Catalog No.
Product Name
Application
Product Information
Citations
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Adrenoreceptor Agonist
Colterol is a selective agonist for adrenergic receptors, demonstrating strong affinity for β1-adrenoreceptors (IC50 = 645 nM) and β2-adrenoreceptors (IC50 = 147 nM). This compound exhibits significant bronchodilator activity, making it useful in respiratory research and the study of cardiovascular effects. Its affinity profile also supports applications in pharmacological studies aimed at understanding adrenergic signaling pathways. -
Adrenergic Receptor
Tolamolol is a selective beta-adrenergic antagonist primarily targeting the beta-adrenergic receptor, known for its efficacy in reducing exercise-induced ST-segment depression. It demonstrates significant activity in alleviating angina, offering greater cardiac selectivity compared to other non-selective beta-blockers. Tolamolol effectively decreases the frequency of angina attacks and the reliance on glyceryl trinitrate, while also contributing to blood pressure reduction and enhancing exercise capacity prior to angina onset. Additionally, Tolamolol provides beneficial effects in the suppression of arrhythmias. -
alpha 2 Antagonist
R 47 243 is a potent racemic antagonist of the alpha-2 adrenergic receptor. This compound demonstrates significant activity that may be leveraged in the study and exploration of Parkinson's disease mechanisms and treatment strategies. Its ability to modulate α2 adrenergic signaling makes it a valuable tool for researchers investigating neurodegenerative conditions. -
Adrenergic Receptor Antagonist
Medroxalol hydrochloride is an orally active adrenergic receptor antagonist that inhibits both α- and β-adrenergic receptors. This compound demonstrates significant antihypertensive and vasodilating properties, making it valuable for studies related to cardiovascular pharmacology. Its ability to modulate adrenergic signaling pathways is useful in researching conditions such as hypertension and heart disease. -
Metabolites
5-Hydroxy propranolol is a key metabolite of Propranolol, primarily targeting β-adrenergic receptors. This compound plays an important role in studying the pharmacological effects associated with β-blockade, providing insights into cardiovascular function and neuropharmacology. Its application in biochemical research aids in understanding the metabolism and therapeutic implications of propranolol and its derivatives. -
Adrenergic Receptor Agonist
Dopexamine is a selective β2 adrenergic receptor agonist that enhances cardiac output and improves myocardial contractility. It is primarily utilized in research to study cardiovascular function and inotropic effects. This compound is often employed in investigations related to heart failure and hemodynamic support. -
Adrenergic Receptor Ligand
AR Ligand-50 is an adrenergic receptor ligand with a pKi value of 7.14 for the human α2-adrenergic receptor, assessed in CHO cells. This compound demonstrates significant biological activity that can be utilized in the investigation of neurological disorders. Its potential therapeutic implications make it a valuable tool for research focused on adrenergic signaling pathways and related disease mechanisms. -
Adrenergic Receptor Agonist
KUL-7211 is a selective β-adrenoceptor agonist that activates β-adrenergic receptors, facilitating various physiological responses. This compound is primarily utilized in research focused on cardiovascular function, neuropharmacology, and the modulation of metabolic processes. Its ability to selectively engage β-adrenoceptors makes KUL-7211 valuable for studying the role of adrenergic signaling in health and disease. -
Stable Isotope
Silodosin-d4 is a deuterium-labeled form of Silodosin, a potent and selective α1A-adrenergic receptor (α1A-AR) blocker. This compound demonstrates a high affinity for the α1A-AR with a Ki value of 0.036 nM, while showing significantly lower binding to α1B-AR and α1D-AR, with Ki values of 21 nM and 2.0 nM, respectively. Silodosin-d4 can be utilized in research focused on lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), allowing for in-depth studies on receptor dynamics and pharmacokinetics. -
Stable Isotope
Ractopamine-d3 (hydrochloride) is a deuterated form of the potent β-adrenergic receptor (βAR) agonist, Ractopamine hydrochloride. With a Kd value of approximately 25 nM for pig β1AR and β2AR, this compound is known to promote muscle mass development, limit fat deposition, reduce feed consumption, and enhance protein synthesis in swine. It serves as a valuable tool in research focused on improving production efficiency and increasing lean tissue growth in agricultural settings. -
β3-AR Antagonist
L-748328 is a potent and selective antagonist of the human β3-adrenergic receptor (β3-AR), displaying a Ki value of 3.7 nM in assays with human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. This compound effectively inhibits the lipolytic response triggered by the β3-AR agonist L-742791 in isolated non-human primate adipocytes. L-748328 is valuable for research into metabolic regulation and adipocyte function, particularly in studies examining β3-AR signaling pathways and their implications in obesity and metabolic disorders. -
Stable Isotope
(rac)-Nebivolol-d4 is a stable isotope-labeled form of the racemic compound Nebivolol, which selectively targets the β1-adrenergic receptor with an IC50 of 0.8 nM. This reagent is valuable for pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of Nebivolol in biological systems. Its stable isotope labeling facilitates investigations into drug interactions and receptor dynamics, offering insights into cardiovascular pharmacology. -
beta-3 Adrenoreceptor Agonist
β3-AR agonist 3 is a potent agonist of the beta-3 adrenergic receptor, known for its role in mediating metabolic processes. This compound exhibits key biological activity in the modulation of lipolysis and thermogenesis, making it relevant for studies related to adipose tissue regulation and metabolic disorders. β3-AR agonist 3 can also be utilized in research focused on prostatitis and other urogenital conditions, contributing valuable insights into therapeutic applications. -
Adrenergic Receptor Agonist
Cicloprolol hydrochloride is a partial agonist of the β1-adrenergic receptor. It exhibits cardiovascular effects through the modulation of heart rate and contractility, making it a valuable tool in studies related to hypertension and heart failure. This compound is useful for investigating adrenergic receptor signaling and the physiological responses associated with β1-adrenergic activation. -
Adrenergic Receptor Agonist
TD-5471 hydrochloride is a potent and selective full agonist of the human β2-adrenoceptor. This compound is instrumental in studying adrenergic signaling pathways and has implications in respiratory research, particularly in the context of asthma and chronic obstructive pulmonary disease (COPD). Additionally, TD-5471’s selective activity makes it a valuable tool for exploring β2-adrenoceptor-mediated physiological responses in various biological systems. -
Adrenergic Receptor Antagonist
Pamatolol is a cardioselective beta-adrenoceptor antagonist that exhibits no sympathomimetic activity. This compound selectively inhibits beta-adrenergic receptors, leading to potential applications in the treatment of cardiovascular diseases. Pamatolol is utilized in research related to heart function regulation and the exploration of adrenergic signaling pathways. -
Adrenergic Receptor Inhibitor
Teoprolol is a selective β-adrenergic receptor inhibitor that effectively modulates adrenergic signaling pathways. It exhibits key biological activities including the reduction of heart rate and myocardial contractility, making it valuable for cardiovascular research. Teoprolol is widely used in studies investigating hypertension, anxiety, and heart failure, contributing to our understanding of adrenergic receptor function and pharmacological interventions. -
α1/β1-Adrenergic Receptor Inhibitor
Amosulalol hydrochloride functions as a dual inhibitor of α1 and β1-adrenergic receptors, demonstrating pronounced antihypertensive effects. By inhibiting α1-adrenergic receptors, it effectively lowers blood pressure, while β1-adrenergic receptor inhibition reduces reflexive increases in heart rate and plasma renin activity. This compound is particularly useful in studies involving spontaneously hypertensive rats, providing valuable insights into cardiovascular mechanisms and potential therapeutic interventions in hypertension. -
α2-Adrenergic Receptor Antagonist
Delequamine is a selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in the rat cortex. It exhibits over 1000-fold selectivity against 5-HT1A receptors and α1-adrenoceptors. This compound is valuable for researching erectile dysfunction and exploring therapeutic options targeting adrenergic signaling pathways. -
ADRA2A Antagonist
Yohimbic acid ethyl ester is a selective antagonist of the alpha-2 adrenergic receptor subtype ADRA2A, exhibiting an IC50 of 31 nM. This compound is significant for studies investigating the modulation of adrenergic signaling pathways and has potential applications in researching cardiovascular function and neuropharmacology. Its specificity for ADRA2A makes it a valuable tool for exploring therapeutic strategies targeting adrenergic receptor-related disorders. -
α-adrenergic Receptor Agonist
Tuaminoheptane sulfate is an α-adrenergic receptor agonist that acts primarily by inhibiting norepinephrine reuptake and promoting its release. This compound exhibits pronounced decongestant and irritant effects, making it a valuable tool in the study of nasal pathologies. Its applications extend to research focused on nasal congestion and related disorders. -
Stable Isotope
(Rac)-Nebivolol-d4 hydrochloride is a stable isotope-labeled analog of racemic Nebivolol, which serves as a selective β1-adrenergic receptor inhibitor with an IC50 of 0.8 nM. This reagent is primarily utilized in pharmacokinetic studies and metabolic profiling, offering insights into drug metabolism and receptor interactions in various biological systems. Its application in research facilitates a deeper understanding of adrenergic signaling pathways and cardiovascular pharmacotherapy. -
β3 Adrenergic Receptor Agonist
L-770644 is a potent and selective agonist of the human β3 adrenergic receptor, with an EC50 of 13 nM, demonstrating oral bioactivity. This compound is primarily utilized in research exploring metabolic disorders, obesity, and diabetes, where modulation of β3 receptor activity may contribute to therapeutic strategies. Its specificity for the β3 receptor makes it a valuable tool for studying adrenergic signaling pathways and their physiological effects. -
Vasoconstrictor
Cafaminol, also known as Methylcoffanolamine, is a potent vasoconstrictor that selectively targets alpha-1 adrenergic receptors, leading to constriction of blood vessels. This xanthine derivative demonstrates significant activity in decongestion and offers potential applications in antitumor research. Its ability to modulate vascular response makes Cafaminol a valuable tool in studies related to vascular biology and therapeutic interventions. -
β-blocker
(S)-Alprenolol hydrochloride is a potent nonselective β-blocker that primarily targets β-adrenergic receptors. It exhibits significant antagonistic activity, which is useful in research involving cardiovascular pharmacology and the modulation of sympathetic nervous system responses. Applications of (S)-Alprenolol hydrochloride include studying hypertension, heart disease, and various conditions related to adrenergic signaling. -
Adrenergic Receptor Agonist
Adrenergic a2C receptor agonist-1 is a selective agonist of the adrenergic receptor a2C subtype. This compound modulates neurotransmitter release, contributing to its role in cardiovascular regulation and central nervous system activity. It is valuable for research applications focusing on adrenergic signaling pathways, neuropharmacology, and the investigation of disorders such as hypertension and anxiety. -
Calcium Entry-Blocking
YM-430 is a calcium entry-blocking and beta-adrenoceptor-blocking agent. It effectively inhibits Amifampridine-induced rhythmic contractions with an IC50 value of 59.2 nM and blocks arginine vasopressin-induced ST-segment depression with an IC50 of 36.6 mg/kg. This compound is valuable for research into angina pectoris and related cardiovascular conditions. -
Formoterol Metabolite
Formoterol O-β-D-glucuronide is a key metabolite of the long-acting β2-adrenoceptor agonist Formoterol. This compound serves as an important marker for studying the pharmacokinetics and metabolic pathways associated with β2-adrenergic receptor activation. Its examination can aid in understanding therapeutic applications in respiratory conditions and the overall pharmacological effects of Formoterol. -
Stable Isotope
Tamsulosin-d4 is a deuterium-labeled analog of Tamsulosin, a selective antagonist of the α1-adrenergic receptor. This compound is primarily utilized in the study of benign prostatic hyperplasia and offers insights into its pharmacological effects. Additionally, Tamsulosin has been shown to mitigate abdominal aortic aneurysm growth in preclinical models, making it a valuable reagent for cardiovascular research. -
Adrenergic Receptor Agonist
Isoxsuprine is a beta-adrenergic receptor agonist with binding affinities of 13.65 µM and 3.48 µM for myometrial and placental beta-adrenergic receptors, respectively. Additionally, isoxsuprine hydrochloride functions as an NMDA receptor antagonist. This compound is primarily utilized in research exploring its role in cardiovascular functions and its potential therapeutic applications in obstetrics. -
beta-Adrenergic Receptor Blocker
Brefonalol is a selective beta-adrenergic receptor blocker that plays a crucial role in modulating cardiovascular functions. It has demonstrated efficacy in the study of hypertension, arrhythmias, and angina pectoris, making it a valuable tool for research into cardiovascular diseases. Researchers can utilize Brefonalol to explore mechanisms of beta-receptor signaling and potential therapeutic interventions in heart-related disorders. -
AR Inhibitor
Amidephrine hydrochloride is an adrenergic receptor (AR) agonist that functions primarily by stimulating adrenergic signaling pathways. It demonstrates key biological activities relevant to neurological research, making it a valuable reagent for studying various neurological diseases and disorders. Its effects on AR modulation can facilitate investigations into therapeutic interventions and pharmaceutical development in the field of neuroscience. -
Adrenergic Receptor Antagonist
SU-4029 dihydrochloride is an adrenergic receptor antagonist that selectively interacts with alpha receptors. It effectively inhibits the action of norepinephrine, exhibiting a unique mechanism of action by differentiating between reversible and irreversible adrenergic blockers. Biological responses to SU-4029 include a spectrum of effects on pressor phenylalkylamines, indicating its potential utility in elucidating receptor interactions and mechanisms in cardiovascular research. The compound serves as a valuable tool for studying adrenergic signaling pathways and developing therapeutic strategies targeting alpha-adrenergic receptors. -
Neuroleptic Agent
(±)-Butaclamol hydrochloride is a neuroleptic agent that acts as an antagonist for adrenergic and dopamine receptors. It effectively antagonizes stereotyped behaviors and emesis induced by amphetamine and apomorphine, as well as inhibiting discriminative avoidance behavior. Additionally, it induces catalepsy in rat models, making it a valuable tool for research in behavioral pharmacology and neuropharmacology. -
β-adrenergic Receptor Antagonist
Ridazolol is a selective β-adrenergic receptor antagonist with a primary affinity for the β-1 adrenergic receptor (β1AR). It exhibits moderate intrinsic sympathomimetic activity (ISA) and effectively competes with isoproterenol to inhibit its relaxation effects. This compound is valuable in the investigation of cardiovascular diseases, providing insights into β-adrenergic signaling pathways and potential therapeutic approaches. -
β(3)-adrenergic Receptor Agonist
L-796568 free base is a potent β(3)-adrenergic receptor agonist. This compound plays a crucial role in research related to obesity and metabolic disorders, facilitating the investigation of adipose tissue regulation and energy expenditure. By targeting the β(3)-adrenergic receptor, L-796568 free base aids in understanding potential therapeutic approaches for weight management and related conditions. -
α1-Adrenergic Receptor Blocker
Trimazosin hydrochloride hydrate is an α1-adrenergic receptor blocker that demonstrates significant hypotensive effects. As a quinazoline derivative structurally related to prazosin, it selectively inhibits α1-adrenergic receptors, contributing to the regulation of blood pressure. This compound is primarily utilized in research on hypertension and related cardiovascular conditions. -
β3 Adrenergic Receptor Agonist
L-770644 dihydrochloride is a potent and selective agonist of the human β3 adrenergic receptor, with an EC50 value of 13 nM. This compound is primarily utilized in research applications exploring metabolic regulation, adipocyte function, and energy expenditure. Its oral bioactivity makes it a valuable tool for studying β3 adrenergic receptor-mediated pathways in various biological contexts. -
β3-Adrenergic Agonist
Trecadrine is a potent β3-adrenergic agonist that selectively activates β3-adrenergic receptors. This compound is known for its role in promoting lipolysis and thermogenesis, making it a valuable tool in metabolic research. Trecadrine is commonly utilized in studies examining obesity, energy expenditure, and the physiological roles of β3-adrenergic signaling pathways. -
Adrenergic Receptor Agonist
β3-AR agonist 2 is a selective agonist of the β3-adrenergic receptor, exhibiting high potency with an EC50 of 8 nM. This compound is instrumental in various research applications, particularly in studies related to metabolic regulation, thermogenesis, and obesity. Its ability to selectively activate β3-AR makes it a valuable tool for exploring adipocyte function and potential therapeutic pathways for metabolic disorders. -
Adrenergic Receptor Modulator
α1 adrenoceptor-MO-1 is an S enantiomer that selectively targets the alpha-1 adrenergic receptor. This compound exhibits alpha-lytic activity and demonstrates analgesic properties, making it more effective than its R enantiomer counterpart. α1 adrenoceptor-MO-1 is suitable for research applications focused on adrenergic signaling and pain modulation. -
Adrenergic Receptor Modulator
D2343 is a β2-adrenoceptor agonist and α1-adrenoceptor inhibitor. This compound exhibits a dual mechanism of action, enhancing β2 receptor activation while simultaneously blocking α1 receptors. It is utilized in research applications that investigate adrenergic signaling pathways and the physiological effects mediated by these receptors. -
Adrenergic Receptor Agonist
Epanolol is a selective β-adrenoceptor partial agonist, demonstrating a higher affinity for β1-adrenoceptors compared to β2-adrenoceptors. This compound exhibits significant cardiovascular effects, making it useful in research focused on heart-related therapies and the modulation of adrenergic signaling pathways. Its specificity for β1-adrenergic receptors lends valuable insight into cardiac function and potential treatments for hypertension and other cardiovascular diseases. -
Adrenergic Receptor Antagonist
Fiduxosin is a potent α1-adrenoceptor antagonist, exhibiting Ki values of 0.160 nM, 24.9 nM, and 0.920 nM for the α1a, α1b, and α1d subtypes, respectively. This compound inhibits adrenergic signaling, making it a valuable tool in the study of cardiovascular and urological diseases. Its selective modulation of α1-adrenoceptors allows for targeted research applications in pharmacology and drug development. -
Adrenergic Receptor Antagonist
MG 1 is a selective α1 adrenergic receptor antagonist, primarily designed to inhibit the activity of these receptors. This compound demonstrates significant biological activity in modulating vascular smooth muscle contraction and has applications in studying cardiovascular function and related signal transduction pathways. MG 1 is valuable for researchers investigating the roles of adrenergic signaling in various physiological and pathological conditions. -
Adrenergic Receptor Inhibitor
Tropodifene is an α-adrenergic receptor inhibitor that modulates adrenergic signaling pathways. It is primarily utilized in research related to cardiovascular pharmacology and the study of sympathetic nervous system functions. Its unique mechanism of action makes it valuable for investigating the role of adrenergic receptors in various physiological and pathological conditions. -
Adrenergic Receptor Inhibitor
Benzquinamide is an adrenergic receptor inhibitor that selectively binds to the α2A, α2B, and α2C adrenergic receptors, exhibiting Ki values of 1,365, 691, and 545 nM, respectively. This compound demonstrates antiemetic properties and is utilized in research applications relating to nausea and vomiting. Its mechanism of action involves modulation of adrenergic signaling pathways, making it a valuable tool for studying the role of adrenergic receptors in various physiological and pathological conditions. -
Adrenergic Receptor
GP2-114 is a selective adrenergic receptor modulator that exhibits current-dependent cardiovascular effects. It is utilized in experimental models to study the physiological impacts on cardiovascular function and adrenergic signaling pathways. The compound offers valuable insights into the role of adrenergic receptors in cardiovascular responses, supporting various research applications in pharmacology and cardiovascular physiology. -
Adrenergic Receptor Agonist
ZK-90055 hydrochloride is a selective β2 adrenergic receptor agonist known for its ability to activate β2 receptors, influencing various physiological responses. This compound is primarily utilized in cardiovascular research and studies related to asthma and bronchial dilation. Its potent agonistic effects on β2 receptors make it a valuable tool for investigating adrenergic signaling pathways and developing therapeutic interventions for related disorders. -
Adrenergic Receptor Antagonist
Fenmetozole Tosylate is an adrenergic receptor antagonist primarily targeting the α2-adrenergic receptor. This compound has been shown to counteract the actions of ethanol and exhibits potential antidepressant properties. It is useful in research applications focused on understanding the mechanisms of alcohol-related effects and the modulation of mood disorders.
