Catalog No.
Product Name
Application
Product Information
Citations
-
Impurity of Hydroxychloroquine
Hydroxychloroquine Impurity E is a chemical impurity associated with Hydroxychloroquine, a synthetic antimalarial agent. Hydroxychloroquine is known to inhibit Toll-like receptor 7/9 (TLR7/9) signaling and has demonstrated efficacy in reducing SARS-CoV-2 infection in vitro. This impurity may be useful for studies investigating the purity and activity of Hydroxychloroquine in various biological contexts. -
Biochemical Assay Reagent
Lactobionic acid calcium dihydrate is a biomimetic acid that primarily acts as a biochemical assay reagent. This compound exhibits antioxidant and antimicrobial properties, making it useful in various research applications, including food safety and functional product development. Additionally, it has demonstrated the ability to inhibit DNA repair and protein synthesis, as well as induce oxidative stress and block specific metabolic pathways against methicillin-resistant Staphylococcus aureus (MRSA). Lactobionic acid calcium dihydrate can be sourced through electrolytic methods, microbial fermentation, or biocatalytic approaches. -
Biochemical Assay Reagent
Cephalin from bovine brain is a phospholipid that serves as a key biochemical assay reagent. It plays a crucial role in the formation of autophagosome membranes by acting as a lipid anchor for the autophagy-related protein Atg8/LC3. This compound enhances autophagic flux, facilitates cell differentiation, regulates lipid droplet fusion, and influences lipid metabolism, contributing to membrane integrity and potential anti-aging effects. Its applications in research include studies on autophagy, lipid metabolism, and cellular differentiation. -
Phosphoramidite Monomer
2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer targeting oligonucleotide synthesis. This reagent is instrumental in the production of RNA oligonucleotides, offering enhanced stability and improved biochemical properties. Its applications include the development of antiviral agents and therapeutics through the manipulation of RNA structures. -
dIPhosphoramidite
DMT-dA(PAc) Phosphoramidite is a dIPhosphoramidite that serves as an essential building block for the synthesis of DNA and RNA oligonucleotides. This reagent is specifically designed to facilitate the incorporation of deoxyadenosine into nucleic acid sequences, providing researchers with the ability to produce modified oligonucleotides for various applications, including genetic engineering, antisense therapy, and molecular diagnostics. Its protective groups ensure stable synthesis while maintaining high efficiency in coupling reactions. -
Phosphoramidite Monomer
S-cEt-U phosphoramidite is a modified phosphoramidite monomer designed for use in oligonucleotide synthesis. This reagent facilitates the incorporation of modified nucleotides into DNA or RNA sequences, expanding the versatility of synthetic oligonucleotides. Its application is critical in various fields, including gene therapy, antisense oligonucleotide development, and the creation of innovative bioconjugates. -
Phosphoramidites
DMT-2'-F-dA(bz) phosphoramidite is a phosphoramidite specifically designed for the synthesis of oligonucleotides. This compound facilitates the incorporation of 2'-fluoro-deoxyadenosine residues into nucleic acid sequences, enhancing the stability and biological activity of the resulting oligonucleotides. Its applications are significant in fields such as gene therapy, antisense oligonucleotide research, and RNA interference studies. -
Phosphoramidites
DMT-2'O-Methyl-rC(tac) Phosphoramidite is a specialized phosphoramidite utilized in the synthesis of oligonucleotides. This compound facilitates the incorporation of 2'-O-methyl modified ribonucleosides, enhancing the stability and binding affinity of RNA sequences. Its applications are significant in molecular biology for constructing RNA oligonucleotides with improved properties for research and therapeutic purposes. -
Biochemical Reagent
Cytarabine-daunorubicin, also known as CPX-351, is a liposomal formulation that synergistically combines cytarabine and daunorubicin in a 5:1 ratio. This targeted delivery system enhances the concentration of both compounds in leukemia cells while minimizing exposure to normal bone marrow cells. It is utilized in research focused on leukemia treatment and mechanisms, making it a valuable tool for investigating therapeutic strategies and drug efficacy in hematological malignancies. -
Phosphoramidite Monomer
DMT-dI Phosphoramidite is a modified phosphoramidite monomer that serves as a key building block in oligonucleotide synthesis. This compound facilitates the efficient incorporation of deoxyinosine into nucleic acid strands, enhancing the diversity of synthetic oligonucleotides. Its application is essential for various research areas, including gene synthesis, RNA interference studies, and the development of diagnostic tools. -
Cytosine Phosphoramidite
Ac-rC Phosphoramidite is a cytosine phosphoramidite utilized in the chemical synthesis of RNA oligonucleotides. It facilitates the incorporation of cytidine nucleotides into synthetic RNA strands while maintaining the structural integrity of the molecule during complex synthetic procedures through its specialized protecting groups. This reagent is essential for advances in RNA-based research and applications in genetic engineering and antiviral studies. -
Phosphoramidite Monomer
Fmoc-protected DMT-Dt PEG2 NH2 amidite is a phosphoramidite monomer designed for oligonucleotide synthesis. This compound features a protective Fmoc group and a PEG2 linker, enhancing solubility and facilitating the incorporation of amine functionalities into nucleic acids. It is ideal for applications in DNA and RNA synthesis, enabling the development of complex oligonucleotide structures for research in genomics and therapeutic applications. -
Phosphoramidites
DMT-2'-OMe-dA(bz) phosphoramidite is a versatile phosphoramidite used primarily for the synthesis of oligonucleotides. This modified nucleoside contributes to enhanced stability and solubility in synthetic applications. It is suitable for various research applications, including molecular biology, gene synthesis, and diagnostic development. -
Phosphoramidites
N4-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-3’-deoxy-3’-fluoro-beta-D-xylofuranosyl cytidine-2’-CED-phosphoramidite is a phosphoramidite utilized in the synthesis of oligonucleotides. Its structural properties enhance the incorporation of modified nucleotides, contributing to the development of oligonucleotides with improved stability and biological activity. This reagent is valuable for applications in gene modulation, nucleic acid research, and the exploration of antisense and RNA interference strategies. -
Phosphoramidites
DMT-2'-F-dA Phosphoramidite is a modified phosphoramidite that serves as a key reagent in the synthesis of oligonucleotides. Its unique structure incorporates a fluorine atom at the 2' position, enabling enhanced stability and functionality of nucleic acids. This compound is essential for researchers in the fields of molecular biology and genetic engineering, facilitating the development of tailored oligonucleotide sequences for various applications, including diagnostics and therapeutics. -
Phosphoramidites
DMT-LNA-5mA phosphoramidite is a versatile phosphoramidite used primarily for the synthesis of oligonucleotides. Its unique structure features an LNA (locked nucleic acid) modification, enhancing the binding affinity and specificity of oligonucleotide probes. This reagent is essential for applications in molecular biology, including gene expression analysis, antisense oligonucleotide development, and RNA interference studies. -
Phosphoramidites
DMT-LNA-G phosphoramidite is a phosphoramidite that facilitates the synthesis of locked nucleic acid (LNA) containing oligonucleotides. Its unique chemical structure enhances binding affinity and stability of nucleic acid probes, improving their performance in various applications such as molecular diagnostics, RNA interference, and antisense therapy. This reagent is essential for researchers focused on the development of innovative nucleic acid-based therapeutics and tools. -
Phosphoramidites
DMT-2'-O-TBDMS-G(dmf)-CE-phosphoramidite is a phosphoramidite utilized in the synthesis of oligonucleotides. This compound serves as a key building block, facilitating the incorporation of modified nucleotides during solid-phase synthesis. Its biological activity supports research applications in gene synthesis, antisense oligonucleotide development, and RNA interference studies. As a versatile reagent, it enables advancements in nucleic acid research and therapeutic applications. -
Phosphoramidites
DMT-2'-F-Cytidine Phosphoramidite is a specialized phosphoramidite compound used in the synthesis of oligonucleotides. This reagent facilitates the introduction of a 2'-fluorine modification, enhancing the stability and affinity of oligonucleotide therapeutics. Its application is crucial in studying nucleic acid interactions and developing novel antisense and RNAi strategies. -
Biochemical Assay Reagent
Sodium chloride functions as a biochemical assay reagent and is crucial for cell culture applications. This compound induces the expression of ATP1A1 and promotes the secretion of pro-inflammatory cytokines such as IL-2, TNFα, IL-9, alongside various chemokines. Additionally, sodium chloride has been shown to augment the anti-tumor efficacy of Digoxin in small cell lung cancer models. Its role in driving autoimmune disease is linked to the induction of pathogenic Th17 cells, making it significant for studies in inflammation and immune response. -
Biochemical Assay Reagent
(2S)-OMPT triethylamine, in ethanol:chloroform (1:1), 98% is a selective agonist for the LPA3 G-protein-coupled receptor. This compound triggers downstream signaling events by activating calcium ion influx and promoting IL-6 release in cancer cells. Additionally, it has been shown to activate MAPK and Akt signaling pathways, making it valuable for research applications focused on ovarian cancer. -
Iimpurity of Lenvatinib
Lenvatinib N-oxide is a significant impurity of Lenvatinib, a multi-targeted tyrosine kinase inhibitor known for its oral bioactivity. This compound serves as an important reference standard in pharmacological studies, aiding the characterization and quality control of Lenvatinib. Researchers may utilize Lenvatinib N-oxide for analytical purposes to assess the purity and stability of Lenvatinib formulations in various biological research contexts. -
MOF
4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis, specifically targeting the biosynthetic pathway of porphyrins. It exhibits biological activity by interfering with key enzymatic processes involved in heme formation. This compound is useful in studies related to iron metabolism, porphyrias, and the regulation of heme-dependent enzymes in various biological contexts. Its application in chemical research provides valuable insight into metabolic regulation and related disorders. -
Biochemical Reagent
Citrate synthase is an essential enzyme that catalyzes the initial step of the citric acid cycle, facilitating the condensation of acetyl-CoA and oxaloacetate to produce citrate. This enzyme is primarily located in the mitochondrial matrix of eukaryotic cells. Citrate synthase plays a crucial role in cellular metabolism and energy production, making it a valuable biochemical reagent for research applications related to metabolic pathways and mitochondrial function. -
Biochemical Assay Reagent
β-D-Glucose is a monosaccharide that serves as a primary energy source for cells and plays a crucial role in various metabolic pathways. Its chemical properties allow it to be a significant component in both plant and animal tissues, where it is easily metabolized to produce cellular energy. In research applications, β-D-Glucose is utilized as a biochemical assay reagent and serves essential roles in studying metabolic processes, cell culture, and energy production mechanisms. -
MOF
Glutaric acid, a C5 dicarboxylic acid, serves as a key intermediate in the catabolic pathways of lysine and tryptophan. It plays a critical role in influencing pericyte contractility and migration, thereby impacting vascular dynamics. In addition, glutaric acid is recognized as a biomarker in the diagnosis of glutaric aciduria type I, making it relevant for studies in metabolic disorders and related pathways. -
Biochemical Assay Reagent
Fumaric acid disodium, a biochemical assay reagent, serves as a crucial tool in various life science research applications. This compound is utilized for its role in metabolic processes, enabling investigations into biochemical pathways and cellular functions. Its ability to modulate enzymatic activity makes it an essential component for experimental setups aimed at understanding metabolic disorders and cellular metabolism. -
Biochemical Reagent
(S)-2-Aminohexanedioic acid is a biochemical reagent primarily utilized in life science research as a building block in the synthesis of peptides and other organic compounds. This compound plays a crucial role in studies involving amino acid metabolism and protein function. Its application extends to various biochemical assays and experimental models aimed at understanding metabolic pathways and cellular processes. -
Drug Intermediate
m-Tolylacetic acid, also known as 3-Methylbenzeneacetic acid, serves as a hydroaromatic dicarboxylic acid and is commonly found as a metabolite of tolueneacetic acid in urine. This compound is primarily utilized as a drug intermediate, facilitating the synthesis of more complex organic molecules in pharmaceutical research. Its unique structure makes it a valuable component in the development of various bioactive compounds. -
Eszopiclone Impurity
RP 48497 is a photodegradation product and impurity of Eszopiclone, a non-benzodiazepine compound utilized in the management of insomnia. This compound serves as a valuable tool in pharmaceutical research and quality control, aiding in the assessment of Eszopiclone's stability and purity. Its analysis can contribute to a deeper understanding of the drug's degradation pathways and potential effects on efficacy and safety. -
Fexofenadine Impurity
Meta-Fexofenadine is a known impurity of Fexofenadine, which serves as an antihistamine by targeting the H1 receptor (H1R) and is primarily utilized for the treatment of allergic conditions such as seasonal allergic rhinitis and chronic idiopathic urticarial. This compound can be critical for analytical research, particularly in the study of drug purity, metabolic pathways, and formulation development. Its presence is significant in ensuring the quality and safety of Fexofenadine-based therapeutic products. -
Nifedipine Impurity
m-Nifedipine is an impurity associated with Nifedipine, a well-known calcium channel blocker. Nifedipine primarily targets L-type calcium channels, resulting in the relaxation of vascular smooth muscle, which is beneficial in the treatment of cardiac insufficiencies and hypertension. The study of m-Nifedipine may provide insights into the stability, quality, and potential side effects of Nifedipine formulations in pharmaceutical research. -
Impurity of Methotrexate
1,1,3-Tribromoacetone is identified as an impurity of Methotrexate, an established antimetabolite and antifolate that targets dihydrofolate reductase. By inhibiting this enzyme, Methotrexate effectively disrupts the conversion of folic acid to tetrahydrofolate, leading to a significant reduction in DNA synthesis. This compound can be utilized in the study of Methotrexate's pharmacological profiles and potential impurities in biological research. -
Biochemical Assay Reagent
2-(Benzhydrylsulfinyl)acetic acid is a biochemical assay reagent and a known metabolite of modafinil. This compound serves as a useful tool for studying metabolic pathways and pharmacokinetics of modafinil and related compounds. Its unique chemical structure can aid in investigations related to neurotransmitter regulation and cognitive enhancement research. -
Impurity of Palbociclib
N-Methyl Palbociclib is an impurity of Palbociclib, a selective inhibitor of CDK4 and CDK6. This compound is primarily used in analytical studies to assess the purity and quality of Palbociclib formulations. Its relevance in research includes characterization of CDK inhibition and investigations into cell cycle regulation in cancer therapy. -
Impurity of Febuxostat
Febuxostat amide impurity is a known impurity associated with the compound Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. The presence of this impurity can be significant for analytical applications and the assessment of the purity in pharmaceutical formulations. It serves as an important reference material for researchers investigating the chemical integrity and efficacy of xanthine oxidase inhibitors in various biological contexts. -
Osimertinib Mesylate Impurity
Rezivertinib analogue 1 is recognized as a process impurity of osimertinib mesylate, a potent inhibitor of EGFR mutations. This compound serves as a valuable tool in the research of non-small cell lung cancer, facilitating the investigation of drug efficacy and safety profiles in therapeutic applications. Its role in characterizing impurities enhances understanding of the pharmacological landscape surrounding osimertinib-related treatments. -
Labetalol Impurity
Labetalone hydrochloride is an impurity of Labetalol, an orally active adrenoceptor blocking agent. It functions as a competitive antagonist at both alpha- and beta-adrenoceptor sites, contributing to the pharmacological profile of Labetalol. This compound is primarily used in research applications related to cardiovascular pharmacology and the study of adrenoceptor interactions. -
Febuxostat Impurity
Febuxostat sec-butoxy acid is a known impurity of Febuxostat, a selective inhibitor of xanthine oxidase with a Ki of 0.6 nM. This compound serves as a reference standard for analytical and quality control processes in pharmaceutical research. It is essential for investigating the purity and composition of Febuxostat formulations, as well as for understanding the implications of impurities in therapeutic contexts. -
Atorvastatin Impurity
Atorvastatin 3-Deoxyhept-2E-Enoic Acid, a known impurity of Atorvastatin, functions primarily as an HMG-CoA reductase inhibitor. This compound plays a critical role in lipid metabolism regulation and is utilized for analysis in pharmaceutical development and quality control of Atorvastatin formulations. Its presence and characterization are essential for ensuring the purity and efficacy of atorvastatin-based therapies to manage hyperlipidemia and cardiovascular diseases. -
Venetoclax Impurity
Venetoclax N-oxide is an impurity of the Bcl-2 inhibitor Venetoclax (ABT-199; GDC-0199), which exhibits exceptional potency with a Ki value lower than 0.01 nM. This compound serves as a valuable reference for the synthesis and characterization of Venetoclax, and is essential for ensuring the quality and consistency of research involving Bcl-2 modulation. Its analysis is relevant for studies investigating therapeutic applications in hematological malignancies and other conditions associated with dysregulated Bcl-2 activity. -
Cetirizine Impurity
Deschloro Cetirizine dihydrochloride is an impurity of Cetirizine, a second-generation antihistamine and a carboxylated metabolite of hydroxyzine. This compound acts as a selective and orally active histamine H1-receptor antagonist, exhibiting long-lasting antihistaminic effects. It is primarily used in biochemical research aimed at understanding the purity and composition of antihistamine formulations. -
Gefitinib Impurity
Gefitinib impurity 5 is a chemical impurity associated with Gefitinib, a selective EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. This compound effectively inhibits EGF-stimulated tumor cell proliferation (IC50 of 54 nM) and blocks EGFR autophosphorylation in tumor cells, contributing to its antitumor efficacy. Additionally, Gefitinib has been shown to induce autophagy, making it a valuable reagent for research in cancer biology and drug development. -
Acetaminophen Impurity
4-Hydroxyacetophenone oxime is recognized as an impurity of Acetaminophen (Paracetamol), a widely used antipyretic and analgesic. This compound acts as an inhibitor of cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2), contributing to the pharmacological profile of Acetaminophen. It serves as a useful reference for analytical and quality control studies related to Acetaminophen formulations. -
Linezolid Impurity
(R)-Linezolid is an impurity associated with Linezolid (PNU-100766), the first oxazolidinone-synthetic antibiotic. It functions by inhibiting the initiation phase of bacterial protein synthesis, effectively targeting various gram-positive bacteria. This reagent is valuable for research focused on antibiotic characterization, development of new antibacterial agents, and understanding resistance mechanisms. -
Rapamycin Impurity
28-Epirapamycin is an impurity of Rapamycin, a well-characterized inhibitor of the mechanistic target of rapamycin (mTOR). It exhibits potent biological activity with an inhibitory concentration (IC50) of 0.1 nM in HEK293 cells. This compound is primarily utilized for research involving mTOR signaling pathways and cellular growth regulation. It is valuable for studies focused on cancer, metabolic disorders, and age-related diseases. -
Impurity of Febuxostat
Febuxostat dicarboxylic acid impurity is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. This impurity is utilized in chemical analysis and quality control processes in the pharmaceutical industry to ensure the purity and efficacy of Febuxostat formulations. Its characterization is crucial for compliance with regulatory standards and for optimizing drug development protocols. -
Impurity
Captopril EP Impurity D is identified as an impurity associated with Captopril, an angiotensin-converting enzyme (ACE) inhibitor. It serves as a reference standard in pharmaceutical quality control and analytical testing to ensure the purity and compliance of Captopril formulations. This compound is critical for researchers monitoring the chemical profile and safety of ACE inhibitors in drug development and therapeutic applications. -
Chlorthalidone Impurity
Chlorthalidone impurity is a metabolite of the thiazide-like diuretic Chlorthalidone, primarily targeting sodium reabsorption in the renal tubules. This impurity is important for studies involving metabolic pathways and pharmacokinetics of Chlorthalidone. It is particularly relevant for research into hypertension treatment and the identification of potential off-target effects or interactions. -
Drug intermediate
4-Methoxybenzenecarbothioamide is a synthetic intermediate primarily employed in pharmaceutical synthesis. This compound is synthesized through the reaction of 4-methoxybenzamide with phosphorus pentasulfide, facilitating the creation of various thioamide derivatives. Its unique structure and reactivity make it a valuable building block for the development of biologically active molecules in chemical research.
