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- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
Biological Activity
Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 69.34 mL | 346.72 mL | 693.43 mL |
| 0.5 mM | 13.87 mL | 69.34 mL | 138.69 mL |
| 1 mM | 6.93 mL | 34.67 mL | 69.34 mL |
| 5 mM | 1.39 mL | 6.93 mL | 13.87 mL |
*The above data is based on the productmolecular weight 144.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17323 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 99-66-1 |
| Formula | C8H16O2 |
| M. Wt | 144.21 |
| Purity | >98% |
| Synonyms | Valproic acid; Depakin; Erganyl; Stavzor; Valproate |
| SMILES | CCCC(CCC)C(O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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