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Z-VAD-FMK
Catalog No.: A12373
Pan Caspase Inhibitor
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
Adooq Products cited in reputable paper
Adooq's Z-VAD-FMK has been cited by 44 publications
Lara Ebbert, .et al. , Antioxidants (Basel) , 2024, Jul; 13(7): 864 PMID: 39061932 Rushikesh Deshpande, .et al. , Int J Mol Sci , 2024, Jan 18;25(2):1157 PMID: 38256231 Sarah Metcalfe, .et al. , J Leukoc Biol , 2023, Jul 27;qiad089 PMID: 37497744 Kazutoshi Toriyama, .et al. , Oncol Lett , 2023, Nov 10;27(1):12 PMID: 38028184 Bopei Cui, .et al. , Signal Transduct Target Ther , 2023, Sep 25;8(1):366 PMID: 37743418 Akira Endo, .et al. , Dev Cell , 2023, Oct 9;58(19):1819-1829 PMID: 37716356 Rui Zhou, .et al. , Nagoya J Med Sci , 2023, Aug;85(3):579-591 PMID: 37829490 Chantal-Kristin Wenzel, .et al. , Toxicol In Vitro , 2023, Sep;91:105625 PMID: 37268255 Joshua H Choe, .et al. , Cancer Discov , 2023, May 4;13(5):1250-1273 PMID: 37067901 Yu-Chih Hsu, .et al. , Int J Med Sci , 2023, 20(4): 444-454 PMID: 37057216 Debin Qi, .et al. , Cell Cycle , 2023, Apr;22(7):818-828 PMID: 36482709 Ming-Chun Hung, .et al. , Cell Biosci , 2022, 12: 122 PMID: 35918763 Kaori Kanemaru, .et al. , Nat Commun , 2022, May 9;13(1):2347 PMID: 35534464 Chie Ishikawa, .et al. , Invest New Drugs , 2022, Aug;40(4):718-727 PMID: 35477814 Aida Falgas, .et al. , Biomed Pharmacother , 2022, Jun;150:112940 PMID: 35421785 Sumire Suzuki, .et al. , Oncol Rep , 2022, Feb;47(2):40 PMID: 34958115 Lina Y Abou Zeid, .et al. , Cell Stress Chaperones , 2022, Jan;27(1):11-25 PMID: 34719748 Simon Boudreault, .et al. , Viruses , 2022, Dec 3;14(12):2710 PMID: 36560714 Kosar Jabbari, .et al. , Cancers (Basel) , 2021, Sep 8;13(18):4521 PMID: 34572749 Xiaoyue Deng, .et al. , Invest Ophthalmol Vis Sci , 2021, May 3;62(6):1 PMID: 33938913 Liqun Zhao, .et al. , Apoptosis , 2021, Apr 27 PMID: 33905036 Hideyuki Kinoshita, .et al. , Anticancer Res , 2021, Dec;41(12):6013-6021 PMID: 34848455 Sofia Giacosa, .et al. , Cancers (Basel) , 2021, Feb 2;13(3):576 PMID: 33540838 Hideyuki Kinoshita, .et al. , Anticancer Res , 2021, Oct;41(10):4947-4955 PMID: 34593442 Hannes Schmid, .et al. , Haematologica , 2021, Jan 14 PMID: 33440919 Hua Xu, .et al. , Cancers (Basel) , 2020, Apr; 12(4): 831 PMID: 32235588 El-Ashmawy NE, .et al. , Pathol Oncol Res , 2020, Jan 4 PMID: 31902118 Schneider D, .et al. , Clin Epigenetics , 2019, Jul 2;11(1):98 PMID: 31266541 Fujiki K, .et al. , Cell Death Differ , 2019, Feb 25 PMID: 30804470 T Yamamoto, .et al. , Cell Microbiol , 2019, 2019 PMID: 30702185 Maeda N, .et al. , J Biol Chem , 2019, Nov 13. pii: jbc.RA119.010379 PMID: 31723031 Miyazawa S, .et al. , Breast Cancer , 2019, Oct 17 PMID: 31625014 Yeh HT, .et al. , Eur J Pharmacol , 2019, Sep 10;863:172658 PMID: 31518562 D. Bosc, .et al. , Sci Rep , 2018, 8: 11653 PMID: 30076329 Tsukamoto H, .et al. , J Biol Chem , 2018, Jun 29;293(26):10186-10201 PMID: 29760187 Hiroshi Kuribayashi, .et al. , Cell Death Dis , 2018, Sep; 9(9): 891 PMID: 30166529 Matsuo J, .et al. , Can J Microbiol , 2018, Oct 18:1-9 PMID: 30336068 Orly Ravid, .et al. , Front Cell Neurosci , 2018, 12: 359 PMID: 30459557 Im E, .et al. , Life Sci , 2018, Sep 15;209:259-266 PMID: 30107166 Szalai P, .et al. , Cell Calcium , 2018, Dec;76:48-61 PMID: 30261424 Im E, .et al. , Life Sci , 2018, Jan 1;192:286-292 PMID: 29128513 Iriyama N, .et al. , Leuk Lymphoma , 2018, Jun;59(6):1439-1450 PMID: 28918692 Birte Plitzko, .et al. , J Biol Chem , 2017, Dec 22; 292(51): 21102-21116 PMID: 29074620 Akashi E, .et al. , Oncol Rep , 2017, Jul;38(1):506-514 PMID: 28586026
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Biological Activity
Discription
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
Targets
Solubility
In vitro (25°C)
DMSO
80 mg/mL (171.12 mM)
Water
Insoluble
Ethanol
Insoluble
In vivo
2% DMSO+35 %PEG 300+2%Tween 80+ddH2O
5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
0.1 mM
21.39 mL
106.95 mL
213.91 mL
0.5 mM
4.28 mL
21.39 mL
42.78 mL
1 mM
2.14 mL
10.7 mL
21.39 mL
5 mM
0.43 mL
2.14 mL
4.28 mL
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
* Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1 V1 = C2 V2
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