Catalog No.
Product Name
Application
Product Information
Citations
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Drug Metabolite
Mebendazole-amine is a metabolite of the broad-spectrum benzimidazole anti-helminthic agent Mebendazole. This compound is relevant for studying drug metabolism and pharmacokinetics in parasitic infections. Its primary applications include investigating the metabolic pathways of anti-helminthic drugs and evaluating potential efficacy and safety profiles in clinical research. -
Drug Metabolite
Dimethadione is the primary metabolite of trimethadione, acting primarily as a central nervous system depressant. It exerts its effects by inhibiting neuromuscular transmission, leading to decreased transmitter release from nerve terminals. This compound is essential for research into drug metabolism and the mechanisms underlying neuromuscular disorders. -
Drug Metabolite
Methyl 2,4,6-trihydroxybenzoate is a metabolite derived from 2,4,6-trihydroxybenzoate, primarily recognized for its antioxidant properties. It demonstrates significant lipid-lowering and anticancer activities, making it a valuable compound in pharmacological research. Its mechanisms of action may provide insights into therapeutic strategies for managing oxidative stress and related diseases. -
Drug Metabolite
Paeoniflorgenin is a deglucosylated metabolite of Paeoniflorin, primarily targeting drug metabolism pathways. It exhibits significant biological activity, contributing to the understanding of the pharmacokinetics of specific compounds. This metabolite is applicable in research focused on the enzymatic processes involved in drug metabolism and the study of herbal medicine components. -
Drug Metabolite
16α-Hydroxyprednisolone is a stereoselective metabolite of the glucocorticoid Budesonide, specifically the 22(R) epimer. It is formed through the catalytic action of isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. This compound serves as a valuable tool in studies related to drug metabolism and pharmacokinetics, allowing researchers to investigate the enzymatic pathways and potential inhibitory effects of specific antibodies on CYP3A enzymes. -
Drug Metabolite
Hydroxy Iloperidone is a key metabolite of Iloperidone, an atypical antipsychotic agent. This compound plays an essential role in the pharmacokinetics of Iloperidone, contributing to its therapeutic effects and side effect profile. Research involving Hydroxy Iloperidone is crucial for understanding drug metabolism and the physiological impacts of antipsychotic therapies. It is valuable for studies related to pharmacology, toxicology, and the exploration of drug interactions. -
Drug Metabolite
4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, functioning primarily as a drug metabolite. This compound plays a crucial role in pharmacokinetic studies, particularly in understanding the metabolism and efficacy of beta blockers and alpha-1 blockers. Its analysis is vital for examining drug interactions and assessing the therapeutic potential of cardiovascular agents. -
Drug Metabolite
ω-Hydroxy-DEET is a significant metabolite of the widely used insect repellent N,N-diethyl-meta-toluamide (DEET). This compound exhibits anti-proliferative effects, making it of interest in studies related to cell growth regulation. Its primary applications include research into the metabolic pathways of DEET and the evaluation of its biological effects on insect and human cells. -
Drug Metabolite
5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is a drug metabolite derived from (-)-Epicatechin, primarily targeting antioxidant pathways. This compound demonstrates significant antioxidant activity, making it a valuable reagent for research into the metabolic effects of flavonoids. Its relevance extends to studies investigating the role of gut microbiota in modulating bioactive compounds and their physiological impacts. -
Drug Metabolite
O-desmethyl Mebeverine acid is a primary metabolite of the musculotropic antispasmodic drug Mebeverine. It plays a significant role in pharmacokinetic studies and drug metabolism research. This metabolite is used to investigate the safety and efficacy of Mebeverine in various biological systems, contributing to a better understanding of its therapeutic mechanisms. -
Drug Metabolite
4-Desmethoxy Omeprazole is an active metabolite of the proton pump inhibitor Omeprazole, primarily targeting acid-related gastrointestinal disorders. This compound exhibits competitive inhibition of CYP2C19, with a Ki value ranging from 2 to 6 μM, influencing drug metabolism. Additionally, 4-Desmethoxy Omeprazole demonstrates antimicrobial activity by inhibiting the growth of both Gram-positive and Gram-negative bacteria, making it relevant for various pharmacological and microbiological research applications. -
Drug Metabolite
Quetiapine sulfoxide hydrochloride is a primary metabolite of Quetiapine, a second-generation antipsychotic. This compound acts primarily as a 5-HT receptor agonist and dopamine receptor antagonist, contributing to the pharmacological profile of Quetiapine. It is valuable in research focusing on the metabolism and pharmacokinetics of antipsychotic medications, providing insights into their therapeutic effects and potential side effects. -
Drug Metabolite
6-Azathymine acid is a metabolite of the pesticide Pymetrozine, which targets the nervous system of plant-sucking insects, including aphids and whiteflies. This compound plays a crucial role in understanding the degradation pathways of Pymetrozine in various agricultural settings. Research applications include studying metabolic processes of pesticides and their environmental impact on non-target species. -
Drug Metabolite
(Rac)-3′-Hydroxy simvastatin is a drug metabolite derived from Simvastatin, which acts as a competitive inhibitor of HMG-CoA reductase. With a Ki value of 0.2 nM, it plays a crucial role in cholesterol biosynthesis regulation. This compound is relevant in pharmacokinetic studies and investigations into the metabolic pathways of statins. -
Drug Metabolite
2-Hydroxymethyl olanzapine is a significant metabolite of the antipsychotic agent Olanzapine. It plays a crucial role in pharmacokinetic studies by providing insights into drug metabolism and efficacy. This compound is utilized in research applications focusing on psychiatric disorders, drug interactions, and pharmacological profiling of Olanzapine. -
Drug Metabolite
DCBA is a significant metabolite of the insect repellent N,N-diethyl-meta-toluamide (DEET). Measurement of DCBA levels in urine serves as a biomarker to evaluate exposure to DEET, providing insight into its pharmacokinetics and environmental impact. This compound is essential for studies on human health safety and the efficacy of insect repellents. -
Drug Metabolite
3-Methyl-2-quinoxalinecarboxylic acid (MQCA) is an active metabolite derived from Quinocetone and Olaquindox. It exhibits significant growth-inhibitory effects on Chang liver cells, predominantly through the induction of S phase arrest in the cell cycle. This compound is of interest in drug metabolism studies and cellular response research. -
Drug Metabolite
Hydroxy lenalidomide (5-Hydroxy lenalidomide) is a pharmacologically active metabolite of lenalidomide, primarily identified as a minor component in plasma and excreta following oral administration. It constitutes less than 5% of the total radioactivity in the system. This compound is relevant for studies focusing on the pharmacokinetics and metabolic pathways of lenalidomide, aiding in the understanding of its therapeutic effects and safety profile in clinical settings. -
Drug Metabolite
2-epi-Abamectin is a degradation product of Abamectin, functioning primarily as a drug metabolite. It exhibits notable toxicity against the two-spotted spider mite, with an LC50 value of 4 ppm, indicating a contact activity approximately 100-fold less potent than its parent compound, Abamectin. This compound is relevant for studies involving pesticide effectiveness and resistance management in agricultural research. -
Drug Metabolite
2-Hydroxy atorvastatin lactone is a pharmacologically active metabolite of Atorvastatin, a potent HMG-CoA reductase inhibitor. This compound plays a significant role in lipid metabolism by effectively reducing cholesterol levels in the bloodstream. Its application is essential for research into lipid disorders and the pharmacokinetics of statin therapies. -
Drug Metabolite
Folic acid methyl ester is a methyl ester derivative of folic acid, primarily studied for its role as a drug metabolite. This compound exhibits significant biological activity relevant to neuropsychiatric conditions, including depression. Its use in research facilitates the exploration of folate metabolism and its implications in mental health disorders. -
Drug Metabolite
Prucalopride N-oxide is a primary metabolite of Prucalopride, acting as a drug metabolite with significant relevance in pharmacokinetic studies. It exhibits motility-enhancing effects, making it a valuable compound for research into gastrointestinal motility disorders and the evaluation of drug metabolism pathways. Its role in understanding the physiological effects of Prucalopride enhances its applicability in clinical research. -
Drug Metabolite
Resveratrol-3-O-sulfate sodium is a key metabolite of the polyphenolic compound Resveratrol. This compound exhibits various biological activities, including antioxidant and anti-inflammatory properties, contributing to its potential health benefits. It is primarily used in research applications focused on drug metabolism, pharmacokinetics, and the investigation of Resveratrol's effects on cellular signaling pathways. -
Drug Metabolite
11β-Prostaglandin F2α is a metabolite associated with drug metabolism, particularly as a hepatic product of PGD2-EA derived from the enzymatic activity of COX-2 on the endogenous cannabinoid anandamide (AEA). This compound plays a role in various biological processes and is relevant in research applications involving inflammation and pain response. It is commonly studied in the context of its synthesis in activated RAW 264.7 macrophages upon treatment with AEA, helping elucidate the pathways of prostaglandin metabolism. -
Drug Metabolite
Safinamide acid is the primary metabolite of Safinamide, formed through the hydrolysis of its intermediate under alkaline or acidic conditions. This compound serves as an important analytical tool for monitoring process-related impurities and degradation products in safinamide samples. Its applications extend to quality control and stability testing in pharmaceutical research, contributing to the understanding of safinamide's metabolic pathways and its pharmacokinetic profile. -
Drug Metabolite
Quetiapine sulfoxide, the primary metabolite of Quetiapine, primarily targets the 5-HT receptors and exhibits dopaminergic antagonist activity. This compound plays a crucial role in studying the pharmacokinetics and pharmacodynamics of Quetiapine, which is utilized in the treatment of various psychiatric disorders. Research applications include investigating the effects of Quetiapine’s active metabolites on neurotransmitter systems and their contribution to therapeutic outcomes. -
Drug Metabolite
O-Desmethylmetoprolol is a key drug metabolite derived from Metoprolol, primarily formed through the catalytic activity of the CYP2D6 enzyme. This metabolite is important for studying pharmacokinetics and drug interactions, as it shows significant impact on cardiovascular responses. Research applications include investigations in pharmacogenomics and personalized medicine, providing insights into variability in drug response among individuals. -
Drug Metabolite
Ibuprofen carboxylic acid is a major metabolite of Ibuprofen that serves as a valuable marker in environmental studies. This compound is notable for its prevalent concentrations in wastewater and aquatic ecosystems, and it is known for its rapid biodegradation in comparison to other ibuprofen metabolites. Research applications include monitoring pharmaceutical contaminants and assessing the environmental impact of non-steroidal anti-inflammatory drugs. -
Drug Metabolite Control
(2-Amino-5-bromophenyl)(pyridin-2-yl)methanone serves as a key precursor in the synthesis of benzodiazepines and acts as a hydrolysis product of Clonazepam. This compound is useful for research applications involving drug metabolism studies and the investigation of pharmacokinetic profiles for benzodiazepine derivatives. -
Drug Metabolite
Ritonavir metabolite is a key drug metabolite of Ritonavir, a well-known HIV protease inhibitor. This compound is primarily utilized in pharmacokinetic studies to understand the metabolism and pharmacological effects of Ritonavir. Its biological activity contributes to the assessment of drug interactions and therapeutic efficacy in HIV treatment research. -
Drug Metabolite Control
2-Amino-5-bromo-2'-chlorobenzophenone is a significant drug metabolite with applications in drug metabolism studies. It serves as a precursor in the synthesis of Phenazepam and is also identified as an active metabolite of this compound. Its relevance in pharmacokinetic research makes it a valuable reagent for investigations related to benzodiazepine metabolism. -
Drug Metabolite
N-Desbutyl Bupivacaine is a significant metabolite of Bupivacaine, functioning primarily as an NMDA receptor inhibitor and SCN5A antagonist. This compound plays a crucial role in the pharmacokinetics of Bupivacaine, contributing to its analgesic properties. It is utilized in research focused on pain management and the study of local anesthesia mechanisms, helping to better understand drug metabolism and efficacy. -
Drug Metabolite
Mono(3-carboxypropyl) phthalate (MCPP) is a metabolite of Di-n-octyl phthalate, a commonly used plasticizer in various polymer applications. MCPP serves as a valuable compound for studying the metabolic pathways and environmental impact of phthalates. Its analysis is important in toxicological assessments and understanding the biological effects of phthalate exposure. Researchers utilize MCPP to investigate the mechanisms of toxicity and potential health implications associated with phthalate metabolites. -
Drug Metabolite
Hydroxy desmethyl Bosentan is a metabolite of Bosentan, primarily produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. As a dual antagonist of endothelin-1 (ET) at the ETA and ETB receptors, it exhibits inhibitory constants (Ki) of 4.7 nM and 95 nM, respectively, in human smooth muscle cells. This compound is relevant for studies related to pulmonary arterial hypertension and provides insight into drug metabolism and pharmacokinetics of Bosentan. -
Stable Isotope
Omeprazole sulfone (methoxy-d3) is a deuterium-labeled metabolite of Omeprazole, a well-known proton pump inhibitor. This stable isotope is utilized to study metabolic pathways and pharmacokinetics of Omeprazole in various biological systems. Its unique labeling provides enhanced sensitivity and specificity in analytical applications, making it a valuable tool for researchers investigating drug metabolism and interactions. -
Stable Isotope
4-Desmethoxy Omeprazole-d3 is a deuterium-labeled form of 4-Desmethoxy Omeprazole, the active metabolite of the proton pump inhibitor Omeprazole. This compound primarily targets the CYP2C19 enzyme, exhibiting competitive inhibition with an inhibition constant (Ki) ranging from 2 to 6 μM. It has significant biological activity, including the suppression of gastric acid secretion and the inhibition of growth in both Gram-positive and Gram-negative bacteria. This reagent is valuable for studies involving drug metabolism, pharmacokinetics, and antimicrobial activity. -
Drug Metabolite
Citreoindole is a diketopiperazine metabolite derived from a hybrid cell fusion of two strains of Pseudomonas citreovirdi. It exhibits cytotoxic activity in vitro, demonstrating effectiveness against HeLa cells at a concentration of 8.4 μM. This compound serves as a valuable tool for research in cancer biology, particularly for investigating cytotoxic mechanisms and the metabolic pathways of drug metabolites. -
Drug Metabolite
Descarbamoyl cefuroxime is a drug metabolite that serves as a degradation product of the antibiotic Cefuroxime. This compound is significant in the synthesis of Cephalosporin antibiotics, making it a valuable intermediate for research in antibiotic development and metabolic studies. Its characterization aids in understanding the pharmacokinetics and efficacy of cefuroxime-based therapies. -
Drug Metabolite
trans-Hydroxy Glimepiride is an active metabolite of the sulfonylurea Glimepiride, primarily formed in the liver by the cytochrome P450 isoform CYP2C9. This metabolite exhibits significant biological activity relevant to glucose homeostasis and insulin secretion. It is utilized in pharmacokinetic studies and metabolic research to understand the influence of drug metabolism on therapeutic efficacy and safety profiles. -
Drug Metabolite
N-Desmethyl imatinib mesylate is an active metabolite of imatinib, primarily functioning as a selective inhibitor of the c-Abl kinase. It effectively binds to the c-Abl catalytic domain, obstructing substrate phosphorylation and inhibiting the c-Abl-mediated activation of α-synuclein, as well as associated inflammatory signaling pathways. This compound promotes apoptosis in K562 human leukemia cells and demonstrates enhanced plasma concentrations in gastrointestinal stromal tumor contexts, especially following mild SARS-CoV-2 infection. N-Desmethyl imatinib mesylate is valuable for research into Parkinson's disease, gastrointestinal stromal tumors, and chronic myeloid leukemia. -
Drug Metabolite
2S,4R-Sacubitril is a drug metabolite of Sacubitril, which inhibits neprilysin, leading to increased levels of natriuretic peptides. Its biological activity supports the treatment of heart failure in combination with valsartan, enhancing cardiovascular outcomes. This compound is valuable for research on drug metabolism and the pharmacological effects of heart failure therapies. -
Drug Metabolite
(S)-O-Desmethyl Venlafaxine N-Oxide is a major N-oxide metabolite of the active compound (S)-O-Desmethyl Venlafaxine, which itself is an important metabolite of the antidepressant Venlafaxine. This compound primarily targets serotonin and norepinephrine reuptake mechanisms, contributing to its pharmacological effects. It is valuable for research in understanding metabolic pathways and the pharmacodynamics of SNRIs in therapeutic settings. -
Drug Metabolite
(R)-Desmethylcitalopram oxalate is a drug metabolite derived from Citalopram. It plays a significant role in research related to neurological diseases, serving as a valuable tool for studying the pharmacokinetics and pharmacodynamics of antidepressant therapies. This compound allows for the exploration of synaptic mechanisms and potential therapeutic applications in mood disorders. -
Drug Metabolite
(±)17(18)-EpETE methyl ester is a drug metabolite derived from eicosapentaenoic acid (EPA). This compound functions as a mediator in various physiological processes and exhibits anti-inflammatory properties. It is essential in research investigating the metabolic pathways of EPA and its role in modulating inflammatory responses, potentially contributing to therapeutic strategies for inflammatory diseases. -
Drug metabolite
Ginsenoside V is a bioactive metabolite derived from Ginsenoside Rb1, primarily known for its role in modulating cellular signaling pathways. It exhibits various biological activities, including anti-inflammatory and antioxidant effects, making it relevant in research focused on pharmacological applications and herbal medicine studies. Ginsenoside V serves as an important compound for investigating the therapeutic potential of ginseng and its effects on human health. -
Drug Metabolite
1-epi-Regadenoson is an α-isomer impurity of Regadenoson, a potent and selective agonist for the adenosine A2A receptor. This compound is primarily used in research to investigate the pharmacological effects of adenosine receptor activation and its implications in cardiovascular function. The study of 1-epi-Regadenoson can aid in understanding the metabolic pathways and potential therapeutic effects associated with adenosine receptor modulation. -
Drug Metabolite
Pseudoerythromycin A enol ether is a notable degradation product of Erythromycin. As a drug metabolite, it serves as a valuable tool for studying metabolic pathways and the pharmacokinetics of macrolide antibiotics. While it does not exhibit significant antimicrobial activity, its role in research is crucial for understanding the biotransformation of erythromycin and its derivatives. -
Drug Metabolite
Trimetazidine-N-oxide is the primary active metabolite of Trimetazidine, known for its selective inhibition of long-chain 3-ketoyl coenzyme A thiolase, with an IC50 of 75 nM. This compound exhibits significant antianginal effects and possesses additional biological activities, including antioxidant, anti-inflammatory, antinociceptive, and gastroprotective properties. Trimetazidine-N-oxide serves as a valuable reagent for studies related to cardiac health, metabolic disorders, and the exploration of therapeutic mechanisms underlying these actions. -
Drug Metabolite
3α-Hydroxy pravastatin sodium is the principal metabolite of pravastatin, functioning as a competitive inhibitor of HMG-CoA reductase. This compound is implicated in the regulation of cholesterol biosynthesis and plays a crucial role in lipid metabolism studies. Its biological activity makes it valuable for research applications focusing on cardiovascular diseases and the pharmacokinetics of statin therapies. -
Drug Metabolite
N-(2-Hydroxyethyl)oxamic acid is a drug metabolite that results from the reduction of Metronidazole, either through chemical means or the action of intestinal bacteria. As a derivative of the nitroimidazole antibiotic, it exhibits activity against a range of protozoans as well as most Gram-negative and Gram-positive anaerobic bacteria. This metabolite is valuable for research into antibiotic metabolism and the pharmacokinetics of Metronidazole.
