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Pepluanin A

Catalog No.: A67868
Natural Compound
Pepluanin A is a natural compound derived from Euphorbia peplus L., exhibiting potent inhibitory activity against P-glycoprotein (Pgp). This jatrophane diterpene demonstrates more than double the effectiveness of Cyclosporin A in inhibiting Pgp-mediated transport of Daunomycin. Its significant biological activity positions Pepluanin A as a valuable reagent for research involving drug resistance and pharmacokinetics.
Pepluanin A 670257-89-3 Natural Compound
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Size Price Stock Qty
5mg
$1,810.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPepluanin A is a natural compound derived from Euphorbia peplus L., exhibiting potent inhibitory activity against P-glycoprotein (Pgp). This jatrophane diterpene demonstrates more than double the effectiveness of Cyclosporin A in inhibiting Pgp-mediated transport of Daunomycin. Its significant biological activity positions Pepluanin A as a valuable reagent for research involving drug resistance and pharmacokinetics.
Product Information
Catalog NumA67868
FormulaC43H51NO15
Molecular Weight821.86
CAS Number670257-89-3
SMILESO=C(C1=CC=CN=C1)O[C@H]([C@H](OC(C)=O)[C@H]2OC(C)=O)C(C)(C)/C=C/[C@H](C)[C@H](OC(C)=O)[C@](C[C@@](C)(OC(C)=O)[C@@H]3OC(C4=CC=CC=C4)=O)(O)[C@@]3([H])[C@@H](OC(C)=O)C2=C
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