Z-VAD-FMK

Name: Z-VAD-FMK
SKU: A12373
Price: 28 USD
Rating: 5 (44 reviews)

Catalog No.: A12373

Pan Caspase Inhibitor

Adooq's Z-VAD-FMK has been cited by 44 publications

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

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Grouped product items
Size	Price	Stock
1mg	Special Price $28.00 Regular Price $40.00	In stock
5mg	Special Price $98.00 Regular Price $120.00	In stock
10mg	Special Price $140.00 Regular Price $200.00	In stock
25mg	Special Price $245.00 Regular Price $350.00	In stock
*10mM 1mL in DMSO**	Special Price $170.00 Regular Price $246.00	In stock
50mg	Special Price $420.00 Regular Price $600.00	In stock
Bulk Size	Bulk Discount

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Adooq Products cited in reputable paper

Adooq's Z-VAD-FMK has been cited by 44 publications

Lara Ebbert, .et al. , Antioxidants (Basel), 2024, Jul; 13(7): 864 PMID: 39061932

Rushikesh Deshpande, .et al. , Int J Mol Sci, 2024, Jan 18;25(2):1157 PMID: 38256231

Sarah Metcalfe, .et al. , J Leukoc Biol, 2023, Jul 27;qiad089 PMID: 37497744

Kazutoshi Toriyama, .et al. , Oncol Lett, 2023, Nov 10;27(1):12 PMID: 38028184

Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418

Akira Endo, .et al. , Dev Cell, 2023, Oct 9;58(19):1819-1829 PMID: 37716356

Rui Zhou, .et al. , Nagoya J Med Sci, 2023, Aug;85(3):579-591 PMID: 37829490

Chantal-Kristin Wenzel, .et al. , Toxicol In Vitro, 2023, Sep;91:105625 PMID: 37268255

Joshua H Choe, .et al. , Cancer Discov, 2023, May 4;13(5):1250-1273 PMID: 37067901

Yu-Chih Hsu, .et al. , Int J Med Sci, 2023, 20(4): 444-454 PMID: 37057216

Debin Qi, .et al. , Cell Cycle, 2023, Apr;22(7):818-828 PMID: 36482709

Ming-Chun Hung, .et al. , Cell Biosci, 2022, 12: 122 PMID: 35918763

Kaori Kanemaru, .et al. , Nat Commun, 2022, May 9;13(1):2347 PMID: 35534464

Chie Ishikawa, .et al. , Invest New Drugs, 2022, Aug;40(4):718-727 PMID: 35477814

Aida Falgas, .et al. , Biomed Pharmacother, 2022, Jun;150:112940 PMID: 35421785

Sumire Suzuki, .et al. , Oncol Rep, 2022, Feb;47(2):40 PMID: 34958115

Lina Y Abou Zeid, .et al. , Cell Stress Chaperones, 2022, Jan;27(1):11-25 PMID: 34719748

Simon Boudreault, .et al. , Viruses, 2022, Dec 3;14(12):2710 PMID: 36560714

Kosar Jabbari, .et al. , Cancers (Basel), 2021, Sep 8;13(18):4521 PMID: 34572749

Xiaoyue Deng, .et al. , Invest Ophthalmol Vis Sci, 2021, May 3;62(6):1 PMID: 33938913

Liqun Zhao, .et al. , Apoptosis, 2021, Apr 27 PMID: 33905036

Hideyuki Kinoshita, .et al. , Anticancer Res, 2021, Dec;41(12):6013-6021 PMID: 34848455

Sofia Giacosa, .et al. , Cancers (Basel), 2021, Feb 2;13(3):576 PMID: 33540838

Hideyuki Kinoshita, .et al. , Anticancer Res, 2021, Oct;41(10):4947-4955 PMID: 34593442

Hannes Schmid, .et al. , Haematologica, 2021, Jan 14 PMID: 33440919

Hua Xu, .et al. , Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588

El-Ashmawy NE, .et al. , Pathol Oncol Res, 2020, Jan 4 PMID: 31902118

Schneider D, .et al. , Clin Epigenetics, 2019, Jul 2;11(1):98 PMID: 31266541

Fujiki K, .et al. , Cell Death Differ, 2019, Feb 25 PMID: 30804470

T Yamamoto, .et al. , Cell Microbiol, 2019, 2019 PMID: 30702185

Maeda N, .et al. , J Biol Chem, 2019, Nov 13. pii: jbc.RA119.010379 PMID: 31723031

Miyazawa S, .et al. , Breast Cancer, 2019, Oct 17 PMID: 31625014

Yeh HT, .et al. , Eur J Pharmacol, 2019, Sep 10;863:172658 PMID: 31518562

D. Bosc, .et al. , Sci Rep, 2018, 8: 11653 PMID: 30076329

Tsukamoto H, .et al. , J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187

Hiroshi Kuribayashi, .et al. , Cell Death Dis, 2018, Sep; 9(9): 891 PMID: 30166529

Matsuo J, .et al. , Can J Microbiol, 2018, Oct 18:1-9 PMID: 30336068

Orly Ravid, .et al. , Front Cell Neurosci, 2018, 12: 359 PMID: 30459557

Im E, .et al. , Life Sci, 2018, Sep 15;209:259-266 PMID: 30107166

Szalai P, .et al. , Cell Calcium, 2018, Dec;76:48-61 PMID: 30261424

Im E, .et al. , Life Sci, 2018, Jan 1;192:286-292 PMID: 29128513

Iriyama N, .et al. , Leuk Lymphoma, 2018, Jun;59(6):1439-1450 PMID: 28918692

Birte Plitzko, .et al. , J Biol Chem, 2017, Dec 22; 292(51): 21102-21116 PMID: 29074620

Akashi E, .et al. , Oncol Rep, 2017, Jul;38(1):506-514 PMID: 28586026

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Biological Activity

Discription

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Targets

Target	Value

Product Information

Catalog Num	A12373
Formula	C22H30FN3O7
Molecular Weight	467.49
CAS Number	187389-52-2
SMILES	C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	80 mg/mL (171.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+35 %PEG 300+2%Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.39 mL	106.95 mL	213.91 mL
0.5 mM	4.28 mL	21.39 mL	42.78 mL
1 mM	2.14 mL	10.7 mL	21.39 mL
5 mM	0.43 mL	2.14 mL	4.28 mL

Useful Calculator

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂