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Catalog No.
Product Name
Application
Product Information
Citations
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β-Lactamase Inhibitor
Ledaborbactam etzadroxil is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes. It is designed to provide enhanced protection for β-lactam antibiotics from hydrolysis by these enzymes, thereby improving their efficacy. This compound is particularly relevant in research applications focused on combating antibiotic resistance and expanding the therapeutic options for bacterial infections. -
β-lactamase Inhibitor
β-Lactamase-IN-8 is a potent β-lactamase inhibitor with a broad-spectrum profile, utilizing a cyclic boronate structure to enhance oral bioavailability. It effectively inhibits various β-lactamases, making it a valuable tool for studying antibacterial resistance mechanisms and developing new therapeutic strategies against resistant bacterial strains. Researchers can utilize β-Lactamase-IN-8 for investigating the efficacy of β-lactam antibiotics in microbial infections. -
Metallo-β-lactamase Inhibitor
β-Lactamase-IN-7 is a potent inhibitor of VIM-type metallo-β-lactamases, exhibiting inhibition constants (Ki) of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. This compound demonstrates effective inhibition against Klebsiella pneumoniae, making it valuable for studies focused on antibiotic resistance and the development of novel therapeutic strategies against resistant bacterial infections. Its role in characterizing metallo-β-lactamase activity positions it as an important tool in chemical biology research. -
β-lactamase inhibitor
ETX0282 is a β-lactamase inhibitor that functions as an orally active prodrug, converted in the liver to its active form, ETX1317. This compound demonstrates excellent stability during intestinal absorption and enhances the efficacy of antibiotics, like Cefpodoxime Proxetil, in reducing bacterial load in models of neutropenic infections. ETX0282 is useful for research focused on combating infections caused by drug-resistant Gram-negative bacteria. -
Beta-lactamase Inhibitor
Doxazosin impurity 12 is identified as a CTX-M β-lactamase inhibitor, exhibiting a Ki value of 0.7 mM against the CTX-M enzyme. This compound is valuable for research applications aimed at overcoming antibiotic resistance mediated by β-lactamases, particularly in the study of bacterial infections and the development of novel antimicrobial strategies. -
Metallo-β-Lactamase Inhibitor
Metallo-β-lactamase-IN-14 is a potent inhibitor of metallo-β-lactamases, specifically targeting VIM-1 and VIM-2 enzymes. This compound demonstrates significant antibacterial activity against Gram-negative bacteria, including Pseudomonas aeruginosa. It is a valuable tool for research applications aimed at combating resistance in clinical pathogens. -
Metallo-β-Lactamase Inhibitor
Metallo-β-lactamase-IN-13 is a potent inhibitor of metallo-β-lactamases, targeting enzymes that confer resistance in Gram-negative bacteria. This compound demonstrates significant antibacterial activity against Pseudomonas aeruginosa, making it an important tool for research into combating antibiotic resistance. Its broad-spectrum activity against various metallo-β-lactamases supports investigations into novel therapeutic strategies for treating resistant bacterial infections. -
β-lactamase II Inhibitor
N-Cbz-D-Cysteine is a potent inhibitor of β-lactamase II with a Ki value of 20.1 µM. This compound can be utilized in the study of antibiotic resistance mechanisms and the development of novel β-lactamase inhibitors. N-Cbz-D-Cysteine's biological activity makes it a valuable reagent in research focusing on antimicrobial strategies and enzymatic inhibition. -
β-lactamase II Inhibitor
N-Cbz-L-Cysteine is a potent inhibitor of β-lactamase II, demonstrating a Ki value of 97 µM. This compound is useful in biochemical research aimed at overcoming antibiotic resistance by targeting β-lactamase enzymes. N-Cbz-L-Cysteine may be employed in studies exploring the inhibition of β-lactamase-mediated antibiotic degradation and enhancing the efficacy of β-lactam antibiotics. -
Beta-lactamase Inhibitor
Xeruborbactam isoboxil is a novel beta-lactamase inhibitor that effectively targets and inhibits the activity of various beta-lactamases. Its primary mechanism involves the binding to the active site of these enzymes, preserving the efficacy of beta-lactam antibiotics. This compound is particularly valuable in combating antibiotic resistance and is utilized in research focused on understanding and overcoming beta-lactam resistance in bacterial infections. -
β-lactamase Inhibitor
GT-055 is a potent β-lactamase inhibitor that demonstrates broad-spectrum activity against a variety of β-lactamase enzymes. This compound effectively enhances the efficacy of β-lactam antibiotics by preventing their hydrolysis, making it a valuable tool in combating antibiotic resistance. GT-055 is suitable for research applications focused on understanding β-lactamase mechanisms and developing new therapeutic strategies. -
Metallo-β-lactamases (MBLs) Inhibitor
epi-D-Captopril is a stereoisomer of Captopril that serves as an inhibitor of metallo-β-lactamases (MBLs). It demonstrates inhibitory activity with IC50 values against NDM-1, IMP-1, and VIM-2 of 64 μM, 173 μM, and 5.5 μM, respectively. This reagent is useful for research applications focused on understanding and addressing drug-resistant bacterial infections associated with MBLs. -
Beta-lactamase Inhibitor
ANT431 is a metallo-β-lactamase inhibitor that enhances the efficacy of beta-lactam antibiotics, particularly Meropenem. This compound is designed for applications in combating antibiotic resistance by restoring the effectiveness of β-lactam antibiotics in bacterial infections, specifically in models involving Escherichia coli. Its potential utility in therapeutic contexts makes it a valuable reagent for microbiological and pharmacological research. -
β-lactamase Inhibitor
Izumenolide is a potent β-lactamase inhibitor derived from the strain Micromonospora chalcea subsp. izumensis. It exhibits significant inhibitory activity against certain β-lactamases, with an IC50 value of 0.01 μg/mL specifically for TEM-2 β-lactamase. This compound is valuable for research applications focused on antibiotic resistance and the development of new therapeutic strategies targeting bacterial infections. -
Serine β-Lactamase Inhibitor
Pilabactam is a potent covalent inhibitor of serine β-lactamases, exhibiting IC50 values between 1 nM and 175 nM across various serine β-lactamase types. This compound significantly enhances the efficacy of β-lactam antibiotics against challenging pathogens such as Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam is valuable in research focused on bacterial infections and antibiotic resistance mechanisms. -
β-lactamase Inhibitor
β-Lactamase-IN-5 is a potent β-lactamase inhibitor that serves to enhance the efficacy of β-lactam antibiotics against resistant bacterial strains. Its primary mechanism involves the inhibition of β-lactamase enzymes, which are responsible for antibiotic resistance. This compound is valuable for research applications aimed at understanding and combating bacterial infections, particularly those caused by multidrug-resistant pathogens. -
β-lactamase Inhibitor
CB-618 is a β-lactamase inhibitor that reversibly covalently interacts with Ambler class A, C, and select class D serine β-lactamases. While it exhibits limited antibacterial activity on its own, CB-618 notably enhances the effectiveness of Meropenem against enzyme-producing Enterobacteriaceae. This compound is a valuable tool for research focused on combating drug-resistant bacterial strains. -
β-Lactamase Inhibitor
LN-1-255 sodium is a β-lactamase inhibitor designed to effectively combat resistance in bacteria. It exhibits a broad-spectrum inhibitory effect on type D carbapenemases, demonstrating an IC50 of 3 nM against OXA-48, while also showing strong activity against OXA-23 and OXA-24/40. The compound enhances the efficacy of carbapenem antibiotics through a synergistic mechanism. LN-1-255 sodium is a valuable tool for researching the challenges posed by carbapenem-hydrolyzing class D β-lactamases (CHDLs) in bacterial resistance. -
Beta-lactamase Inhibitor
Relebactam sodium is a potent and selective β-lactamase inhibitor that functions to inhibit the enzymatic breakdown of β-lactam antibiotics. By binding to a diverse range of β-lactamases, Relebactam sodium enhances the effectiveness of these antibiotics and delays the emergence of bacterial resistance. This compound is particularly valuable in research focusing on combating complex bacterial infections and improving antibiotic therapeutic options. -
Beta-lactamase Inhibitor
Ent-Avibactam sodium is a β-lactamase inhibitor designed to combat a wide range of bacterial infections. It effectively inhibits Ambler A and C type β-lactamases produced by Enterobacteriaceae, enhancing the efficacy of β-lactam antibiotics like Cefazidime. With an IC50 value significantly lower than other commonly used β-lactamase inhibitors, ent-Avibactam sodium demonstrates superior potency against TEM-1 and P99 enzymes, making it a valuable tool for bacterial resistance research and antibiotic development. -
Metallo-β-lactamase Inhibitor
Metallo-β-lactamase-IN-8 is a potent reversible and competitive inhibitor of metallo-β-lactamases (MβLs), exhibiting IC50 values of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM against L1, ImiS, IMP-1, and VIM-2 respectively. This compound demonstrates significant antibacterial activity, making it a valuable tool for studying β-lactam resistance mechanisms in bacterial pathogens. Its ability to inhibit a broad spectrum of MβLs highlights its potential for research applications in antimicrobial resistance and drug development. -
β-lactamase/PBP Inhibitor
FPI-1465 is a dual inhibitor targeting serine β-lactamases and penicillin-binding proteins (PBPs). This compound effectively inhibits PBP2 with an IC50 value of 1.0 µg/mL, demonstrating significant activity against β-lactamase enzymes CTX-M-15 and OXA-48, with Kd values of 0.011 µM and 5.3 µM, respectively. FPI-1465 is suitable for research applications focused on antibiotic resistance and the modulation of β-lactam antibiotic efficacy. -
Beta-lactamase Inhibitor
Xeruborbactam is a potent boronic acid beta-lactamase inhibitor that targets both serine and metallo beta-lactamases with high efficacy. Demonstrating activity in the nanomolar range, it serves as an ultra-broad-spectrum agent in combating antibiotic resistance. Xeruborbactam is valuable for research applications focused on understanding beta-lactamase activity and developing novel antimicrobial strategies.
