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Catalog No.
Product Name
Application
Product Information
Citations
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PRRSV Inhibitor
PRRSV-IN-1 is a non-structural protein 4 (nsp4) protease inhibitor specifically targeting Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). This compound demonstrates potent antiviral activity, exhibiting an EC50 of 0.45 μM and effectively inhibiting nsp4 protease activity with an IC50 of 80.36 pM. PRRSV-IN-1 is a valuable tool for investigating antiviral strategies and understanding PRRSV pathogenesis in research applications. -
Bacterial Inhibitor
FR-202306 is a bacterial inhibitor that targets peptide deformylase, an enzyme crucial for bacterial protein synthesis. This compound displays significant antibacterial activity against Staphylococcus aureus by effectively inhibiting its peptide deformylase activity. FR-202306 is valuable for research applications focused on developing antibacterial agents and exploring mechanisms of bacterial resistance. -
Bacterial Inhibitor
LF11 is a peptide that functions as a bacterial inhibitor by disrupting microbial cell membrane integrity. It exhibits potent antibacterial activity, making it a valuable tool for research focused on combating bacterial infections and studying antimicrobial mechanisms. Its application is particularly relevant in the development of new therapies and understanding resistance in pathogenic bacteria. -
Bacterial Inhibitor
Rifametane is a novel 3-azamethyl-rifamycin that acts as a bacterial inhibitor. It exhibits a pharmacokinetic profile that surpasses that of rifampin, demonstrating higher peak serum concentrations in healthy volunteers. This compound is primarily used in research focused on antibacterial activity and the evaluation of new therapeutic strategies against resistant bacterial strains. -
Bacterial Inhibitor
BMS-247243 is a β-lactam antibiotic that targets methicillin-resistant Staphylococcus aureus (MRSA). It exhibits significant antibacterial activity, making it a valuable tool for research into bacterial resistance mechanisms and the development of new antimicrobial therapies. BMS-247243 is particularly relevant for studies focused on treating infections caused by resistant bacterial strains. -
Bacterial Inhibitor, Translation Inhibitor
Sancycline hydrochloride is a bacterial inhibitor that functions by reversibly binding to the 30S ribosomal subunit, thereby inhibiting protein translation. It effectively blocks the entry of aminoacyl-tRNA into the ribosomal A site, similar to other tetracycline derivatives. This semi-synthetic tetracycline, characterized by its four linearly fused six-membered rings and four stereocenters, is primarily utilized in research focusing on bacterial protein synthesis and the development of antibacterial agents. -
InhA Inhibitor/Antibiotic
Pyridomycin is a selective inhibitor of InhA, an essential enzyme in Mycobacterium tuberculosis, providing a targeted approach in combating this pathogen. As an antibiotic derived from the metabolites of Dactylosporangium fulvum, Pyridomycin exhibits low cytotoxicity while effectively impeding the growth of Mycobacterium tuberculosis. Its application is significant in the study and treatment of bacterial infections, particularly tuberculosis, making it a valuable reagent for research in infectious disease mechanisms and antibiotic development. -
Antibiotic Inhibitor
Levorin A0 is an aromatic polyene antibiotic known for its potent antifungal properties. It primarily acts by disrupting the integrity of fungal cell membranes, leading to cell death. This compound is essential for research focused on antifungal drug development and understanding membrane-targeting mechanisms in fungal pathogens. Its efficacy against a range of fungi makes it a valuable tool in both in vitro and in vivo studies. -
Bacterial Inhibitor
Celastramycin A (isomer) is an antibiotic targeting Gram-negative bacteria and Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MIC) between 0.05-3.1 μg/mL. This compound has notable immunosuppressive effects, demonstrated in Drosophila ex vivo through the immunodeficiency pathway with an IC50 of 8 ng/mL. Additionally, Celastramycin A (isomer) inhibits human innate immune responses mediated by the TNF-α pathway and reduces IL-8 production in human umbilical vein endothelial cells (HUVEC) with an IC50 of 60 ng/mL, making it a valuable reagent for research in microbiology and immunology. -
Bacterial Inhibitor
Pivmecillinam is an orally active prodrug of mecillinam, functioning primarily as a bacterial inhibitor. It exhibits potent activity against various gram-negative bacteria by interfering with the synthesis of bacterial cell walls. Pivmecillinam is utilized in research to investigate mechanisms of antibiotic resistance and the efficacy of beta-lactam antibiotics. -
Bacterial Inhibitor
Altromycin F is an anthraquinone-derived antibiotic that functions as a bacterial inhibitor by targeting and disrupting bacterial cell function. This compound exhibits significant antibacterial activity specifically against Gram-positive bacteria, including Streptococcus and Staphylococcus, with a microbial inhibitory concentration (MIC) ranging from 0.2 to 3.12 μg/mL. Altromycin F is valuable for research applications focused on understanding bacterial resistance and developing new antibacterial strategies. -
Bacterial Inhibitor
Cefoselis hydrochloride is a fourth-generation cephalosporin and a β-lactam antibiotic that targets bacterial cell wall synthesis. It demonstrates potent antibacterial activity against a broad spectrum of both Gram-positive and Gram-negative bacteria. Furthermore, cefoselis hydrochloride effectively penetrates the blood-brain barrier, making it a valuable compound for research applications in infectious diseases and central nervous system infections. -
Bacterial Inhibitor
KKL-40 is a small molecule inhibitor that targets the trans-transcription process in bacteria. It exhibits effective antibacterial activity against methicillin-sensitive and -resistant Staphylococcus aureus, as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 demonstrates a synergistic effect with the human antimicrobial peptide LL-37 against S. aureus, while showing no synergy with commonly used antibiotics such as daptomycin, kanamycin, or erythromycin. Notably, KKL-40 selectively inhibits trans-transcription without toxicity to HeLa cells, making it a valuable tool for research in bacterial genetics and antibiotic resistance. -
Parasite Inhibitor
Clindamycin B is a derivative of Clindamycin, primarily targeting parasitic infections. It exhibits potent inhibitory activity against various protozoa, making it useful in research related to parasitic diseases. Clindamycin B is valuable for studying mechanisms of action in parasite biology and evaluating therapeutic strategies for parasitic infections. -
β-lactamase Inhibitor
AM-112 is a potent β-lactamase inhibitor that targets class A, C, and D β-lactamase enzymes, demonstrating IC50 values as low as 0.0002 μg/mL. Its mechanism involves the inhibition of PBP2, a penicillin-binding protein in E. coli, thereby protecting Ceftazidime from enzymatic hydrolysis and enhancing its antibacterial activity against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability, making it a valuable tool for research into bacterial infections. -
Bacterial Inhibitor
Norfloxacin hydrochloride is a broad-spectrum antibacterial agent that targets and inhibits DNA gyrase, thus interfering with bacterial DNA replication and repair. It exhibits activity against a wide range of Gram-positive and Gram-negative bacteria, making it a valuable reagent for microbiological research and the study of bacterial resistance mechanisms. This compound is utilized in the investigation of bacterial infections and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Ceforanide (lysine) is a second-generation cephalosporin that functions as a bacterial inhibitor by interfering with bacterial cell wall synthesis. It exhibits a broad spectrum of in vitro antibacterial activity against various Gram-positive and Gram-negative bacteria. Ceforanide is primarily utilized in microbiological research to study bacterial resistance and the effects of cephalosporins on different bacterial strains. -
Bacterial Inhibitor
Deoxypheganomycin D is a specific antimycobacterial agent that demonstrates selective inhibition of Mycobacterium 607 growth without cross-resistance to other antibiotics. At a concentration of 28 μM, it significantly reduces bacterial proliferation while showing minimal impact on DNA, RNA, or protein synthesis pathways. Notably, at 7 μM, Deoxypheganomycin D interferes with leucine influx and alters efflux dynamics, suggesting its action may involve interactions with the cell membrane and distinct mycobacterial lipid components. This reagent is valuable for researchers studying mycobacterial resistance mechanisms and developing alternative treatment strategies. -
Bacterial Inhibitor
Lysostaphin targets the bacterial cell wall, acting as an antistaphylococcal agent. This enzyme exhibits the activities of glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase, and N-acetyl muramyl-L-alanine amidase, leading to effective inhibition of Staphylococcus species. Due to its specific enzymatic action, lysostaphin is valuable in research focused on bacterial resistance, pathogen biology, and the development of antimicrobial therapeutics. -
Bacterial Inhibitor
Cefotaxime is a third-generation cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative bacteria and is notably stable against β-lactamase enzymes. This compound is widely used in microbiological research and clinical settings for the treatment and study of bacterial infections. -
Bacterial Inhibitor
Gastric mucin is a glycoprotein that acts as a bacterial inhibitor, particularly effective against Helicobacter pylori infection. It exhibits natural antibiotic properties and scavenges hydroxyl radicals, contributing to its protective role in the gastrointestinal tract. Gastric mucin plays a critical role in safeguarding against acid, proteases, and pathogenic microorganisms, while also providing defense against mechanical trauma. This functionality makes it a valuable reagent for research focused on gastrointestinal health and microbiome interactions. -
Beta-lactamase Inhibitor
Avibactam sodium hydrate is a reversible non-β-lactam β-lactamase inhibitor that specifically targets β-lactamase enzymes TEM-1 and CTX-M-15, demonstrating IC50 values of 8 nM and 5 nM, respectively. This compound is crucial for enhancing the efficacy of β-lactam antibiotics against resistant bacterial strains. Its use in research applications includes investigations into antibiotic resistance mechanisms and the development of combination therapies to overcome β-lactamase-mediated resistance. -
Bacterial Inhibitor
Mecillinam, a β-lactam antibiotic, primarily targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins in gram-negative organisms. It demonstrates a broad spectrum of antibacterial activity, making it valuable in studying bacterial infections and resistance mechanisms. Researchers often utilize Mecillinam for its effectiveness against various pathogenic strains, aiding in the development of therapeutic strategies and understanding bacterial physiology. -
Bacterial Inhibitor
Cecropin A is a linear antimicrobial polypeptide composed of 37 residues that exhibits potent antibacterial activity. Additionally, it demonstrates anticancer and anti-inflammatory properties, making it a valuable tool for research in infectious diseases, cancer therapy, and inflammatory response studies. Its ability to disrupt bacterial membranes can be leveraged in the development of novel antimicrobial agents. -
Parasite Inhibitor
Milbemycin oxime is an orally active macrolide that serves as a potent inhibitor of parasite activity. This compound, a mixture of oxime derivatives related to milbemycin A4 and A3, selectively binds to glutamate-gated chloride channels, leading to paralysis and death of various intestinal nematodes and lung/heart worms. It is widely utilized in research focused on antiparasitic drug development and mechanisms of parasitic resistance. -
Bacterial Biofilm Formation Inhibitor
Ethyl acetoacetate is an ester compound that acts as an inhibitor of bacterial biofilm formation. Its unique chemical structure facilitates its role in impairing the ability of bacteria to adhere and form protective biofilms, making it a valuable research tool in studying microbial resistance and infection control. This reagent is useful in various biological applications, particularly in investigations aimed at understanding bacterial behavior and developing new antimicrobial strategies. -
β-lactamase Inhibitor
Clavulanate potassium is a potent β-lactamase inhibitor that enhances the effectiveness of β-lactam antibiotics by inhibiting bacterial enzyme activity. It is primarily used in research to study antimicrobial resistance mechanisms and to evaluate the synergy of antibiotic combinations. Clavulanate potassium is essential in elucidating bacterial adaptations and informing therapeutic strategies against resistant organisms. -
β-lactamase Inhibitor
Clavulanate lithium is a potent β-lactamase inhibitor that enhances the efficacy of β-lactam antibiotics by inhibiting bacterial enzymes responsible for antibiotic resistance. Its ability to combat antibiotic resistance makes it invaluable in research focused on understanding and overcoming treatment failures caused by resistant pathogens. Clavulanate lithium is commonly used in studies investigating the mechanisms of resistance and in the development of novel therapeutics. -
Bacterial Inhibitor
Flomoxef sodium is an oxacephem antibiotic that primarily targets bacterial ribosomes, inhibiting protein synthesis. It exhibits potent activity against a range of Gram-positive bacteria, making it suitable for research in antimicrobial resistance and bacterial infections. Flomoxef sodium can be utilized in studies exploring antibiotic efficacy and drug resistance mechanisms. -
Bacterial Inhibitor
Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic that inhibits bacterial protein synthesis by targeting aminoacyl-tRNA binding and peptide bond formation. As a type B compound in the streptogramin family, it exhibits potent bactericidal activity against a diverse array of Gram-positive bacteria. Virginiamycin S1, particularly in combination with virginiamycin M1, is valuable in research focused on overcoming multidrug-resistant bacterial infections. Its application is relevant in fields such as microbiology and pharmacology, particularly in the study of antibiotic efficacy and resistance mechanisms. -
Antitumor Antibiotic/AdoHcy hydrolase Inhibitor
Neplanocin A is an antitumor antibiotic that functions as an irreversible inhibitor of AdoHcy hydrolase, with a Ki of 8.39 nM. It exhibits significant antitumor activity against murine L1210 leukemia cells and also demonstrates antiviral properties, notably against the vaccinia virus. This compound is isolated from the marine-derived organism Ampulariella regularis, making it a valuable reagent for research in cancer therapeutics and virology. -
Bacterial Inhibitor
PNU-105368 is an antibacterial compound that serves as a metabolite of linezolid. It demonstrates efficacy in inhibiting bacterial growth and is primarily excreted via the kidneys and feces. This compound is relevant for research focusing on bacterial resistance and the pharmacokinetics of oxazolidinones. -
Bacterial Inhibitor
Sisomicin is a broad-spectrum aminoglycoside antibiotic that targets bacterial ribosomes, inhibiting protein synthesis. It exhibits potent activity against Gram-positive bacteria, making it valuable in microbiological research. Sisomicin is commonly used in studies investigating bacterial resistance mechanisms and in the evaluation of antibacterial efficacy. -
Bacterial Inhibitor
Thiamphenicol-d3 is a deuterium-labeled variant of the broad-spectrum antibiotic Thiamphenicol, which targets the 50S ribosomal subunit. By binding to this subunit, it inhibits protein synthesis, exhibiting bacteriostatic activity against a wide range of Gram-negative and Gram-positive aerobic and anaerobic bacteria. This reagent is valuable for research applications involving microbiology and the study of antibiotic mechanisms. -
Bacterial Inhibitor
2,2':5',2''-Terthiophene is a heterocyclic oligomer that primarily targets bacterial inhibition. This compound exhibits significant antimicrobial activity, making it a valuable tool for studying bacterial growth and resistance mechanisms. Additionally, 2,2':5',2''-Terthiophene serves as an essential building block in the synthesis of organic semiconductor materials, particularly polythiophene, which has applications in electronic devices and sensors. -
GAK Inhibitor
GAK Inhibitor 2 is a selective inhibitor of cyclin G-associated kinase (GAK), exhibiting a potent IC50 value of 0.024 μM. This compound demonstrates significant antiviral activity, with an effective concentration (EC50) of 1.049 μM against dengue virus (DENV). GAK Inhibitor 2 is suitable for research exploring GAK's role in viral pathogenesis and therapeutic strategies against DENV. -
β-lactamase Inhibitor
Sulbactam pivoxil is a prodrug of Sulbactam, functioning primarily as a β-lactamase inhibitor. It demonstrates significant antibacterial activity by overcoming resistance mechanisms associated with β-lactam antibiotics. This compound is characterized by enhanced absorption compared to Sulbactam, leading to elevated serum concentrations following oral administration, making it a valuable tool for research on antibiotic resistance and evaluation of combination therapies. -
Bacterial Inhibitor
Moxifloxacin hydrochloride monohydrate is a potent bacterial inhibitor that targets DNA gyrase and topoisomerase IV, leading to the disruption of bacterial DNA replication and transcription. It exhibits strong efficacy against Streptococcus pneumoniae and is primarily utilized in the study of bacterial infections, including research on tuberculosis. Its oral bioavailability and broad-spectrum activity make it a valuable reagent for microbiological studies and antibiotic efficacy testing. -
Bacterial Inhibitor
Helvolic acid, also known as Fumigacin, is a natural antibiotic derived from Xylaria sp. It exhibits potent activity against Gram-positive bacteria, making it a valuable tool for investigating bacterial inhibition. This compound can be utilized in microbiological studies to explore mechanisms of antibiotic action and resistance. -
HIV-1 Inhibitor
Formycin A is a purine nucleoside antibiotic that acts as a potent inhibitor of human immunodeficiency virus type 1 (HIV-1), exhibiting an EC50 of 10 μM. This compound demonstrates notable antiviral and antitumor activities, making it a valuable tool for research in virology and cancer biology. Its efficacy against HIV-1 makes it a relevant candidate for studies aimed at developing antiviral therapies. -
Calcium Ionophore Antibiotic, Methanogenic Bacteria Inhibitor
Chlortetracycline is a calcium ionophore antibiotic that primarily targets bacterial protein synthesis by inhibiting the binding of aminoacyl-tRNA to ribosomes. This compound demonstrates potent bactericidal activity and serves as a selective inhibitor of methanogenic bacteria. Chlortetracycline is widely utilized in research applications involving antibiotic resistance studies and metabolic pathway investigations in anaerobic organisms. -
Bacterial Inhibitor
Cefamandole is a semi-synthetic second-generation cephalosporin antibiotic that functions as a bacterial inhibitor by disrupting cell wall synthesis. It exhibits broad-spectrum antimicrobial activity against various Gram-positive cocci and several Gram-negative bacilli, while maintaining resistance to hydrolysis by certain β-lactamases. Although effective in many contexts, it shows limited efficacy against species such as Pseudomonas, Proteus vulgaris, and Providencia stuartii. Cefamandole is primarily excreted in the urine in its active form and is utilized in research applications focused on bacterial infections, although its penetration across the blood-brain barrier is minimal. -
Bacterial Inhibitor
Cinnamycin is a tetracyclic peptide antibiotic that specifically targets phosphatidylethanolamine (PE). Its primary mechanism involves disrupting bacterial membrane integrity, leading to inhibition of growth in Gram-positive bacteria. Cinnamycin is commonly utilized in microbiological research to study antibiotic resistance and bacterial membrane dynamics. -
Bacterial Inhibitor
Aureothricin is a dithiolopyrrolone (DTP) antibiotic with a primary mechanism of inhibiting bacterial growth. It demonstrates broad-spectrum antibiotic activity and has the ability to impede the adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin. This compound is valuable for research applications focused on bacterial inhibition and the modulation of cell adhesion processes. -
Bacterial Inhibitor
Flomoxef is an oxacephem antibiotic that exerts its bactericidal effects primarily by inhibiting bacterial cell wall synthesis. It demonstrates significant activity against a range of Gram-positive bacteria. This compound is utilized in research settings to investigate antibiotic resistance mechanisms and to develop novel antibacterial agents. -
Bacterial Inhibitor
Flucloxacillin is a β-lactam antibiotic that primarily targets bacterial cell wall synthesis by inhibiting transpeptidation enzymes. It exhibits potent antibacterial activity against a variety of gram-positive and some gram-negative bacteria, making it valuable in treating infections caused by staphylococci and streptococci. This reagent is widely utilized in microbiological studies and antibiotic susceptibility testing to evaluate bacterial resistance. -
Bacterial Inhibitor
Sulfadimethoxine-d6 is a deuterated form of Sulfadimethoxine, a sulfonamide antibiotic that acts as a bacterial inhibitor by interfering with folate synthesis in pathogenic microorganisms. This reagent is primarily utilized in pharmacokinetics and metabolic studies, allowing for improved tracking of the compound in biological systems. Its deuterium labeling enhances analytical sensitivity in various applications, including drug metabolism research and isolation studies. -
Bacterial Inhibitor
Bacampicillin is a penicillin antibiotic that serves as a prodrug of ampicillin, designed to enhance oral bioavailability. It exerts its antibacterial activity through the inhibition of cell wall synthesis in susceptible bacteria. This compound is utilized primarily in microbiological research and studies targeting bacterial infections. -
SARS-CoV-2 3CL Proteas Inhibitor
SARS-CoV-2 3CLpro-IN-13 is a highly effective inhibitor of the SARS-CoV-2 3CL protease, exhibiting an IC50 value of 21 nM. This compound demonstrates significant anti-coronavirus activity, making it a valuable tool for research focused on SARS-CoV-2 inhibition and antiviral drug development. It is suitable for studies investigating the biochemical mechanisms underlying coronavirus replication and the potential therapeutic strategies against SARS-CoV-2. -
SARS-CoV-2 PLpro and Mpro Inhibitor
LY1 is a selective covalent inhibitor targeting the SARS-CoV-2 proteases PLpro and Mpro, demonstrating Kd values of 1.5 μM and 2.3 μM for Mpro C145A and PLpro C111A, respectively. It exhibits potent antiviral activity with IC50 values of 0.12 μM against Mpro and 0.99 μM against PLpro. Additionally, LY1 showcases high selectivity, distinguishing itself from other kinases, human proteases, and metalloenzymes, making it a valuable tool for research into SARS-CoV-2 protease inhibition.
