Other inhibitors

Items 201-250 of 980

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  1. Bioluminescent substrate

    D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications.
  2. Clodronate disodium is the disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate.
  3. leukemia inhibitory factor (LIF) inhibitor

    EC330 is a leukemia inhibitory factor (LIF) inhibitor.
  4. DCPS inhibitor

    RG3039 (PF-06687859) is orally bioavailable, brain-penetrant small molecule that has been shown to be an inhibitor of the mRNA decapping enzyme, DcpS.
  5. AC 42 is an allosteric agonist.
  6. morpholino antisense oligomer

    Eteplirsen is an experimental drug, currently in clinical trials.
  7. METAP2 inhibitor

    Beloranib, an analog of the natural chemical compound fumagillin, is an inhibitor of the enzyme METAP2.
  8. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. Doxepin is a tricyclic antidepressant.
  9. Noscapine is an orally administrable drug used worldwide for cough suppression, primarily mediated by its sigma receptor agonist activity, and possess anticancer activity.
  10. sympathetic ganglioblocker

    Fluorocurarine chloride is a short-acting selective sympathetic ganglioblocker with weak antagonist activity on the nicotinic receptor at the neuromuscular junction.
  11. SM-130686 is a potent, orally active growth hormone secretagogue, with around half the potency of the endogenous agonist ghrelin as a stimulator of growth hormone release.
  12. TPT-260 is a thiophene thiourea derivative.
  13. PR-104 is a non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard pre-prodrug with potential antitumor activity.
  14. Fosfluconazole is a water-soluble phosphate prodrug of fluconazole - a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
  15. K-252a is a metabolite originally isolated from the culture broth of Nocardiopsis sp.. Experiments have shown that at high concentrations this compound is an ATP-competitive inhibitor of cyclic nucleotide-dependent protein kinases.
  16. MetAP-2 inhibitor

    TNP 470 is an analog of Fumagillin that displays potent antiangiogenic activity in vitro. Shown to inhibit MetAP-2 (methionine aminopeptidase type II ).
  17. Alpha-galactosidase inhibitor

    Deoxygalactonojirimycin Hydrochloride is a potent and selective Alpha-gal A (Alpha-galactosidase) inhibitor.
  18. Maleimidoacetic Acid is an organic heterocycle.
  19. BMPS is a short, sulfhydryl and amino reactive heterobifunctional crosslinking reagent.
  20. YH249 is the first highly specific, direct p300/β-catenin antagonist.
  21. neuronal differentiation inducer

    Neuropathiazol is a synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells.
  22. Tomeglovir is a novel nonnucleosidic inhibitor of human cytomegalovirus replication.
  23. Cyclosporin D is a weak immunosuppressor but potent inhibitor of tumor promoting phorbol ester TPA/PMA.
  24. Thymalfasin is a chemically synthesized version of thymosin alpha 1 that is identical to human thymosin alpha 1. Thymosin alpha 1 is an acetylated polypeptide.
  25. Thymosin β4 is naturally occuring, potent regulator of actin polymerization present in human platelets at a concentration of 200 - 500 uM.
  26. CM 346 is an anxiolytic drug, produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.
  27. Picoplatin is a new generation organic platinum analog with an extended spectrum of antineoplastic activity.
  28. Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
  29. FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.
  30. squalene epoxidase inhibitor

    NB-598 is a potent competitive inhibitor of squalene epoxidase.
  31. neuroprotective agent

    TH-237A is a novel neuroprotective agent, which possess protective properties against β-amyloid (Aβ)-induced neurodegeneration associated with Alzheimer's disease.
  32. Antineoplastic agent

    TRX-818 is a new, potent and multi-targeted anti-cancer agent in numerous human cancer cell lines.
  33. Enhances differentiation of induced pluripotent stem cells (iPSCs) to hepatocytes; also promotes the maturation of iPSC-derived hepatocytes.
  34. PDHK inhibitor

    AZD7545 is a novel, selective small-molecule inhibitor of PDHK2 (PDH kinase2) with an IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively.
  35. OSC Inhibitor

    Ro 48-8071 is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.
  36. Abscisic Acid is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism.
  37. Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
  38. NQO1 inhibitor

    Dicoumarol is a competitive NADH quinone oxidoreductase (NQO1) inhibitor.
  39. cholinephosphotransferase inhibitor

    Meclofenoxate HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.
  40. L-Mimosine is a non-protein amino acid, and acts as an iron chelator.
  41. mTOT-modulating insulin sensitizer

    MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease.
  42. FPH1 is a small molecule, which promotes expansion of iPS-derived hepatocytes.
  43. Ro 48-8071 inhibits cholesterol biosynthesis at the level of 2,3-oxidosqualene cyclase (OSC). It blocks OSC and cholesterol synthesis in HepG2 cells in the nanomolar range. A novel lipid lowering agent.
  44. Isomalt is a sugar substitute, a type of sugar alcohol, used primarily for its sugar-like physical properties.
  45. Jasmonic acid is derived from the fatty acid linolenic acid.
  46. Tazarotenic Acid is the principle active metabolite of Tazarotene.
  47. cPLA2α inhibitor

    CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor.
  48. Factor VIIa Inhibitor

    PCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa) with potential antineoplastic and antithrombotic activities.
  49. beta-hexosaminidase inhibitor

    AB05831 is a highly potent and specific inhibitor of beta-hexosaminidase.
  50. YL-109 has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo.

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