Membrane Transporters-Ion Channels

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  1. CFTR potentiator

    Ivacaftor benzenesulfonate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.
  2. CFTR potentiator

    Ivacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.
  3. CFTR potentiator

    PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. PG 01 is effective on G970R although with a significant decrease in potency relative to E193K and δF508.
  4. CFTR potentiator

    GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.
  5. CFTR potentiator

    GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
  6. AMPA receptors potentiator

    Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

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