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Biological Activity
AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.8 mL | 113.98 mL | 227.95 mL |
| 0.5 mM | 4.56 mL | 22.8 mL | 45.59 mL |
| 1 mM | 2.28 mL | 11.4 mL | 22.8 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
*The above data is based on the productmolecular weight 438.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12446 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 613260-13-2 |
| Formula | C16H8ClF5N2O5 |
| M. Wt | 438.69 |
| Purity | >98% |
| Synonyms | AVE 5688, AVE-5688 |
| SMILES | O=C(O)C1=CC=C(NC(NC(C2=CC(F)=C(F)C=C2Cl)=O)=O)C(OC(F)(F)F)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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