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Catalog No.
Product Name
Application
Product Information
Citations
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Fungal Inhibitor
BHBM is an aromatic acylhydrazone compound that acts as a potent antifungal agent targeting Cryptococcus neoformans. Its high bactericidal activity makes it a valuable tool for research applications focused on fungal infections and the development of new antifungal therapies. BHBM can be used to explore mechanisms of action and resistance in fungi, contributing to advancements in infectious disease research. -
Group II introns Inhibitor
Group II intron-IN-1 acts as an inhibitor of fungal Group II introns, demonstrating an IC50 of 3 μM. This compound is valuable for research focusing on fungal infections, particularly those caused by Candida species. Its ability to selectively target intronic processes makes it a significant tool for studying fungal biology and the mechanisms of infection. -
Laccase Inhibitor
Laccase-IN-6 is a potent laccase inhibitor with an IC50 of 0.097 nM. This compound demonstrates a broad-spectrum anti-fungal activity, effectively disrupting normal fungal morphology. Laccase-IN-6 is suitable for research applications focused on fungal infections and the role of laccase in pathogenicity. -
Yck2 Inhibitor
GW461484A is a selective inhibitor of Candida albicans Yck2, demonstrating an IC50 of 0.11 µM. This compound exhibits significant antifungal activity, with a MIC80 of 12.5 µM against C. albicans. GW461484A is valuable for research into fungal infections, particularly those involving drug-resistant strains of Candida. -
Yck2 Inhibitor
Yck2-IN-1 is a potent inhibitor of the Yck2 kinase in Candida albicans, exhibiting an IC50 of approximately 80 nM. This compound demonstrates effective antifungal activity, with a MIC80 of 12.5 µM against C. albicans and a favorable metabolic profile, retaining 66% stability in mouse liver microsomes. In preclinical studies, Yck2-IN-1 significantly reduced fungal load in the kidneys of mice with drug-resistant candidiasis, highlighting its potential for research applications in antifungal treatment development. -
CDA Inhibitor
CDA-IN-4 is a chitin deacetylase (CDA) inhibitor. It demonstrates a protective effect of 61.2% against rice blast disease at a concentration of 100 μg/mL. This compound is pertinent for research applications targeting fungal infections in plants and exploring mechanisms of disease resistance. -
Fungal Inhibitor
Methoxyanigorufone is a fungal inhibitor derived from Musa acuminata var. "Yangambi km 5." This compound exhibits significant antifungal activity, demonstrating effectiveness against a range of pathogenic fungi. It is particularly useful in studies exploring fungal resistance mechanisms and the development of antifungal agents in research applications. -
BcSDH Inhibitor
SDH-IN-45 is an inhibitor of succinate dehydrogenase (BcSDH) that targets Botrytis cinerea, exhibiting an IC50 of 5.97 μg/mL. This compound impedes fungal energy metabolism through a distinct binding mode, leading to morphological disruptions, including structural collapse and shrinkage of mycelial forms. SDH-IN-45 demonstrates potent in vitro fungicidal activity against Botrytis cinerea, making it a valuable reagent for research focused on cucumber gray mold and related phytopathological studies. -
TMV Inhibitor
TMV-IN-15 is a potent inhibitor of Tobacco Mosaic Virus (TMV) by targeting the TMV coat protein (TMV-CP). This compound effectively suppresses viral particle assembly, leading to significant aggregation and structural fusion of viral components. TMV-IN-15 also demonstrates inhibitory activity against important fungal pathogens such as Physalospora piricola and Rhizoctonia cerealis. This reagent is valuable for research applications in antiviral and antifungal pesticide development. -
Succinate Dehydrogenase Inhibitor
SDH-IN-38 is a potent inhibitor of succinate dehydrogenase, primarily targeting mycelial respiration. Demonstrating significant antifungal activity, SDH-IN-38 exhibits an EC50 value of 0.009 μg/mL against R. solani mycelia, effectively inhibiting mycelial growth. Additionally, this compound induces cellular senescence and reduces mitochondrial membrane potential in fungal cells, making it a valuable tool for research in fungal biology and disease management. -
Calcineurin Inhibitor
JH-FK-08 is a potent inhibitor of the serine/threonine-specific phosphatase calcineurin. It demonstrates significant antifungal activity against Cryptococcus neoformans, with a MIC80 of 0.8 µg/mL, and displays immunosuppressive properties by inhibiting IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 also shows efficacy in mouse models for anti-infectious applications, making it valuable for research in immunology and infectious disease. -
Fungal Inhibitor
Bromomonilicin is a selective inhibitor of fungal cell membranes. It exerts its antifungal activity by disrupting the integrity of fungal cell membranes, making it a valuable tool for studying plant pathogenic fungal infections, such as those caused by Monilinia fructicola leading to brown rot, as well as superficial mycoses, including dermatophyte infections. This compound is essential for research aimed at understanding and combating fungal diseases in both agricultural and clinical settings. -
Squalene Synthase Inhibitor
E5700 is a potent squalene synthase inhibitor, exhibiting an IC50 of 0.49 nM against squalene synthase from Trypanosoma cruzi epimastigotes. This compound demonstrates notable antiparasitic activity, effectively inhibiting the growth of Trypanosoma cruzi and Leishmania amazonensis. Additionally, E5700 impacts the lipid profile and ultrastructure of multi-drug resistant Candida tropicalis strains, making it a valuable tool for research on parasitic infections and antifungal resistance mechanisms. -
Fungal Inhibitor
Butenafine-d4 is a deuterium-labeled analogue of Butenafine, a potent benzylamine antifungal agent. It exerts its antifungal activity by specifically inhibiting ergosterol biosynthesis at the squalene epoxidation step, which disrupts fungal cell membrane integrity. Butenafine displays effectiveness against a range of dermatophyte infections, including tinea pedis, tinea cruris, and tinea versicolor. This reagent is suitable for research applications focused on antifungal mechanisms and the study of fungal pathogens. -
Aminoacyl tRNA Synthetase Inhibitor
Aminoacyl tRNA synthetase-IN-4 is a potent inhibitor of aminoacyl tRNA synthetase, exhibiting an IC50 value of 0.026 μM against Candida albicans prolyl-tRNA synthetase. This compound is valuable for antifungal research, providing insights into the role of aminoacyl tRNA synthetase in fungal biology and potential therapeutic strategies against infections. Its selective inhibition profile makes it an important tool for exploring the mechanisms of antifungal resistance and treatment efficacy. -
SDH Inhibitor
SDH-IN-37 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.0263 μM. Additionally, this compound demonstrates significant antifungal activity against pathogens such as Rhizoctonia solani, Sclerotinia sclerotiorum, and Fusarium graminearum, with EC50 values of 0.0144, 0.882, and 1.99 μg/mL, respectively. SDH-IN-37 is therefore a valuable tool for research applications focused on fungal pathogenesis and metabolic regulation in various organisms. -
Histidine kinase Inhibitor
RWJ-49815 is a potent inhibitor of histidine kinases, exhibiting an IC50 value of 1.6 µM. It effectively inhibits the autophosphorylation activity of kinase A within the KinA-Spo0F two-component signaling system in vitro. This compound demonstrates significant antimicrobial activity against resistant bacterial strains, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. Additionally, RWJ-49815 shows inhibitory effects on fungal species such as Saccharomyces cerevisiae and Candida albicans, making it a valuable tool for studying kinase-mediated processes and developing antimicrobial strategies. -
Fungal Inhibitor
Fenpyrazamine is an antifungal agent that primarily targets 3-keto reductase within the ergosterol biosynthesis pathway. It exhibits significant antifungal, preventative, systemic, and lesion-inhibiting properties, providing a prolonged therapeutic effect. Fenpyrazamine is efficacious against pathogens such as gray mold, stem rot, and brown rot, making it a valuable reagent for research focused on fungal infections and plant pathology. -
Fungal Inhibitor
Inz-4 is a selective inhibitor of mitochondrial cytochrome bc1 in fungi, demonstrating an IC50 of 0.026 μM. This compound effectively disrupts mitochondrial respiration in fungal species, making it a valuable tool for studying fungal metabolism and potential therapeutic applications in antifungal research. Its potent activity underscores its utility in investigating the biochemical pathways of fungi and the development of antifungal agents. -
Fungal Inhibitor
Candicidin A3 is a potent antifungal antibiotic that demonstrates significant inhibitory activity against fungal growth. Its unique three-dimensional structure and seven-membered ring configuration enhance its biological efficacy and interaction with fungal targets. This compound presents potential for development as a therapeutic agent in the treatment of fungal infections, making it a valuable tool for researchers studying antifungal mechanisms and developing new treatments for mycotic diseases. -
14α-lanosterol demethylase Inhibitor
Arasertaconazole is a potent inhibitor of 14α-lanosterol demethylase, an enzyme critical in the biosynthesis of sterols in fungi. This compound exhibits significant antifungal and antibacterial activities, making it valuable in studies focused on the treatment of fungal infections and bacterial pathogens. Its inhibition of key enzymatic pathways underscores its research applications in drug development and microbiology. -
Fungal Inhibitor
Stichloroside B1 is a triterpenoid oligosaccharide that acts as a fungal inhibitor. Isolated from the sea cucumber Stichopus chloronotus, it exhibits significant antifungal activity, making it valuable for research in mycology and the development of antifungal agents. Its unique structure and mechanism of action are of particular interest in studying fungal biology and potential therapeutic applications. -
Cytochrome Bc1 Inhibitor
Inz-1 is a selective inhibitor of mitochondrial cytochrome bc1, exhibiting an IC50 of 8.092 μM in yeast and 45.320 μM in human cells. This compound effectively reverses resistance to Fluconazole and other triazole antifungals in Candida albicans, making it a valuable tool for studying antifungal resistance mechanisms and developing new therapeutic strategies. Researchers can utilize Inz-1 to investigate the role of cytochrome bc1 in fungal pathogenesis and drug resistance. -
Chitin Deacetylase Inhibitor
CDA-IN-5 is a chitin deacetylase inhibitor with a Ki value of 27.5 μM against PstCDA. This compound exhibits antifungal activity, effectively inhibiting the growth of pathogens such as Rhizoctonia solani, Pyricularia oryzae, and Botrytis cinerea. CDA-IN-5 demonstrates moderate efficacy in controlling rice sheath blight, making it a valuable tool for research in agricultural plant pathology and fungal disease management. -
Inhibitor of Uredospore Germination
Methyl 3,4-dimethoxycinnamate is a potent inhibitor of uredospore germination, targeting fungal spores to impede their growth and development. In addition to its antifungal properties, it also suppresses global DNA methylation in Hep3B cells, making it a valuable reagent for research on epigenetic modifications. This compound is suitable for studies in plant pathology and epigenetics, facilitating further investigation into its biological roles and potential applications. -
SDH Inhibitor
SDH-IN-29 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.0709 μM. This compound demonstrates broad-spectrum antifungal activity, with EC50 values of 0.356 μg/mL for Fusarium graminearum, 0.798 μg/mL for Sclerotinia sclerotiorum, and 0.146 μg/mL for Rhizoctonia solani. SDH-IN-29 also shows moderate to significant protective effects against rice blast, wheat scab, and cucumber powdery mildew, making it a valuable tool for agricultural research and fungal disease management. -
CYP51 Inhibitor
CYP51-IN-32 is a selective inhibitor of CYP51, demonstrating a potent antifungal activity with an IC50 of 0.331 μM against Candida albicans. This compound not only inhibits the growth of Candida albicans by disrupting hyphal formation and biofilm development, but it also releases hydrogen sulfide (H2S), contributing to its antifungal effects. CYP51-IN-32 is suitable for investigating Candida albicans infections and can be formulated into PEG-based nanovesicles for enhanced delivery in research applications. -
Fungal Inhibitor
Prumycin dihydrochloride is an antifungal compound that targets fungal pathogens, specifically demonstrating efficacy against cucumber powdery mildew. This reagent significantly inhibits disease progression while not inducing plant defense gene expression, suggesting its mechanism does not rely on host defensive responses. Additionally, it has shown effectiveness in preventing spore germination of P. fusca, making it valuable for research into fungal pathogenesis and disease management in agriculture. -
CYP51 Inhibitor
(Rac)-Ketoconazole is an imidazole antifungal agent that acts as a potent inhibitor of cytochrome P450-dependent 14α-sterol demethylase (CYP51). By disrupting ergosterol synthesis, it induces membrane dysfunction, thereby inhibiting the growth and reproduction of various fungi. This compound is primarily utilized in research relating to fungal infections and the mechanisms of antifungal resistance. -
OSBP Inhibitor
Antifungal agent 107 is an oxysterol-binding protein (OSBP) inhibitor that exhibits antifungal activity. This compound is effective in managing cucumber downy mildew and potato late blight in greenhouse settings, making it a valuable tool for researchers investigating plant pathology and disease control strategies. Its targeted mechanism of action provides a means to explore the role of OSBP in fungal biology. -
Cer1 Inhibitor
Cs-2d is a selective inhibitor of ceramide synthase 1 (Cer1) with notable potency against C. neoformans. This compound demonstrates significant antifungal activity, effectively inhibiting growth while exhibiting minimal off-target effects on human ceramide synthase 1 (hCerS1). Cs-2d is a valuable tool for research focused on invasive fungal infections, facilitating the study of therapeutic strategies targeting ceramide metabolism. -
Fungal Inhibitor
Griseofulvic acid is a metabolite of the antifungal agent Griseofulvin, acting as a potent fungal inhibitor. It is known to induce protein aggregation and facilitate tubulin polymerization in cell-free assays, making it a valuable tool in the study of fungal biology and cell dynamics. This compound can be utilized in research applications focusing on the mechanisms of antifungal activity and cytoskeletal interactions. -
Fungi Inhibitor
Acremine I is a potent fungi inhibitor derived from the endophytic fungus Acremonium byssoides. It has demonstrated effective inhibition of Plasmopara viticola, making it a valuable tool for research on plant diseases, particularly grape downy mildew. This compound is useful for studying the mechanisms of fungal resistance and developing strategies for disease management in agriculture. -
Fungal Inhibitor
Mollugogenol A is a potent fungal inhibitor that disrupts cellular integrity in fungal cells. It induces lipid peroxidation, leading to damage to sperm membranes, demonstrating significant sperm-killing activity. This compound is valuable for research applications focused on antifungal mechanisms and reproductive toxicity studies. -
Bc1 Complex Inhibitor
bc1 Complex-IN-1 is a potent inhibitor of the bc1 complex, demonstrating significant antifungal activity. This compound effectively exhibits fungicidal properties against Cucumber downy mildew (CDM), making it a valuable tool for studying fungal pathogenesis and potential therapeutic interventions. Its application in research can aid in understanding the mechanisms underlying fungal resistance and the development of effective fungicides. -
Chitin Synthase Inhibitor
Asulam potassium is a potent chitin synthase inhibitor that targets the biosynthesis of chitin in fungal cell walls. By disrupting the structural integrity of fungal cells, Asulam potassium effectively impedes normal growth and reproduction, demonstrating significant antifungal activity. This compound is valuable for research applications focused on managing fungal diseases, including downy mildew and gray mold, particularly in crops such as spinach, tulips, daffodils, and lilies. -
Fungal Inhibitor
Kayahope is a potent fungal inhibitor that targets key enzymes involved in fungal cell wall biosynthesis. This compound demonstrates significant antifungal activity against various fungal pathogens, making it a valuable tool in the study of fungal infections and their treatment. Kayahope's utility extends to research applications in microbiology and pharmacology, aiding in the development of new antifungal therapies. -
Staphylococcus aureus Inhibitor, Candida albicans Inhibitor
5,6,7,8-Tetramethoxyflavone is a flavonoid that acts as an inhibitor of *Staphylococcus aureus* and *Candida albicans*. This compound exhibits significant antibacterial and antifungal activities, making it valuable for research focused on microbial infections. Its ability to impede the growth of these pathogens supports its use in studies investigating therapeutic strategies against bacterial and fungal infections. -
Fungal Inhibitor
Dactylfungin A is an α-pyrone-containing compound that functions as a potent antifungal agent, primarily targeting fungal cell processes. Isolated from Dactylaria parvispora, it exhibits significant inhibitory activity against various fungal strains. This compound is valuable for research applications focused on understanding fungal biology and developing antifungal therapies. -
CYP51 Inhibitor
Pipercroside A is a potent CYP51 inhibitor derived from Piper crocatum Ruiz & Pav. This compound exhibits significant antifungal activity, making it a valuable tool in studies of fungal infections and drug resistance mechanisms. Its role in inhibiting sterol biosynthesis positions Pipercroside A as a candidate for further investigation in antifungal therapeutic development. -
Fungal Inhibitor
Hyalodendrin is a fungal growth inhibitor that targets wood decay fungi, demonstrating significant inhibitory activity. This compound exhibits low phytotoxicity and has an acute toxicity (LD50) value of 75 mg/kg in mice, making it suitable for research applications in the study of fungal inhibition and plant health. Its unique properties make it an important reagent for investigating fungal resistance and developing environmentally friendly agricultural solutions. -
Fungal Inhibitor
Iodiconazole is a potent antifungal agent that targets fungal cell membrane synthesis. It exhibits significant inhibitory activity against a broad spectrum of pathogenic fungi, making it a valuable tool in antifungal research. This compound is particularly useful for studying fungal resistance mechanisms and the development of new therapeutic strategies against fungal infections. -
Aflatoxin Production Inhibitor
Cyclo(L-leucyl-L-valyl) is an aflatoxin production inhibitor that targets the transcription of specific Aflatoxin-related genes in Aspergillus parasiticus, including aflR, hexB, pksL1, and dmtA. This compound is used to study the regulation of aflatoxin biosynthesis and its impact on fungal pathogenicity. It serves as an important tool in mycology and food safety research, particularly in understanding the molecular mechanisms behind mycotoxin production. -
SDH Inhibitor
SDH-IN-44 is a succinate dehydrogenase (SDH) inhibitor that demonstrates an IC50 of 12.5 μg/mL against Alternaria solani. This compound exhibits significant antifungal activity by inhibiting fungal mycelial growth, making it a valuable tool in the study of fungal infections. Research applications include understanding mechanisms of fungal pathogenicity and exploring therapeutic strategies for fungal diseases. -
Fungal Inhibitor
Benz[g]isoquinoline-5,10-dione is a potent fungal inhibitor derived from the ethanolic extract of Mitracarpus scaber. It exhibits significant in vitro activity against various pathogens associated with AIDS, as well as notable antibacterial and antifungal effects demonstrated through agar well-diffusion assays. This compound is valuable for research applications focused on antimicrobial activity and the development of therapeutic strategies against opportunistic infections. -
Prp8 intein Inhibitor
Antifungal agent 151 is a selective inhibitor of the Prp8 intein, targeting its self-splicing mechanism and disrupting the maturation of the Prp8 protein. This compound demonstrates significant in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 is valuable for research applications focused on cryptococcal pneumonia and related fungal infections. -
Fungal Inhibitor
13-Hydroxy-9-octadecenoic acid is a hydroxy unsaturated fatty acid (HUFA) that functions as a fungal inhibitor. This compound exhibits notable antifungal properties, making it valuable in the study of fungal growth and pathogenicity. It is suitable for research applications focused on fungal diseases and the development of antifungal therapies. -
CYP51 Inhibitor
Pipercroside B is a potent inhibitor of CYP51, an essential enzyme in sterol biosynthesis. Isolated from Piper crocatum Ruiz & Pav, this compound exhibits significant antifungal activity, making it valuable for research into antifungal therapeutics. Its role in modulating CYP51 provides insights into fungal metabolism and potential treatment strategies against fungal infections. -
Pyruvate Kinase Inhibitor
PKR-IN-1 is an inhibitor of pyruvate kinase, demonstrating potent antifungal activity with an EC50 of 0.21 μg/mL against Rhizoctonia solani. Its primary mechanism involves the inhibition of glycolytic metabolism, which is crucial for fungal growth and survival. This compound is valuable for research applications focused on the development of antifungal strategies and the study of metabolic pathways in fungi. -
Fungal Inhibitor
Etisazole is a potent antifungal agent primarily targeting fungal infections. It exhibits significant antifungal activity against various dermatophytes and yeast species, making it valuable in studying skin-related fungal infections. Its skin sensitizing properties also provide insight into dermal reactions and safety assessments for antifungal therapies. This compound is applicable in both in vitro and in vivo research settings to explore antifungal efficacy and skin interaction mechanisms.
