Catalog No.
Product Name
Application
Product Information
Citations
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Plasmin Substrate
Boc-Val-Leu-Lys-AMC is a sensitive fluorogenic substrate specifically designed for the enzyme plasmin. This compound also serves as a substrate for acrosin derived from the ascidian Halocynthia roretzi, as well as porcine calpain isozymes I and II, and papain. Its distinct properties make it an invaluable tool for studying proteolytic activity and enzyme kinetics in various biological research applications. -
TNIK Inhibitor
TNIK-IN-1 is a potent inhibitor of Traf2 and Nck-interacting kinase (TNIK), exhibiting an IC50 of 65 nM. This compound demonstrates significant antitumor activity and is valuable for research investigating the role of TNIK in cancer progression and proliferation. Applications include studying TNIK-mediated signaling pathways and exploring its potential as a therapeutic target in oncology. -
Sperm Acrosin Inhibitor
4-Nitrophenyl 4-guanidinobenzoate hydrochloride is a potent inhibitor of sperm acrosin, a serine protease involved in fertilization. Its mechanism of action facilitates the inhibition of acrosin activity, crucial for sperm-egg fusion. Additionally, this compound acts as a substrate for trypsin, making it valuable for biochemical studies in protease activity and regulation. Researchers can utilize it in studies focused on reproductive biology and enzyme kinetics. -
Mast Cell Tryptase Inhibitor
APC 366 is a selective inhibitor of mast cell tryptase, exhibiting a Ki of 7.1 μM. This compound effectively inhibits antigen-induced early and late asthmatic responses, as well as bronchial hyperresponsiveness in sheep models of allergic asthma. APC 366 serves as a valuable tool for research in asthma pathophysiology and the development of therapeutic strategies targeting mast cell activity. -
TNIK Inhibitor
TNIK-IN-7 is a selective inhibitor of Traf2 and Nck-interacting kinase (TNIK), exhibiting an IC50 of 11 nM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. Its specificity for TNIK allows for the exploration of signaling pathways involved in tumor progression and offers potential insights into targeted therapies for various cancers. -
Serine/threonine Kinase Inhibitor
Tilpisertib fosmecarbil TFA is the trifluoroacetic acid salt form of Tilpisertib, a potent inhibitor of serine/threonine kinases. This compound exhibits significant anti-inflammatory activity, making it valuable for research applications focused on inflammatory pathways and related diseases. Its mechanism of action allows for detailed exploration of kinase-related signal transduction processes in cellular models. -
Chymotrypsin Aα Substrate
Suc-AAPA-pNA is a synthetic peptide substrate specifically designed for the enzyme chymotrypsin Aα. This reagent is employed to evaluate the enzymatic activity of chymotrypsin Aα, providing insights into proteolytic processes involved in various biological functions. Its utility extends to research applications focused on enzyme kinetics and inhibitor studies. -
γ-Tryptase Substrate
D-Leu-Thr-Arg-pNA is a specific substrate for γ-Tryptase, enabling the quantitative assessment of γ-Tryptase activity in biochemical assays. This compound is valuable for studying the inhibition effects of small molecule inhibitors on γ-Tryptase, facilitating research in areas such as allergic responses and inflammation. Its application in enzyme activity assays makes it essential for exploring therapeutic interventions related to protease-mediated diseases. -
Ultraviolet Absorber
4,4'-Dihydroxybenzophenone is a phenolic ultraviolet absorber that primarily targets UV radiation, functioning as a protective agent in various applications. This compound serves as a crucial intermediate in the synthesis of several anticancer agents, including Sivifene. It has been shown to bind to the active site of trypsin, resulting in structural abnormalities and potential impacts on digestive function with prolonged exposure. Additionally, 4,4'-dihydroxybenzophenone exhibits low toxicity to Chlorella vulgaris and moderate toxicity to Daphnia magna, indicating its relevance in ecotoxicological studies. -
Protease Inhibitor
Patamostat is a potent protease inhibitor targeting trypsin, plasmin, and thrombin, with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively. This compound has demonstrated potential in suppressing the pathogenesis and development of acute pancreatitis. Its efficacy in inhibiting critical proteolytic enzymes makes Patamostat a valuable tool for research into protease-related disorders and therapeutic interventions. -
Matriptase Inhibitor
Matriptase-IN-2 free base is a potent matriptase inhibitor, exhibiting a Ki of 5 nM. This compound has significant potential for research applications focused on disorders of the musculoskeletal system. It provides a valuable tool for investigating the role of matriptase in various biological processes and therapeutic interventions. -
TNIK Inhibitor
PF-794 is a selective and potent inhibitor of Traf2- and Nck-interacting kinase (TNIK), exhibiting an IC50 of 39 nM. This ATP-competitive compound specifically targets the TNIK family, leading to a reduction in endogenous p120-catenin phosphorylation in cellular models. PF-794 is utilized in research related to psychiatric disorders, providing a valuable tool for studying the underlying mechanisms of these conditions. -
TAO Kinase Inhibitor
TAO Kinase Inhibitor 2 targets TAO Kinase and exhibits inhibitory activity with an IC50 range of 50 to 500 nM. Additionally, this compound inhibits KIAA1361 and JIK within the same IC50 range. Its selectivity and potency make it a valuable tool for studying the role of TAO Kinase and its related pathways in various biological contexts and disease models. -
Chymotrypsin Inactive Precursor
Chymotrypsinogen is the inactive precursor of the serine protease chymotrypsin, synthesized in the pancreas. Upon activation, it plays a crucial role in protein digestion by hydrolyzing peptide bonds. This reagent is important for biochemical studies involving protease activation and enzymatic activity, as well as for investigating digestive processes in vitro. -
Protease Inhibitor
[Des-Pro2]-Bradykinin is a potent protease inhibitor that effectively prevents the degradation of methionine enkephalin. By inhibiting proteolytic enzymes, it enhances the stability and activity of enkephalins, which are important neuropeptides involved in pain modulation and stress response. This reagent is valuable for studies focused on neurobiology, pain research, and peptide pharmacology. -
Landmark
STn/sialyl-Tn is a sialic acid glycan primarily associated with breast cancer, particularly in HER2-positive tumors. Its expression serves as a valuable biomarker for the identification and quantification of malignant cells in pathological nipple discharge (PND). This reagent is instrumental in cancer research and diagnostics, aiding in the assessment of tumor progression and treatment response. -
HGF-activating Serine Proteases Inhibitor
VD2173 is a macrocyclic peptide inhibitor specifically targeting HGF-activating serine proteases, including matriptase and hepsin. Demonstrating potent inhibition, VD2173 serves as a valuable tool for investigating the role of these proteases in various biological processes. Its use in research on lung cancer can elucidate mechanisms of tumor progression and potential therapeutic interventions. -
Serine/Threonine Kinase Inhibitor
Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases, demonstrating significant anti-inflammatory activity. This compound is valuable for research focused on inflammatory pathways and related signaling mechanisms. Its application may extend to studies investigating various diseases associated with dysregulated kinase activity. -
WNK Inhibitors
STOCK2S-26016 is a selective inhibitor of the WNK (With No K) signaling pathway, targeting WNK4 and WNK1 with IC50 values of 16 μM and 34.4 μM, respectively. This compound exhibits potential biological activity in the modulation of blood pressure regulation and hypertension-related research applications. Its specificity for WNK kinases makes it a valuable tool for studying the physiological and pathological roles of WNK signaling in various cellular processes. -
Tryptase Inhibitor
CRA-2059 is a highly selective tryptase inhibitor with a Ki of 620 pM for recombinant human tryptase-β (rHTβ). This compound demonstrates potent inhibition of tryptase activity, making it a valuable tool for research focused on allergic responses and tissue remodeling. Its specificity for tryptase positions CRA-2059 as an important reagent in studies of inflammatory diseases and related therapeutic development. -
Tripeptidyl-peptidase II Substrate
AAA-pNA is a chromogenic substrate specifically designed for the enzyme Tripeptidyl-peptidase II. This compound enables the quantification of Tripeptidyl-peptidase II activity through colorimetric analysis, facilitating studies on enzyme kinetics and functionality. It is useful in various research applications, including investigations into proteolytic processes and the role of Tripeptidyl-peptidase II in biological systems. -
TMPRSS6 Inhibitor
TMPRSS6-IN-1 is a potent inhibitor of TMPRSS6 (Matriptase-2), a type II transmembrane serine protease (TTSP). Inhibition of TMPRSS6 has been shown to alleviate symptoms associated with conditions such as hemochromatosis and beta thalassemia in preclinical models. This compound is valuable for studies targeting iron metabolism and therapeutic strategies aimed at managing related disorders. -
HtrA Serine Protease Inhibitor
JO146 is a selective inhibitor of the Chlamydia trachomatis high-temperature requirement A (CtHtrA) serine protease, exhibiting IC50 values of 21.86 μM for CtHtrA and 1.15 μM for human neutrophil elastase (HNE). This compound effectively inhibits the proteolytic activity associated with bacterial infections, making it a valuable tool for research into Chlamydia pathogenesis and potential therapeutic interventions. Its ability to target HtrA highlights its relevance in studies focused on bacterial virulence factors and protease biology. -
Urokinase Substrate
Z-Val-Gly-Arg-pNA is a chromogenic substrate specifically designed for the activity assessment of urokinase. Upon cleavage by urokinase, this substrate releases a p-nitroaniline (pNA) product, allowing for the quantification of urokinase activity through spectrophotometric measurement. This reagent is ideal for applications in studies of fibrinolysis, tissue remodeling, and related pathways where urokinase plays a crucial role. -
Protease Inhibitor
(Rac)-Telmesteine is a protease inhibitor that functions as an enzyme stabilizer. This compound is utilized in various applications, including enhancing the stability of proteases in detergents and cleaning agents. Its role as an enzyme stabilizer makes it applicable in research focused on enzyme activity and formulation development in the detergent industry. -
Fluorogenic Substrate
Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate specifically designed for the serine proteases factor XIIa and trypsin. Upon cleavage of the amide bond between arginine and the methylcoumarin amide moiety, it releases the fluorescent compound 7-Amino-4-methylcoumarin, enabling sensitive detection. This substrate is instrumental in studying proteolytic activity and can be utilized in various biochemical assays to monitor enzyme function. -
Urokinase Substrate
Ac-Gly-Lys-OMe acetate is a substrate for urokinase, facilitating the study of its enzymatic activity. This compound is essential for assessing the effects of small molecule inhibitors on urokinase functionality, providing valuable insights in biochemical and pharmacological research related to fibrinolysis and tissue remodeling. -
Oligptide
Suc-AAPY-pNA is an oligopeptide compound that serves as a substrate for various proteases. It undergoes hydrolysis at the peptide bond between tyrosine and p-nitroaniline, resulting in the release of p-nitroaniline, which can be quantified by its absorption peak at OD410. This reagent is utilized in preclinical assays to assess the activity of acidic, neutral, and alkaline proteases, making it valuable for studies on proteolytic processes. -
TMPRSS6 Inhibitor
MD5 is a selective inhibitor of TMPRSS6, demonstrating an IC50 of 22 nM and a Ki of 3.4 nM for recombinant human TMPRSS6. It shows limited inhibition of Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM, and a weak effect on thrombin (Ki of 120 nM). Due to its favorable target specificity and initial drug-like properties, MD5 is suitable for research into iron overload diseases, including hereditary hemochromatosis and β-thalassemia. -
Chymosin substrate
H-Leu-Ser-Phe(NO2)-Nle-Ala-OMe TFA is a substrate specifically designed for the enzyme chymosin. This compound facilitates the study of chymosin activity and its substrate specificity, making it valuable for research in enzymology and protein processing. Its use in biochemical assays can aid in understanding the mechanisms underlying chymosin function in various physiological and industrial contexts. -
Monoclonal Antibody
Exerenibart is an immunoglobulin G4-κ monoclonal antibody that targets human transmembrane serine protease 6 (TMPRSS6). This reagent is instrumental in studying diseases related to iron metabolism disorders, including conditions of iron overload and iron deficiency. Its specificity for TMPRSS6 makes it a valuable tool for research focused on understanding the regulatory mechanisms of iron homeostasis. -
Trypsin Fluorogenic Substrate
Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate specifically designed for the enzyme trypsin. It serves as an effective tool for measuring proteolytic activity, including that of TMPRSS2. This compound is valuable in various biochemical assays and research applications focused on proteolysis and enzyme activity analysis. -
Tryptase Inhibitor
AMG-126737 is a highly selective oral inhibitor of human mast cell tryptase, exhibiting a Ki value of 90 nM. This compound effectively suppresses both early and late-phase bronchoconstriction in sheep models. AMG-126737 is an important tool in the research of asthma and allergic diseases, enabling investigations into novel therapeutic strategies for these conditions. -
FXIIa Inhibitor
Thrombin inhibitor 7 is a selective inhibitor of Factor XIIa (FXIIa) with an IC50 value of 28 nM, demonstrating strong potency. It exhibits minimal activity against Factor XIa (FXIa) with an IC50 value exceeding 132 µM. This compound's low cytotoxicity makes it suitable for various biochemical studies and therapeutic research focused on coagulation pathways. -
Plasminogen Activator Inhibitor
PAI-1, or Plasminogen Activator Inhibitor-1, is a critical regulator of fibrinolysis, functioning primarily as an inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators. As a member of the Ser Protease inhibitor superfamily, PAI-1 exhibits significant antiprotease activity. This reagent is widely utilized in research applications related to thrombosis, tissue remodeling, and cancer metastasis, providing valuable insights into the mechanisms underlying these complex biological processes. -
TNIK Inhibitor
TNIK-IN-4 is a selective inhibitor of TNIK (TRAF2 and NCK interacting kinase) with an IC50 of 0.61 μM. It demonstrates significant inhibitory activity against the colorectal cancer cell line HCT116, making it a valuable tool for studying TNIK's role in oncogenic signaling pathways. This reagent is suited for research applications focused on cancer biology and targeted therapeutic development. -
Serine Protease Inhibitor
Alpha 1 Antichymotrypsin, Human Plasma is a serine protease inhibitor involved in various physiological processes. Its presence in amyloid lesions is associated with Alzheimer’s disease, making it a significant marker in neurodegenerative research. This reagent is valuable for studies focused on Alzheimer's disease pathophysiology and related therapeutic investigations. -
Trypsin Substrate
Boc-Phe-Ser-Arg-AMC is a trypsin substrate featuring a Boc protecting group. Upon cleavage by trypsin, this peptide substrate releases the fluorescent compound AMC, enabling the measurement of trypsin activity through fluorescence. It is an effective tool for studying trypsin function and kinetics in various biochemical assays and research applications. -
Tripeptidyl Peptidase Substrate
Ala-Phe-Pro-pNA is a chromogenic substrate specifically designed for tripeptidyl peptidase. This substrate allows for the assessment of tripeptidyl peptidase activity by producing a colorimetric change upon cleavage. Its properties make it a valuable tool for studying protease functions and for applications in biochemical assays involving tripeptidyl peptidases. -
Protease Inhibitor
Patamostat hydrochloride is a highly effective protease inhibitor, targeting trypsin, plasmin, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively. It demonstrates potential in suppressing the pathogenesis and progression of acute pancreatitis, making it a valuable tool for research focused on protease-related diseases and therapeutic interventions. -
Trypsin Acyl-Enzymes
Suc-AAPR-pNA is a synthetic substrate specifically designed for the detection of trypsin acyl-enzymes activity. Upon hydrolysis by trypsin, it releases p-nitroaniline, allowing for quantification of enzyme activity. This compound is useful in biochemical assays to evaluate trypsin function and investigate related proteolytic pathways. -
Fluorogenic Substrate
Ac-KQL-AMC is a fluorogenic substrate designed to quantify Trypsin-like activity. Upon cleavage by the proteasome, it produces a detectable fluorescence, making it a valuable tool for studying proteolytic activities in various biological contexts. This compound is particularly useful in research applications focused on protein degradation and turnover mechanisms. -
Trypsin Inhibitior
Nostosin G is a linear peptide that acts as a potent trypsin inhibitor, exhibiting an IC50 value of 0.1 μM. Comprised of three subunits—4-hydroxyphenyllactic acid, homotyrosine, and argininal—Nostosin G effectively modulates proteolytic activity. This compound is valuable for research applications focusing on digestive enzymes, protein processing, and potential therapeutic interventions in related disorders. -
Kallikrein Inhibitor
Kallikrein-IN-1 is a selective inhibitor of kallikrein enzymes. By modulating kallikrein activity, this compound plays a vital role in regulating various physiological processes including blood pressure and inflammation. It is valuable for research into cardiovascular diseases and potential therapeutic approaches targeting the kallikrein-kinin system. Kallikrein-IN-1's specificity makes it an important tool for studying enzymatic pathways and their implications in disease states. -
Protease Inhibitor
Dansyl-Glu-Gly-Arg-Chloromethylketone is a potent protease inhibitor that specifically targets serine/threonine proteases. Its mechanism involves the irreversible modification of the enzyme active site, effectively blocking protease activity. This compound is valuable for research applications focusing on blood coagulation processes and the role of serine proteases in various biological systems. Its use facilitates the study of proteolytic regulation mechanisms and contributes to the understanding of protease-targeted therapies. -
Trypsin Inhibitor
Bz-D-Arg-pNA hydrochloride is a competitive inhibitor of trypsin, a serine protease involved in protein digestion and regulation. This compound effectively modulates trypsin activity, making it a valuable tool for investigating protease functions and interactions in various biological systems. Its applications extend to studying enzyme kinetics and exploring the role of trypsin in physiological and pathological processes. -
Trypsin Substrate
Boc-QAR-pNA is a chromogenic substrate specifically designed for the detection of trypsin activity. Upon cleavage by trypsin, Boc-QAR-pNA releases a colored product, allowing for quantitative analysis of enzyme activity. This reagent is valuable in various research applications, including studies of proteolytic enzyme activity and screening for trypsin inhibitors. -
Tryptase Inhibitor
MOL-6131 is a highly selective, reversible inhibitor of tryptase, exhibiting a Ki value of 45 nM. This compound effectively reduces key features of allergic airway inflammation, including eosinophil infiltration in lung tissue, goblet cell hyperplasia, and mucus occlusion of airways. It serves as a valuable tool for research focused on respiratory diseases and allergic responses. -
FVII Inhibitor
Factor VII-IN-1 is a potent inhibitor of factor VII (FVII), exhibiting an IC50 of 1.1 μM. This compound demonstrates anticoagulant properties, making it a valuable tool for research applications focused on coagulation processes and thrombotic disorders. Factor VII-IN-1 can be utilized in studies aimed at understanding the mechanisms of blood coagulation and the development of anticoagulant therapies. -
Chymase Inhibitor
NK3201 is an orally active chymase inhibitor, demonstrating IC50 values of 2.5 nM, 1.2 nM, and 28 nM against human, dog, and hamster chymase, respectively. This compound effectively mitigates Bleomycin-induced pulmonary fibrosis and inhibits vascular proliferation in grafted veins. NK3201 serves as a valuable tool in research focused on fibroproliferative diseases and vascular complications.
