Z-VAD-FMK

Name: Z-VAD-FMK
SKU: A12373

Catalog No.: A12373

Pan Caspase Inhibitor

Product Citations (16)

Miyazawa S, .et al. Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines, Breast Cancer, 2019, Oct 17 PMID: 31625014
Yeh HT, .et al. Flavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells, Eur J Pharmacol, 2019, Sep 10;863:172658 PMID: 31518562
Schneider D, .et al. The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells, Clin Epigenetics, 2019, Jul 2;11(1):98 PMID: 31266541
Fujiki K, .et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
T Yamamoto, .et al. Mycoplasma pneumoniae protects infected epithelial cells from hydrogen peroxide‐induced cell detachment, Cell Microbiol, 2019, 2019 PMID: 30702185
D. Bosc, .et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B, Sci Rep, 2018, 8: 11653 PMID: 30076329
Tsukamoto H, .et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKε-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
Hiroshi Kuribayashi, .et al. Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation, Cell Death Dis, 2018, Sep; 9(9): 891 PMID: 30166529
Matsuo J, .et al. Activation of caspase-3 during Chlamydia trachomatis-induced apoptosis at a late stage, Can J Microbiol, 2018, Oct 18:1-9 PMID: 30336068
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Z-VAD-FMK Chemical Structure

CAS NO. 187389-52-2

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Availability: In stock

Package	Price	Qty
1 mg	$40.00
5 mg	$120.00
10 mg	$200.00
25 mg	$350.00
10mM * 1mL in DMSO	$246.00

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

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Biological Activity

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Targets

Pan-caspase (THP.1, Jurkat T-cells)
0.0015 - 5.8 mM (IC50)

Solubility *

In vitro (25°C)	DMSO	93 mg/mL (198 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	24 mg/mL heating (51 mM)
In vivo	DMF	84 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.39 mL	106.95 mL	213.91 mL
0.5 mM	4.28 mL	21.39 mL	42.78 mL
1 mM	2.14 mL	10.7 mL	21.39 mL
5 mM	0.43 mL	2.14 mL	4.28 mL

*The above data is based on the productmolecular weight 467.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12373
Actions	Inhibitor
M. Wt	467.49
Formula	C22H30FN3O7
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	187389-52-2
SMILES	C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](C(C)C)NC(=O)OCC1=CC=CC=C1