Fig. 1 · Structure
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Pilabactam
Cat. No.
A49784
CAS
2410688-60-5
Serine β-Lactamase Inhibitor
Pilabactam is a potent covalent inhibitor of serine β-lactamases, exhibiting IC50 values between 1 nM and 175 nM across various serine β-lactamase types. This compound significantly enhances the efficacy of β-lactam antibiotics against challenging pathogens such as Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam is valuable in research focused on bacterial infections and antibiotic resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2410688-60-5 |
| Applications | Serine β-Lactamase Inhibitor |
| Formula | C6H9FN2O5S |
| Molecular Weight | 240.21 |
| Synonyms | ANT3310 |
| SMILES | O=S(ON1[C@H]2C[N@]([C@@H](CC2)F)C1=O)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.