Trimetazidine-N-oxide

Trimetazidine-N-oxide is the primary active metabolite of Trimetazidine, known for its selective inhibition of long-chain 3-ketoyl coenzyme A thiolase, with an IC50 of 75 nM. This compound exhibits significant antianginal effects and possesses additional biological activities, including antioxidant, anti-inflammatory, antinociceptive, and gastroprotective properties. Trimetazidine-N-oxide serves as a valuable reagent for studies related to cardiac health, metabolic disorders, and the exploration of therapeutic mechanisms underlying these actions.