Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz is a versatile PROTAC linker designed for targeted protein degradation applications. This compound facilitates the assembly of PROTAC molecules, enabling the selective degradation of target proteins. It is particularly useful in synthesizing complex structures, including those related to Deruxtecan research, thus contributing to studies in cancer therapy and biochemistry. -
PROTAC Linker
Undecane-1,11-diol serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the bioconjugation of Target proteins, allowing for the selective degradation of intracellular proteins. Its linear structure promotes efficient target engagement and contributes to the efficacy of targeted protein degradation strategies in research applications. -
PROTAC Linker
9-Decyn-1-ol serves as an alkyl/ether-based linker in the synthesis of PROTACs, facilitating the conjugation of various compounds. It is central to the generation of INY-03-041 by linking GDC-0068 and Lenalidomide, resulting in a potent pan-Akt degrader that selectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Additionally, 9-Decyn-1-ol features an alkyne group suitable for click chemistry applications, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, which is invaluable in chemical biology research. -
PROTAC Linkers
Amino-PEG16-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves enhancing the solubility and stability of PROTACs while facilitating the selective degradation of target proteins through the ubiquitin-proteasome pathway. This reagent is essential for researchers developing novel approaches for targeted protein degradation in various biological studies and therapeutic applications. -
PROTAC Linkers
m-PEG24-Mal is a polyethylene glycol (PEG)-based linker designed for the synthesis of Protein Targeting Chimeras (PROTACs). This compound features a maleimide moiety that facilitates the conjugation of target proteins, enabling the effective degradation of specific proteins via the ubiquitin-proteasome pathway. Its application in the development of PROTACs supports research in targeted protein degradation and therapeutic strategies against various diseases. -
PROTAC Linker
Boc-PEG4-C2-NHS ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase ligands with target proteins, enhancing the selective degradation of specific proteins via the ubiquitin-proteasome system. Its application in PROTAC development makes it an essential reagent for researchers investigating targeted protein degradation and its therapeutic potential. -
PROTAC Linker
Bromo-PEG6-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the recruitment of E3 ligases, enhancing the degradation of specific target proteins. Its versatile chemistry supports the development of novel therapeutic agents in drug discovery and chemical biology research. -
PROTAC Linker
Carboxy-PEG4-phosphonic acid is a polyethylene glycol (PEG) based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the development of bifunctional molecules that can selectively target and degrade specific proteins within cells. Its application is crucial in advancing research on targeted protein degradation and the modulation of intracellular protein levels for therapeutic purposes. -
PROTAC Linker
Ald-Ph-PEG2-NH-Boc is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by providing a flexible and stable connection between the target protein and the E3 ligase. Its PEG moiety enhances solubility and improves pharmacokinetic properties, making it an essential tool for researchers investigating targeted protein degradation pathways and related therapeutic strategies. -
PROTAC Linker
tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate serves as a versatile linker in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds. This compound is particularly utilized in the development of the PROTAC degrader TrimTAC1, facilitating targeted protein degradation through the recruitment of E3 ligases. Its application in chemical biology enables researchers to investigate protein function and modulation in various biological pathways. -
PROTAC Linker
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its robust chemical properties make it ideal for applications in targeted protein degradation research and chemical biology studies. -
PROTAC Linker
Azido-PEG3-aldehyde is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its azide functionality. It is suitable for use in click chemistry applications, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. In addition, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, contributing to the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
3,4-Dibromo-Mal-PEG2-N-Boc is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, thereby promoting selective degradation of undesired proteins. Its utility extends to various applications in chemical biology and drug discovery, allowing researchers to explore targeted protein modulation strategies. -
PROTAC linker
DSPE-PEG4-DBCO is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs. This compound features a dibenzocyclooctyne (DBCO) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. As a versatile click chemistry reagent, DSPE-PEG4-DBCO facilitates the construction of bifunctional probes for targeted protein degradation studies and other applications in chemical biology. -
PROTAC Linker
Aminooxy-PEG3-propargyl is a PEG-based linker designed for use in PROTAC synthesis. This compound features an alkyne functionality that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its primary application lies in the development of targeted protein degradation agents, advancing research in cellular protein modulation and therapeutic interventions. -
PROTAC Linkers
N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based linker specifically designed for the development of PROTAC molecules. This compound facilitates targeted protein degradation by connecting E3 ligases to the protein of interest, enhancing therapeutic efficacy. It is commonly used in chemical biology and drug discovery applications, enabling precise modulation of protein levels in various cellular contexts. -
PROTAC Linker
Biotin-PEG3-propionic hydrazide is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the conjugation of biotin and other moieties, enhancing the targeted degradation of specific proteins. Its key applications include advancing protein degradation studies and optimizing drug discovery processes through the development of novel PROTAC therapies. -
PROTAC Linkers
m-PEG6-O-CH2COOH is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by providing a flexible linker that enhances the potency and selectivity of targeted protein degradation. Its application in PROTAC development allows researchers to explore novel therapeutic strategies for various diseases, including cancer. -
PROTAC Linker
Benzyl-PEG4-amine is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient conjugation of proteins, enhancing the specificity and efficacy of targeted protein degradation. It is particularly useful in research applications focused on cellular signaling pathways and the development of novel therapeutic strategies for various diseases. -
PROTAC Linkers
Azido-PEG24-alcohol functions as a PEG-based linker for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. It features an azide functional group that enables click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities possessing DBCO or BCN groups. This reagent is essential for the development of targeted protein degradation strategies in biochemical research. -
PROTAC Linker
Ms-PEG2-C2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the conjugation of E3 ligases to target proteins, thereby promoting ubiquitination and subsequent degradation of specific intracellular targets. The incorporation of Ms-PEG2-C2-Boc into PROTAC development enables the modulation of protein levels, making it a valuable tool for targeted protein degradation studies and related therapeutic research applications. -
PROTAC Linkers
m-PEG15-amine is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic linkage, which enhances the solubility and pharmacokinetic properties of the resulting molecules. Its application in drug discovery and development enables targeted degradation of proteins, offering a novel approach for therapeutic intervention in various diseases. -
PROTAC Linkers
Azide-PEG8-alcohol is a polyethylene glycol (PEG)-derived linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. Its versatility in click chemistry makes it a valuable tool for the development of targeted protein degradation systems in biochemical research. -
PROTAC Linker
Bromoacetamido-PEG5-azide is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules. This versatility makes it a valuable tool for researchers in the development of targeted protein degradation strategies. -
PROTAC Linker
Cl-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation strategies by enabling the selective recruitment of E3 ligases to the target protein. Cl-PEG4-acid demonstrates high versatility in various chemical conditions, making it an essential component for researchers focusing on targeted protein modulation and degradation in therapeutic applications. -
PROTAC Linker
NH-bis(PEG2-C2-Boc) is a versatile alkyl/ether-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the assembly of PROTACs by providing a flexible and effective connection between target proteins and E3 ligases. Its application in chemical biology enhances the development of targeted protein degradation strategies, enabling researchers to investigate protein functions and therapeutic interventions in various biological contexts. -
PROTAC Linkers
DBCO-NHCO-PEG6-Biotin is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling the conjugation of biotin for enhanced target protein degradation. This reagent is ideal for applications in chemical biology and drug discovery, particularly in the development of advanced therapeutic modalities. -
PROTAC Linker
Hydroxy-PEG2-CH2-Boc is a polyethylene glycol (PEG) and alkyl-based PROTAC linker that facilitates the synthesis of PROTAC molecules. This compound enhances the solubility and stability of the resulting PROTACs, making it a valuable tool in targeted protein degradation research. Its unique structure allows for improved delivery and activity, enabling enhanced studies in protein interactions and cellular processes. -
PROTAC Linkers
Hydroxy-PEG2-CH2COOH is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC molecules, facilitating their application in targeted protein degradation studies. Its versatile structure makes it suitable for a range of biochemical and cellular assays, contributing to advancements in drug discovery and therapeutic development. -
PROTAC Linker
Azido-PEG1-PFP ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG1-PFP ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, facilitating targeted protein degradation studies in chemical biology research. -
PROTAC Linkers
NH2-PEG8-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of protein ligands and E3 ligase recruiters, enabling targeted protein degradation. It is instrumental in the development of novel therapeutic strategies aimed at modulating protein function in various biological contexts. -
PROTAC Linker
N-Boc-PEG10-alcohol is a polyethylene glycol (PEG)-based linker designed for the construction of PROTACs (proteolysis-targeting chimeras). This compound facilitates the selective degradation of target proteins by linking a ligand for the target protein to an E3 ubiquitin ligase. Its application in PROTAC synthesis underscores its significance in the development of targeted protein degradation strategies for therapeutic intervention. -
PROTAC Linkers
Azido-PEG9-NHS ester is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. Characterized by its azide functional group, this compound facilitates click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile reagent for chemical biology applications. -
PROTAC Linker
PC DBCO-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs, functioning as a critical component in targeted protein degradation. This compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized molecules. It serves as a valuable tool in chemical biology for developing novel therapeutic strategies by enabling the creation of bifunctional compounds that can modulate protein interactions. -
PROTAC linker
Cbz-NH-PEG1-CH2CH2COOH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by promoting the action of E3 ligases. Its unique structure allows for enhanced solubility and biocompatibility, making it suitable for applications in targeted protein degradation research and drug development. -
PROTAC Linker
Cl-PEG2-acid is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. It facilitates the efficient synthesis of PROTACs, enabling targeted protein degradation in various biological systems. This compound can be utilized in the development of novel therapeutics aimed at specific protein targets, enhancing both the selectivity and efficacy of drug discovery efforts. -
PROTAC Linker
Azido-PEG4-4-nitrophenyl carbonate functions as a potent linker for the creation of PROTACs, facilitating targeted protein degradation. This PEG-based compound incorporates an azide group, enabling its use in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules. This reagent is valuable in chemical biology studies focused on targeted therapeutics and protein manipulation. -
PROTAC Linkers
N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based linker designed for use in the synthesis of PROTACs. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized compounds, making it a versatile tool for modular assembly in chemical biology research. -
PROTAC Linkers
SMPH Crosslinker is an alkyl/ether-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of stable ternary complexes between a target protein and an E3 ligase, promoting targeted ubiquitination and degradation. Its unique structure supports various research applications in protein degradation studies, therapeutic development, and targeted protein modulation. -
PROTAC Linkers
Azido-PEG23-amine is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis, enabling targeted protein degradation. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for chemical biology and drug discovery applications. -
PROTAC Linker
Biotin-PEG7-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation. This compound plays a crucial role in the development of targeted protein degradation strategies, enabling researchers to manipulate protein levels in various biological contexts. Biotin-PEG7-amine is essential for advancing research in the field of targeted therapies and cellular protein regulation. -
PROTAC Linker
Mal-amido-PEG6-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation through the ubiquitin-proteasome system. It serves as a crucial tool in chemical biology for developing novel therapeutic agents and understanding cellular protein regulation. -
PROTAC Linker
Azido-PEG4-(CH2)3OH is a PEG-based linker specifically designed for the synthesis of PROTACs. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified partners, making it a versatile tool for modular drug design and protein degradation applications in chemical biology research. -
PROTAC Linker
Tos-PEG4-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby promoting ubiquitination and degradation of specific proteins of interest. Its versatile application makes it invaluable for researchers exploring targeted protein degradation and novel therapeutic strategies. -
PROTAC Linker
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Its unique properties make it suitable for applications in targeted protein degradation research, aiding in the development of innovative therapeutic strategies. -
PROTAC Linkers
Azido-PEG3-chloroacetamide is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities bearing DBCO or BCN groups, facilitating the assembly of complex PROTACs for targeted protein degradation studies. -
PROTAC Linker
Bpin-Cyclohexene-C-COOEt is a PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC SMARCA2/4-degrader-8, enabling selective degradation of specific proteins within the cell. Its structural properties enhance the effectiveness of PROTAC compounds in research related to protein regulation and therapeutic development. -
PROTAC Linker
5-Hexynal is a versatile PROTAC linker that facilitates the synthesis of target-specific PROTAC molecules, such as iRucaparib-TP3. It plays a crucial role in the formation of proteolysis-targeting chimeras, enabling the selective degradation of proteins of interest. This compound is essential for researchers investigating novel therapeutic strategies in targeted protein degradation and drug discovery applications. -
PROTAC Linkers
m-PEG5-SH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. It facilitates the formation of PROTACs by providing a flexible, hydrophilic spacer that enhances solubility and improves the efficacy of targeted protein degradation. This reagent is essential for researchers developing novel therapeutic strategies aimed at manipulating cellular protein turnover and studying protein interactions. Its application is pivotal in advancing the field of targeted protein degradation and drug discovery. -
PROTAC Linkers
m-PEG13-NHS ester is a polyethylene glycol (PEG) derivative designed for use as a linker in PROTAC (Proteolysis Targeting Chimera) synthesis. This reactive NHS ester enables the efficient conjugation of target ligands to E3 ligase moieties, facilitating the assembly of bifunctional molecules that promote targeted protein degradation. Its application enhances the development of novel therapeutic agents in drug discovery and functional proteomics research.
