Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
N1,N4-dimethylcyclohexane-1,4-diamine is a key linker used in the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the recruitment of E3 ubiquitin ligases, thereby promoting the targeted degradation of specific proteins. Its utility extends to applications in cellular assays and drug discovery, enabling enhanced studies of protein interaction and degradation pathways. -
PROTAC Linker
N-(m-PEG4)-N'-(hydroxy-PEG2)-Cy5 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates selective degradation of target proteins through its ability to connect E3 ligases with the protein of interest. Its unique structure enhances solubility and biocompatibility, making it suitable for a variety of research applications in targeted protein degradation studies. -
PROTAC Linker
tert-Butyl ((3-aminocyclobutyl)methyl)(methyl)carbamate serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound enables the targeted degradation of specific proteins by linking ligands to an E3 ligase. Its application in research focuses on studying protein turnover, modulating cellular pathways, and exploring potential therapeutic strategies in various diseases. -
PROTAC Linker
4-(2-Aminoethyl)cyclohexan-1-amine is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of stable covalent bonds between target proteins and E3 ligases, enabling targeted protein degradation. Its application in chemical biology research supports the development of innovative therapeutics aimed at selectively modulating protein levels in various disease contexts. -
PROTAC Linker
Boc-Octahydrocyclopenta[c]pyrrole-amino is a specialized linker used in the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins by linking a ligand to an E3 ligase, enhancing the efficacy of protein modulation in research applications. Its unique structure allows for increased versatility and optimization in PROTAC synthesis. -
PROTAC Linker
4-(2-Chloroethoxy)benzaldehyde is a molecular linker designed for the synthesis of PROTAC (proteolysis-targeting chimera) compounds. It serves as an important component in the construction of PROTACs that facilitate targeted protein degradation. This compound is essential for advancing research in drug discovery and the development of innovative therapeutic strategies by selectively modulating protein levels within cells. -
PROTAC Linker
Di-tert-butyl adipate is a linker specifically utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the formation of bifunctional small molecules that promote targeted protein degradation. Its key applications include drug discovery and development, particularly in biochemistry and cellular biology research involving protein homeostasis and regulation. -
PROTAC Linker
tert-Butyl (2-(azetidin-3-yl)ethyl)carbamate is a synthetic linker designed for use in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of a target protein and an E3 ligase, promoting targeted protein degradation. Its application is crucial in the field of drug discovery for the study of protein function and regulation. -
PROTAC Linker
11-Hydroxyundecanoic acid serves as a PROTAC linker, playing a crucial role in the design and synthesis of protein-targeting chimeras. Its structural properties facilitate the effective conjugation of target proteins with E3 ligases, enhancing proteasome-mediated degradation pathways. This compound is valuable in research applications aimed at the development of targeted protein degradation strategies. -
PROTAC Linker
Boc-PEG3-I is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligands for target proteins, enhancing the degradation of selected substrates through the ubiquitin-proteasome system. Its application in PROTAC development allows researchers to harness targeted protein degradation for therapeutic purposes, making it an essential tool in drug discovery and development. -
PROTAC Linker
3-{[4-(Dihydroxyboranyl)phenyl]formamido}propanoic acid serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound plays a crucial role in synthesizing proteolysis-targeting chimeras (PROTACs), enhancing the delivery of E3 ligase-binding and target protein-binding moieties. Its unique structure allows for efficient assembly of PROTACs, making it valuable in chemical biology research and therapeutic development targeting disease-causing proteins. -
PROTAC Linker
tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate functions as a PROTAC linker, facilitating the development of protein-targeting chimeras. This compound is instrumental in the synthesis of various PROTACs, offering potential for targeted protein degradation in therapeutic applications. Its unique structural properties enhance the efficiency and specificity of target ubiquitination, making it valuable for research in drug discovery and molecular biology. -
PROTAC Linker
15-Bromopentadecanoic acid serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by promoting interactions between E3 ligases and ubiquitinated substrates. Its application is crucial in advancing research on targeted protein degradation and developing novel therapeutic strategies. -
PROTAC Linker
m-PEG16-Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates targeted protein degradation by enabling the conjugation of E3 ligase and target proteins. Its prolonged hydrophilicity enhances solubility and bioavailability, making it a valuable tool for researchers studying protein dynamics and interactions in both cellular and molecular biology applications. -
PROTAC Linker
Thalidomide-O-PEG1-OH is a PROTAC linker that incorporates thalidomide, a ligand for E3 ligases that facilitates the ubiquitination and subsequent degradation of target proteins. The O-ethyl alcohol moiety serves as a versatile functional handle for further chemical modifications, enabling the synthesis of complex molecular architectures. This reagent is ideal for research involving targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
tert-Butyl N-(3-[(3-aminopropyl)(methyl)amino]propyl)carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for creating bifunctional molecules that can selectively target and degrade specific proteins, making it invaluable for research in targeted protein degradation and related therapeutic applications. Its structural properties aid in the efficient conjugation of targeting and ubiquitination motifs necessary for effective PROTAC assembly. -
PROTAC Linker
Henicosanedioic acid is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for creating efficient molecular tools aimed at targeted protein degradation. Its structural properties enhance the connectivity and stability of PROTACs, enabling advanced research in protein regulation and therapeutic applications. -
PROTAC Linker
2-(4-(2-Hydroxyethyl)piperazin-1-yl)acetic acid serves as a PROTAC linker, playing a crucial role in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, contributing to advancements in targeted protein modulation and drug discovery. It is essential for research in the fields of cellular biology and pharmacology. -
PROTAC Linker
tert-Butyl (trans-3-(aminomethyl)cyclobutyl)carbamate functions as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances targeted protein degradation by conjugating E3 ligase ligands and target proteins, thereby promoting targeted therapeutic applications in cancer research and beyond. Its distinct structure allows for improved selectivity and stability in the synthesis of novel PROTAC compounds. -
PROTAC Linker
11-Aminoundecan-1-ol is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By enabling the selective degradation of target proteins, this compound plays a crucial role in targeted protein modulation and therapeutic development. It is widely utilized in drug discovery research, particularly in the study of protein interactions and cellular pathways. -
PROTAC Linker
Hex-5-yn-1-amine hydrochloride acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for conjugating E3 ligase ligands with target proteins, thereby promoting targeted degradation pathways in cellular systems. Its use is pivotal in research applications focused on protein regulation and therapy development. -
PROTAC Linker
Benzyl (4-aminobutyl)carbamate is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). By providing a flexible and stable linkage, it enhances the effectiveness of target protein degradation in cellular environments. This compound is a valuable tool for researchers investigating protein regulation and degradation mechanisms in various biological contexts. Its application spans across drug discovery and the study of disease-related protein interactions. -
PROTAC Linker
tert-Butyl 2-(piperazin-1-yl)acetate hydrochloride serves as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This reagent is essential for the synthesis of PROTACs that engage the ubiquitin-proteasome system, enabling targeted protein degradation. Its utility extends to various research applications in drug discovery and cellular biology, particularly in studies focused on targeted therapeutics. -
PROTAC Linker
Tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate serves as a versatile PROTAC linker, facilitating the design and synthesis of PROTAC molecules. This compound enables the development of targeted protein degradation strategies, enhancing the specificity and efficacy of therapeutic applications. Its ability to create stable linkages makes it a valuable tool in chemical biology research focused on protein modulation and degradation pathways. -
PROTAC Linker
Acid-PEG8-S-S-PEG8-acid is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This bifunctional linker facilitates the conjugation of ligands to E3 ligases, enabling selective degradation of target proteins. It is particularly valuable in chemical biology research focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
PEG1-bis(4,4,5,5-tetramethyl-2-phenyl-1,3,2-dioxaborolane) is an efficient PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by recruiting E3 ligases, enabling the modulation of protein levels for therapeutic purposes. Its unique structure enhances solubility and stability, making it suitable for various biochemical applications, including drug development and target validation studies. -
PROTAC Linker
cis-Ethyl 2-(4-aminocyclohexyl)acetate hydrochloride is a versatile PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural properties enhance the selective targeting and degradation of specific proteins, thereby providing valuable insight into protein function and cellular pathways. This compound is essential for researchers investigating targeted protein degradation strategies in therapeutic applications. -
PROTAC Linker
BnO-PEG2-Br is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins with E3 ligase, enabling the modulation of protein degradation pathways. Its application in drug discovery allows for the targeted degradation of specific proteins, presenting opportunities for innovative therapeutic strategies in cancer and other diseases. -
PROTAC Linker
13-((tert-Butoxycarbonyl)amino)tridecanoic acid is a versatile PROTAC linker utilized in the construction of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective recruitment of E3 ubiquitin ligases to target proteins, promoting their degradation in cellular contexts. It represents a valuable tool for researchers investigating targeted protein degradation and associated pathways in chemical biology. -
PROTAC Linker
Propargyl-PEG1-NH2 hydrochloride is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of specific ligands to target proteins, enabling targeted degradation and modulation of protein function. Its versatile structure supports various applications in chemical biology and drug development, particularly in the study of protein homeostasis and targeted therapeutics. -
PROTAC Linker
2-(but-3-yn-1-yloxy)ethan-1-amine serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. This compound exhibits key biological activity by enabling the selective recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent proteosomal degradation. Its utility extends to research applications in drug discovery, biomarker validation, and elucidation of protein function. -
PROTAC Linker
tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate dihydrochloride is a specialized linker designed for use in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enhancing targeted protein degradation. Its application in PROTAC synthesis supports research in drug discovery, particularly for therapeutic interventions involving protein modulation. -
PROTAC Linker
Pentane-1,5-dithiol serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by linking E3 ubiquitin ligases to the protein of interest, promoting targeted protein downregulation. Its application is crucial in studies focusing on protein clearance mechanisms and therapeutic strategies aimed at modulating protein levels within cellular environments. -
PROTAC Linker
NH2-bicyclo[1.1.1]pentane-C-OH hydrochloride serves as a potent linker for PROTAC (Proteolysis Targeting Chimera) development. This compound facilitates the creation of bifunctional molecules that engage E3 ubiquitin ligases for targeted protein degradation. Its application is critical in exploring protein regulation mechanisms and developing novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Cis-3-(Aminomethyl)cyclobutanol hydrochloride serves as a PROTAC linker, facilitating the development of protein-targeting chimeras. This compound enables the conjugation of target proteins with E3 ligases, promoting targeted protein degradation pathways. Its application in the synthesis of PROTACs contributes to advances in drug discovery and the study of protein function regulation. -
PROTAC Linker
DBCO-PEG5-GGG-NH2 is a versatile PROTAC linker that facilitates the creation of proteolysis-targeting chimeras (PROTACs). This compound efficiently connects target proteins with E3 ligases, enabling the modulation of protein degradation pathways. Its application in synthetic biology allows researchers to explore targeted protein degradation strategies for therapeutic interventions. -
PROTAC Linker
Boc-CH2-O-(CH2)4-OTs functions as a PROTAC linker, facilitating the design and synthesis of targeted protein degraders. This compound is essential for creating PROTAC AR Degrader-5, contributing to the strategy of regulation of protein levels in cellular systems. Its unique structure enables effective conjugation to ligands, enhancing selectivity and efficacy in targeted degradation applications. This reagent is instrumental for research focused on protein modulation and potential therapeutic interventions in diseases involving protein dysregulation. -
PROTAC Linker
Ethyl 3-(N-BOC-piperidin-4-yl)propioate serves as a PROTAC linker, facilitating the generation of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by connecting E3 ligases and substrates, thus enabling precise modulation of cellular pathways. It is valuable in researchers' efforts to develop novel therapeutics and study protein turnover mechanisms. -
PROTAC Linker
Tetracosanedioic acid is a PROTAC (Proteolysis Targeting Chimeras) linker that facilitates the synthesis of PROTACs for targeted protein degradation. Its structure allows for enhanced solubility and bioconjugation, making it a valuable component in the development of novel therapeutic agents. This compound is instrumental in advancing research in targeted therapeutics and elucidating cellular pathways through protein regulation. -
PROTAC Linker
trans-3-(Aminomethyl)cyclobutanol hydrochloride is a chemical compound utilized as a linker in the development of Proteolysis Targeting Chimeras (PROTACs). This reagent is critical for facilitating the targeted degradation of specific proteins, thus enabling detailed studies on protein function and regulation. Its application in PROTAC synthesis underscores its importance in advancing therapeutic strategies and enhancing drug discovery research. -
PROTAC Linker
3-(4-Boronophenyl)propanoic acid serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is crucial for enhancing the specificity and efficacy of PROTAC-mediated degradation of target proteins. Its incorporation in research applications contributes to the advancement of targeted protein degradation strategies within cellular and molecular biology studies. -
PROTAC Linker
Hydroxy-PEG4-NH-CO-OBn is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates targeted protein degradation by connecting a ligand for the target protein with an E3 ubiquitin ligase. Its chemical stability and hydrophilicity make it particularly suited for enhancing solubility and bioavailability in research applications focused on protein modulation and degradation pathways. -
PROTAC Linker
Docosane-1,22-diol is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins, enhancing the efficacy of targeted therapies. Its unique structure enables efficient conjugation to both warheads and E3 ligases, making it a valuable tool in drug discovery and development. -
PROTAC linker
Ethyne-C2-Pip-CO-Pip-Boc is a versatile PROTAC linker designed to facilitate targeted protein degradation. This compound plays a crucial role in the synthesis of novel PROTACs, such as QA-68, enabling the selective modulation of protein function. Its unique structure allows for efficient conjugation to target proteins, making it an essential tool for researchers investigating protein interactions and degradation pathways. -
PROTAC Linker
Boc-PEG2-but-1-yne is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligands to target proteins, enabling targeted degradation through the ubiquitin-proteasome system. Its unique structure enhances solubility and provides a versatile option for research applications aimed at studying protein regulation and signaling pathways. -
PROTAC Linker
17-Bromoheptadecanoic acid serves as a versatile PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound is pivotal in enhancing the efficacy of targeted protein degradation by facilitating the connection between a protein of interest and an E3 ligase. Its unique structural features enable efficient cellular uptake and conjugation, making it a valuable tool for researchers investigating targeted protein modulation and therapeutic interventions in various diseases. -
PROTAC Linker
PEG3-bis(carbonochloridic acid) is a versatile linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the efficient assembly of bifunctional molecules that can simultaneously bind a target protein and an E3 ligase, promoting the ubiquitin-proteasome mediated degradation of specific proteins. This compound is instrumental in molecular biology research aimed at exploring targeted protein degradation pathways and developing therapeutic agents. -
PROTAC Linkers
Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its application is crucial in the development of therapeutics aimed at modulating protein levels and function in various biological pathways. -
PROTAC Linker
Tert-butyl(hex-5-yn-1-yloxy)dimethylsilane serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). Its structure enables the efficient conjugation of target proteins and E3 ligases, thereby promoting targeted protein degradation. This compound is valuable in the design of novel therapeutic agents for drug discovery and development in various biological studies. -
PROTAC Linker
Diethyl heptanedioate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through the ubiquitin-proteasome system. It is essential for researchers aiming to explore targeted protein degradation mechanisms and develop novel therapeutic strategies in various disease contexts.
