Catalog No.
Product Name
Application
Product Information
Citations
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Drug Metabolite
N-(2-Hydroxyethyl)oxamic acid is a drug metabolite that results from the reduction of Metronidazole, either through chemical means or the action of intestinal bacteria. As a derivative of the nitroimidazole antibiotic, it exhibits activity against a range of protozoans as well as most Gram-negative and Gram-positive anaerobic bacteria. This metabolite is valuable for research into antibiotic metabolism and the pharmacokinetics of Metronidazole. -
Drug Metabolite
(3R,5R)-Octahydrocurcumin is a gut microbial metabolite of Curcumin that acts as a neuroprotective agent. It demonstrates protective efficacy against Aβ25-35-induced cytotoxicity in SH-SY5Y cells and exhibits anti-inflammatory effects in LPS-stimulated mouse microglial BV-2 cells. This compound is valuable for research applications focused on neurodegenerative diseases and inflammation-related studies. -
Drug Metabolite
1-β-D-Glucosylsphingadienine (d18:2 (4E8E)) is a glucosylsphingosine derivative that serves as a key metabolite in the metabolism of glucosylcerebrosides. This compound exhibits important biological activity, influencing cellular signaling pathways and lipid metabolism. Its applications are significant in the study of lysolipid function and the pathological mechanisms underlying certain metabolic disorders. -
Drug Metabolite
2-Methylamino-1-phenylbutane hydrochloride is a primary metabolite of various stimulant agents, specifically involved in the pharmacokinetics of these compounds. This reagent is significant for research applications in toxicology and pharmacology, assisting in the analysis of drug metabolism and the assessment of stimulant effects in biological samples. Its utility extends to studies focused on understanding the biochemical pathways influenced by stimulant drugs. -
Drug Metabolite
2-Deoxokanshone M, a drug metabolite derived from Nardosinone, exhibits significant vasodilatory properties. This compound serves as a valuable tool in studying vascular biology and the pharmacokinetics of Nardosinone, contributing to research on its therapeutic applications in cardiovascular conditions. Its ability to modulate vascular tone makes it an important reagent for investigations into blood pressure regulation and related disorders. -
Drug metabolite
Isokotanin B is a metabolite derived from bicoumarin, obtained from the sclerotia of Aspergillus alliaceus. It demonstrates noteworthy biological activity against agricultural pests, specifically the corn earworm (Helicoverpa zea) and the dried fruit beetle (Carpophilus hemipterus). This compound serves as a valuable tool for research in pest management and biopesticide development. -
Drug Metabolite
N-Desmethyl-U-47700 is the primary metabolite of U-47700, functioning as an opioid receptor agonist. This compound exhibits significant analgesic properties and is relevant in research focused on opioid metabolism and pharmacokinetics. It serves as a critical tool for studying the effects and mechanisms of action associated with opioid compounds in various biological settings. -
Drug Metabolite
Silodosin Glucuronide sodium is the sodium salt of Silodosin β-D-glucuronide, a metabolite of the selective α1A-adrenergic receptor antagonist Silodosin. It exhibits high affinity for the α1A-AR, facilitating a Ki value of 0.036 nM. This compound is crucial for studying the pharmacokinetics and metabolic pathways of Silodosin, contributing to research applications in urology and cardiovascular studies. -
Drug Metabolite
Cyclo(Tyr-Val), also known as Cyclo(L-Tyr-L-Val), is a diketopiperazine secondary metabolite derived from the fungus Neurospora gilva. It has been identified for its potential role in drug metabolism studies, serving as a valuable tool for researchers investigating metabolic pathways and the pharmacokinetics of various compounds. Its unique structure and biological activity make it suitable for applications in biochemical research and drug development. -
Drug Metabolite
Buspirone N-oxide is a metabolite of Buspirone, a known 5-HT1A receptor agonist and dopamine D2 autoreceptor antagonist. This compound is significant in studying the pharmacokinetics and metabolic pathways of Buspirone. Due to its origin from an established anxiolytic agent, Buspirone N-oxide can be utilized in research related to generalized anxiety disorder and the evaluation of anxiety-modulating pathways. -
Drug Metabolite
Oxoprolintane is a primary metabolite of the psychoactive compound Prolintane, targeting the central nervous system. It plays a crucial role in the regulation of neurophysiological processes and presents potential neuroprotective properties. This compound is utilized in research focused on neurological diseases, providing insight into its therapeutic implications and mechanisms of action. -
Drug Metabolite
Tetranor-12(R)-HETE is a significant metabolite of 12(R)-HETE, formed through β-oxidation processes. This compound plays a crucial role in various metabolic pathways and has implications in studies involving lipid signaling and inflammatory responses. Its investigation can provide insights into the physiological and pathological mechanisms associated with eicosanoids. Tetranor-12(R)-HETE is useful for research applications in drug metabolism and the study of bioactive lipid mediators. -
Drug Metabolite
Carvedilol Glucuronide is a significant metabolite of the β/α-1 adrenergic receptor antagonist, Carvedilol. This compound demonstrates key biological activity by modulating β-adrenergic signaling and exhibits potential application in studying the metabolic pathway of Carvedilol. Research indicates that Carvedilol can inhibit lipid peroxidation and has properties as an antihypertensive agent, as well as an autophagy inducer that affects the NLRP3 inflammasome. Carvedilol Glucuronide serves as an important reagent for investigating drug metabolism and pharmacokinetics in cardiovascular research. -
Drug Metabolite
Florfenicol amine is the active metabolite of the veterinary antibiotic Florfenicol, known for its efficacy in combating susceptible bacterial infections in aquaculture. This compound plays a critical role in understanding the pharmacokinetics and safety of Florfenicol in various biological systems. Research applications include studying drug metabolism and evaluating the environmental impact of veterinary pharmaceuticals. -
Drug Metabolite
16-Phenyl tetranor Prostaglandin F2α is a metabolically stable analog of Prostaglandin F2α, targeting the FP receptor. Although it exhibits lower affinity at the FP receptor in ovine luteal cells (8.7%) compared to its parent compound, it serves as a valuable tool in pharmacological research. Its unique stability and receptor interaction profile make it suitable for studies involving prostaglandin signaling pathways and reproductive biology. -
Free Radical Scavenger
Cirsiliol 4′-glucoside is a free radical scavenger derived from Ruellia tuberosa L. This compound exhibits significant antioxidant properties, contributing to its potential anti-diabetic activity. Its ability to modulate oxidative stress makes it a valuable reagent for research in diabetes and related metabolic disorders. -
Tibolone Metabolite
3a-Hydroxytibolone is a metabolite of Tibolone, primarily targeting estrogen receptors. This compound exhibits significant biological activity relevant to breast cancer research, providing insights into hormone-related tumor proliferation. Its application extends to studies on the hormonal modulation of breast tissue and the development of therapeutic strategies for hormone-sensitive cancers. -
Active Metabolite
Dabigatran acyl-β-D-glucuronide is an active metabolite of the direct thrombin inhibitor Dabigatran. This compound enhances activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma, reflecting its anticoagulant properties. It is valuable for studying the pharmacokinetics and pharmacodynamics of anticoagulants in various research applications. -
Quinidine Metabolite
3-Hydroxyquinine is a metabolite of Quinidine, primarily targeting cardiac arrhythmias. It has been shown to prevent ventricular fibrillation and ventricular tachycardia in an isolated rat heart model after coronary reperfusion, demonstrating concentration-dependent effects. This compound is valuable for research focusing on cardiac pathophysiology and the mechanistic study of arrhythmias. -
Drug Metabolite
Ichangin is a drug metabolite derived from the ponderosa lemon (Citrus pyriformis) that exhibits significant antioxidant and anti-inflammatory properties. This compound is of interest in biochemical research for its potential therapeutic applications in oxidative stress-related disorders and inflammation. Its ability to modulate biological pathways makes Ichangin a valuable tool for investigating the effects of natural products in drug metabolism and pharmacology. -
Metabolite of Mosapride
Mosapride N-Oxide is a significant active metabolite of Mosapride, a gastroprokinetic agent that selectively targets the 5HT4 receptor. This compound plays a crucial role in enhancing gastrointestinal motility and is utilized in research exploring gastrointestinal disorders and neurogastroenterology. Its pharmacological properties offer valuable insights into the mechanisms underlying gut function and related therapeutic strategies. -
Tertiary Amine Metabolite
Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine, a skeletal muscle relaxant that exerts its effects on the central nervous system. This compound is formed in liver particles and is subject to enzymatic reduction by liver cytosolic reductases, converting it back to the parent amine. Cyclobenzaprine N-oxide serves as a valuable tool for studying the pharmacological activity and metabolism of Cyclobenzaprine in research applications related to muscle relaxation and neuropharmacology. -
Unsaturated Hydroxy Fatty Acid
(9Z)-16-Hydroxy-9-hexadecenoic acid is an unsaturated hydroxy fatty acid that serves as a bioactive compound in various biological processes. This fatty acid can be generated through the fermentation of Methyl palmitoleate using the yeast Torulopsis apicola. Its unique structural features contribute to its role in lipid metabolism and may have implications in studying metabolic pathways and related diseases. -
Azelastine Metabolite
Desmethylazelastine is the primary active metabolite of Azelastine, functioning as a selective and high-affinity antagonist of the histamine H1 receptor. With a protein binding rate of 97% and an elimination half-life of 54 hours, it plays a significant role in the pharmacological effects of Azelastine. This compound is valuable for research applications involving allergic rhinitis, asthma, diabetic hyperlipidemia, and studies related to SARS-CoV-2. -
Metabolite of Felbamate
SCH 54388 is an orally active metabolite of Felbamate, primarily targeting GABA and NMDA receptors. This compound significantly diminishes functional impairments associated with cognitive deficits induced by agents such as Scopolamine and Dizocilpine. SCH 54388 is suitable for research focused on cognitive impairment and neuroprotective mechanisms. -
Arachidonic acid Metabolite
8(S),9(R)-EET is an eicosanoid metabolite derived from arachidonic acid, produced through the enzymatic action of cytochrome P450. This compound exhibits potent vasodilatory effects, demonstrated by its ability to dilate canine epicardial arterioles in a concentration-dependent manner, with an EC50 value of 121 nM. 8(S),9(R)-EET is valuable in research applications focused on cardiovascular function and the role of arachidonic acid metabolites in vascular biology. -
H1R Antagonist
Fexofenadine Impurity F is a derivative of Fexofenadine, primarily acting as a histamine H1 receptor (H1R) antagonist. This compound exhibits biological activity associated with anti-allergic properties, making it relevant in the study of allergic reactions and potential therapeutic interventions for conditions such as seasonal allergic rhinitis and chronic idiopathic urticaria. It serves as a useful reagent for research in drug development and impurity profiling. -
Drug Metabolite
Bifenazate-diazene is a significant degradation product of Bifenazate, a selective carbazate acaricide and insecticide. This compound serves as a valuable tool for studying the metabolic pathways of Bifenazate, enabling researchers to investigate its environmental fate and bioactivity. Its applications extend to evaluating the effects of Bifenazate and its metabolites on various biological systems, contributing to the understanding of pesticide behavior and safety. -
Drug Metabolite
Ro 14-6113 is an inactive phenolic metabolite of the carotenoid compound Ro 15-0778, which is a derivative of vitamin A. This reagent serves as an important tool in studying the metabolic pathways of carotenoids and their influence on biological systems. It can be utilized in various research applications related to vitamin A metabolism and its physiological effects. -
Drug Metabolite
Avitinib-methyl is a drug metabolite of Avitinib, primarily functioning as a biomarker for pharmacokinetic studies. It plays a significant role in assessing drug metabolism and pharmacodynamics, particularly in understanding the bioavailability and efficacy of Avitinib in clinical research. This compound is valuable for researchers investigating the therapeutic window and safety profiles associated with Avitinib treatments. -
Drug Metabolite
Lurasidone Metabolite 14283-d8 is the deuterated form of the Lurasidone metabolite 14283, serving as a valuable tool for drug metabolism studies. This particular metabolite plays a significant role in understanding the pharmacokinetics and pharmacodynamics of Lurasidone. Researchers can utilize Lurasidone Metabolite 14283-d8 to trace metabolic pathways and quantify drug levels in biological samples, aiding in the development of therapeutic strategies. -
Drug Metabolite
8-Demethyl Ivabradine is a drug metabolite of Ivabradine, specifically targeting hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. This compound can be utilized in research to study the pharmacokinetics and pharmacodynamics of Ivabradine. Its role in modulating cardiac rhythm makes it relevant for investigations into cardiovascular physiology and therapeutic interventions. -
Drug Metabolite
Simvastatin Acyl-β-D-glucuronide is a primary metabolite of Simvastatin, which functions as a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. This compound plays a significant role in the pharmacokinetics of Simvastatin and is utilized in research applications focused on lipid metabolism and cholesterol regulation. Its analysis can provide insights into the metabolic pathways and efficacy of statin therapeutics. -
Drug Metabolite
T-705RMP is a phosphorylated metabolite of T-705 that primarily targets IMP dehydrogenase (IMPDH) activities in host cells. It demonstrates a very weak inhibitory effect, with an IC50 value of 601 μM. This compound can be utilized in research applications examining the metabolic pathways of antiviral agents and their effects on cellular processes. -
Drug Metabolite
5,6-Epoxy-13-cis retinoic acid is a drug metabolite of 13-cis retinoic acid, primarily involved in retinoid metabolism. This compound serves as a relevant research tool for studying the pharmacokinetics and pharmacodynamics of retinoids, particularly in the context of skin and cancer therapies. Its structural properties make it significant for investigations into metabolite interactions and their biological effects. -
Ilaprazole Metabolite
Ilaprazole sulfone is the primary metabolite of Ilaprazole, primarily formed through the activity of cytochrome P450 enzymes CYP3A4 and CYP3A5. As a metabolite of an oral proton pump inhibitor, Ilaprazole sulfone holds relevance in pharmacokinetic studies and the evaluation of drug interactions. Its examination may provide insights into the efficacy and safety profiles of proton pump inhibitors in clinical settings. -
Drug Metabolite
(S)-2-Ketodoxapram is a drug metabolite of Doxapram, which functions as a respiratory stimulant. This compound is crucial for studying the pharmacokinetics and metabolic pathways of Doxapram in various biological systems. It enables researchers to investigate its effects on respiration and potential therapeutic applications in respiratory disorders. -
Drug Metabolite
Chondroitin disaccharide Δdi-0S sodium is a drug metabolite derived from the degradation of Chondroitin sulfate. This unsaturated disaccharide can undergo derivatization with 2-aminopyridine to generate a fluorescent pyridylamino derivative, facilitating investigations into the metabolic pathway of Chondroitin sulfate. It is particularly useful for studying related disease mechanisms and elucidating the role of chondroitin in biologic systems. -
Drug Metabolite
2-Deoxokanshone L is a drug metabolite derived from the degradation of Nardosinone. It serves as a valuable marker in pharmacokinetic studies, aiding in the understanding of drug metabolism and disposition. This compound is essential for researchers investigating the metabolic pathways and therapeutic implications of Nardosinone and related compounds. -
Drug Metabolite Control
S-Methyl-D-penicillamine is a metabolite of the chelating agent Penicillamine, primarily involved in drug metabolite control. This compound exhibits significant biological activity in metal ion chelation, contributing to the detoxification and clearance of heavy metals from biological systems. It is employed in research applications focused on understanding metal metabolism and the biochemical pathways of chelation therapy. -
Drug Metabolite Control
7-APB hydrochloride is a benzofuran compound and a known metabolite of 7-MAPB. It serves as a valuable tool in drug metabolite control studies, enabling researchers to investigate the pharmacokinetics and metabolic pathways of related substances. Its application in toxicology and pharmacology research enhances the understanding of drug interactions and safety profiles in various biological contexts. -
Drug Metabolite
S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SF-cysteine) serves as a drug metabolite derived from Sulforaphane. This compound has demonstrated the ability to enhance the survival rate of Nalm-6 cells in cellular studies. Its potential applications in research may include investigations into cellular response mechanisms and protective effects of dietary phytochemicals. SF-cysteine represents a valuable tool for exploring the biochemical pathways associated with cancer and other diseases. -
Drug Metabolite
4,5-Desisopropylidene topiramate is a significant metabolite of Topiramate, primarily serving as a drug metabolite. This compound is important for studying the pharmacokinetics and pharmacodynamics of Topiramate, which is utilized in the treatment of epilepsy and migraine disorders. Researchers can leverage its unique properties to explore metabolic pathways and the drug's efficacy in various clinical contexts. -
Drug Metabolite
7-Hydroxy etodolac is a metabolite of etodolac, a non-steroidal anti-inflammatory drug that functions as a cyclooxygenase (COX) inhibitor. This compound is of interest in pharmacokinetic studies and metabolism research, providing insights into the metabolic pathways of NSAIDs. Its investigation can enhance the understanding of drug efficacy and safety profiles in therapeutic applications. -
Drug Metabolite
15-Hydroxy Lubiprostone is an active metabolite of the laxative drug Lubiprostone, primarily targeting chloride channels. This compound exhibits biological activity by promoting fluid secretion in the intestinal lumen, thereby facilitating bowel movements. It is mainly utilized in research applications focused on gastrointestinal pharmacology and the mechanisms of action related to chloride channel activation. -
Drug Metabolite
3-Hydroxy desalkylgidazepam is the active metabolite of Gidazepam, playing a crucial role in the pharmacokinetics of this compound. This metabolite exhibits biological activity relevant to the study of benzodiazepine metabolism and its effects on the central nervous system. Research applications include investigations into drug interactions, toxicology studies, and the assessment of pharmacological profiles of related compounds. -
Drug Metabolite
3-(Methylphosphinico)propionic acid is a known metabolite of the herbicide glufosinate ammonium, with implications for environmental monitoring and toxicology studies. This compound's biological activity can provide insights into the degradation pathways of glufosinate and its potential effects on ecosystems. Researchers utilize this metabolite to assess the presence and impact of herbicide residues in agricultural environments. -
Drug Metabolite
Raloxifene Bismethyl Ether is a drug metabolite derived from Raloxifene, characterized by the absence of both hydroxyl groups, rendering it inactive at estrogen receptors. This compound serves as a useful tool in pharmacokinetic studies to explore metabolic pathways and the biological effects of Raloxifene and its derivatives. Its stability and metabolic profile can aid in understanding its role in therapeutic applications and safety evaluations. -
Drug Metabolite Control
AB-CHMINACA metabolite M5A is a liver-derived metabolite of the synthetic cannabinoid AB-CHMINACA. It serves as a crucial component for drug metabolite control studies, offering insights into the pharmacokinetics of AB-CHMINACA and its effects on human health. This metabolite is valuable for toxicological research and forensic analysis related to synthetic cannabinoids. -
Drug Metabolite Control
(±)13,14-EDT is an oxylipin and a metabolite of adrenic acid, produced through the cytochrome P450 (CYP) metabolic pathway. This compound serves as a valuable control in drug metabolism studies, aiding in the understanding of the biotransformation processes of various pharmaceuticals. Its biological activity is crucial for elucidating the effects of drug metabolites on physiological responses, making it an important reagent for researchers investigating drug metabolism and toxicity.
