Catalog No.
Product Name
Application
Product Information
Citations
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Benzylamine
N-Methyl-1-phenylpropan-1-amine hydrochloride is a benzylamine derivative that primarily acts as a monoamine transporter inhibitor. This compound exhibits significant biological activity by modulating neurotransmitter levels, making it useful in studies related to neuropharmacology and behavioral research. It serves as a valuable tool for investigating the mechanisms of action in various neurological disorders. -
3,4-MDMA Metabolite
3,4-DHMA TFA (3,4-Dihydroxymethamphetamine) is an active metabolite of 3,4-MDMA, primarily targeting monoamine transporters. This compound exhibits potential biological activity in modulating neurotransmitter levels, contributing to the understanding of its psychoactive effects. It is commonly used in research to study the metabolic pathways and neuropharmacology associated with MDMA. -
Drug Derivative
Doramectin aglycone is a drug derivative with potent antiparasitic activity. Primarily targeting glutamate-gated chloride channels, it exhibits effectiveness against a variety of parasites, making it valuable in veterinary medicine and research into antiparasitic drug development. Its biological activity supports studies on mechanisms of action within the context of parasitic infections and resistance. -
Drug Impurity
Amlodipine impurity 6 is a specific impurity associated with Amlodipine, a calcium channel blocker. This compound is primarily utilized in analytical and quality control applications to ensure the purity of Amlodipine formulations. Its characterization is crucial for regulatory compliance and the development of safe and effective therapeutic agents. -
Drug Impurity
Amlodipine impurity 8 is a drug impurity associated with Amlodipine, a calcium channel blocker. This impurity may arise during the synthesis of Amlodipine and is important for quality control and regulatory compliance in pharmaceutical development. It can also be utilized in analytical studies to assess the purity and stability of Amlodipine formulations. -
Drug Impurity
Amlodipine Impurity 1 is a synthesized impurity associated with Amlodipine, a calcium channel blocker. It is utilized primarily in drug analysis and quality control to ensure the purity and safety of pharmaceutical formulations. This compound can serve as a reference standard in research and development, aiding in the identification and quantification of impurities in Amlodipine products. -
Drug Impurity
Lidocaine impurity 12 is a known impurity of the local anesthetic Lidocaine, which primarily acts as a sodium channel blocker. This compound is valuable for research involving drug formulation and stability studies, as it aids in understanding the impact of impurities on pharmacological profiles. Its characterization is essential for ensuring the quality and safety of Lidocaine-containing formulations. -
Drug Impurity
Clevidipine butyrate impurity 1 is a known impurity of Clevidipine butyrate, which is a calcium channel blocker used in the management of hypertension. This compound serves as a reference standard for analytical tests and quality control assessments in pharmaceutical development. Researchers can utilize this impurity to ensure the purity and safety of drug formulations containing Clevidipine butyrate. -
Natural Product
16-HydroxyCapsaicin is a natural product derived from chili peppers, exhibiting its biological activity primarily through interaction with TRPV1 (transient receptor potential vanilloid 1) channels. This compound is known for its potential analgesic and anti-inflammatory properties, making it a valuable reagent for research in pain relief and sensory biology. Its unique mechanism of action underscores its relevance in studies exploring the modulation of pain pathways and the physiological responses to capsaicinoids. -
Drug Derivative
N-Isopropyl hexylone hydrochloride is a novel drug derivative with potential stimulant properties. It primarily acts on the monoamine transporters, leading to increased levels of neurotransmitters such as dopamine and serotonin. This compound is often utilized in research related to psychostimulant effects and the exploration of new therapeutic avenues for mood disorders and attention-related conditions. -
Benzofuran
4-APB hydrochloride is a benzofuran derivative that acts as a selective serotonin and dopamine reuptake inhibitor. It exhibits significant biological activity, influencing neurotransmitter release and modulating synaptic signaling. 4-APB hydrochloride is commonly utilized in neuropharmacological research to study the effects of monoamine transporters and their role in various neurological disorders. Its properties make it a valuable tool for investigating serotonin and dopamine-related pathways in both in vitro and in vivo studies. -
Drug Derivative
Metfendrazine is a drug derivative that acts primarily as a monoamine transporter inhibitor. It exhibits significant activity in modulating neurotransmitter levels, making it valuable for research in neuropharmacology and behavioral studies. This compound is particularly relevant for investigations into mood disorders and the mechanisms underlying addiction. -
Natural Product
17-Hydroxy Capsaicin is a natural product derived from chili peppers, exhibiting significant activity as a vanilloid receptor (TRPV1) agonist. This compound is known to modulate pain perception and has demonstrated anti-inflammatory properties. Its applications in research include exploring mechanisms of pain relief and the development of novel analgesics, making it a valuable tool in pharmacological studies. -
Drug Derivative
Nav1.7-IN-17 is a derivative compound targeting the voltage-gated sodium channel NaV1.7. This compound demonstrates significant inhibitory activity, making it a valuable tool for studying pain mechanisms and nociception. Its application is particularly relevant in pain research and the development of novel analgesics. -
Anesthetic Agent
Clibucaine is a piperidine derivative with potent local anesthetic properties. It functions by blocking sodium channels, thereby inhibiting neuronal excitability and transmission of pain signals. This compound is primarily utilized in pain management applications, particularly for localized pain relief during surgical procedures and other medical interventions. -
Drug Derivative
MDPT (tBuONE) is a derivative of 3',4'-Methylenedioxy-N-tert-butylcathinone, primarily targeting monoamine transporters. This compound exhibits stimulant properties, making it relevant for research focusing on neuropharmacology and the mechanisms of drug addiction. Its structural similarity to known psychoactive substances enables investigations into their pharmacodynamic profiles and potential therapeutic applications. -
Stable Isotope
rac Felodipine-(Methoxy-d3) is a deuterium-labeled analog of rac Felodipine, a potent calcium channel blocker that primarily targets L-type calcium channels. This stable isotope variant is useful for pharmacokinetic studies, metabolic tracing, and isotopic labeling in drug development research. Its deuterium labeling enhances the analytical sensitivity and specificity in mass spectrometry applications, facilitating the investigation of drug absorption, distribution, metabolism, and excretion (ADME) profiles. -
Stable Isotope
Zonisamide-13C2,15N is a deuterated derivative of Zonisamide, designed to serve as a stable isotope for various research applications. Its primary mechanism targets multiple neuronal pathways, primarily focusing on inhibiting voltage-gated sodium channels and modulating neurotransmitter release. This stable isotope variant is invaluable in pharmacokinetic studies, metabolic labeling, and tracer applications, enabling enhanced tracking of Zonisamide in biological systems. -
Isotope-Labeled Compound
Dibucaine-d9 is a deuterium-labeled derivative of dibucaine, a potent sodium channel inhibitor. It serves as a selective inhibitor of pseudocholinesterase (SChE), making it valuable for studying cholinergic signaling. This isotope-labeled compound is particularly useful in pharmacokinetic studies and metabolic profiling, providing insights into drug metabolism and safety evaluation in chemical research. -
Stable Isotope
Atomoxetine-d5 is a deuterium-labeled derivative of Atomoxetine, a selective norepinephrine reuptake inhibitor that demonstrates Ki values of 5, 77, and 1451 nM for norepinephrine (NE), serotonin (5-HT), and dopamine (DA) transporters, respectively. This compound enhances catecholaminergic neurotransmission and increases DAEX and NEEX levels in the prefrontal cortex (PFC). Atomoxetine-d5 is valuable for research applications related to attention-deficit hyperactivity disorder (ADHD) and the study of sodium channel (VGSC) modulation. -
Stable Isotope
cis-Dihydro Tetrabenazine-d7 is a deuterium-labeled analog of cis-Dihydro Tetrabenazine, primarily utilized as a stable isotope in research applications. Its incorporation of deuterium enhances the precision of metabolic studies and pharmacokinetic analyses. This reagent is valuable in the investigation of vesicular monoamine transporters and can aid in the understanding of neurological disorders where dopaminergic signaling is implicated. -
Cypermethrin Isomer
(1R,2S,1'R)-Cypermethrin is a specific isomer of the pyrethroid pesticide Cypermethrin, classified as Class II due to its moderate toxicity. This compound exhibits significant neurotoxic activity by interacting with voltage-gated sodium channels, leading to prolonged neuronal depolarization. (1R,2S,1'R)-Cypermethrin is primarily employed in research focusing on its effects on nervous system function and insecticidal action. Its ability to cross the blood-brain barrier allows for studies on its impact on both invertebrate and vertebrate models. -
Isotope-Labeled Compounds
Cilnidipine-d3 is a deuterium-labeled derivative of Cilnidipine, primarily acting as a calcium channel blocker. This isotope-labeled compound is valuable for research applications involving pharmacokinetic studies and metabolic profiling. Its use enhances the understanding of Cilnidipine's pharmacological effects and its interactions within biological systems. -
Stable Isotope
Pantoprazole-d4 is a deuterated derivative of Pantoprazole, a potent proton pump inhibitor that targets the H+/K+-ATPase enzyme with an IC50 of 6.8 μM. This stable isotope is utilized primarily in pharmacokinetic studies and metabolic research to enhance the accuracy of drug absorption and distribution analysis. Pantoprazole exhibits anti-secretory and anti-ulcer properties, while its combination with Doxorubicin has been shown to significantly increase tumor growth delay, underscoring its potential utility in cancer research. -
Stable Isotope
Cinnarizine-d8 dihydrochloride is a deuterium-labeled form of the calcium channel blocker Cinnarizine. This stable isotope compound allows for precise tracking and analysis in pharmacokinetic studies. It is primarily utilized in research applications involving metabolic studies and the investigation of drug interactions, enhancing the understanding of pharmacological mechanisms. -
Isotope-Labeled Compounds
Digitoxin-d3 is a deuterated derivative of digitoxin, a cardiac glycoside that primarily targets the Na+/K+ ATPase enzyme, enhancing intracellular calcium levels and improving myocardial contractility. This isotope-labeled compound is utilized in pharmacokinetic studies, providing insights into the metabolism and distribution of digitoxin in biological systems. It serves as a valuable tool for researchers examining heart function and the therapeutic mechanisms of cardiac glycosides. -
Calcium Channel Blocker
Verapamil-d6 hydrochloride is a deuterated derivative of Verapamil, a selective calcium channel blocker. It exhibits potent inhibition of P-glycoprotein (P-gp) and CYP3A4, making it valuable in cardiovascular research, particularly for conditions such as hypertension, arrhythmias, and angina. This isotopically labeled compound aids in pharmacokinetic studies and offers insights into drug metabolism and transport mechanisms. -
Stable Isotope
N-Desalkylflurazepam-d4 is a deuterated analog of N-Desalkylflurazepam, a long-acting metabolite of benzodiazepine compounds, including Flurazepam. This stable isotope is primarily used for research applications involving metabolic studies and pharmacokinetics of benzodiazepines. N-Desalkylflurazepam exhibits inhibitory effects on L-type voltage-gated calcium channels, with reported IC50 values of 55 μM for Cav1.2 and 37 μM for Cav1.3, making it a valuable tool for investigating calcium channel modulation in various biological contexts. -
Stable Isotope
Nifedipine dehydro nitroso-d6 is a deuterium-labeled derivative of Nifedipine dehydro nitroso, primarily utilized as a stable isotope. This compound plays a crucial role in the study of pharmacokinetics and metabolic pathways of calcium channel blockers. Its isotopic labeling facilitates advanced analytical techniques such as mass spectrometry in chemical research applications. -
Stable Isotope
Cyhalothrin-d5 is a deuterated version of Cyhalothrin, a synthetic pyrethroid insecticide that primarily targets voltage-gated sodium channels in insect nerves. This stable isotope is essential for chemical research and environmental studies, particularly in trace analysis and bioaccumulation studies of pesticides. Cyhalothrin-d5 allows for precise quantification in analytical applications, enhancing the understanding of pest management and its ecological impacts. -
Stable Isotope
Desacetyl Diltiazem-d3 is a deuterium-labeled derivative of Desacetyl Diltiazem, designed to serve as a stable isotope standard in analytical applications. This compound can be employed in pharmacokinetic studies and metabolic labeling to trace drug interactions and bioavailability. Its precise labeling enhances accuracy in mass spectrometry and other analytical techniques, making it an invaluable tool for researchers investigating calcium channel blocking activities and cardiovascular-related pharmacology. -
Stable Isotope
2-[(2-Azidoethoxy-d4)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine is a deuterium-labeled compound that targets dihydropyridine receptors. This stable isotope variant is significant in researching the pharmacokinetics and metabolic pathways of dihydropyridine derivatives. It is particularly valuable in studies involving the pharmacological effects and interactions of calcium channel blockers, facilitating advanced analysis in medicinal chemistry and drug development. -
Pregabalin Impurity
Pregabalin lactam is an impurity of Pregabalin, a compound primarily targeting calcium channels. This metabolite is often utilized in quality control and analytical studies of Pregabalin formulations. Its presence in research can provide insights into compound stability and purity, contributing to a better understanding of Pregabalin's pharmacological profile. -
Drug Impurity
Flecainide Impurity 3 is a known impurity of the antiarrhythmic agent Flecainide, which primarily targets sodium channels to exert its pharmacological effects. This compound is crucial for quality control in the pharmaceutical industry, allowing researchers to assess the purity and stability of Flecainide formulations. Its identification and quantification are essential for ensuring compliance with regulatory standards in drug development and manufacturing. -
Pantoprazole Impurity
Pantoprazole N-oxide is a known impurity associated with the synthesis of Pantoprazole, a proton pump inhibitor (PPI) utilized in the treatment of conditions linked to excessive gastric acid, including gastric ulcers and gastroesophageal reflux disease (GERD). This compound is valuable for analytical research and quality control processes, aiding in the characterization and assessment of Pantoprazole formulations. Its presence in pharmaceutical development highlights the importance of monitoring impurities to ensure product safety and efficacy. -
Antiarrhythmic Agent
R-(–)-Flecainide is an orally active antiarrhythmic agent that primarily targets voltage-gated sodium channels to inhibit ectopic ventricular activity. It effectively stabilizes cardiac cell membranes and is utilized in the management of various cardiac arrhythmias. Research applications include studies on cardiac electrophysiology and drug interactions in arrhythmogenic conditions. -
KM-001 Isomer
KM-001-E2 is the (S)-enantiomer of KM-001, a selective antagonist of the TRPV3 channel. This compound plays a significant role in investigating the mechanisms underlying skin itching and keratinization disorders. Its application in research may provide insights into TRPV3-related pathophysiology and potential therapeutic strategies for skin conditions. -
Drug Isomer
2-Methylethcathinone hydrochloride is an isomer of the psychoactive compound ethcathinone. It primarily functions as a stimulant, exerting its effects by interacting with monoamine transporters, leading to increased levels of neurotransmitters such as dopamine and norepinephrine. This compound is utilized in research focused on neuropharmacology and the study of designer drugs, contributing to the understanding of their mechanisms of action and potential therapeutic applications. -
S-isomer Of Ranolazine
(S)-Ranolazine is the S-isomer of the antianginal agent Ranolazine, which primarily targets the cardiomyocyte sodium channels. It demonstrates significant biological activity in reducing myocardial ischemia and angina by modulating ion currents and improving cardiac energy metabolism. This compound is used in cardiovascular research to explore mechanisms of action related to cardiac function and ischemia. -
Drug Isomer
2-Methylethcathinone (2-MEC) is an isomer of the psychoactive substance methcathinone, primarily acting as a monoamine transporter inhibitor. This compound exhibits stimulant properties, influencing the release and reuptake of neurotransmitters such as dopamine, norepinephrine, and serotonin. 2-MEC is utilized in research exploring its pharmacological effects, potential therapeutic implications, and the underlying mechanisms of psychostimulants. -
Isomer of 4-Bromoamphetamine
2-Bromoamphetamine hydrochloride is an isomer of 4-Bromoamphetamine, primarily targeting monoamine transporters. This compound exhibits psychoactive properties, influencing neurotransmitter systems such as serotonin and dopamine. It is utilized in scientific research to explore the mechanisms underlying mood regulation and behavioral responses. -
VMAT2 Substrate
FFN 206 dihydrochloride is a selective substrate for the Vesicular Monoamine Transporter 2 (VMAT2), exhibiting an apparent Km of 1.16 μM. This fluorescent probe enables the detection of VMAT2 activity in intact cells via fluorescence microscopy, allowing for the visualization of subcellular localization to VMAT2-expressing acidic compartments while minimizing labeling of other organelles. Its application is essential for studying monoamine transport dynamics and cellular compartmentalization in neurobiological research. -
H+, K+-ATPase Inhibitor
Esomeprazole magnesium, a potent H+, K+-ATPase inhibitor, is utilized in research related to upper intestinal disorders and gastroesophageal reflux disease. Its primary mechanism involves the inhibition of proton pumps, leading to decreased gastric acid secretion. Additionally, Esomeprazole magnesium exhibits properties as an exosome inhibitor by blocking exosome release through the inhibition of vacuolar H+-ATPases, making it valuable for studies on cellular communication and disease progression. -
Antiarrhythmic Agent
Propafenone, a sodium channel blocker, functions as an antiarrhythmic agent by modulating cardiac ion currents. It displays significant binding affinity for β receptors (IC50 = 32 nM) and effectively inhibits the transient outward current (Ito) and sustained delayed rectifier potassium current (Isus) with IC50 values of 4.9 μM and 8.6 μM, respectively. Additionally, Propafenone demonstrates potential in anticancer research by suppressing the proliferation of esophageal cancer cells through the induction of mitochondrial dysfunction and apoptosis. -
Anti-malarial Agent
Quinine hydrochloride dihydrate is an anti-malarial agent primarily known for its inhibitory action on potassium channels. It effectively inhibits wild-type mouse Slo3 (KCa5.1) channel currents in response to voltage pulses, exhibiting an IC50 value of 169 μM. This compound is essential for research into malaria treatment and the study of ion channel modulation in various biological contexts. -
Antiepileptic Agent
Rufinamide is an oral antiepileptic agent that primarily inhibits sodium channel activation, leading to reduced neuronal hyperexcitability and anticonvulsant effects. This compound is particularly relevant in the study of Lennox-Gastaut syndrome, providing insights into its mechanisms and potential therapeutic strategies. Rufinamide's efficacy in mitigating seizures makes it a valuable tool for research in epilepsy and related neurological disorders. -
Stable Isotope
Atazanavir-d9 is a deuterated analog of Atazanavir, a highly selective HIV-1 protease inhibitor. This compound targets the HIV-1 protease enzyme, facilitating the treatment of HIV infections with its ability to inhibit viral replication. Additionally, Atazanavir acts as both a substrate and inhibitor of CYP3A4, as well as an inducer of P-glycoprotein (P-gp). Furthermore, Atazanavir possesses inhibitory activity against SARS-CoV 3CLpro, with an IC50 of 3.49 μM, making it relevant for research in antiviral therapies. -
Na+/Ca2+ Channel Blocker
Flunarizine dihydrochloride is a potent dual blocker of Na+ and Ca2+ channels, specifically targeting T-type calcium channels. This compound exhibits significant anticonvulsant and antimigraine properties, making it valuable for neurological research. Additionally, Flunarizine dihydrochloride demonstrates peripheral vasodilatory effects, enhancing its potential applications in vascular studies. -
Sodium Channel Inhibitor
Mepivacaine hydrochloride is a sodium channel inhibitor that selectively binds to voltage-gated sodium ion channels in neuronal cell membranes. By inhibiting sodium influx and membrane depolarization, it provides significant local anesthetic effects. This compound is widely used in research applications related to nerve conduction studies and pain management investigations. -
Muscarinic Receptor Antagonist
Afacifenacin is a potent and orally active muscarinic receptor antagonist that targets the bladder afferent pathway. It exerts its biological activity by inhibiting sodium channels, leading to increased bladder volume and a reduction in the frequency of urination and incontinence. This compound is valuable for research focused on overactive bladder (OAB) and related urological conditions.
