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Catalog No.
Product Name
Application
Product Information
Citations
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Aminoacyl tRNA Synthetase Inhibitor
Aminoacyl tRNA synthetase-IN-4 is a potent inhibitor of aminoacyl tRNA synthetase, exhibiting an IC50 value of 0.026 μM against Candida albicans prolyl-tRNA synthetase. This compound is valuable for antifungal research, providing insights into the role of aminoacyl tRNA synthetase in fungal biology and potential therapeutic strategies against infections. Its selective inhibition profile makes it an important tool for exploring the mechanisms of antifungal resistance and treatment efficacy. -
SDH Inhibitor
SDH-IN-37 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.0263 μM. Additionally, this compound demonstrates significant antifungal activity against pathogens such as Rhizoctonia solani, Sclerotinia sclerotiorum, and Fusarium graminearum, with EC50 values of 0.0144, 0.882, and 1.99 μg/mL, respectively. SDH-IN-37 is therefore a valuable tool for research applications focused on fungal pathogenesis and metabolic regulation in various organisms. -
Histidine kinase Inhibitor
RWJ-49815 is a potent inhibitor of histidine kinases, exhibiting an IC50 value of 1.6 µM. It effectively inhibits the autophosphorylation activity of kinase A within the KinA-Spo0F two-component signaling system in vitro. This compound demonstrates significant antimicrobial activity against resistant bacterial strains, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. Additionally, RWJ-49815 shows inhibitory effects on fungal species such as Saccharomyces cerevisiae and Candida albicans, making it a valuable tool for studying kinase-mediated processes and developing antimicrobial strategies. -
Fungal Inhibitor
Fenpyrazamine is an antifungal agent that primarily targets 3-keto reductase within the ergosterol biosynthesis pathway. It exhibits significant antifungal, preventative, systemic, and lesion-inhibiting properties, providing a prolonged therapeutic effect. Fenpyrazamine is efficacious against pathogens such as gray mold, stem rot, and brown rot, making it a valuable reagent for research focused on fungal infections and plant pathology. -
Fungal Inhibitor
Inz-4 is a selective inhibitor of mitochondrial cytochrome bc1 in fungi, demonstrating an IC50 of 0.026 μM. This compound effectively disrupts mitochondrial respiration in fungal species, making it a valuable tool for studying fungal metabolism and potential therapeutic applications in antifungal research. Its potent activity underscores its utility in investigating the biochemical pathways of fungi and the development of antifungal agents. -
Fungal Inhibitor
Candicidin A3 is a potent antifungal antibiotic that demonstrates significant inhibitory activity against fungal growth. Its unique three-dimensional structure and seven-membered ring configuration enhance its biological efficacy and interaction with fungal targets. This compound presents potential for development as a therapeutic agent in the treatment of fungal infections, making it a valuable tool for researchers studying antifungal mechanisms and developing new treatments for mycotic diseases. -
14α-lanosterol demethylase Inhibitor
Arasertaconazole is a potent inhibitor of 14α-lanosterol demethylase, an enzyme critical in the biosynthesis of sterols in fungi. This compound exhibits significant antifungal and antibacterial activities, making it valuable in studies focused on the treatment of fungal infections and bacterial pathogens. Its inhibition of key enzymatic pathways underscores its research applications in drug development and microbiology. -
Fungal Inhibitor
Stichloroside B1 is a triterpenoid oligosaccharide that acts as a fungal inhibitor. Isolated from the sea cucumber Stichopus chloronotus, it exhibits significant antifungal activity, making it valuable for research in mycology and the development of antifungal agents. Its unique structure and mechanism of action are of particular interest in studying fungal biology and potential therapeutic applications. -
Cytochrome Bc1 Inhibitor
Inz-1 is a selective inhibitor of mitochondrial cytochrome bc1, exhibiting an IC50 of 8.092 μM in yeast and 45.320 μM in human cells. This compound effectively reverses resistance to Fluconazole and other triazole antifungals in Candida albicans, making it a valuable tool for studying antifungal resistance mechanisms and developing new therapeutic strategies. Researchers can utilize Inz-1 to investigate the role of cytochrome bc1 in fungal pathogenesis and drug resistance. -
Chitin Deacetylase Inhibitor
CDA-IN-5 is a chitin deacetylase inhibitor with a Ki value of 27.5 μM against PstCDA. This compound exhibits antifungal activity, effectively inhibiting the growth of pathogens such as Rhizoctonia solani, Pyricularia oryzae, and Botrytis cinerea. CDA-IN-5 demonstrates moderate efficacy in controlling rice sheath blight, making it a valuable tool for research in agricultural plant pathology and fungal disease management. -
Inhibitor of Uredospore Germination
Methyl 3,4-dimethoxycinnamate is a potent inhibitor of uredospore germination, targeting fungal spores to impede their growth and development. In addition to its antifungal properties, it also suppresses global DNA methylation in Hep3B cells, making it a valuable reagent for research on epigenetic modifications. This compound is suitable for studies in plant pathology and epigenetics, facilitating further investigation into its biological roles and potential applications. -
SDH Inhibitor
SDH-IN-29 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.0709 μM. This compound demonstrates broad-spectrum antifungal activity, with EC50 values of 0.356 μg/mL for Fusarium graminearum, 0.798 μg/mL for Sclerotinia sclerotiorum, and 0.146 μg/mL for Rhizoctonia solani. SDH-IN-29 also shows moderate to significant protective effects against rice blast, wheat scab, and cucumber powdery mildew, making it a valuable tool for agricultural research and fungal disease management. -
CYP51 Inhibitor
CYP51-IN-32 is a selective inhibitor of CYP51, demonstrating a potent antifungal activity with an IC50 of 0.331 μM against Candida albicans. This compound not only inhibits the growth of Candida albicans by disrupting hyphal formation and biofilm development, but it also releases hydrogen sulfide (H2S), contributing to its antifungal effects. CYP51-IN-32 is suitable for investigating Candida albicans infections and can be formulated into PEG-based nanovesicles for enhanced delivery in research applications. -
Fungal Inhibitor
Prumycin dihydrochloride is an antifungal compound that targets fungal pathogens, specifically demonstrating efficacy against cucumber powdery mildew. This reagent significantly inhibits disease progression while not inducing plant defense gene expression, suggesting its mechanism does not rely on host defensive responses. Additionally, it has shown effectiveness in preventing spore germination of P. fusca, making it valuable for research into fungal pathogenesis and disease management in agriculture. -
CYP51 Inhibitor
(Rac)-Ketoconazole is an imidazole antifungal agent that acts as a potent inhibitor of cytochrome P450-dependent 14α-sterol demethylase (CYP51). By disrupting ergosterol synthesis, it induces membrane dysfunction, thereby inhibiting the growth and reproduction of various fungi. This compound is primarily utilized in research relating to fungal infections and the mechanisms of antifungal resistance. -
OSBP Inhibitor
Antifungal agent 107 is an oxysterol-binding protein (OSBP) inhibitor that exhibits antifungal activity. This compound is effective in managing cucumber downy mildew and potato late blight in greenhouse settings, making it a valuable tool for researchers investigating plant pathology and disease control strategies. Its targeted mechanism of action provides a means to explore the role of OSBP in fungal biology. -
Cer1 Inhibitor
Cs-2d is a selective inhibitor of ceramide synthase 1 (Cer1) with notable potency against C. neoformans. This compound demonstrates significant antifungal activity, effectively inhibiting growth while exhibiting minimal off-target effects on human ceramide synthase 1 (hCerS1). Cs-2d is a valuable tool for research focused on invasive fungal infections, facilitating the study of therapeutic strategies targeting ceramide metabolism. -
Fungal Inhibitor
Griseofulvic acid is a metabolite of the antifungal agent Griseofulvin, acting as a potent fungal inhibitor. It is known to induce protein aggregation and facilitate tubulin polymerization in cell-free assays, making it a valuable tool in the study of fungal biology and cell dynamics. This compound can be utilized in research applications focusing on the mechanisms of antifungal activity and cytoskeletal interactions. -
Fungi Inhibitor
Acremine I is a potent fungi inhibitor derived from the endophytic fungus Acremonium byssoides. It has demonstrated effective inhibition of Plasmopara viticola, making it a valuable tool for research on plant diseases, particularly grape downy mildew. This compound is useful for studying the mechanisms of fungal resistance and developing strategies for disease management in agriculture. -
β-lactamase Inhibitor
Kalafungin is a β-lactamase inhibitor derived from marine Streptomyces, exhibiting an IC50 value of 225.37 μM. This compound demonstrates potent antimicrobial activity against a range of pathogenic fungi, yeasts, and protozoa, as well as significant effects on gram-positive bacteria like Staphylococcus aureus. Additionally, Kalafungin shows moderate activity against select gram-negative bacteria, making it a valuable tool for research in antibiotic resistance and microbial pathogenesis. -
Fungal Inhibitor
Mollugogenol A is a potent fungal inhibitor that disrupts cellular integrity in fungal cells. It induces lipid peroxidation, leading to damage to sperm membranes, demonstrating significant sperm-killing activity. This compound is valuable for research applications focused on antifungal mechanisms and reproductive toxicity studies. -
Bc1 Complex Inhibitor
bc1 Complex-IN-1 is a potent inhibitor of the bc1 complex, demonstrating significant antifungal activity. This compound effectively exhibits fungicidal properties against Cucumber downy mildew (CDM), making it a valuable tool for studying fungal pathogenesis and potential therapeutic interventions. Its application in research can aid in understanding the mechanisms underlying fungal resistance and the development of effective fungicides. -
Chitin Synthase Inhibitor
Asulam potassium is a potent chitin synthase inhibitor that targets the biosynthesis of chitin in fungal cell walls. By disrupting the structural integrity of fungal cells, Asulam potassium effectively impedes normal growth and reproduction, demonstrating significant antifungal activity. This compound is valuable for research applications focused on managing fungal diseases, including downy mildew and gray mold, particularly in crops such as spinach, tulips, daffodils, and lilies. -
Fungal Inhibitor
Kayahope is a potent fungal inhibitor that targets key enzymes involved in fungal cell wall biosynthesis. This compound demonstrates significant antifungal activity against various fungal pathogens, making it a valuable tool in the study of fungal infections and their treatment. Kayahope's utility extends to research applications in microbiology and pharmacology, aiding in the development of new antifungal therapies. -
Staphylococcus aureus Inhibitor, Candida albicans Inhibitor
5,6,7,8-Tetramethoxyflavone is a flavonoid that acts as an inhibitor of *Staphylococcus aureus* and *Candida albicans*. This compound exhibits significant antibacterial and antifungal activities, making it valuable for research focused on microbial infections. Its ability to impede the growth of these pathogens supports its use in studies investigating therapeutic strategies against bacterial and fungal infections. -
Fungal Inhibitor
Dactylfungin A is an α-pyrone-containing compound that functions as a potent antifungal agent, primarily targeting fungal cell processes. Isolated from Dactylaria parvispora, it exhibits significant inhibitory activity against various fungal strains. This compound is valuable for research applications focused on understanding fungal biology and developing antifungal therapies. -
CYP51 Inhibitor
Pipercroside A is a potent CYP51 inhibitor derived from Piper crocatum Ruiz & Pav. This compound exhibits significant antifungal activity, making it a valuable tool in studies of fungal infections and drug resistance mechanisms. Its role in inhibiting sterol biosynthesis positions Pipercroside A as a candidate for further investigation in antifungal therapeutic development. -
Fungal Inhibitor
Hyalodendrin is a fungal growth inhibitor that targets wood decay fungi, demonstrating significant inhibitory activity. This compound exhibits low phytotoxicity and has an acute toxicity (LD50) value of 75 mg/kg in mice, making it suitable for research applications in the study of fungal inhibition and plant health. Its unique properties make it an important reagent for investigating fungal resistance and developing environmentally friendly agricultural solutions. -
Fungal Inhibitor
Iodiconazole is a potent antifungal agent that targets fungal cell membrane synthesis. It exhibits significant inhibitory activity against a broad spectrum of pathogenic fungi, making it a valuable tool in antifungal research. This compound is particularly useful for studying fungal resistance mechanisms and the development of new therapeutic strategies against fungal infections. -
Aflatoxin Production Inhibitor
Cyclo(L-leucyl-L-valyl) is an aflatoxin production inhibitor that targets the transcription of specific Aflatoxin-related genes in Aspergillus parasiticus, including aflR, hexB, pksL1, and dmtA. This compound is used to study the regulation of aflatoxin biosynthesis and its impact on fungal pathogenicity. It serves as an important tool in mycology and food safety research, particularly in understanding the molecular mechanisms behind mycotoxin production. -
SDH Inhibitor
SDH-IN-44 is a succinate dehydrogenase (SDH) inhibitor that demonstrates an IC50 of 12.5 μg/mL against Alternaria solani. This compound exhibits significant antifungal activity by inhibiting fungal mycelial growth, making it a valuable tool in the study of fungal infections. Research applications include understanding mechanisms of fungal pathogenicity and exploring therapeutic strategies for fungal diseases. -
Antibiotic, PKC Inhibitor
RK-286D is a potent antibiotic and selective protein kinase C (PKC) inhibitor that exhibits significant antimicrobial properties. This compound effectively inhibits bleb formation induced by phorbol 12,13-dibutyrate (PDBu) and demonstrates notable activity in vitro against PKC. RK-286D is suitable for research applications exploring microbial resistance and PKC-related cellular signaling pathways. -
Fungal Inhibitor
Benz[g]isoquinoline-5,10-dione is a potent fungal inhibitor derived from the ethanolic extract of Mitracarpus scaber. It exhibits significant in vitro activity against various pathogens associated with AIDS, as well as notable antibacterial and antifungal effects demonstrated through agar well-diffusion assays. This compound is valuable for research applications focused on antimicrobial activity and the development of therapeutic strategies against opportunistic infections. -
Prp8 intein Inhibitor
Antifungal agent 151 is a selective inhibitor of the Prp8 intein, targeting its self-splicing mechanism and disrupting the maturation of the Prp8 protein. This compound demonstrates significant in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 is valuable for research applications focused on cryptococcal pneumonia and related fungal infections. -
Fungal Inhibitor
13-Hydroxy-9-octadecenoic acid is a hydroxy unsaturated fatty acid (HUFA) that functions as a fungal inhibitor. This compound exhibits notable antifungal properties, making it valuable in the study of fungal growth and pathogenicity. It is suitable for research applications focused on fungal diseases and the development of antifungal therapies. -
CYP51 Inhibitor
Pipercroside B is a potent inhibitor of CYP51, an essential enzyme in sterol biosynthesis. Isolated from Piper crocatum Ruiz & Pav, this compound exhibits significant antifungal activity, making it valuable for research into antifungal therapeutics. Its role in modulating CYP51 provides insights into fungal metabolism and potential treatment strategies against fungal infections. -
Pyruvate Kinase Inhibitor
PKR-IN-1 is an inhibitor of pyruvate kinase, demonstrating potent antifungal activity with an EC50 of 0.21 μg/mL against Rhizoctonia solani. Its primary mechanism involves the inhibition of glycolytic metabolism, which is crucial for fungal growth and survival. This compound is valuable for research applications focused on the development of antifungal strategies and the study of metabolic pathways in fungi. -
Parasite Inhibitor
Pervicoside B is a glycoside C derived from the sea cucumber Neothyone gibbosa, exhibiting potent antiparasitic activity as it effectively inhibits Leishmania mexicana promastigotes at concentrations of 5-10 μg/mL. Additionally, Pervicoside B displays significant antifungal properties against Aspergillus niger, with minimum inhibitory concentration (MIC) values ranging from 4.65 to 16.7 μg/mL. This compound holds promise for research applications focused on addressing parasitic infections and fungal diseases. -
Fungal Inhibitor
Etisazole is a potent antifungal agent primarily targeting fungal infections. It exhibits significant antifungal activity against various dermatophytes and yeast species, making it valuable in studying skin-related fungal infections. Its skin sensitizing properties also provide insight into dermal reactions and safety assessments for antifungal therapies. This compound is applicable in both in vitro and in vivo research settings to explore antifungal efficacy and skin interaction mechanisms. -
Fungal Inhibitor
Demethoxypiplartine is an amide alkaloid derived from Piper flaviflorum and Piper sarmentosum, exhibiting potent antifungal activity. It demonstrates efficacy against Cryptococcus neoformans, with an IC50 value of 18.1 μg/mL. This compound is valuable for researchers investigating antifungal mechanisms and developing therapeutic strategies for fungal infections. -
Chitin synthase Inhibitor
Chitin Synthase Inhibitor 1 is a potent and selective inhibitor of chitin synthase (CHS) with an IC50 value of 0.12 mM. This compound exhibits significant antifungal activity against drug-resistant fungal variants, making it a valuable tool for research in antifungal drug development and fungal pathogenesis studies. Its mechanism of action provides insight into chitin metabolism and its role in fungal cell wall synthesis. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 9 is a selective inhibitor of chitin synthase (CHS), which plays a critical role in fungal cell wall synthesis. This compound exhibits broad-spectrum antifungal activity, making it suitable for investigating fungal infections. It serves as a valuable tool in research aimed at understanding the mechanisms of fungal pathogenesis and evaluating potential therapeutic strategies against fungal diseases. -
Antibacterial Agent, Antifungal Agent, Cell Proliferation Inhibitor
Deacetylnomilin, derived from Citrus reticulata, exhibits significant antibacterial and antifungal properties. Additionally, it serves as a potent inhibitor of cell proliferation, demonstrating an IC50 value of 0.005 µg/mL against estrogen receptor-positive (ER+) cells. This compound is valuable for research in microbiological studies and cancer biology. -
Succinate Dehydrogenase Inhibitor
Siccanin is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.9 μM with selective activity across species. In addition to its role as an SDH inhibitor, Siccanin demonstrates antimicrobial properties against pathogenic fungi. This compound is valuable for research applications focused on metabolic processes and the treatment of fungal infections. -
Succinate Dehydrogenase Inhibitor
SDH-IN-7 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 26 nM against porcine SDH. This compound demonstrates significant fungicidal activity, making it a valuable tool for research applications focused on mitochondrial metabolism and fungal pathogenicity. Its inhibitory effect on SDH suggests potential implications in cancer research and metabolic studies. -
Fungal Inhibitor
NSC-670224 is a potent fungal inhibitor that demonstrates toxicity to Saccharomyces cerevisiae with an LC50 of 3.2 μM. This compound is useful for studying the effects of fungal inhibition and can serve as a vital tool in antifungal research and the exploration of yeast biology. -
Cyclic AMP Phosphodiesterase Inhibitor, Antifungal Agent
Sequosempervirin B is a norlignan that acts as an inhibitor of cyclic AMP phosphodiesterase, demonstrating notable antifungal activity. Isolated from the branches and leaves of Sequoia sempervirens, this compound is significant in the study of fungal infections and the modulation of intracellular signaling pathways. Its ability to inhibit cyclic AMP degradation positions it as a valuable tool for research in both pharmacology and mycology. -
Chitin Deacetylase Inhibitor
CDA-IN-2 is a potent inhibitor of chitin deacetylase (CDA), effectively targeting the enzymes PxCDA1 and PxCDA2 in the pathogen P. xanthii. At a concentration of 100 μM, CDA-IN-2 demonstrates significant antifungal activity, achieving inhibition rates of 83.7% and 74.5%, respectively. This compound is valuable for research into managing agricultural fungal diseases, particularly against resistant strains of powdery mildew and Botrytis cinerea. -
1,3-β-glucan Synthase Inhibitor
Arborcandin D is a potent inhibitor of 1,3-β-glucan synthase, functioning as an effective antifungal antibiotic. It demonstrates notable inhibitory activity with IC50 values of 3 μg/mL against Candida albicans and 0.35 μg/mL against Aspergillus fumigatus. Furthermore, Arborcandin D exhibits a minimal inhibitory concentration (MIC) of 4 μg/mL against the Candida genus, making it a valuable tool for research on fungal infections and treatment development. -
Fungal Inhibitor
Antifungal agent 20 is a potent fungal inhibitor that demonstrates significant antifungal activity against a range of pathogens, including Colletotrichum gloeosporioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum. This compound is utilized in research applications focusing on fungal diseases, providing a valuable tool for studying plant pathology and developing effective control measures.
