2H)-one is a fungal inhibitor that displays significant antibacterial and antifungal activity. This compound is utilized in agricultural applications to safeguard crops against pathogenic fungi, making it an essential ingredient in pesticides. Additionally, it is incorporated into coatings to deter mold and algae growth. Its preservative properties also make it valuable in personal care formulations, helping to extend product shelf life. -
Fungal Inhibitor
2-Ethylnaphthalene is an alkyl-substituted polyaromatic compound that serves as a fungal inhibitor. It has been shown to negatively correlate with the abundance of Glomus species within arbuscular mycorrhizal fungi communities. This property makes 2-Ethylnaphthalene a valuable reagent for investigating fungal interactions and dynamics in various biological research applications. -
SPT Inhibitor
Myriocin is a potent serine palmitoyltransferase (SPT) inhibitor derived from various fungal species such as Myriococcum albomyces, Isaria sinclairi, and Mycelia sterilia. By inhibiting SPT, Myriocin plays a crucial role in the disruption of de novo sphingolipid synthesis. It has demonstrated significant antiviral activity, effectively suppressing the replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL. This compound is valuable for research into sphingolipid metabolism and hepatitis C virus infection mechanisms. -
FgGpmk1 Inhibitor
FgGpmk1-IN-1 is a selective inhibitor of the Fusarium graminearum mitogen-activated protein kinase (FgGpmk1), exhibiting an EC50 value of 3.46 μg/mL. This compound is valuable for investigating the biological role of FgGpmk1 in fungal pathogenesis and offers potential applications in the study of plant-fungal interactions. Researchers can utilize FgGpmk1-IN-1 to explore therapeutic strategies against Fusarium-related diseases. -
Chitinase Inhibitor
Argifin is a potent chitinase inhibitor that demonstrates sub-nanomolar activity, targeting multiple chitinase enzymes. It exhibits impressive IC50 values of 0.025 μM for SmChiA from Serratia marcescens, 6.4 μM for SmChiB, 1.1 μM for Aspergillus fumigatus chitinase B1, and 4.5 μM for human chitotriosidase. Argifin is instrumental in studies exploring chitin metabolism and offers potential applications in antifungal research and elucidation of chitinase-related diseases. -
SDH Inhibitor
Succinate dehydrogenase-IN-2 is a potent inhibitor targeting succinate dehydrogenase (SDH) with an IC50 value of 1.22 mg/L. This compound demonstrates significant antifungal activity, effectively inhibiting a range of fungal pathogens including S. sclerotiorum, V. mali, G. graminis, R. solani, and B. cinerea, with EC50 values in the range of 0.52-3.42 mg/L. It is a valuable tool for research applications focusing on fungal infections and metabolic pathways involving SDH. -
Myosin I Inhibitor
ZJS178 is a selective inhibitor of myosin I, exhibiting significant antifungal activity against Fusarium graminearum. This compound effectively reduces the synthesis of the mycotoxin deoxynivalenol (DON) and is valuable for research on plant diseases, particularly wheat scab. ZJS178 serves as a potent tool for studies aimed at understanding myosin I functions in fungal pathogenesis and developing strategies for disease management in crops. -
DHPS Inhibitor
Dihydropteroate synthase-IN-1 is a potent inhibitor of dihydropteroate synthase (DHPS), primarily targeting the folate biosynthesis pathway. This compound exhibits significant antimicrobial and antifungal properties, making it valuable for research in microbial resistance and pathogenicity studies. Additionally, Dihydropteroate synthase-IN-1 has implications in diagnostics as a potential radio imaging agent, advancing the exploration of therapeutic interventions. -
MabA (FabG1) Inhibitor
FabG1-IN-1 is a selective inhibitor of MabA (FabG1), exhibiting an IC50 of 38 µM. This compound effectively impedes the enzymatic activity of FabG1, playing a crucial role in fatty acid biosynthesis. FabG1-IN-1 is applicable in research focusing on metabolic pathways and the development of antifungal therapies targeting lipid synthesis. -
Nematode Growth Inhibitor
5-(4-Methoxyphenyl)oxazole is a nematode growth inhibitor that targets Caenorhabditis elegans, effectively interfering with hatching and growth processes. This compound, derived from fungal culture broth, exhibits potential in studying nematode biology and assessing the efficacy of nematicidal agents. Its application in research provides valuable insights into nematode management and development. -
FREP1 Inhibitor
P-orlandin is a specific inhibitor of FREP1, a protein that mediates the binding of Plasmodium gametocytes and ookinetes. This fungal metabolite demonstrates potent activity in blocking Plasmodium falciparum infections in mosquito vectors, making it a valuable tool for research in malaria transmission and vector control studies. Its unique mode of action offers insights into potential strategies for disrupting the lifecycle of malaria parasites. -
TMV Inhibitor
TMV-IN-12 is a potent inhibitor of tobacco mosaic virus (TMV), targeting the aggregation and self-assembly of TMV capsid protein (TMV-CP) with a dissociation constant (Kd) of 0.142 μM. This compound effectively disrupts TMV particle formation, thereby preventing the infection of tobacco plants. Additionally, TMV-IN-12 exhibits antifungal properties, making it a valuable reagent for studying viral and fungal interactions in plant biology and for developing strategies to combat TMV-related diseases. -
Quorum Sensing Inhibitor
Aculene D is a quorum sensing inhibitor derived from fungal metabolites that targets the signaling mechanisms in bacteria. It effectively reduces violacein production in Chromobacterium violaceum CV026 cultures induced by N-hexanoyl-L-homoserine lactone (C6-HSL) at sub-inhibitory concentrations. This compound is valuable for research exploring bacterial communication and the modulation of biofilm formation, with potential applications in combating antibiotic resistance and developing new antimicrobial strategies. -
AgrA Quorum-sensing Inhibitor
Apicidin D2 is a specific inhibitor of the accessory gene regulator A (AgrA), which plays a pivotal role in bacterial quorum sensing. This fungal metabolite demonstrates notable anti-virulence properties by effectively suppressing AgrA activation in Staphylococcus aureus, including methicillin-resistant strains (MRSA), without exhibiting biocidal effects. Apicidin D2 is a valuable reagent for research focused on understanding MRSA infections and developing strategies to combat quorum-sensing related pathogenicity. -
DGK Inhibitor
Cochlioquinone A is a potent diacylglycerol kinase (DGK) inhibitor, exhibiting ATP-competitive properties with a Ki value of 3.1 μM. Isolated from the fungal species Drechslera sacchari, Cochlioquinone A serves as a valuable tool for studying DGK's role in cellular signaling pathways. Its inhibitory effects on DGK activity make it pertinent for research in lipid signaling and related biological processes. -
ACAT Inhibitor
Phenylpyropene A is a potent inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), exhibiting an IC50 of 0.8 μM. This fungal metabolite has shown significant biological activity in modulating cholesterol esterification. Its application is particularly relevant in research focused on cholesterol metabolism and related disorders. -
ACAT Inhibitor
Terpendole I is a fungal indoloditerpene that functions as an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, exhibiting an IC50 value of 145 µM. This compound demonstrates significant biological activity in modulating cholesterol metabolism, making it a valuable tool for studying lipid regulation and related metabolic disorders. Terpendole I can be utilized in research focused on atherogenesis, cholesterol homeostasis, and the therapeutic exploration of cardiovascular diseases. -
Acyltransferase Inhibitor
Amidepsine D is an acyltransferase inhibitor derived from the fungal metabolite isolated from the culture broth of Humicola sp. FO-2942. It specifically inhibits diacylglycerol acyltransferases (DGAT), playing a crucial role in lipid metabolism regulation. This compound is valuable for research applications focused on examining lipid biosynthesis pathways and exploring potential therapeutic targets in metabolic disorders. -
ACAT Inhibitor
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), derived from the mycelial cake of Gibberella lateritium IFO 7188. This compound exhibits significant biological activity by inhibiting the growth of various human cancer cell lines, as well as displaying antibacterial effects against gram-positive bacteria and antifungal activity against Candida albicans. Lateritin is a valuable tool for research in cancer therapeutics and the study of lipid metabolism. -
ACAT Inhibitor
Glisoprenin A is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), targeting cholesterol metabolism. It has demonstrated significant activity in inhibiting the formation of appressorium on hydrophobic surfaces in the fungal pathogen Magnaporthe grisea. This compound is valuable for research into fungal plant pathogens and cholesterol metabolism dynamics. -
ACAT Inhibitor
Glisoprenin D is an ACAT inhibitor that selectively targets cholesterol acyltransferase, thereby influencing lipid metabolism. It has been shown to inhibit the formation of appressorium on the hydrophobic surfaces of Magnaporthe grisea, making it a valuable tool for studying fungal pathogenesis and plant-fungal interactions. This compound has potential applications in both basic and applied research within mycology and plant sciences. -
ACAT Inhibitor
Glisoprenin C is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol metabolism. By inhibiting ACAT, Glisoprenin C effectively disrupts cholesterol esterification, impacting the pathogenicity of organisms such as Magnaporthe grisea by preventing appressorium formation on hydrophobic surfaces. This compound is valuable in studying cholesterol-related pathways and evaluating potential therapeutic strategies against fungal pathogens. -
ACAT Inhibitor
Glisoprenin E is an ACAT inhibitor that effectively inhibits cholesterol acyltransferase activity. This compound has demonstrated biological activity by preventing the formation of appressorium on hydrophobic surfaces in the phytopathogen Magnaporthe grisea. Its applications are significant in studying fungal pathogenicity and the role of lipid metabolism in plant-fungal interactions. -
Mitotic kinesin Inhibitor
Mitotic kinesin-IN-1 hydrochloride is a potent inhibitor of mitotic kinesin, specifically designed to disrupt the process of mitosis. This compound effectively impairs cell proliferation and has applications in cancer research, as well as investigations into cardiac hypertrophy, immune and inflammatory disorders, and fungal infections. Its ability to hinder mitotic activity makes it a valuable tool for studying various cellular processes and pathways related to these conditions. -
Melanin Biosynthesis Inhibitor
Scytalol A is a selective inhibitor of dihydroxynaphthalene melanin biosynthesis in Lachnellula sp. A32-89, effectively disrupting melanin production without affecting the growth of the organism. This compound is valuable for research investigating melanin biosynthesis pathways and can be utilized in studies focused on fungal pigmentation and its applications in various biotechnological fields. -
fungal inhibitor
Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL. -
fungal Cyp51 inhibitor
Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes. -
SDHI Inhibitor
Boscalid is a succinate dehydrogenase inhibitor that exhibits significant antifungal activity. By binding to the ubiquinone-binding site of mitochondrial complex II in fungi, Boscalid disrupts ATP production and aerobic respiration, effectively controlling a range of plant fungal diseases, such as gray mold, sclerotinia rot, and powdery mildew. In addition to its agricultural applications, research indicates that Boscalid induces apoptosis and alters lipid metabolism while causing mitochondrial dysfunction, oxidative stress, and ROS accumulation in zebrafish models. Furthermore, it demonstrates chronic toxicity and impacts foraging behavior in honeybees, alongside exhibiting genotoxic and cytotoxic effects in cellular systems.
