Thiostrepton

Catalog No.: A12890

natural cyclic oligopeptide antibiotic

Thiostrepton

Thiostrepton Chemical Structure

CAS NO. 1393-48-2

Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

Availability: In stock

Package Price Qty
100 mg
$60.00
250 mg
$120.00
500 mg
$200.00
1000 mg
$350.00
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Biological Activity

Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 6.01 mL 30.03 mL 60.06 mL
0.5 mM 1.2 mL 6.01 mL 12.01 mL
1 mM 0.6 mL 3 mL 6.01 mL
5 mM 0.12 mL 0.6 mL 1.2 mL

*The above data is based on the productmolecular weight 1664.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12890
CAS No. 1393-48-2
Formula C72H85N19O18S5
M. Wt 1664.89
Solubility DMSO
Purity >98%
Synonyms a-8506
SMILES CC[[email protected]](C)[[email protected]@H]1C(=O)N[[email protected]](C(=O)NC(=C)C(=O)N[[email protected]](C(=O)N[[email protected]]23CCC(=N[[email protected]@H]2C4=CSC(=N4)[[email protected]]([[email protected]](OC(=O)C5=NC6=C(C=CC([[email protected]@H]6O)N1)C(=C5)[[email protected]](C)O)C)NC(=O)C7=CSC(=N7)[[email protected]@H](NC(=O)C8CSC(=N8)/C(=C/C)/NC(=O)[[email protected]@H](NC(=O)C9=CSC3=N9)[[email protected]@H](C)O)[[email protected]@](C)([[email protected]@H]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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