Catalog No.
Product Name
Application
Product Information
Citations
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Drug Metabolite Control
α-Hydroxy flualprazolam is a hydroxylated metabolite of flualprazolam, functioning primarily as a drug metabolite control. This compound exhibits key biological activity by interacting with GABA-A receptors, contributing to its pharmacological effects. Its applications extend to forensic toxicology and drug screening, providing valuable insights in the detection of benzodiazepine metabolites in biological samples. -
Drug Metabolite
Para-hydroxy 2-methyl AP-237 hydrochloride is a key metabolite of 2-methyl AP-237. This compound is significant in drug metabolism studies, aiding in the understanding of metabolic pathways and the pharmacokinetics of its parent compound. Research applications include evaluating metabolic stability and assessing the impact of metabolism on therapeutic efficacy and safety profiles. -
Drug Metabolite Control
2-Amino-2'-fluoro-5-nitrobenzophenone is a key precursor in the synthesis of benzodiazepines, functioning as an important metabolite in drug development and research. This compound serves as an acid hydrolysis product of Flunitrazepam, making it significant for studies on drug metabolism and pharmacokinetics. Its ability to be utilized in the synthesis of benzodiazepine compounds highlights its relevance in medicinal chemistry and therapeutic research. -
Drug Metabolite
Aripiprazole N,N-Dioxide is a metabolite of the atypical antipsychotic agent aripiprazole, produced through its oxidative metabolism. This compound serves as an important research tool for studying the pharmacokinetics and metabolic pathways of aripiprazole. Its characterization can aid in understanding the drug's efficacy and side effects, as well as investigations into antipsychotic drug mechanisms. -
Drug Metabolite Control
5-Methoxy-N-isopropyl tryptamine is a tryptamine derivative primarily utilized as a drug metabolite control. This compound plays a significant role in pharmacological studies, providing insights into the metabolic pathways of psychoactive substances. Its biological activity facilitates research applications in neuropharmacology and toxicology, aiding in the understanding of drug interactions and effects. -
Drug Metabolite
N-desmethyl Netupitant is a drug metabolite of Netupitant, primarily involved in the pharmacokinetic evaluation of antiemetic therapies. This compound plays a significant role in understanding the drug's metabolism, bioavailability, and overall efficacy in clinical applications. Researchers can utilize N-desmethyl Netupitant in studies focused on drug interactions, metabolic pathways, and therapeutic outcomes in the treatment of nausea and vomiting. -
Drug Metabolite Control
Alphitonin is a flavonoid that serves as a metabolic intermediate in the catabolic pathway of Quercetin by the human gut bacterium E. ramulus. Its role in drug metabolism makes it a valuable compound for studies investigating the biotransformation and bioavailability of flavonoids. Research applications include examining the interactions between gut microbiota and flavonoid metabolism, as well as investigating potential health benefits associated with flavonoid consumption. -
Drug Metabolite Control
PB-22 N-pentanoic acid metabolite is a primary metabolite of the synthetic cannabinoid PB-22. This compound serves as a crucial marker for drug metabolite control, aiding in the detection and quantification of cannabinoid presence in biological samples. Its analytical utility is essential for pharmacokinetic studies and substance abuse research. -
Drug Metabolite Control
14S(15R)-EET methyl ester is a cytochrome P450 metabolite of arachidonic acid, functioning as an oxylipin. It plays a critical role in various biological processes, including modulating vascular tone and inflammation. This compound is valuable for research applications focusing on lipid signaling pathways and drug metabolism studies. -
Drug Metabolite
Norzopiclone is the inactive metabolite of the hypnotic drug Zopiclone. It exhibits notable anxiolytic properties, contributing to its potential applications in research focused on sleep disorders and anxiety-related conditions. This compound is useful for studying the pharmacokinetics of Zopiclone and its effects on the central nervous system. -
Drug Metabolite
Desmethyl Bosentan is an active metabolite of the endothelin receptor antagonist bosentan. It functions primarily by activating the pregnane X receptor (PXR), as demonstrated in CV-1 monkey kidney cells expressing the human receptor in a reporter assay at a concentration of 25 μM. This compound is valuable for studying drug metabolism and the regulatory pathways involved in pharmacokinetics and toxicology research. -
Drug Metabolites
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of dehydroepiandrosterone (DHEA), generated through the action of intracellular steroid 7α-hydroxylases, notably P450 2A1. This compound exhibits biological activity akin to DHEA while lacking the potential for androgenic or estrogenic conversion. 7α-Hydroxy-DHEA enhances the activity of thermogenic enzymes, including mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, promoting heat production and decreasing food utilization efficiency. This metabolite presents a promising avenue for research in obesity, metabolic diseases, and adrenal carcinoma. -
Drug Metabolite
Paraxanthine, a primary metabolite of caffeine, exerts neuroprotective effects by stimulating Ryanodine Receptor Channels, thereby offering protection against dopaminergic cell death. This compound is valuable in research focusing on neurodegenerative diseases and the role of caffeine metabolites in cellular signaling and survival pathways. Its utility extends to studies investigating the therapeutic potential of caffeine-related compounds in brain health. -
Drug Metabolite
3,4-Dihydroxybenzeneacetic acid is a key metabolite of dopamine, primarily associated with neuronal activity. This compound plays a significant role in the metabolism of neurotransmitters and can be used in research studies focused on neurochemistry and dopamine-related disorders. Its analysis aids in understanding the biochemical pathways involved in neurotransmission and the effects of dopamine in various neurological conditions. -
Drug Metabolite
4'-Hydroxy diclofenac is a drug metabolite derived from diclofenac, primarily processed by cytochrome P450 2C9 (CYP2C9). This compound exhibits anti-inflammatory and analgesic activities, making it valuable in pharmacological research focused on pain management and inflammation. Its role as a bioactive metabolite offers insights into drug metabolism and therapeutic efficacy. -
Drug Metabolite
Ternidazole hydrochloride is a hydroxymetabolite of nitroimidazole that targets protozoa, exhibiting notable antiprotozoic activity. It is primarily utilized in research related to drug metabolism and the pharmacokinetics of nitroimidazole derivatives. Its applications extend to studies of parasitic infections and the evaluation of therapeutic efficacy against protozoal pathogens. -
Drug Metabolite
1-Methylxanthine is a key metabolite derived from caffeine and theophylline, primarily functioning as a drug metabolite. It has been shown to enhance the radiosensitivity of tumor cells, making it relevant for cancer research and therapeutic studies involving radiation treatment. Its role in understanding drug metabolism and potential impacts on treatment efficacy make it an important reagent in pharmacological and biochemical investigations. -
Drug Metabolite
N-Desmethyl imatinib is an active metabolite of Imatinib, primarily targeting the c-Abl kinase by binding to its catalytic domain, thus inhibiting substrate phosphorylation. This compound exhibits significant biological activity by inhibiting c-Abl-mediated α-synuclein activation and modulating downstream inflammatory signaling pathways, which leads to apoptosis in K562 human leukemia cells. Research applications include the investigation of pediatric gastrointestinal stromal tumors, chronic myeloid leukemia, and potential implications in neurodegenerative disorders such as Parkinson's disease. Elevated plasma levels of N-Desmethyl imatinib following certain viral infections can offer insights into its therapeutic roles. -
Drug Metabolite
1-Methyluric acid is a metabolite of various drugs that primarily targets the urinary bladder mucosa. It is associated with increased levels of blood glucose, insulin, triglycerides, and cholesterol. This compound is relevant in research pertaining to metabolic disorders and the pharmacokinetics of drug metabolism, providing insights into the biochemical pathways involved in energy regulation and lipid metabolism. -
Drug Metabolite
Lignocaine N-oxide is a metabolite of lidocaine, primarily formed through the metabolism of lidocaine in liver microsomes. This compound serves as an important biomarker in pharmacokinetic studies, aiding in the understanding of lidocaine's metabolic pathways. It is utilized in research to investigate drug metabolism and potential pharmacological effects associated with lidocaine administration. -
Drug Metabolite
N-Deschlorobenzoyl indomethacin is a primary metabolite of indomethacin that lacks the N-p-chlorobenzoyl group. This alteration results in a significant reduction of its inhibitory activity against the enzymes AKR1C2 and AKR1C3, with an IC50 of 100 μM for AKR1C2 and an IC50 greater than 100 μM for AKR1C3, indicating no selectivity. This compound serves as a useful tool for studying the metabolic pathways and pharmacokinetics of indomethacin in various research applications. -
Drug Metabolite
N-Desmethyl Clomipramine Hydrochloride is a primary plasma N-desmethyl metabolite of Clomipramine, a tricyclic antidepressant. This compound serves as a significant biomarker in pharmacokinetic studies and therapeutic monitoring of Clomipramine treatment. Its relevance in understanding drug metabolism and efficacy makes it a valuable reagent in clinical and pharmaceutical research applications. -
Drug Metabolite
DL-Laudanosine, a metabolite of Atracurium and Cisatracurium, acts on the central nervous system by crossing the blood-brain barrier. It is known to induce excitatory responses and has been linked to seizure activity. This compound is used in research related to neuromuscular blockade and CNS effects of anesthetic agents. -
Drug Metabolite
3'-Hydroxy Repaglinide is a primary metabolite of Repaglinide, primarily formed through CYP2C8 enzymatic activity. As a carbamoylmethyl benzoic acid (CMBA) derivative, it plays a significant role in the pharmacokinetics of Repaglinide, a drug used for the management of type II diabetes. This compound is essential for understanding the metabolism and efficacy of Repaglinide in clinical research and drug development. -
Drug Metabolite
Clopidogrel carboxylic acid hydrochloride is an inactive metabolite of the antiplatelet agent clopidogrel, serving as a reference standard for the analysis of clopidogrel metabolism. It constitutes approximately 85% of the circulating clopidogrel, formed by hydrolysis of the active compound via esterase activity. This metabolite is essential for evaluating the pharmacokinetics and bioavailability of clopidogrel in both clinical and research environments, facilitating a deeper understanding of its therapeutic profile. -
Drug Metabolite
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole, produced via hepatic oxidative metabolism. This compound exhibits a plasma concentration that correlates with the administered dosage of Fomepizole and has a relatively short half-life. It acts as an inhibitor of alcohol dehydrogenase (ADH) in humans and monkeys; however, its inhibition constant is significantly higher than that of its parent compound, suggesting a minimal in vivo impact. It is primarily used for research on metabolic pathways and drug interactions. -
Drug Metabolite
Eicosapentaenoic acid methyl ester is a metabolite of monogalactosyl diacylglycerol, known for its role in inducing apoptosis. This compound demonstrates key biological activities that could be beneficial in cancer research, specifically in studies focused on apoptosis pathways and therapeutic interventions. Its applications extend to investigating the metabolic pathways of drug degradation and the evaluation of anticancer effects in various biological settings. -
Drug Metabolite
Apovincaminic acid hydrochloride salt is an active metabolite of Vinpocetine, primarily targeting neuroprotection. It possesses the ability to penetrate the blood-brain barrier, making it suitable for research into neuronal health and cognitive enhancement. This compound is utilized in studies focusing on neuroprotection and potential therapeutic applications in neurodegenerative disorders. -
Drug Metabolite
7-Hydroxymethotrexate is a key metabolite of Methotrexate, primarily produced through the hepatic metabolism of the drug. It is involved in the inhibition of dihydrofolate reductase, thereby blocking the conversion of folic acid to tetrahydrofolate and subsequently disrupting DNA synthesis. This compound is significant in pharmacokinetic studies and therapeutic monitoring of Methotrexate, aiding in understanding its efficacy and safety profiles in various treatment regimens. -
Drug Metabolite
Niraparib metabolite M1 is a bioactive metabolite of the poly(ADP-ribose) polymerase (PARP) inhibitor niraparib. This compound retains the biological effects associated with PARP inhibition, contributing to the understanding of niraparib's pharmacokinetics and pharmacodynamics. Niraparib metabolite M1 is relevant for investigating the mechanisms of action and therapeutic effects of PARP inhibitors in cancer research, particularly in the context of DNA repair and cellular response to genotoxic stress. -
Drug Metabolite
Monobenzyl phthalate is an aromatic alkyl chain monophthalate and a known drug metabolite. It exhibits significant antiandrogenic properties and has been shown to inhibit male reproductive development in rat fetuses. This compound is valuable for research focused on endocrine disruption and developmental toxicity assessments in toxicology studies. -
Drug Metabolite
Tofacitinib metabolite-1 is a metabolite derived from Tofacitinib, a selective inhibitor of Janus kinase (JAK) enzymes. This compound plays a critical role in pharmacokinetic and metabolic studies of Tofacitinib, facilitating the understanding of its bioavailability, metabolism, and overall therapeutic efficacy. Researchers can utilize Tofacitinib metabolite-1 to investigate its biological activity and potential impacts on various signaling pathways involved in inflammatory processes. -
Drug Metabolite
Quetiapine sulfoxide dihydrochloride is a primary metabolite of the second-generation antipsychotic quetiapine. This compound functions as a 5-HT receptor agonist and a dopamine receptor antagonist, contributing to its pharmacological effects. It is commonly utilized in research related to neuropharmacology and metabolic profiling of antipsychotic drugs, offering insights into the drug's therapeutic activity and safety profile. -
Drug Metabolite
Ribavirin carboxylic acid is a key metabolite of Ribavirin, primarily involved in antiviral mechanisms. This compound exhibits biological activity through its interaction with viral RNA polymerases, contributing to the inhibition of viral replication. It is commonly used in research to study the pharmacokinetics and therapeutic effects of Ribavirin, as well as to explore antiviral strategies against related viral infections. -
Drug Metabolite
Olanzapine N-oxide is a drug metabolite derived from the antipsychotic medication olanzapine. This compound is primarily studied for its role in the metabolic pathways of antipsychotics, specifically involving N-oxidation and N-demethylation processes, which are mediated by distinct enzymatic activities. Research indicates that the plasma concentration and clearance of Olanzapine N-oxide are influenced by multiple factors rather than being determined by single variables such as genotype or smoking status. -
Drug Metabolite
Ternidazole is a hydroxymetabolite of nitroimidazole, acting primarily as a drug metabolite. It exhibits notable antiprotozoal activity, making it relevant in the study of protozoan infections. This compound is utilized in research to investigate drug metabolism and the therapeutic efficacy of nitroimidazole derivatives. -
Drug Metabolite
Imipramine N-oxide is a primary metabolite of the tricyclic antidepressant Imipramine, classified as a tertiary amine. This compound exhibits neuropharmacological activity and is critical for studies on antidepressant metabolism and pharmacokinetics. Research applications include investigations into drug efficacy, side effects, and the metabolic pathways of tricyclic antidepressants in both in vitro and in vivo models. -
Drug Metabolite
1,3-Dimethyluric acid is a metabolite of theophylline, primarily involved in purine metabolism. This compound is significant in understanding metabolic pathways and can serve as a biomarker in studies related to theophylline pharmacokinetics. Additionally, it can contribute to research on urinary calculi formation due to its role as a purine component. -
Metabolin
5-Hydroxyomeprazole is the primary metabolite of Omeprazole, functioning as a proton pump inhibitor. It inhibits gastric acid secretion by targeting the proton pump in gastric parietal cells, thereby reducing acidity. This compound is valuable in research related to gastrointestinal physiology and pharmacokinetics, as well as in studies examining the effects of acid suppression on various physiological processes. -
Drug Metabolite
15-Acetyl-deoxynivalenol is a toxic trichothecene metabolite of deoxynivalenol, primarily affecting cellular health. This compound demonstrates significant toxicity in HepG2 liver cells, making it a valuable tool for studying the toxicological impacts of mycotoxins in food safety research. Its role in cellular responses to xenobiotic exposure offers insights into metabolic pathways and potential health risks associated with cereal contaminants. -
Drug Metabolite
2-Aminoflubendazole is a prominent metabolite of Benzimidazoles, a class of compounds known for their efficacy against fungi, protozoa, and helminths. This compound serves as a valuable tool in research applications aimed at understanding the metabolic pathways and pharmacological effects of benzothiazole derivatives. Its role in studying drug metabolism and toxicology offers important insights into the therapeutic potential and safety profiles of related therapeutic agents. -
Drug Metabolite
Ingenol disoxate is a drug metabolite known for its potential to mitigate actinic keratosis. It functions through a mechanism that may enhance cellular proliferation and modulate immune responses. This compound is valuable for research focused on dermatological conditions and the development of topical treatments for skin disorders. -
Drug Metabolite
Biprofen is a nonsteroidal anti-inflammatory drug metabolite that primarily targets cyclooxygenase enzymes. It exhibits significant anti-inflammatory and analgesic properties, making it valuable in research related to pain management and inflammatory diseases. Biprofen is utilized in studies investigating drug metabolism and the effects of anti-inflammatory therapies. -
Drug Metabolite
3-Hydroxy Medetomidine is a primary metabolite of the α2-adrenergic receptor agonist medetomidine. This compound exhibits important biological activity as it participates in modulating adrenergic signaling pathways. Research applications include studies on drug metabolism and the pharmacokinetics of sedatives in both veterinary and medical contexts. -
Drug Metabolite
T-705RMP ammonium is the ammonium derivative of T-705RMP and serves as a drug metabolite. It exhibits weak inhibition of inosine monophosphate dehydrogenase (IMPDH), which plays a critical role in purine biosynthesis. This compound is useful for investigating metabolic pathways and evaluating the pharmacokinetics of T-705RMP in biological research settings. -
Drug Metabolite
Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide that primarily functions as a hypoglycemic agent. This compound plays a significant role in glucose metabolism and insulin regulation, making it relevant in the study of diabetes and other metabolic disorders. Its biological activity is of particular interest for research applications focused on the development of antidiabetic therapies and understanding the pharmacokinetics of related compounds. -
Drug Metabolite
Dopamine 4-sulfate is an inactive metabolite of the neurotransmitter dopamine, generated through the catalytic action of the sulfotransferase enzyme SULT1A3. Although it exists in lower concentrations compared to other sulfated forms such as dopamine 3-O-sulfate, its presence in the brain and circulation is relevant for studies on dopamine metabolism and regulation. This compound is utilized in biochemical research examining dopamine's pharmacokinetics and its role in neurological pathways. -
Drug Metabolite
Acetaminophen metabolite 3-hydroxy-acetaminophen primarily targets oxidative stress through its role as a non-toxic metabolite and antioxidant of acetaminophen. This compound exhibits free radical scavenging activity, effectively reducing oxidative damage via electron donation facilitated by its phenolic hydroxyl groups. Research applications include studying the toxicity mechanisms and metabolic pathways associated with acetaminophen, thereby providing insights into its pharmacological effects. -
Drug Metabolite
N-Demethyl Ivabradine hydrochloride is a metabolite of Ivabradine, targeting the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. This compound exhibits significant activity in modulating cardiac rhythm by inhibiting the funny current (If), making it relevant for research in cardiovascular physiology and pharmacology. Its role in understanding drug metabolism and pharmacokinetics enhances its utility in studies related to cardiovascular diseases and treatment responses. -
Drug Metabolite
5-Hydroxythiabendazole is a notable drug metabolite of Thiabendazole. This compound serves as a critical biomarker for monitoring Thiabendazole exposure in biological samples. Its detection and quantification can aid in pharmacokinetic studies and investigations into drug metabolism and safety profiles in research settings.
