NF-kB/IkB

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  1. Trichostatin-A (TSA)

    Catalog No. A10947
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    HDAC Inhibitor
    Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. Learn More
  2. Romidepsin (FK228 ,Depsipeptide)

    Catalog No. A11920
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    HDAC inhibitor
    Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively. Learn More
  3. BRD73954

    Catalog No. A15489
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    HDAC inhibitor
    BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively). Learn More
  4. ACY-738

    Catalog No. A15934
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    HDAC6 inhibitor
    ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. Learn More
  5. Tubacin

    Catalog No. A10954
    HDAC6 inhibitor
    Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM. Learn More
  6. TCS HDAC6 20b

    Catalog No. A15387
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    HDAC6 inhibitor
    TCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen. Learn More
  7. Droxinostat

    Catalog No. A10337
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    HDAC inhibitor
    Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively. Learn More
  8. BRD9757

    Catalog No. A12911
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    HDAC6 inhibitor
    BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. Learn More
  9. Resminostat hydrochloride

    Catalog No. A15220
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    HDAC inhibitor
    Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. Learn More
  10. BG45

    Catalog No. A11361
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    HDAC inhibitor
    BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). Learn More
  11. ACY-1215 (Rocilinostat)

    Catalog No. A11940
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    HDAC6 inhibitor
    ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. Learn More
  12. ACY-241

    Catalog No. A12758
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    HDAC6 inhibitor
    ACY-241 is a new, selective and orally available inhibitor of HDAC6. Learn More
  13. Tubastatin A HCl

    Catalog No. A11042
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    HDAC6 inhibitor
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Learn More
  14. Resminostat

    Catalog No. A12556
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    HDAC inhibitor
    Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. Learn More
  15. KD 5170

    Catalog No. A15354
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    HDAC inhibitor
    KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Learn More
  16. CAY10603

    Catalog No. A16431
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    HDAC6 inhibitor
    CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs. Learn More
  17. Nexturastat A

    Catalog No. A14032
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    HDAC6 inhibitor
    Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Learn More
  18. HPOB

    Catalog No. A14197
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    HDAC6 inhibitor
    HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM). Learn More

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