L-748328 is a potent and selective antagonist of the human β3-adrenergic receptor (β3-AR), displaying a Ki value of 3.7 nM in assays with human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. This compound effectively inhibits the lipolytic response triggered by the β3-AR agonist L-742791 in isolated non-human primate adipocytes. L-748328 is valuable for research into metabolic regulation and adipocyte function, particularly in studies examining β3-AR signaling pathways and their implications in obesity and metabolic disorders.
L-748328 is a potent and selective antagonist of the human β3-adrenergic receptor (β3-AR), displaying a Ki value of 3.7 nM in assays with human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. This compound effectively inhibits the lipolytic response triggered by the β3-AR agonist L-742791 in isolated non-human primate adipocytes. L-748328 is valuable for research into metabolic regulation and adipocyte function, particularly in studies examining β3-AR signaling pathways and their implications in obesity and metabolic disorders.
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