Catalog No.
Product Name
Application
Product Information
Citations
- NCGC00262650 is an inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity.
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hypoglycemic agent
Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity. -
active oxygen formation inducer
Methoxy-PMS (1-Methoxy PMS), an active oxygen formation inducer, is stable electron-transport mediator between NAD(P)H and tetrazolium dyes. -
transcriptional inhibitor of G0/G1 switch 2
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease. -
anticonvulsant/antiepileptic agent
Lvguidingan (Anticonvulsant 7903, 3,4-dichlorophenyl propenylisobutylamide) is an anticonvulsant/antiepileptic agent. Lvguidingan (Anticonvulsant 7903) is found to be able to increase the concentration of 5-HT and 5-HIAA in mice brain. - Tri-Salicylic Acid (Trisalicylic Acid), a product of the thermal decomposition of aspirin, is a biochemical for proteomics research.
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Biochemical Assay Reagent
Rhodamine B isothiocyanate (RBITC) is a reactive fluorescent dye widely used for covalent labeling of biomolecules in imaging and analytical applications. The isothiocyanate functional group readily reacts with primary amines on proteins, peptides, and other biomolecules to form stable thiourea linkages, enabling durable fluorescent tagging. RBITC emits bright orange-red fluorescence upon green light excitation, providing strong signal intensity and excellent photostability for visualization in complex biological systems. Owing to its high sensitivity, chemical stability, and compatibility with diverse assay conditions, RBITC is extensively utilized in cell biology, immunology, neurobiology, and fluorescence microscopy studies for tracking molecular localization and dynamics. -
Biochemical Assay Reagent
DCIP sodium is a redox indicator utilized primarily in biochemical assays. Its distinctive blue coloration shifts according to the oxidation state of the analyte, making it effective in measuring enzymatic activities, including succinate dehydrogenase. Additionally, it serves as a valuable reagent in protein quantification methods, such as the Lowry assay, facilitating accurate analytical results in various research applications. -
Biochemical Assay Reagent
Bathocuproine disulfonate disodium (BCS) is a highly sensitive colorimetric reagent utilized for the detection of copper ions in biochemical assays. This compound exhibits a bright yellow color and possesses strong absorbance at specific wavelengths, enabling the quantification of trace levels of copper. BCS is instrumental in studying copper's biological roles, as well as in environmental monitoring and water quality testing, where its sensitivity allows for the identification of copper pollution, even at minimal concentrations. Accurate measurement of copper is essential for understanding its physiological effects and ecological impacts. -
Cholesterol-removing Agent
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis. Methyl-β-cyclodextrin blocks cell migrasome formation. -
Globular Protein
Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications. -
Skin Depigmenting Agent
Monobenzone is a potent skin depigmenting agent that primarily targets the enzyme ribonucleotide reductase (RNR) by inhibiting its regulatory subunit, RRM2. It effectively induces depigmentation, making it a valuable compound in vitiligo research. Additionally, Monobenzone demonstrates significant anti-leukemic properties, inhibiting the proliferation and DNA synthesis of acute myeloid leukemia (AML) cells, and promoting cell cycle arrest and apoptosis. These dual functionalities position Monobenzone as a critical reagent in both dermatological and oncology studies. -
Excipient
SBE-β-CD is a sulfobutylether derivative of β-cyclodextrin primarily utilized as an excipient in pharmaceutical formulations. It enhances the solubility of poorly soluble compounds, thereby improving their bioavailability. SBE-β-CD is valuable in drug development, particularly for improving the delivery of hydrophobic agents in various therapeutic applications. -
Biochemical Assay Reagent
(±)-myo-Inositol-1-phosphate is a biochemical assay reagent known for its role as a phosphoinositide signaling molecule. This compound is involved in cellular processes such as insulin signaling, cell proliferation, and regulation of ion channels. It is utilized in various research applications, including studies on diabetes, neurodegenerative diseases, and cell signaling pathways. -
Iron Colorimetric Reagent
Bathophenanthrolinedisulfonic acid disodium salt (BPS) is a colorimetric reagent primarily used for the detection of iron, exhibiting an optimal absorbance at 535 nm for iron complexes. This reagent facilitates the determination of iron concentrations in aqueous solutions without the necessity for extraction solvents. Additionally, BPS is utilized as a precursor in the synthesis of specialized complexes, including Europium(III) tris(dibenzoylmethanate) bis(bathophenanthrolinedisulfonate) and ruthenium(II) tris(bathophenanthrolinedisulfonate), and plays a role in catalyst systems for the oxidation of 2-hexanol by forming stable water-soluble complexes with palladium. -
Colorimetric Reagent
2-Thiobarbituric acid is a colorimetric reagent primarily used for the quantitative detection of malondialdehyde (MDA), a key biomarker of lipid peroxidation. It forms a chromogenic complex with MDA that can be measured at 532 nm. This reagent is essential for studies investigating oxidative stress and lipid peroxidation in various biological samples. -
Biochemical Reagent
Copper sulfate pentahydrate is a biochemical reagent commonly used in cell culture applications. This compound demonstrates the ability to reduce the production of reactive oxygen species (ROS) and downregulate the expression of MyD88 and c-Rel genes. Additionally, copper sulfate pentahydrate affects enzymatic activities by decreasing T-superoxide dismutase (T-SOD), catalase (CAT), and glutathione (GSH) levels, while promoting the activities of caspase-3, -8, and -9. Its cytotoxic effects make it valuable for studies involving cellular apoptosis and oxidative stress. -
Biochemical Reagent
Mutanolysin is a muralytic enzyme that acts as a bacteriolytic agent, targeting bacterial cell walls. It exhibits significant protective effects against hepatic injury and has been shown to decrease TNF-α production in isolated Kupffer cells stimulated with peptidoglycan-polysaccharide. Additionally, Mutanolysin mitigates the elevation of plasma anti-peptidoglycan antibodies and TNF-α levels in rat models, making it a valuable reagent for studying inflammation and bacterial infections. Its applications extend to biochemical research, particularly in exploring immune responses and hepatic health. -
Ester Product
Dodecane is an aliphatic hydrocarbon classified as an ester product. It has been demonstrated to induce elevated levels of TNF-α expression, a key cytokine involved in inflammatory responses, and can also lead to increased transepidermal water loss (TEWL), which is critical for studies on skin barrier function. This compound is relevant for research applications in inflammation, dermatological studies, and understanding skin permeability. -
Biochemical Assay Reagent
Manganese chloride (tetrahydrate) is a biochemical assay reagent that plays a critical role in regulating enzyme activities, particularly histone acetyltransferase (HAT) and histone deacetylase (HDAC), influencing gene expression. This compound exhibits biological activities including neurotoxicity, embryotoxicity, and reproductive toxicity. It is predominantly utilized in research related to neurodegenerative diseases and toxicology, providing valuable insights into cellular and molecular mechanisms. -
Drug Intermediate
5-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide serves as an essential drug intermediate in the synthesis of diverse bioactive molecules. This compound's structural framework enables exploration in medicinal chemistry and drug development, facilitating the creation of therapeutically relevant agents. Researchers utilize this intermediate to optimize pharmacological properties and enhance biological activity across various applications. -
Biochemical Reagent
1-Pyrenedecanoic acid is a biochemical reagent primarily utilized to assess membrane fluidity. This compound intercalates into lipid bilayers, enabling the study of membrane dynamics and properties. It is valuable in research focusing on cellular membrane behavior and related physiological processes. -
Biochemical Reagent
Xanthomegnin is a yellow pigment with biochemical properties isolated from the fungus Trichophyton megnini. This compound is widely utilized in various research applications, particularly in the study of fungal metabolism and pigment biosynthesis. Its unique colorimetric characteristics make it a valuable reagent in biochemical assays and analytical studies involving enzymatic activity and compound interactions within biological systems. -
Biochemical Reagent
Zapotin is a polymethoxyflavone that functions as a biochemical reagent, exhibiting multiple biological activities. It demonstrates significant antidepressant, anticancer, antifungal, and antioxidant properties, making it a candidate for chemopreventive and chemotherapeutic applications. Studies show that Zapotin effectively reduces large aberrant crypt foci in CF-1 mouse models and inhibits autophagosome formation. Additionally, it displays inhibitory activity in mouse mammary organ culture, with an IC50 value of 50 µg/mL. -
Drug Intermediate
Camphorsulfonate sodium functions as an organic synthesis intermediate with significant utility in the development of derivatives exhibiting succinate dehydrogenase (SDH) inhibitory activity through scaffold hopping. Additionally, it serves as an organocatalyst, effectively modulating the porosity of graphene films as a pore-forming additive. This compound is valuable in research applications focused on binder-free porous graphene films and fungicide development. -
Impurity
Gefitinib impurity 2 is an impurity of the EGFR tyrosine kinase inhibitor, Gefitinib. While Gefitinib exhibits potent and selective inhibition of EGFR with an IC50 of 33 nM, this impurity may be relevant for studies focused on the characterization and validation of Gefitinib-related compounds. Research applications primarily include analytical chemistry and quality control in the synthesis of Gefitinib. Additionally, the impurity may provide insights into the pharmacological behavior and metabolic pathway analysis of EGFR inhibitors. -
Olanzapine Impurity
Olanzapine ketolactam is an impurity associated with Olanzapine, a selectively acting monoaminergic antagonist. This compound may be utilized in chemical research to study the structural and functional properties of Olanzapine and its metabolites. Its presence could provide insights into the pharmacological profiles and safety assessments of olanzapine formulations. -
Drug Impurity
Methotrexate impurity 4 is a known impurity associated with Methotrexate, primarily classified as a drug impurity. This compound is utilized in research to assess drug purity and stability, as well as to study potential side effects and metabolic pathways related to Methotrexate. Its characterization is critical for quality control and regulatory compliance in pharmaceutical formulations. -
Biochemical Reagent
Ethyl methanesulfonate is a potent alkylating agent known for its ability to induce DNA damage. By modifying DNA structure through alkylation, it triggers apoptosis and can lead to mutations and cell death. This compound is extensively utilized in genetic toxicology research to facilitate the study of gene function, mechanisms of genetic diseases, and the impacts of environmental mutagens on cellular systems. Additionally, it has been shown to induce tumors in kidney and nervous system tissues, highlighting its relevance in cancer research. -
Cetirizine Impurity
Cetirizine methyl ester is a known impurity of Cetirizine, a second-generation antihistamine that functions as a selective, orally active, and long-lasting antagonist of the histamine H1 receptor. This compound serves as an important analytical reference for the study of Cetirizine's purity and quality control processes. Its relevance in biochemical research and pharmaceutical development makes it a valuable tool for investigating the pharmacological profile of antihistamines. -
Biochemical Reagent
L-Ascorbic acid calcium dihydrate functions primarily as a biochemical reagent. This compound serves as a stable source of Vitamin C, acting as a potent antioxidant that scavenges free radicals and reduces oxidative stress. It plays a crucial role in collagen synthesis and is widely utilized in various life science research applications, including studies on cellular metabolism, skin health, and enzymatic reactions. -
Biochemical Reagent
Ap2A disodium is a symmetrical dinucleoside polyphosphate that serves as a biochemical reagent. It exhibits a significant capacity to promote the proliferation of vascular smooth muscle cells. This compound is commonly utilized in research focused on cellular growth and cardiovascular studies. -
Biochemical Assay Reagent
Chitin, derived from crab carapace, is a long-chain polymer of N-acetylglucosamine featuring β-(1-4) linkages. This biopolymer serves as a biochemical assay reagent and is noted for its ability to inhibit the activation of NF-κB p65, as well as alter its translocation to the nucleus. Chitin also interacts with the cell wall of Candida species, exhibiting antifungal and anti-inflammatory properties. It is valuable for research into gastric ulcers and candidiasis, contributing to the understanding of related pathophysiological processes. -
Biochemical Assay Reagent
Ammonium bicarbonate is an analytical reagent used primarily in biochemical assays. It exhibits antifungal activity and is instrumental in various research applications, including laboratory analysis and food processing. Additionally, it serves as a nitrogen source in agricultural fertilization. This reagent's high purity ensures reliable results in experimental setups. -
Biochemical Assay Reagent
Chitosan (≥95% deacetylated, viscosity 100-200 mPa.s) is a biopolymer derived from the deacetylation of chitin, targeting a wide range of microorganisms. It demonstrates notable antimicrobial properties against various bacteria and fungi, making it suitable for a variety of biochemical assays and applications. Its unique properties also lend themselves to research in drug delivery, wound healing, and food preservation. -
Biochemical Assay Reagent
L-Ascorbic acid magnesium serves as an essential biochemical assay reagent and functions as an electron donor and endogenous antioxidant. It selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM, highlighting its pharmacological significance. Additionally, L-Ascorbic acid promotes collagen deposition while inhibiting elastin production. Its anticancer properties are attributed to the generation of reactive oxygen species (ROS), which selectively induce damage in cancer cells, making it a valuable tool for research in cellular and molecular biology. -
Impurity of Hydroxychloroquine
Hydroxychloroquine Impurity E is a chemical impurity associated with Hydroxychloroquine, a synthetic antimalarial agent. Hydroxychloroquine is known to inhibit Toll-like receptor 7/9 (TLR7/9) signaling and has demonstrated efficacy in reducing SARS-CoV-2 infection in vitro. This impurity may be useful for studies investigating the purity and activity of Hydroxychloroquine in various biological contexts. -
Biochemical Assay Reagent
Sodium chloride functions as a biochemical assay reagent and is crucial for cell culture applications. This compound induces the expression of ATP1A1 and promotes the secretion of pro-inflammatory cytokines such as IL-2, TNFα, IL-9, alongside various chemokines. Additionally, sodium chloride has been shown to augment the anti-tumor efficacy of Digoxin in small cell lung cancer models. Its role in driving autoimmune disease is linked to the induction of pathogenic Th17 cells, making it significant for studies in inflammation and immune response. -
Biochemical Assay Reagent
(2S)-OMPT triethylamine, in ethanol:chloroform (1:1), 98% is a selective agonist for the LPA3 G-protein-coupled receptor. This compound triggers downstream signaling events by activating calcium ion influx and promoting IL-6 release in cancer cells. Additionally, it has been shown to activate MAPK and Akt signaling pathways, making it valuable for research applications focused on ovarian cancer. -
Iimpurity of Lenvatinib
Lenvatinib N-oxide is a significant impurity of Lenvatinib, a multi-targeted tyrosine kinase inhibitor known for its oral bioactivity. This compound serves as an important reference standard in pharmacological studies, aiding the characterization and quality control of Lenvatinib. Researchers may utilize Lenvatinib N-oxide for analytical purposes to assess the purity and stability of Lenvatinib formulations in various biological research contexts. -
Phosphoramidite Monomer
2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer designed for oligonucleotide synthesis. This compound incorporates a 2'-O-methyl modification and a benzoyl protective group, enhancing the stability and efficiency of synthesized oligonucleotides. It is highly relevant in research applications involving gene expression studies, antisense oligonucleotide design, and RNA interference.
