Catalog No.
Product Name
Application
Product Information
Citations
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ADC/PROTAC Linker
m-PEG12-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). This non-cleavable linker consists of a 12-unit polyethylene glycol chain, facilitating stable conjugation in bioconjugation applications. Its properties enable efficient delivery of biologically active drugs to target cells, making it suitable for research in targeted therapy and drug development. -
ADC Linker
PC Biotin-PEG3-NHS ester is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This highly soluble pegylated compound allows for efficient conjugation to antibodies, enhancing stability and facilitating targeted delivery of cytotoxic agents. Its primary applications include the development of ADCs for cancer therapeutics and research into targeted treatment strategies. -
ADC Linker
MC-AAA-NHCH2OCH2COOH is a cleavable linker designed for use in antibody-drug conjugates (ADCs). This compound facilitates the targeted delivery of cytotoxic agents to specific cells, enhancing therapeutic efficacy while minimizing off-target effects. Its unique structure enables effective release of the drug payload in the tumor microenvironment, making it suitable for various oncology research applications. -
Click Chemistry Reagent
2-Azidoethyl β-D-lactoside is a versatile click chemistry reagent designed for the selective conjugation of biomolecules. It features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, offering high efficiency and specificity. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives. This reagent is useful in various biological research applications, including the labeling and tracking of nucleic acids, proteins, and lipids within complex biological systems. -
ADC Linker
Propargyl-PEG5-acid is a non-cleavable polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) applications. It facilitates the synthesis of ADCs targeting Galectin-3 and serves as a versatile PROTAC linker. This compound features an alkyne functional group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry in chemical biology research. Researchers can utilize Propargyl-PEG5-acid in various applications, including drug conjugation and the development of therapeutic agents. -
ADC Linker
Propargyl-Tos is a cleavable linkers designed for use in the synthesis of antibody-drug conjugates (ADCs). Featuring an alkyne group, Propargyl-Tos facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This property makes it valuable for constructing complex bioconjugates, enhancing the therapeutic efficacy of ADCs in targeted cancer therapy research. -
ADC linker
Mal-NH-ethyl-SS-propionic acid is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the selective release of the cytotoxic drug upon internalization, enhancing therapeutic efficacy. Its application in ADC development enables targeted delivery of therapeutic agents, making it valuable in various cancer research studies and the advancement of targeted therapies. -
ADC Linker
Mal-PEG1-Val-Cit-PABC-OH is a cleavable polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the attachment of cytotoxic agents to antibodies while maintaining stability in circulation. Upon reaching the target site, the linker can be cleaved, releasing the therapeutic payload and enhancing cytotoxic efficacy. This compound is valuable for research applications focusing on ADC development and optimization. -
PROTAC Linker
Tr-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This non-cleavable linker, featuring a two-unit PEG structure, facilitates the development of antibody-drug conjugates (ADCs). Its key biological activity includes promoting targeted protein degradation and enhancing the solubility and pharmacokinetics of conjugated molecules, making it a valuable tool in chemical biology and therapeutic research applications. -
ADC/PROTAC Linker
Propargyl-PEG8-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. It features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing biomolecules. Its utility in creating cleavable linkers makes it valuable for targeted drug delivery applications, particularly against Gram-negative bacterial infections. This versatile reagent supports the development of innovative therapeutic strategies in chemical biology and drug discovery. -
ADC Linker
Tetrazine-PEG4-amine hydrochloride functions as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). This compound features a tetrazine group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) functionalized molecules. It is essential for the development of targeted therapies, facilitating the selective delivery of cytotoxic agents to cancer cells while minimizing off-target effects. -
ADC Linker
Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable linker specifically designed for antibody-drug conjugation (ADC) applications. Comprising a four-unit polyethylene glycol (PEG) structure, it facilitates stable attachment of therapeutic agents to antibodies, enhancing the efficacy of targeted therapies. This reagent is suitable for use in research focused on developing advanced ADC formulations with improved pharmacokinetics and therapeutic index. -
ADC Linker
Hydroxy-PEG3-(CH2)2-Boc is an uncleavable linker employed in the synthesis of antibody-drug conjugates (ADCs). This compound enhances the stability of ADCs, facilitating the targeted delivery of cytotoxic agents to tumor cells. Additionally, Hydroxy-PEG3-(CH2)2-Boc can serve as a valuable component in the development of PROTACs, expanding its utility in targeted protein degradation research. -
ADC Linker
H-cis-Hyp-OMe hydrochloride is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs). This compound provides stability and efficacy in the development of ADCs by ensuring prolonged circulation time and effective drug delivery. Additionally, H-cis-Hyp-OMe hydrochloride serves as an alkyl chain-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras for targeted protein degradation research applications. -
ADC Linker
Tetraethylene glycol monotosylate is a versatile cleavable linker primarily utilized in the synthesis of antibody-drug conjugates (ADCs). Its acylhydrazone moiety facilitates targeted drug delivery while enabling controlled release of cytotoxic agents. In addition to ADC applications, this compound can also serve as a linker in the development of proteolysis-targeting chimera (PROTAC) molecules, enhancing the specificity and efficacy of targeted protein degradation studies. -
ADC Linker
SIA Crosslinker is a non-cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). It facilitates stable conjugation between antibodies and cytotoxic drugs, ensuring effective delivery and controlled therapeutic activity. This reagent is essential for research focused on targeted cancer therapies and ADC development, providing robust stability in diverse biological environments. -
PROTAC Linkers
Mal-PEG1-acid is a non-cleavable linker derived from polyethylene glycol (PEG) that serves as an effective reagent for antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound facilitates the construction of PROTACs by providing a flexible linker that enhances target protein degradation through ubiquitin-proteasome pathways. Its application is crucial for developing novel therapeutics that utilize the PROTAC strategy in chemical biology and drug discovery. -
ADC/PROTAC Linker
Bis-PEG10-NHS ester is a cleavable linker designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis. The compound features a polyethylene glycol (PEG) structure that enhances solubility and stability while promoting efficient drug delivery. Its primary mechanism involves facilitating the conjugation of drugs to antibodies or target proteins, making it essential in developing targeted therapies. Bis-PEG10-NHS ester is suitable for research applications aimed at improving therapeutic efficacy and specificity in drug development. -
Click Chemistry Reagent
TCO-NHS Ester (axial) is a versatile click chemistry reagent primarily used for site-specific labeling in amine reactions. The compound features TCO groups that participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. It is valuable in bioconjugation and molecular imaging applications, enabling researchers to construct complex biomolecular structures. -
ADC Linker
Gly-Gly-Gly-PEG3-TCO is a polyethylene glycol (PEG) linker featuring a TCO moiety, primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates click chemistry through its ability to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. Its application in ADC development enhances targeted delivery and therapeutic efficacy in the treatment of various diseases. -
ADC Linker
tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable linker utilized in the development of antibody-drug conjugates (ADCs). This compound serves as an alkyl chain-based PROTAC linker, enabling the synthesis of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation studies. Its unique structural properties make it a valuable tool for enhancing the efficacy of bioconjugates in therapeutic applications. -
ADC linker
Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2 unit polyethylene glycol (PEG) linker designed for use in antibody-drug conjugate (ADC) synthesis. This linker facilitates the selective release of cytotoxic agents upon internalization of the ADC by target cells, enhancing therapeutic efficacy. Its unique structural features support various research applications in the development of targeted cancer therapies. -
Azide
Spermine(N3BBB) is an azide-containing click chemistry reagent designed for bioconjugation applications. It facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatility makes Spermine(N3BBB) a valuable tool for biochemical studies involving targeted labeling and cross-linking in various biological systems. -
PROTAC Linkers
H-Hyp-OMe hydrochloride is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) and also serves as an alkyl chain-based PROTAC linker. This versatile compound facilitates the synthesis of PROTACs, enabling the targeted degradation of specific proteins through the ubiquitin-proteasome system. H-Hyp-OMe hydrochloride is valuable in the development of therapeutic strategies aimed at selectively modulating protein function in various biological research applications. -
ADC Linker
Sulfo-LC-SPDP sodium is a cleavable linker specifically designed for the development of antibody-drug conjugates (ADCs). Its chemical structure enables the selective attachment of drugs to antibodies, facilitating targeted delivery. This reagent is essential for creating ADCs that exhibit enhanced stability and improved therapeutic efficacy in various cancer research applications. -
ADC Linker
Mal-PEG4-bis-PEG4-propargyl is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), targeting efficient drug delivery. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it suitable for click chemistry applications. Its structure supports the development of stable and effective ADCs, enhancing the therapeutic potential in various biomedical research fields. -
ADC Linker
BCN-SS-NHS is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent features a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its unique properties enhance the targeting and delivery of therapeutic agents, making it a valuable tool in the development of ADCs for various cancer research applications. -
ADC Linker
DBCO-PEG2-Val-Cit-PAB-MMAE is an antibody-drug conjugate (ADC) linker that employs a DBCO group for efficient click chemistry with azide moieties. This reagent incorporates a Val-Cit dipeptide, which is cleavable by proteases, facilitating the targeted release of the MMAE warhead within cells through an elimination mechanism. Its design is optimized for applications in targeted cancer therapy, enhancing the specificity and efficacy of drug delivery systems. -
PROTAC/ADC Linker
Hydroxy-PEG4-acid is a non-cleavable linker featuring a four-unit polyethylene glycol (PEG) moiety, primarily utilized in the development of antibody-drug conjugates (ADCs). This linker is also applicable in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted degradation of specific proteins. Its biocompatibility and structural versatility make it valuable in various chemical biology applications, particularly in therapeutic development and research focusing on targeted protein modulation. -
ADC Linker
N-Boc-cis-4-Hydroxy-D-proline serves as a non-cleavable linker for antibody-drug conjugates (ADCs), facilitating the conjugation of therapeutic agents to antibodies. This compound also functions as an alkyl chain-based PROTAC linker, making it useful for the synthesis of both ADCs and PROTACs. Its structural attributes enhance the stability and efficacy of conjugated therapies, supporting research efforts in targeted drug delivery and protein degradation. -
ADC Linker
Azido-PEG9-acid is a non-cleavable 9-unit polyethylene glycol (PEG) linker designed for use in antibody-drug conjugate (ADC) synthesis. This reagent facilitates the creation of conjugates through its azide functionality, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG9-acid supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for bioconjugation applications in chemical and molecular biology research. -
ADC Linker
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). Its structure facilitates the controlled release of cytotoxic agents upon internalization, enhancing therapeutic efficacy. This compound is essential for research applications focusing on the development and optimization of ADC therapies in targeted cancer treatments. -
PROTAC Linkers
Propargyl-PEG2-NHBoc is a cleavable linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG-based linker features an alkyne group, allowing for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties support robust applications in drug development and targeted protein degradation research, making it a valuable tool for chemical biology studies. -
ADC Linker
Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is a branched linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the conjugation of therapeutic agents to antibodies, enhancing their delivery and efficacy in targeting specific cells. Its unique structure allows for improved stability and solubility, making it an essential component in ADC development for cancer therapy and other applications in targeted drug delivery research. -
PROTAC Linker
Bis-PEG8-acid is a polyethylene glycol-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This bifunctional linker facilitates the formation of PROTACs by providing a cleavable connection between the target protein and an E3 ligase. Additionally, Bis-PEG8-acid serves as a linker in the development of antibody-drug conjugates (ADCs), enhancing their stability and efficacy. Its application in chemical biology and therapeutic research supports innovative approaches in targeted protein degradation and drug delivery systems. -
ADC Linker
N-Boc-cis-4-hydroxy-L-proline is a non-cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features an alkyl chain structure suitable for connecting antibody moieties to various cytotoxic agents, facilitating targeted drug delivery. Additionally, it serves as a versatile PROTAC linker, contributing to the development of proteolysis-targeting chimeras for selective degradation of specific proteins. -
ADC/PROTAC Linker
Amino-PEG9-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. This non-cleavable linker facilitates the synthesis of PROTACs and enhances the stability and efficacy of ADC formulations. Its unique properties make it a valuable tool in the development of targeted therapies for various diseases, enabling precise delivery of therapeutic agents to specific cellular targets. -
ADC Linker
m-PEG6-azide is a non-cleavable polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This reagent features an azide functional group, enabling it to participate in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, m-PEG6-azide can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds possessing DBCO or BCN groups, making it a versatile tool for ADC development and other bioconjugation applications. -
ADC Linker
Azide-PEG5-Tos is a cleavable five-unit polyethylene glycol (PEG) linker designed for the synthesis of antibody-drug conjugates (ADCs). It features an azide moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, as well as facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules. This reagent is essential for the development of targeted therapeutics and advancing research in bioconjugation strategies. -
ADC Linker
Mal-C2-NHS ester is a non-cleavable linker that facilitates the synthesis of antibody-drug conjugates (ADCs). This reagent reacts selectively with amine groups, enabling the stable attachment of cytotoxic drugs to antibodies. Its primary application lies in the development of targeted cancer therapies, enhancing the efficacy and specificity of drug delivery systems. -
Methyltetrazine Compound
Bz-(Me)Tz-NHS is a methyltetrazine-based click chemistry reagent designed for copper-free click conjugation. This third-generation Click-Linker enables efficient labeling and conjugation of biomolecules with high specificity. Its unique properties make it ideal for applications in bioconjugation, drug delivery, and the development of imaging agents in chemical biology research. -
ADC/PROTAC Linker
Propargyl-PEG8-NHS ester is a PEG-based linker specifically designed for antibody-drug conjugates (ADCs) and PROTACs. Its primary mechanism involves enabling the synthesis of these bioconjugates through a cleavable linker. This compound features an alkyne group that facilitates click chemistry, specifically the copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. It is a valuable tool for researchers in drug development and bioconjugation studies. -
ADC/PROTAC Linker
Propargyl-PEG6-acid is a PEG-based linker primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs). This cleavable linker facilitates the formation of ADCs and enables targeted protein degradation via a click chemistry reaction, leveraging its alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its versatile applications in chemical biology make it a valuable tool for research in targeted therapeutics and bioconjugation strategies. -
Click Chemistry Reagent
alpha-GalNAc-TEG-N3 is a specialized click chemistry reagent designed for efficient bioconjugation. Featuring an azide functional group, it facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) for reactive alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. This reagent is advantageous for applications in biochemical labeling and molecular imaging, enabling the study of interactions between nucleic acids, proteins, and lipids with high specificity and yield. -
Click Chemistry Reagent
H-D-Aha-OH hydrochloride is a click chemistry reagent featuring an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds. This versatile reagent is essential for bioconjugation applications, enabling the efficient labeling and modification of biomolecules in chemical biology studies. -
ADC Linker
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker that facilitates targeted drug delivery. The Val-Cit moiety is specifically cleaved by Cathepsin B, enabling the release of an amine-containing payload when substituted. The DBCO group allows for efficient click chemistry with azide-bearing compounds, making this linker suitable for various antibody-drug conjugate applications in therapeutic research. -
ADC Linker
Biotin-PEG2-acid is a non-cleavable linker comprising a two-unit polyethylene glycol (PEG) chain, specifically designed for use in antibody-drug conjugates (ADCs). This versatile reagent facilitates the efficient conjugation of biotin to antibodies, enhancing targeting and therapeutic efficacy. Additionally, Biotin-PEG2-acid can be employed as a component in the synthesis of PROTACs, enabling the development of novel therapeutic agents through targeted protein degradation. -
PROTAC Linker
Fmoc-NH-PEG9-CH2CH2COOH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This PEG-based compound facilitates the conjugation of therapeutic agents to targeted antibodies, enhancing efficacy and selectivity in drug delivery. Its unique structure allows for the effective modulation of protein degradation pathways, making it valuable for research applications in targeted protein degradation and drug development. -
ADC Linker
Me-Tet-PEG3-Maleimide is an ADC linker characterized by the presence of three polyethylene glycol (PEG) units and a tetrazine moiety. This compound facilitates a specific inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO)-containing compounds, enabling efficient bioconjugation. Additionally, the maleimide functional group exhibits stability in aqueous environments, making this linker suitable for drug delivery applications and the development of antibody-drug conjugates (ADCs). -
ADC Linker
Biotin-PEG3-aldehyde is a cleavable linker that incorporates a triethylene glycol (PEG) moiety, designed for the synthesis of antibody-drug conjugates (ADCs). This reagent facilitates efficient conjugation by linking biotinylated components to antibodies via an aldehyde, enabling targeted delivery of therapeutics. It is especially valuable in research applications aimed at developing and optimizing ADC formulations for enhanced efficacy and specificity in cancer therapy.
