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2S,4R-Sacubitril

Catalog No.: A70486
Drug Metabolite
2S,4R-Sacubitril is a drug metabolite of Sacubitril, which inhibits neprilysin, leading to increased levels of natriuretic peptides. Its biological activity supports the treatment of heart failure in combination with valsartan, enhancing cardiovascular outcomes. This compound is valuable for research on drug metabolism and the pharmacological effects of heart failure therapies.
2S,4R-Sacubitril 2307668-79-5 Drug Metabolite
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description2S,4R-Sacubitril is a drug metabolite of Sacubitril, which inhibits neprilysin, leading to increased levels of natriuretic peptides. Its biological activity supports the treatment of heart failure in combination with valsartan, enhancing cardiovascular outcomes. This compound is valuable for research on drug metabolism and the pharmacological effects of heart failure therapies.
Product Information
Catalog NumA70486
FormulaC25H31NO5
Molecular Weight425.52
CAS Number2307668-79-5
SMILES[H]N(C(CC(C)C(O)=O)=O)[C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C)C(OCC)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Metabolism > Drug Metabolite