Catalog No.
Product Name
Application
Product Information
Citations
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Protein kinase C substrate
Protein kinase C substrate serves as a substrate for Protein kinase C, enabling the detection of phosphorylated proteins. Protein kinase C is a critical regulator in signal transduction pathways, facilitating cellular responses through the phosphorylation of specific substrates. This reagent is essential for studying kinase activity and elucidating signaling mechanisms in various biological contexts. -
PKC-θ Inhibitor
PKC-theta inhibitor 2 hydrochloride is a highly selective inhibitor of protein kinase C theta (PKC-θ), exhibiting an IC50 of 18 nM. This compound modulates key signaling pathways associated with T cell activation and proliferation. It serves as a valuable tool in research investigating autoimmune diseases, cancer therapeutics, and immune response modulation. -
PKC Activator
Teleocidin A1 is a potent activator of protein kinase C (PKC). This compound exhibits significant antiproliferative activity against HeLa cancer cells, with an IC50 of 9.2 nM. Teleocidin A1 serves as a valuable tool for investigating PKC signaling pathways and its implications in cancer research. -
PKC Inhibitor
Safingol is a lyso-sphingolipid that acts as a selective protein kinase C (PKC) inhibitor. It has demonstrated potential in modulating various cellular signaling pathways, making it an important tool in cancer research and studies of cell survival and apoptosis. Safingol is valuable for investigating the role of PKC in diseases and may aid in the development of therapeutic strategies targeting this kinase. -
PKC Substrate
[Ala9,10, Lys11,12] Glycogen Synthase (1-12) serves as a selective substrate for phosphorylation by protein kinase C (PKC). This reagent is useful for assessing PKC activity in various biological contexts, providing insights into signaling pathways involving PKC and glycogen metabolism. Researchers can utilize this substrate to elucidate the regulatory mechanisms of PKC in cellular processes. -
Signal Accepts Peptide
Protein Kinase C Peptide Substrate is specifically designed to act as a substrate for Protein Kinase C, a crucial player in cellular signal transduction. This substrate participates in the phosphorylation of serine and threonine residues in target proteins, modulating various cellular processes in response to second messengers. Its key biological activities include regulation of nervous, endocrine, exocrine, inflammatory, and immune responses. This reagent is valuable for research applications aimed at understanding signaling pathways and the functional roles of Protein Kinase C in cellular physiology. -
BMP Encephalitogenic Epitope
Ac-MBP (1-11) is a synthetic peptide that represents the primary encephalitogenic epitope derived from myelin basic protein (MBP). This peptide is critical for studies on multiple sclerosis and other autoimmune disorders, as it plays a significant role in immune response and T cell activation. Ac-MBP (1-11) is widely utilized in research to understand the mechanisms of demyelination and to explore potential therapeutic interventions. -
OPN4 Inhibitor
AE 51310 is an inhibitor of the OPN4 receptor, effectively disrupting the activation of protein kinase C (PKC) and the downstream BRAF/MEK/ERK signaling cascade. This compound is valuable for cancer research, particularly in the study of non-small cell lung cancer (NSCLC). Its ability to modulate critical signaling pathways makes AE 51310 a useful tool in investigating tumor biology and potential therapeutic targets. -
C8 Ceramide Negative Control
C8 Dihydroceramide serves as a negative control for C8 Ceramide, an analog of naturally occurring ceramides that can penetrate cell membranes. Unlike its active counterpart, C8-Ceramide exhibits anti-proliferative properties, demonstrating its potential as a chemotherapeutic agent and a stimulant for dendritic cell activation, ultimately promoting T cell responses during viral infections. Additionally, C8-Ceramide has been shown to induce mild activation of protein kinase C (PKC) in in vitro studies, making it relevant for research in cell signaling and immunology. -
Munc13-1 Activator
JH-131e-153 is a diacylglycerol (DAG)-lactone that functions as a small molecule activator of Munc13-1 by targeting its C1 domain. This compound demonstrates a specific activation sequence for Munc13-1, with a comparative hierarchy of WT>I590≈R592A≈W588A. Its activation profile reveals homology with protein kinase C (PKC), indicating potential cross-functional mechanisms. JH-131e-153 plays a crucial role in modulating neuronal processes and serves as a valuable tool for investigating the underlying mechanisms of neurodegenerative diseases. -
PKCα Activator
12-Deoxyphorbol 13-isobutyrate is a potent activator of PKCα, derived from the latex of Euphorbia resinifera. It enhances the proliferation and activation of neural stem cells (NSCs) and promotes the release of TGFα, demonstrating a significant role in neurogenesis. Additionally, this compound has been shown to improve cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models, making it a valuable reagent for research into neurodegenerative diseases. -
PKC-ι Inhibitor
PKCiota-IN-1 is a potent inhibitor of protein kinase C iota (PKC-ι) with an IC50 of 2.7 nM. This compound also exhibits inhibitory activity against PKC-α and PKC-ε, with IC50 values of 45 nM and 450 nM, respectively. PKCiota-IN-1 is valuable for studying the role of PKC-ι in various biological processes and has potential applications in cancer research and therapeutic strategies targeting PKC pathways. -
PKC Inhibitor
CIDD-0072424 is a selective inhibitor of Protein Kinase C-epsilon (PKCε), exhibiting an inhibitory constant (Ki) of 54 nM. This compound has been shown to reduce ethanol consumption and preference in a dose-dependent manner, making it a valuable tool for studying alcohol-related behaviors and signaling pathways. It is applicable in research investigating the role of PKCε in addiction and other neurobiological processes. -
Reaction substrate
KRAKAKTTKKR is a synthetic peptide that serves as a substrate for protein kinase C (PKC). It facilitates the study of PKC activity by enabling the assessment of phosphorylation processes. This peptide is utilized in biochemical assays to explore signaling pathways and cellular mechanisms involving PKC, contributing to research in cancer, diabetes, and other diseases influenced by this kinase. -
Antiarrhythmic Agent
HNS-32 is an antiarrhythmic agent that demonstrates vasodilatory effects, providing protective benefits against ischemic and reperfusion arrhythmias in canine hearts. This compound exhibits significant negative chronotropic effects on mammalian ventricular myocardium, highlighting its potential for applications in acute coronary syndrome research. HNS-32 serves as a valuable tool for exploring the mechanisms and treatment options for cardiac arrhythmias. -
Bioactive Peptide
PKCd (8-17) is a bioactive peptide derived from the V1 domain of protein kinase C (PKC)d. This peptide effectively inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Its inhibitory effects on PKCd contribute to reduced ischemic damage in cardiac and cerebral cells, promote fibroblast proliferation, and inhibit graft coronary artery disease in murine models, making it valuable for research in cardiac and cerebrovascular conditions. -
PKA Substrate
Phosphate acceptor peptide is a specific substrate for cyclic AMP-dependent protein kinase (PKA), facilitating the study of phosphorylation processes. Additionally, it exhibits weak inhibitory activity against protein kinase C (PKC), making it useful in exploring the mechanisms of kinase signaling pathways. This reagent is applicable in various biochemical assays aimed at understanding cellular signaling and regulation. -
Anti-cancer Agent
Bryostatin 2 is a 20-membered ring lactone that acts as an anti-cancer agent, specifically targeting the protein kinase C (PKC) pathway. This compound has demonstrated potential in the research of P-388 lymphocytic leukemia, offering insights into its mechanisms and therapeutic applications. Bryostatin 2 is a valuable tool for investigating the role of PKC in cancer cell growth and survival. -
PKC Inhibitor
MT477 is a potent protein kinase C (PKC) inhibitor that induces both apoptosis and necrosis in target cells. This compound effectively reduces the protein expression levels of Ras-GTP, p-Erk1/2, and p-Elk1. Due to its mechanism of action, MT477 demonstrates significant antitumor activity, making it a valuable tool for cancer research and therapeutic investigations. -
Stable Isotope
Stearoyl-L-carnitine-d9 chloride is a deuterated analogue of Stearoyl-L-carnitine chloride, classified as a stable isotope. It serves as a valuable tool in metabolic studies, particularly in understanding lipid metabolism and energy deficiency in type 2 diabetes models. This compound is known to inhibit protein kinase C (PKC) and lecithin cholesterol acyltransferase (LCAT), while also acting as a metabolomic biomarker for Parkinson's disease. Additionally, it demonstrates reduced potency as an inhibitor of GlyT2, providing insights into neurotransmitter dynamics. -
PKC Inhibitor
PKC-IN-5, a protein kinase C (PKC) inhibitor, disrupts the interaction between PKC epsilon (PKCe) and its adaptor protein RACK2. This inhibition can modulate PKC-mediated signaling pathways, making PKC-IN-5 a valuable tool for studying PKC-related cellular processes. Its application extends to research in cancer biology and neurodegenerative diseases, where PKC signaling plays a critical role. -
Protein Kinase C Inhibitor
Ro 31-8830 is a potent and selective inhibitor of protein kinase C, which plays a crucial role in various cell signaling pathways. This compound demonstrates anti-inflammatory activity and is valuable for research focused on inflammatory disorders. Its capabilities make Ro 31-8830 a significant tool for investigating the mechanisms underlying inflammation and evaluating potential therapeutic strategies. -
Phospholipid
Dioleyl phosphatidylserine is a phospholipid known for its role in membrane dynamics and cellular signaling. It has been shown to activate protein kinase C gamma (PKC-γ) at concentrations of 100 μM, particularly under calcium ion (Ca2+) levels less than 0.5 μM. This reagent is valuable for research in neuroscience and cellular biology, particularly in studies focusing on synaptic transmission and cellular responsiveness. -
Protein Kinase C Activator
Methyl arachidonate is an activator of protein kinase C, functioning as an orally active substrate that is subject to esterase-mediated hydrolysis. It promotes the indirect activation of protein kinase C through the generation of eicosanoid metabolites from the arachidonic acid metabolic pathway, demonstrating differential effects via cyclooxygenase products at low concentrations and lipoxygenase products at elevated concentrations. This compound is valuable for investigations into mechanisms related to lipodystrophy. -
PKC Inhibitor
R8605 is a protein kinase C (PKC) inhibitor with a reported IC50 of 65 μM in the rat brain. This compound also inhibits calcium/phospholipid-independent phosphorylation of protamine, with IC50 values of 70 μM and 100 μM, respectively. R8605 is applicable in cancer research, facilitating studies on PKC-mediated signaling pathways and their implications in tumorigenesis. -
PKC Inhibitor
Safingol hydrochloride is a lyso-sphingolipid that functions as a potent inhibitor of protein kinase C (PKC). This compound exhibits significant biological activity in modulating cellular signaling pathways associated with cancer progression and apoptosis. Safingol hydrochloride is primarily utilized in research focused on cancer biology, cardiovascular disease, and neuroprotection, providing valuable insights into PKC-related mechanisms. -
Derivative of L-Tyrosine
3-Methyl-L-tyrosine is a derivative of L-Tyrosine that features a methyl group at the third position of the aromatic ring. This compound acts as a substrate for the protein tyrosine kinase Csk, demonstrating a catalytic efficiency (kcat/Km) of 38% relative to L-Tyrosine, indicating its role in modulating the enzymatic processing of Gsk. Research applications of 3-Methyl-L-tyrosine include studying the molecular recognition mechanisms of Gsk's substrates, which is essential for the design of specific inhibitors targeting Gsk in various therapeutic areas. -
Stable Isotope
Stearoyl-L-carnitine-d3 is a deuterated form of Stearoylcarnitine, functioning primarily as a stable isotope for research applications. This fatty ester lipid is an endogenous metabolite, known to inhibit protein kinase C (PKC) and accumulate in pancreatic β cells, resulting in impaired insulin synthesis and energy deficiency in type 2 diabetes models. Additionally, Stearoyl-L-carnitine-d3 inhibits lecithin cholesterol acyltransferase (LCAT) in animal plasma and serves as a potential metabolomics biomarker for Parkinson’s disease, further expanding its utility in metabolic research. -
PKCβII Inhibitor
PKCβII Peptide Inhibitor I is a selective inhibitor of Protein Kinase C beta II (PKCβII). This peptide demonstrates significant cardioprotective effects in rat models of ischemia/reperfusion injury, making it a valuable tool in cardiovascular research. Additionally, it has been shown to prevent vascular endothelial dysfunction, highlighting its potential applications in studying vascular health and related pathologies. -
PKC Activator
Farnesylthiotriazole (FTT) is a potent activator of protein kinase C (PKC), with a dissociation constant (Kd) of 0.8 μM. This compound plays a significant role in various signaling pathways, making it a valuable tool in cancer research. Its ability to modulate PKC activity can aid in the investigation of tumor biology and therapeutic strategies targeting PKC-related pathways. -
Diacylglycerol
1-Oleoyl-2-linoleoyl-sn-glycerol is a diacylglycerol that acts as an activator of protein kinase C (PKC). This activation initiates downstream signaling cascades that are vital in promoting tumor growth, making it a relevant compound for cancer research. Its role in the signaling pathways related to breast cancer highlights its potential use in studying tumorigenesis and therapeutic strategies. -
PKC Activator
1,2-Dipentadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium is a potent activator of the protein kinase C (PKC) family. This anionic phospholipid is integral to mitochondrial and microsomal membranes, significantly contributing to the composition and function of lung surfactant, particularly within lamellar body membranes in the lungs. Its unique properties make it a valuable tool for studying PKC-mediated signaling pathways and lung physiology. -
Protein Kinase C Inhibitor/LTD4 Antagonist
LY 170198 is a potent protein kinase C inhibitor and LTD4 antagonist. This compound exhibits significant biological activity relevant to studies on tumor promotion, oncogene activation, and protein phosphorylation. Additionally, it is valuable for investigating feedback mechanisms in signal transduction pathways and cellular responses to growth factors, making it a useful tool for cancer research and related fields. -
PKC Inhibitor
Go 7874 is a protein kinase C (PKC) inhibitor that exhibits neuroprotective effects in models of immune-mediated neurotoxicity. This compound mitigates LPS/IFNg-induced neuronal cell death not through conventional PKC inhibition, but by suppressing the expression of inducible nitric oxide synthase (iNOS), leading to decreased nitric oxide (NO) production. Its unique mechanism makes Go 7874 a valuable tool for studying neuroprotective strategies in inflammatory conditions. -
Stable Isotope
(±)-1,2-Diolein-CC3 is a stable isotope-labeled derivative of (±)-1,2-Diolein, also known as 1,2-Dioleoyl-rac-glycerol-13C3. This compound acts as an activator of protein kinase C (PKC) and is known to enhance calcium ion influx in myotubes. It is particularly useful in research applications studying lipid signaling pathways, cell proliferation, and muscle physiology. -
PKCα Inhibitor
Desmethylglycitein (4',6,7-Trihydroxyisoflavone) is an inhibitor of protein kinase C (PKC)α, demonstrating significant anti-cancer and antioxidant activities. It directly binds to CDK1 and CDK2, leading to the suppression of their activity. Additionally, Desmethylglycitein inhibits PI3K in an ATP-competitive manner, affecting downstream signaling pathways and reducing adipogenesis in 3T3-L1 preadipocytes. Its mechanisms make it a valuable tool for research in cancer biology and metabolic disorders. -
PKC Inhibitor
Bisindolylmaleimide X is a potent protein kinase C (PKC) inhibitor that exhibits cell-penetrating properties. It effectively inhibits the proliferation of CD4 T cells in vitro and shows antagonistic activity against cyclin-dependent kinase 2 (CDK2) with an IC50 of 200 nM. Additionally, Bisindolylmaleimide X suppresses eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. This compound is valuable for studying mechanisms in the immune system and cardiovascular diseases. -
PKC Inhibitor
DL-erythro-Dihydrosphingosine is a sphingosine-derived protein kinase C (PKC) inhibitor that functions by directly inhibiting phospholipase A2 (PLA2) activity. This compound also attenuates the function of Bcl-2, a protein that plays a crucial role in regulating apoptosis. Additionally, DL-erythro-Dihydrosphingosine inhibits matrix metalloproteinases (MMPs), which are involved in various cellular processes. Its unique biological activity makes it valuable for research in cancer and inflammatory disease models. -
PKC Activator
1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol that acts as a weak second messenger for the activation of Protein Kinase C (PKC). This compound is utilized in research applications to study PKC signaling pathways, which are crucial in various cellular processes including growth, differentiation, and apoptosis. As a PKC activator, it can help elucidate the role of PKC in different biological contexts and disease models. -
PKC/HCMV Inhibitor
Bisindolylmaleimide IV is a selective inhibitor of protein kinase C (PKC), exhibiting IC50 values between 0.1 and 0.55 μM. It also demonstrates inhibition of protein kinase A (PKA) with IC50 ranging from 3.1 to 11.8 μM. In addition to its kinase inhibitory properties, Bisindolylmaleimide IV effectively inhibits human cytomegalovirus (HCMV) replication in cell culture, displaying an IC50 of 0.2 μM. This reagent is valuable for research applications focused on signal transduction and viral pathogenesis. -
PKC Inhibitor
PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι) with an IC50 value of 0.34 μM. This compound demonstrates significant biological activity relevant to cancer research, making it a valuable tool for investigating the role of PKC-ι in tumorigenesis and signal transduction pathways. It is suitable for studies focused on cancer biology and therapeutic interventions targeting PKC-ι. -
PKC Inhibitor
Sangivamycin is a nucleoside analog that serves as a potent inhibitor of protein kinase C (PKC) with a Ki value of 10 μM. This compound exhibits significant antiproliferative activity against a diverse range of human cancers, making it a valuable tool for cancer research and therapeutic studies focused on PKC modulation. Its targeted mechanism of action positions Sangivamycin as a promising candidate for further exploration in cancer treatment. -
PKCζ/ι Pseudosubstrate Inhibitor
PKCζ/ι Pseudosubstrate Inhibitor serves as a specific inhibitor of protein kinase C (PKC) isoforms ζ and ι. This compound exhibits broad-spectrum inhibitory effects on the PKC enzyme family, making it valuable for studies investigating the role of PKC in cell signaling and neurobiology. Additionally, it has been shown to induce memory impairment, which may be relevant for research on cognitive function and associated disorders.
