Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
m-PEG9-Br is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of specific intracellular proteins. Its application is critical in the development of targeted protein degradation strategies for drug discovery and therapeutic interventions in various diseases. -
PROTAC Linkers
NH-bis(PEG4-C2-NH-Boc) is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating the targeted degradation of proteins. Its bifunctional structure enhances the solubility and stability of PROTACs, promoting effective cellular uptake and engagement with target proteins. This compound is essential for researchers exploring protein degradation pathways and developing novel therapeutic strategies in targeted protein modulation. -
PROTAC Linker
Azido-PEG2-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups. Its application in PROTAC development allows for the effective modification of target proteins, making it a valuable tool for chemical biology research. -
PROTAC Linkers
Propargyl-PEG1-Boc is a versatile PROTAC linker featuring an alkyne functionality that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent is designed for use in click chemistry, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is particularly valuable for bioconjugation applications and the development of targeted protein degradation strategies. -
PROTAC Linker
Acid-PEG4-mono-methyl ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of protein ligands, enabling the targeted degradation of specific proteins within cellular environments. It is widely utilized in chemical biology and drug discovery applications to explore the modulation of protein function and to develop innovative therapeutic strategies. -
PROTAC Linker
Bis-propargyl-PEG11 is a PEG-based PROTAC linker designed for the efficient synthesis of PROTACs. Featuring an alkyne group, this compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the conjugation of azide-containing molecules. Bis-propargyl-PEG11 is a valuable tool for researchers developing targeted protein degradation strategies and investigating protein interactions. -
PROTAC Linker
Biotin-PEG2-C6-azide is a PEG-based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. Featuring an azide functional group, it facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This reagent is instrumental in developing targeted protein degradation strategies and advancing research in cellular protein modulation and therapeutic discovery. -
PROTAC Linker
Boc-NH-Cyclobutane-COOH is a PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of novel molecules that harness the cell's ubiquitin-proteasome system to selectively degrade target proteins. Its application in chemical biology enables researchers to explore new therapeutic strategies by modulating protein levels within cellular systems. -
PROTAC Linker
4,4'-Oxybis(butan-1-ol) is a versatile PROTAC linker that facilitates the development of PROTACs by connecting target proteins and E3 ligases to promote targeted protein degradation. Its unique structure enhances solubility and stability, making it an essential component in the design of compounds for research in targeted protein degradation therapies. This reagent is valuable for studies in cellular biology and drug discovery applications focused on protein homeostasis. -
PROTAC Linker
PEG2-bis(Alkyne) is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the construction of bifunctional molecules that selectively degrade target proteins via the ubiquitin-proteasome system. Its unique alkyne functionality enables efficient click chemistry, making it suitable for various research applications in targeted protein degradation studies and drug discovery. -
PROTAC Linker
4-(2-Bromoethoxy)benzaldehyde serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is integral in synthesizing molecules that promote the targeted degradation of specific proteins within cellular pathways. Its application enhances the potential for targeted therapeutic strategies in the study of protein regulation and degradation. -
PROTAC Linker
4-(Benzyloxy)butan-1-ol is a versatile PROTAC linker that facilitates the construction of PROTAC molecules for targeted protein degradation. This compound enhances the efficacy of degraders by promoting the selective recruitment of E3 ubiquitin ligases. Its application in synthetic biology and drug discovery underscores its importance in developing novel therapeutic strategies against various diseases. -
PROTAC Linker
7-Azaspiro[3.5]nonan-2-ol hydrochloride serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the targeted degradation of specific proteins through the ubiquitin-proteasome pathway, making it a valuable tool in drug discovery and therapeutic development. Its unique spirocyclic structure contributes to effective protein-protein interactions, aiding in the development of novel targeted therapies. -
PROTAC Linker
2,2'-(Piperazine-1,4-diyl)diethanol serves as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound enables the conjugation of target proteins with E3 ligases, promoting ubiquitination and subsequent degradation of specific proteins. Its application in chemical research allows for the exploration of targeted protein degradation mechanisms, with implications for therapeutic strategy development. -
PROTAC Linker
4-Bromobutyronitrile is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its structural attributes enable effective conjugation to both target proteins and E3 ligases, promoting targeted degradation pathways. This compound is essential for researchers investigating innovative therapeutic strategies in drug discovery and cellular protein regulation. -
PROTAC Linker
4-Aminobut-2-yn-1-ol is a versatile PROTAC linker that plays a critical role in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the design and development of innovative therapeutic agents by enabling the selective degradation of target proteins. Its unique structure enhances the stability and efficacy of PROTACs, making it valuable in drug discovery and protein modulation research. -
PROTAC Linker
tert-Butyl N-[6-(methylamino)hexyl]carbamate functions as a PROTAC linker. This compound is essential in the synthesis of Proteolysis-Targeting Chimeras (PROTACs), enabling targeted protein degradation by connecting an E3 ligase ligand to a specific protein of interest. Its utility in research includes the investigation of protein degradation pathways and the development of novel therapeutic strategies targeting disease-related proteins. -
PROTAC Linker
4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound provides a stable and versatile scaffold for the effective targeting and degradation of specific proteins within cellular pathways. Its incorporation into PROTAC constructs enhances their biological activity, making it suitable for research applications in targeted protein degradation studies. -
PROTAC Linker
1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine serves as a potent PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). Its unique structure enhances the stability and efficacy of PROTACs, enabling targeted degradation of specific proteins. This compound is essential in chemical biology research focused on protein modulation and therapeutic intervention. -
PROTAC Linker
tert-Butyl (azetidin-3-ylmethyl)carbamate hydrochloride is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras. This compound plays a crucial role in synthesizing PROTACs by enabling the targeted degradation of specific proteins, which is essential for dissecting biological pathways and therapeutic interventions. Its robust chemical structure promotes the efficient conjugation necessary for effective target engagement in research applications. -
PROTAC Linker
tert-Butyl 4-(hydroxymethyl)benzylcarbamate is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound provides a flexible and stable connection between the target protein and E3 ligase, enhancing selective degradation in cellular contexts. It is valuable for researchers investigating targeted protein degradation and related therapeutic applications in drug discovery. -
PROTAC Linker
(9H-Fluoren-9-yl)methyl (6-hydroxyhexyl)carbamate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins, making it invaluable for studies aimed at elucidating protein function and cellular pathways. Its structural properties enable efficient conjugation to various protein ligands, advancing research in drug discovery and therapeutic interventions. -
PROTAC Linker
3-(1-(tert-Butoxycarbonyl)azetidin-3-yl)propanoic acid functions as a PROTAC linker, facilitating the design and synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound enhances the targeted degradation of specific proteins, contributing to the advancement of targeted protein modulation research. It is a valuable tool for studies aimed at investigating protein interactions and therapeutic applications in cellular biology. -
PROTAC Linker
2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid serves as a linker in PROTAC (proteolysis-targeting chimera) technology. It facilitates the assembly of bifunctional molecules that promote the targeted degradation of proteins through the ubiquitin-proteasome system. This compound is essential for researchers investigating novel therapeutic approaches in targeted protein degradation and related fields. -
PROTAC Linker
2-(4-(Aminomethyl)piperidin-1-yl)ethanol is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to an E3 ubiquitin ligase, enabling selective degradation of specific proteins within the cell. Its application in chemical biology research allows for the investigation of protein functions and the development of innovative therapeutic strategies. -
PROTAC Linker
tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate functions as a PROTAC (Proteolysis Targeting Chimera) linker, facilitating the design and synthesis of targeted protein degraders. This compound enables the selective degradation of specific proteins, making it valuable for research applications in targeted therapy and cellular regulation studies. Its structural properties support the formation of stable PROTACs, thus advancing drug discovery and development initiatives. -
PROTAC Linker
Tert-butyl 4-(3-aminopropyl)piperidine-1-carboxylate is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in connecting ligand-binding domains to E3 ubiquitin ligases, enabling targeted degradation of specific proteins within cellular pathways. Its application in drug development and biochemical research supports the advancement of innovative therapeutic strategies. -
PROTAC Linker
Tert-butyl 4-(3-chloropropyl)piperazine-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis targeting chimeras. This compound plays a crucial role in molecular design by enabling the selective degradation of target proteins. Its application supports valuable research in targeted protein degradation and therapeutic interventions in various diseases. -
PROTAC Linker
tert-Butyl (5-iodopentyl)carbamate serves as a PROTAC linker, facilitating the development of targeted protein degraders. Its structure enables the effective connection of E3 ligases to the protein of interest, enhancing the recruitment and degradation of specific targets in cellular assays. This compound is essential for researchers exploring the potential of PROTAC technology in therapeutic applications. -
PROTAC Linker
1-Iodo-2-(2-iodoethoxy)ethane serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound's unique structure allows for efficient ubiquitination and subsequent degradation of target proteins, making it a valuable tool in targeted protein degradation studies. Researchers can utilize this linker in various applications within chemical biology and drug discovery targeting specific protein interactions. -
PROTAC Linker
4-Bromo-N-methylbutan-1-amine hydrobromide is a PROTAC linker designed to facilitate the synthesis of PROTACs. This compound plays a crucial role in assembling a bifunctional molecule that can simultaneously engage a target protein and an E3 ligase, leading to targeted protein degradation. It is an essential building block for researchers developing protein degradation strategies in various biological contexts. -
PROTAC Linker
Boc-azaspiro[3.3]heptane-NH-Me is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by promoting the recruitment of E3 ligases. Its unique structural features contribute to effective molecular interactions, making it a valuable tool in targeted protein degradation studies and drug discovery applications. -
PROTAC Linker
Ethyl 7-aminoheptanoate hydrochloride functions as a PROTAC linker, facilitating the assembly of proteins for targeted degradation. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs), enabling researchers to selectively degrade specific proteins within cellular environments. Its structural properties make it ideal for enhancing the efficacy of drug discovery and development in cancer research and other therapeutic areas. -
PROTAC Linker
3-(1-{[(9h-fluoren-9-yl)methoxy]carbonyl}piperidin-4-yl)propanoic acid serves as a versatile PROTAC linker, facilitating the assembly of targeted protein degradation agents. Its structure enables the effective conjugation of ligand pairs, promoting selective degradation of target proteins via the ubiquitin-proteasome system. This reagent is instrumental in the development of innovative therapeutic strategies for various diseases, including cancer. -
PROTAC Linker
tert-Butyl N-({3-aminobicyclo[1.1.1]pentan-1-yl}methyl)carbamate functions as a PROTAC linker, facilitating the design and synthesis of targeted protein degraders. This compound plays a crucial role in the construction of PROTACs, enabling selective degradation of protein targets via the ubiquitin-proteasome system. Researchers can utilize this reagent in various applications involving targeted protein modulation and therapeutic development. -
PROTAC Linker
tert-Butyl(4-iodobutoxy)dimethylsilane is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the effective conjugation of target proteins to E3 ligases, facilitating targeted protein degradation. Its utility in the development of novel therapeutic strategies highlights its importance in chemical biology and drug discovery. -
PROTAC Linker
Piperazine-CH2-propargyl is a versatile PROTAC linker designed for the synthesis of protein-targeting chimeras. It facilitates targeted protein degradation by connecting a ligand to an E3 ligase recruiting component, enabling selective degradation of specific proteins. This compound is essential for researchers aiming to develop novel PROTACs for therapeutic applications in cancer and other diseases. -
PROTAC Linker
1,11-Dibromoundecane functions as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This bifunctional molecule is essential for promoting the selective degradation of target proteins through the recruitment of E3 ligases. It serves as a valuable tool in drug discovery and development, particularly in the study of targeted protein degradation pathways. -
PROTAC Linker
4-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid acts as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the targeted degradation of specific proteins within cellular environments. Its applications include advancing research on protein regulation and the development of innovative therapeutic strategies. -
PROTAC Linker
Diglycolic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in connecting target proteins to E3 ligases, enabling selective degradation pathways. Its application in drug discovery and development highlights its potential in studying protein regulation and therapeutic interventions. -
PROTAC Linker
Methyl 3-(methylamino)propanoate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the conjugation of target proteins to E3 ligases, promoting selective protein degradation in cellular systems. This compound is essential for researchers focused on targeted protein modulation and therapeutic development in the field of cellular biology. -
PROTAC Linker
Tert-butyl methyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)carbamate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by connecting ligands to E3 ligases, enabling targeted protein modulation. Its application is crucial in studies aimed at the development of novel therapeutic strategies in cancer and other diseases through protein degradation technology. -
PROTAC Linker
tert-Butyl 3-(2-iodoethyl)azetidine-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in achieving targeted protein degradation, allowing researchers to manipulate cellular pathways through selective protein modulation. Its application is essential in drug discovery and therapeutic development, particularly in the context of oncology and other diseases where protein deregulation occurs. -
PROTAC Linker
Methyl 4-(hydroxymethyl)bicyclo[2.2.2]octane-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the synthesis of PROTACs by linking target proteins to E3 ligases for targeted degradation. Its precise structural properties make it suitable for various applications in chemical biology and drug discovery, particularly in the study and modulation of protein expression levels. -
PROTAC Linker
N1,N6-Dimethylhexane-1,6-diamine serves as a versatile PROTAC linker, facilitating the effective synthesis of PROTAC molecules. Its structural properties enhance the stability and bioavailability of the resulting conjugates, making it crucial for targeted protein degradation studies. This compound plays a significant role in advancing research applications in cancer therapy and other diseases by enabling the selective modulation of protein levels within cells. -
PROTAC Linker
2-(4-Aminocyclohexyl)acetic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins by linking an E3 ubiquitin ligase to the protein of interest, thereby promoting targeted protein regulation. It is a valuable tool in chemical biology for studying protein function and therapeutic applications. -
PROTAC Linker
6-Boc-(6-Azaspiro[3.4]octane)-2-amino is a specialized linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of bifunctional molecules that can simultaneously bind to a target protein and an E3 ligase, leading to targeted degradation of substrates. Its structural attributes make it an important tool for researchers investigating targeted protein degradation and drug discovery applications. -
PROTAC Linker
9-Aminononan-1-ol is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). Its primary mechanism involves facilitating the selective degradation of specific target proteins through the recruitment of E3 ligases. This compound serves as an essential building block in the development of novel therapeutics aimed at modulating protein function, enhancing research in the fields of cancer and other diseases reliant on targeted protein degradation. -
PROTAC Linker
tert-Butyl 4-(3-bromopropyl)piperidine-1-carboxylate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound is crucial for creating bifunctional molecules that promote selectivity in targeted protein degradation. Its unique structure allows researchers to effectively connect ligand components, enhancing the efficacy of PROTAC-mediated degradation pathways in various biological studies. -
PROTAC Linker
1,6-Hexanedithiol serves as a versatile linker in the synthesis of PROTACs (proteolysis targeting chimeras). It facilitates the connection between target proteins and E3 ligases, enabling targeted protein degradation. This compound is integral for research focused on protein modulation and therapeutic applications in cancer and other diseases.
