Z-VAD-FMK

Catalog No.: A12373

Pan Caspase Inhibitor

Z-VAD-FMK Chemical Structure

CAS NO. 187389-52-2

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Availability: In stock

Package Price Qty
1 mg
$40.00
5 mg
$120.00
10 mg
$200.00
25 mg
$350.00
10mM * 1mL in DMSO
$246.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
Targets
Pan-caspase (THP.1, Jurkat T-cells)
0.0015 - 5.8 mM (IC50)
In vitro (25°C) DMSO 93 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol 24 mg/mL heating (51 mM)
In vivo DMF 84 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.39 mL 106.95 mL 213.91 mL
0.5 mM 4.28 mL 21.39 mL 42.78 mL
1 mM 2.14 mL 10.7 mL 21.39 mL
5 mM 0.43 mL 2.14 mL 4.28 mL

*The above data is based on the productmolecular weight 467.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12373
Actions Inhibitor
M. Wt 467.49
Formula C22H30FN3O7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 187389-52-2
Synonyms N/A
SMILES C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](C(C)C)NC(=O)OCC1=CC=CC=C1

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