Silodosin-d4 is a deuterium-labeled form of Silodosin, a potent and selective α1A-adrenergic receptor (α1A-AR) blocker. This compound demonstrates a high affinity for the α1A-AR with a Ki value of 0.036 nM, while showing significantly lower binding to α1B-AR and α1D-AR, with Ki values of 21 nM and 2.0 nM, respectively. Silodosin-d4 can be utilized in research focused on lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), allowing for in-depth studies on receptor dynamics and pharmacokinetics.
Silodosin-d4 is a deuterium-labeled form of Silodosin, a potent and selective α1A-adrenergic receptor (α1A-AR) blocker. This compound demonstrates a high affinity for the α1A-AR with a Ki value of 0.036 nM, while showing significantly lower binding to α1B-AR and α1D-AR, with Ki values of 21 nM and 2.0 nM, respectively. Silodosin-d4 can be utilized in research focused on lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), allowing for in-depth studies on receptor dynamics and pharmacokinetics.
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