MMP

Cat. No.

A15323

CAS No.

230961-08-7

UK 356618

UK 356618 is a selective and potent inhibitor of MMP-3 that shows selectivity over a range of MMPs.

Cat. No.

A15326

CAS No.

130464-84-5

Batimastat sodium salt

Synonyms: BB-94 sodium salt

Batimastat is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor.

Cat. No.

A15408

CAS No.

112246-15-8

20(R)-Ginsenoside Rh2

20(R)-Ginsenoside Rh2 is a matrix metalloproteinase (MMP) inhibitor that acts as a cell antiproliferator.

Cat. No.

A15642

CAS No.

29741-09-1

Apigenin-7-glucuronide

Synonyms: Apigenin 7-O-glucuronide

Apigenin-7-glucuronide is a potent inhibitor of Matrix Metalloproteinases (MMP), demonstrating IC50 values of 12.87 µM for MMP-3, 22.39 µM for MMP-8, 17.52 µM for MMP-9, and 0.27 µM for MMP-13. This compound's ability to modulate MMP activity makes it valuable for investigations into extracellular matrix regulation, tissue remodeling, and various inflammatory conditions. Researchers may utilize Apigenin-7-glucuronide in studies aiming to explore therapeutic interventions in diseases associated with MMP dysregulation.

Cat. No.

A15643

CAS No.

29741-10-4

Luteolin 7-O-glucuronide

Synonyms: Luteolin 7-glucuronide

Luteolin 7-O-glucuronide is a potent inhibitor of Matrix Metalloproteinases (MMPs), demonstrating IC50 values of 17.63 μM for MMP-1, 7.99 μM for MMP-3, 11.42 μM for MMP-8, 12.85 μM for MMP-9, and 0.03 μM for MMP-13. This compound is valuable for research investigating the regulation of MMP activity, which plays a critical role in extracellular matrix remodeling and various pathological conditions. It is suitable for applications in studies related to cancer metastasis, tissue repair, and inflammatory disorders.

Cat. No.

A15671

CAS No.

486-21-5

Isofraxidin

Isofraxidin is a coumarin compound derived from *Acanthopanax senticosus* that exhibits anti-invasive and anti-inflammatory properties. It inhibits MMP-7 expression and suppresses cell invasion in human hepatoma cells by reducing ERK1/2 phosphorylation. Isofraxidin also downregulates the expression of iNOS and COX-2 and inhibits the formation of the TLR4/myeloid differentiation protein-2 (MD-2) complex.

Cat. No.

A15945

CAS No.

1762-34-1

Abametapir

Synonyms: HA-44; BRN 0123183; Xeglyze; 6,6'-Bi-3-picoline

Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice.

Cat. No.

A16043

CAS No.

497061-48-0

DC_AC50

DC_AC50 is an inhibitor of copper trafficking proteins Atox1 and CCS, resulting in a disruption of cellular copper transport.

Cat. No.

A16438

CAS No.

57-09-0

Cetrimonium Bromide(CTAB)

Synonyms: Cetyltrimethylammonium Bromide; Hexadecyltrimethylammonium bromide; CTAB

Cetrimonium bromide is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.

Cat. No.

A16519

CAS No.

24390-14-5

Doxycycline hyclate

Synonyms: Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031

Doxycycline hyclate is a broad-spectrum antibiotic and an effective metalloproteinase (MMP) inhibitor. It demonstrates significant antibacterial properties as well as the ability to inhibit cancer cell proliferation. This compound is valuable for constructing models of gene expression regulation in various biological research applications.

Cat. No.

A16915

CAS No.

35730-78-0

Cynaropicrin

Cynaropicrin is a sesquiterpene lactone originally isolated from artichoke (C. scolymus) that has diverse biological activities. It inhibits the growth of SKOV3, LOX-IMVI, A549, MCF-7, HCT15, and PC-3 cancer cells (IC50s = 1.1-8.7 μg/ml).

Cat. No.

A17025

CAS No.

315705-75-0

JNJ0966

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM.

Cat. No.

A17212

CAS No.

287403-39-8

TMI-1

TMI-1 is a novel orally active dual inhibitor of ADAM17 (TACE) and MMP.

Cat. No.

A17240

CAS No.

15866-90-7

Incyclinide

Synonyms: CMT-3; COL3

Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.

Cat. No.

A17545

CAS No.

564-25-0

Doxycycline

Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

Cat. No.

A17676

CAS No.

5144-89-8

o-Phenanthroline monohydrate

Synonyms: 1,10-Phenanthroline monohydrate

o-Phenanthroline monohydrate is a potent MMP inhibitor that acts by chelating divalent metal ions, particularly iron (Fe2+), forming a stable red complex that absorbs light maximally at 510 nm. This compound has demonstrated the ability to prevent chromosomal aberrations in cells exposed to streptozotocin, thereby highlighting its significance in cellular and molecular biology research. It is widely utilized in studies investigating metalloproteinases and their role in various biological processes and disease states.

Cat. No.

A17713

CAS No.

9067-32-7

Hyaluronic acid sodium

Synonyms: Sodium hyaluronate

Hyaluronic acid sodium, also known as sodium hyaluronate, is a glycosaminoglycan that plays a crucial role in the extracellular matrix (ECM). This biopolymer is involved in key biological activities such as cell proliferation, tissue remodeling, and angiogenesis, particularly in the context of digestive cancers. Hyaluronic acid sodium is implicated in tumor cell growth and migration, and it activates the PI3K-Akt signaling pathway. This reagent can also be utilized in research related to joint diseases, wound healing, and as a drug delivery system to enhance the efficacy of therapeutics in cancer research.

Cat. No.

A17813

CAS No.

17086-28-1

Doxycycline monohydrate

Synonyms: Adoxa; Doxycycline; GS-3065; Monodox; Oracea; Vibramycin

Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.

Cat. No.

A18548

CAS No.

544678-85-5

DB04760

DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity.

Cat. No.

A18617

CAS No.

960113-85-3

BR351

BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.

Cat. No.

A19629

CAS No.

2079-89-2

3-Aminopropionitrile fumarate (2:1)

Synonyms: Di-β-aminopropionitrile fumarate; β-Aminopropionitrile fumarate; β-Ammoniumpropionitrile hemifumarate

3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.

Cat. No.

A19772

CAS No.

145337-55-9

Ro 31-9790

Synonyms: GI4747

Ro 31-9790 is a synthetic metalloproteinase (MMP) inhibitor.

Cat. No.

A19954

CAS No.

143584-75-2

S-methyl-KE-298

Synonyms: M-2

S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.

Cat. No.

A20074

CAS No.

203640-27-1

S 3304

S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

Cat. No.

A20333

CAS No.

1001288-58-9

FT011

FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis.