Natural Products

Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1.

Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.

Retinyl acetate is a vitamin A analog that induces cell differentiation and inhibits cell proliferation.

Mitochonic Acid 5 is a derivative of the plant hormone indole-3-acetic acid.

Daphylloside is an iridoid isolated from the aerial parts of Galium verum.

Fucoxanthin is a carotenoid that occurs naturally in certain algae. It significantly reduces abdominal white adipose tissue (WAT) in mice and rats when included in their diet.

Sabinene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has antifungal and anti-inflammatory properties.

Jionoside B1 is a phenylpropanoid isolated from herbs of Eriophyton wallichii.

Isosakuranetin is a flavanone flavonoid which can be found in the fruit of Citrus bergamia.

Purpureaside C is a phenolic glycoside and has significant proinflammatory action.

Diammonium Glycyrrhizinate, isolated from the licorice root, is a widely used anti-inflammatory agent.

L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.

Harmaline is a psychoactive indole found naturally in certain plants. Its stimulating activities are achieved, in part, through inhibition of monoamine oxidases, thus increasing the levels of monoamine neurotransmitters (e.g., at 7-70 μM/kg in rats). Harmaline (30 mg/kg) induces tremor in mice through the N-methyl-D-aspartate (NMDA) receptor, at which harmaline may act as an inverse agonist.

Lentinan is an intravenous anti-tumor polysaccharide and one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems.

Hydroquinine is a cinchona alkaloid, can be used in the preparation of its derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine and 10,11-dihydroquinine monohydrochloride.

Citral is a vitamin A antagonist; oxygenated monoterpene; inhibits cytosolic dehydrogenases.

Lanatoside C is an anticancer agent, acting through protein kinase C-delta (PKCdelta) to cause apoptosis of human hepatocellular carcinoma cells.

Salicyl alcohol is a saligenin is the aglycone of salicin; it is oxidatively metabolized to gentisic acid..

(L)-alpha-Terpineol is a monoterpene alcohol. It is one of the components responsible for the antifungal activity of Melaleuca alternifolia (tea tree) essential oil. α-Terpineol may be used in the synthesis of α-terpinyl esters of acetic acid and acetic anhydride via lipase-mediated esterification.

Methyl linolenate is a polyunsaturated fattly acid (PUFA). It is used in studies on the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids. The IC50 is 60 uM.

Citric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer.

l-Limonene is a monoterpenoid compound,and is mostly used in perfumery and in flavoring. On irradiation, it undergoes radiolysis, which leads to a reduction in the optical purity. l-Limonene also shows potent antimicrobial activity.

Mandelic acid, is a natural compound isolated from bitter almonds.

Valine is a branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.

Salicylamide is a non-steroidal anti-inflammatory agent with analgesic and antipyretic properties. Its medicinal uses are similar to those of aspirin.

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.

ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA).

Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) is the glycosylation product of Chrysin.

Salvianolic acid F is a synthesized polyphenolic acid.

Kv3 modulator 2 (formula (I)) is a potent Kv3 channels modulator extracted from patent WO2018109484A1, compound formula (I) , has analgesic activity and is used in the prophylaxis or treatment of related disorders.

Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase.

Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.

Procyanidol B4 ((-)-Procyanidin B4) is a flavanol, isolated from Litchi chinensis. Anti-inflammatory properties.

Secoisolariciresinol diglucoside ((S,S)-SDG) is a major component of the lignans in flaxseed, scavenges free radical, with potent antioxidant activity.

(9Z,11E)-Prodlure is the main component of the sex pheromone of female Spodoptera littoralis.

TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1.

Bruceantin(NSC165563) is first isolated from Brucea antidysenterica.

S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model.

Fmoc-1,6-diaminohexane is an analog of Osw-1 which can be used to treat Alzheimer's disease and cancer, extracted from patent US 20140135279 A1.

3,7,4'-Trihydroxyflavone, isolated from Rhus javanica var. roxburghiana, is a flavonoid with DNA strand-scission activity.

Antibacterial compound 1 is a oxazolidinone extracted from patent WO1999037630A1 with antibacterial activities.

2-Hydroxy-4-methoxybenzoic acid is a derivative of methoxybenzoic. 2-Hydroxy-4-methoxybenzoic is a potential biomarker.

Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent.

(E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively.

PF 1022A is a N-methylated cyclooctadepsipeptides (CODPs) with strong anthelmintic properties; acts as an ionophore.

Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation.

Berlambine is a natural alkaloid isolated from many plants.

S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1.

Acetosyringone is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions.

L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.