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Valproic acid

Catalog No.: A17323

HDAC inhibitor

Valproic acid

Valproic acid Chemical Structure

CAS NO. 99-66-1

Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

Availability: In stock

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1 mg
$40.00
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Warning WARNING: Attention California Residents: This product can expose you to chemicals including Valproic acid , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046

Biological Activity

Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 69.34 mL 346.72 mL 693.43 mL
0.5 mM 13.87 mL 69.34 mL 138.69 mL
1 mM 6.93 mL 34.67 mL 69.34 mL
5 mM 1.39 mL 6.93 mL 13.87 mL

*The above data is based on the productmolecular weight 144.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17323
Actions Inhibitor
CAS No. 99-66-1
Formula C8H16O2
M. Wt 144.21
Purity >98%
Synonyms Valproic acid; Depakin; Erganyl; Stavzor; Valproate
SMILES CCCC(CCC)C(O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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